Decision-making changes for patients and medical personnel in the management of acute appendicitis during the COVID-19 pandemic

Decision-making changes for patients and medical personnel in the management of acute appendicitis during the COVID-19 pandemic | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Decision-making changes for patients and medical personnel in the management of acute appendicitis during the COVID-19 pandemic Xuan cai, Jingtao Bi, Zhixue Zheng, Yaqi Liu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1633362/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 8 You are reading this latest preprint version Abstract Background: Acute appendicitis is the most common cause of acute abdomen. During the pandemic, to contain the spread of COVID-19, there were some integral changes in the medical processes based on the pandemic prevention policy, especially about emergency surgery.This study was conducted to investigate whether thi s pandemic had also an impact on the decision-making for both patients and medical personnel along with the treatment outcomes. Methods: Patients of age 18 years or older who were diagnosed radiologically with acute appendicitis between Jan 1, 2017 and Dec 31, 2020 were reviewed. The data of 1991 cases were collected and used for this study. Two groups were formed, one group before and the other group after the outbreak.The gathered data included gender, age, appendiceal fecalith, outcomes of treatment, and long-term outcomes of non-operation (8 months follow-up). We also collected details of surgical cases from above two groups. This data also included age, gender, appendiceal fecalith, fever, jaundice, length of onset before presenting to an emergency department (ED), anesthesia, surgery, white cell count, pathology, complications, and length of stay. We compared above data respectively, and analyzed the differences. Results: Compared to the period before the outbreak, patient visits for acute appendicitis remarkably dropped (19.8%), but surgical cases showed no change (dropped by roughly 5%). There were significant differences (P<0.05) in failure of non-operation(after pandemic 8.31% vs. before pandemic 3.22%), interval appendectomy(after pandemic 6.29% vs. before pandemic 12.84%), recurrence , and outcomes of recurrence. There was a significant difference (P<0.05) in anesthesia method , surgery way, and complications( before pandemic 4.15% vs. after pandemic9.89% P0.05) with respect to age, gender, fever, jaundice, appendiceal fecalith, white cell count, and length of onset before presenting to the ED. Conclusions: Non-operation is a flexible and secure treatment option. Laparoscopic appendectomy might be a better choice than open surgery. The current pandemic prevention policy is very effective, but it affected the decision-making process of patients and medical personnel along with some treatment outcomes. COVID-19 Acute Appendicitis Emergency Treatment Decision-Making Laparoscopic Surgery Figures Figure 1 Figure 2 Background The first case of the novel coronavirus (COVID-19) was confirmed in December 2019 in Wuhan, China. COVID-19 has eventually turned into a global pandemic that is still spreading around the world. Several measures were implemented in various countries and regions to effectively contain the outbreak, and they were regularly altered as the pandemic changed. In China, this disease was specified as a Class B infectious disease by the Law of the People’s Republic of China on the Prevention and Treatment of Infectious Diseases and was regarded as class A infectious disease to warrant anti-epidemic measures. All these indeed blocked the spread of the virus, especially in China, but it also resulted in a change in the overall healthcare strategy with a tremendous impact on the healthcare system. There is little doubt that emergency surgeons are facing unprecedented challenges in this situation [1] . Acute appendicitis is a common disease in acute surgical conditions with a lifetime incidence rate as high as 7-8% [2, 3] . While numerous studies demonstrate that non-operative management with antibiotic therapy is a safe option for people with acute uncomplicated appendicitis [4, 5] , appendicectomy is still the primary management option [6, 7] . There have been multiple studies that reveal and share the experience of performing general surgery, including appendicectomy, as part of regular epidemic prevention and control. The related anti-epidemic process is becoming increasingly mature [8-10] . Beijing Jishuitan Hospital is a large comprehensive medical institution located in Beijing, the capital of China, which has been hit by this outbreak several times, since February 2020. Clinical activities have been carried out under regular epidemic prevention and control, which is a fact we must accept at present. There have been some investigations about the changes in treatment behavior of people with acute appendicitis [8, 11, 12] . However, to improve therapy in the post-pandemic era, we still need to discover and collect additional information, particularly about some of the effects on decision-making by both patients and medical personnel in the course of managing acute appendicitis. This study attempted to review and gather the information and data of patients diagnosed with acute appendicitis and treated in Beijing Jishuitan Hospital. Detecting and investigating this effect will help direct practices for the rest of the COVID-19 epidemic and possibly beyond. Materials And Methods After the COVID-19 breakout in Wuhan, China, several epidemic prevention policies were established and implemented immediately in our hospital. According to the policy, every patient of the emergency department (ED) with fever or epidemiological contact history has to undergo scanning for COVID-19. If the patient was required to be treated in emergency observation wards by a doctor, a Novel Coronavirus nucleic acid test must be done. Patients who were scheduled for emergency surgery were also administered a low-dose lung CT scan and a Novel Coronavirus antibody test. The patient would subsequently be treated under the appropriate pandemic protection level based on the results of these tests. Acute appendicitis was considered present when the appendiceal diameter exceeded 6 mm with wall thickening and at least one of the following was present: 1) abnormal contrast enhancement of the appendiceal wall, 2) inflammatory edema, or 3) fluid collections around the appendix [13, 14] . There have been numerous studies and guidelines that have concluded that non-operative treatment with antibiotics as the initial treatment for patients with uncomplicated acute appendicitis is a feasible alternative. Our hospital, on the other hand, adhered to the traditional principle and recommended an appendectomy as the primary treatment for patients showing symptoms for less than 72 hours, though this was not mandatory. Meanwhile, patients with at least one of the following symptoms or signs were strongly recommended to undergo surgery：fever, shiver, perforation, or diffuse peritonitis. The non-operative approach was used when patients explicitly refused surgery. In this situation, the patient was observed in the emergency ward and critically assessed repeatedly every 6-8 hours. Once the patient’s condition progressed, laparotomy was performed immediately. The criteria included aggravation of abdomen signs or symptoms, white cell count, or temperature rise. Patients with most of the acute inflammation resolved were also advised to have an interval appendectomy 6–8 weeks later. We retrospectively collected clinical data of all patients who were diagnosed with acute appendicitis and were treated in Beijing Jishuitan hospital during two time periods, one from January 1, 2017 to December 31, 2019 and second from February 1, 2020 to December 31, 2020. Inclusion criteria: 1. The diagnosis of acute appendicitis was confirmed by a CT scan of the abdomen; 2. Age of patients was at least 18 years; 3. Patients without any serious complications, ASA classification I or II. Exclusion criteria : 1. Patients with age less than 18 years; 2. Patients undergoing other surgery during the appendectomy; 3. Pregnant females with the appendix. There were 1740 reported cases of appendicitis from the period between January 1, 2017 and December 31, 2019, and 436 cases were included in this study from February 1, 2020 to December 31, 2020. The variation in the pattern of patient visits who were diagnosed as having acute appendicitis in ED is depicted in Figure 2. To obtain the information and details about the treatment during the acute phase of the appendix, all these visitors were followed up after 8 months by telephonic interview. This follow-up also facilitated analysis of recurrence, interval surgery, and outcomes of recurrence for patients who received non-operation treatment. Finally, there were 1582 cases with complete follow-up data during the period between January 1, 2017 and December 31, 2019. The success rate was 90.92%, and 289 underwent an appendectomy. For the data of 409 cases, collected between February 1, 2020 and December 31, 2020, the success rate was 93.81%. Ninety-one patients out of them were treated by surgery. There were two surgical options in this study, laparoscopic and traditional open methods. The above cases with the integrity of data were divided into two groups. One was the post-pandemic group, which consisted of 409 cases from the period between February 1, 2020 and December 31, 2020. The other was the pre-pandemic group, which consisted of 1582 cases over 3 years (2017-2019). Patients’ medical records including gender, age, imaging, laboratory results, appendiceal fecalith, operative details, and pathology results were extracted from the chart. Meanwhile, we also gathered details of the treatment process through telephonic follow-up (Table 1). The criteria of non-operative management failure were based on worsening of the signs and symptoms of patients who were treated by a non-surgical approach first followed by a surgical approach. The long-term prognosis of patients who were cured by antibiotics in their acute phase is shown in Table 2. There were 380 patients treated by appendectomy, and 91 of them were from the post-pandemic surgery group, while 289 were from the pre-pandemic group. We gathered data on the operation for these patients, including time of onset before visit, white blood cell count, temperature, liver function, operation method, anesthesia mode, time of stay in the hospital, pathology, and complications as shown in Table 3. Statistical analysis We used SPSS software version 19.0 (IBM Statistics) to analyze the data. Between-group comparisons for continuous variables were performed with Student’s t-test or Welch’s t-test, the latter if the variances differed significantly. Categorical variables were compared using Pearsonχ 2 test or Fisher’s exact test. Two-tailed P-values of 0.05 or less were considered statistically significant. Results Post-pandemic, the number of visits to the ED of Beijing Jishuitan hospital dropped significantly. The overall reduction was about 19.8% compared to previous years. However, compared to pre-pandemic years, the number of patients who underwent an appendectomy in the acute phase showed no remarkable change (dropped by roughly 5%). There were no significant differences in gender, age, and appendiceal fecalith before and after the pandemic (P>0.05). However, the treatment (P=0.022) and the outcomes of non-operative therapy (P=0.003) had changed significantly (P<0.05). The number of patients who experienced failure of non-operative treatment had increased significantly compared to that in the pre-pandemic period (after pandemic 8.31% vs. before pandemic 3.22%). The overall rate of non-operation approach getting converted to surgery was 8.31%. We also observed that fewer patients with a successful non-operation treatment were willing to opt for an interval appendectomy in the post-pandemic period (before pandemic 12.84% vs. after pandemic 6.89%, P<0.05). However, there was an increased recurrence rate in those patients (14.46% vs 23.27%), and the preference for appendectomy as the preferred treatment in the acute setting was lower in patients with increased recurrence than in patients before the outbreak (39.57% vs. 25.68%, P<0.05). While comparing the baseline characteristics and outcomes of the patients who underwent surgery in the ED before and after the pandemic, we found no statistical differences in age, gender, fever, appendiceal fecalith, jaundice, length of onset before presenting to ED, white cell count, and length of stay (P>0.05). There were significant differences in the way of anesthesia and surgery, pathology, and complications (P<0.05). The incidence rate of lumbar anesthesia and open appendectomy after the outbreak was higher than before. The complication rate in the post-pandemic group was also significantly higher than before (4.15% vs. 9.89% P<0.05). All cases of post-operation complications were surgical site infections except one case of deep vein thrombosis of the lower extremity in the pre-pandemic group. Discussion There are no signs that the pandemic is "winding down," but the healthcare system or hospitals are now prepared for such events. While measures and bills have been put in place to protect the surgical workforce from nosocomial infections by following current local guidelines, the "war" against this virus is expected to be long drawn. We know that the pandemic has not only affected the process of treatment for acute appendicitis deeply but has also changed the treatment decision-making leading to different outcomes. There is no report on the effect of the pandemic on the treatment of acute appendicitis. By comparing data before and after the outbreak, we found that the number of visits of appendicitis patients (roughly 19.8% drop) and the rate of interval appendectomy (pre-pandemic 12.84% vs. post-pandemic 6.29%) significantly declined, but the number of patients who underwent an emergency appendectomy and those who were pre-registered showed no remarkable change (dropped by roughly 5%). The failure rate of non-operation was increased (3.22% vs. 8.31%). Several other studies have also reported similar results of a decrease in visits by patients diagnosed with acute appendicitis during this outbreak. However, long-term follow-up data are not available [15, 16] . When we focused on patients who underwent an emergency appendectomy, the data showed that the length of onset before presenting to ED (20.91±17.06 h vs. 21.01±26.45 h) was similar to the length of onset before the breakout. Therefore, we speculated that there must be a certain number of patients experiencing uncomplicated appendicitis and who opted to stay at home with or without antibiotics, those patients significantly contributed to the decrease in the number of visits. Due to no change of emergency operation numbers and the length of onset, most of them might have eventually recovered. This might have led to a significant increase in the percentage of cases of gangrenous perforative appendicitis (Table.3). This result further confirmed that the non-operation approach can be used as a safe and effective alternative for acute uncomplicated appendicitis. A new meta-analysis in the setting of COVID-19 from Professor Sameh Hany Emile also provided the same result, and the study by professor Vishal K. Patel even included some complicated cases [17, 18] . However, the failure rate of non-operation significantly increased in our study, and there might have been a few patients with acute complicated appendicitis who refused the surgery on the first instance and were treated by non-operative management. Therefore, our view remains conservative and that non-operation treatment should be used only in uncomplicated acute appendicitis. There is certainly more scope to further define conservative treatment during this pandemic. In addition, People have concerns about contracting COVID-19 by visiting hospitals, and more or less some fear, anxiety and stresses by strictly screening and repeated epidemic. To reduce the probability of exposure to this virus, people avoided coming to the hospital or being hospitalized and prefer to take a wait-and-see attitude toward interval appendectomy. Therefore, we could find that the number of visits for interval appendectomy was lower in the post-pandemic period than the pre-pandemic period (12.84% vs. 6.29%), and the rate of emergency surgery for recurrences was also lower than before (39.57% vs. 25.68%, P<0.05) in our study. Meanwhile, that also showed a remarkably increased recurrence rate (23.27% vs. 14.46%) in patients with acute appendicitis 8 months after the treatment with the non-operation approach. But, under the effective pandemic prevention policy, there was actually no reported case of nosocomial infection from our hospital during the pandemic. In any case, we did not anticipate an ideal outcome. The above results also confirmed that the pandemic influenced the decision-making of patients and created an obstacle between hospitals and patients. Despite many studies favoring non-operative management, recent studies have shown that the increase in recurrence rate within 1 year after the first non-surgical treatment for acute appendicitis cannot be ignored. The five-year follow-up result from the famous APPAC trial showed that in the non-operative treatment group, the recurrence rate reached up to 32.8%, and most of these cases emerged during the period within one year after initial treatment [19-21] . However, whether an interval appendectomy after effective non-operative therapy could be considered routine has sparked heated controversy. Routine interval surgery is preferred after non-operative management for acute appendicitis, and this treatment applies only to patients with recurrent symptoms [7, 22, 23] . Acute appendicitis is fatal and should not be overlooked. Our recommendations should not exacerbate the dangerous situation in which patients with the highest recurrence risk are in a worse situation. For patients with recurrence, conservative treatment has repeatedly aggravated the economic burden and increased the health risk. Since the outbreak of COVID-19, the current anti-pandemic policy and measures have already shown their value for the guaranteed running of medical institutions. We should focus on strengthening the healthcare system for patients after their initial treatment. By optimizing the medical processes, we can dispel the fear of this infection and increase patients’ confidence about staying protected from the pandemic. The same strategy was applied to medical workers. After analyzing the data of patients who underwent an appendectomy in our hospital before and after the outbreak, the result showed that there were significant differences in anesthesia method, surgery procedure, and complications. According to the measures of our hospital for COVID-19 control and prevention, every in-patient is needed to undergo a Novel Coronavirus nucleic acid test or antibody test and low dose lung CT scan before admission. Based on the test results and patient histories, we determined the protective class for the surgery. It is up to the surgeon and anesthesiologist to decide whether or not to open the airway during surgery. The number of lumbar anesthesia cases steeply increased. However, there was no positive COVID-19 case, and all patients who were admitted to the hospital were mandatorily ruled out for COVID-19. This result reflected that anesthesiologists preferred lumbar anesthesia over general anesthesia during the pandemic period as chances of viral exposure are considerably higher in the case of airway opening. The literature also supports the importance of aerosol transmission of infectious diseases [24] . Therefore, these factors could have led to a significant decrease in the number of laparoscopic appendectomies. After comparing the treatment outcome of the two periods, the rate of postoperative complications was significantly higher than that before the outbreak (4.5% vs. 9.89%; P<0.05). With the development and popularization of laparoscopic technique, several guidelines and specialist s have recommended laparoscopic appendectomy as the primary treatment for acute appendicitis [7] . Many studies pointed out that compared to an open appendectomy, laparoscopic surgery leads to a desirable outcome, lower rate of complications, shorter postoperative recovery time, less postoperative pain, and scarring. There was no effect on the operation time [25, 26] . In our study, only one patient had to be converted to open surgery during LA. The number of patients who underwent open surgery increased in the post-pandemic era, and the rate of postoperative complications was also significantly higher than before, particularly the rate of surgical site infections. Of course, The increase in gangrenous perforative appendicitis (Table 3) also contributed to these negative outcomes [27] . Therefore, we could not conclude that the significant decrease in the number of laparoscopic appendectomies results in an increased incidence of complications, but it is at least a risk factor. Moreover, as seen with our previous analyses, the incidence of gangrenous perforative appendicitis also increased in the post-pandemic era. Meanwhile, professor Georgios Markides and Gaik S Quah report that LA is superior to open surgery for complicated appendicitis [25, 28] . As a result, given the current anti-pandemic environment, we should make use of laparoscopy to improve treatment outcomes and promote laparoscopic surgery as the first line of treatment for acute appendicitis. The safe and effective pandemic prevention and its influence on the decision of medical personnel is conflicted. More research on anti-pandemic methods will further enhance medical personnel’s confidence and increase the use of general anesthesia. Conclusions In conclusion, the non-operative approach could be an option for acute appendicitis, which is now verified as a flexible and secure treatment approach. However, a thorough clinical examination is necessary to ensure that the surgical intervention may be completed quickly. COVID-19 has spread rapidly to transform into a pandemic and has affected not only our lifestyle but also the decision-making of patients and medical workers. Although these changes did not significantly increase the incidence of serious adverse events related to acute appendicitis, the increased recurrence rate and complications with decreased rates of surgery in patients with recurrent episodes will eventually lift the burden on the whole healthcare system. Under the current anti-pandemic policy, we should work to strengthen the faith and reduce the fear for people. Certainly, the increased vaccination coverage might improve the situation. Further studies on this topic should be pursued. In the context of anti-pandemic efforts, we need to obtain more comprehensive information regarding treatment strategies to ensure patient safety. Abbreviations emergency department (ED); novel coronavirus (COVID-19); open appendectomy (OA); laparoscopic appendectomy (LA) Declarations Ethics: Ethics approval and consent to participate Ethical approval was waived by the local Ethics Committee of Beijing Jishuitan Hospital in view of the retrospective nature of the research and all the procedures being performed were part of the routine care. Statement of Informed Consent: Informed consent was obtained from all individual participants included in the study.The participant has consented to the submission of article to the journal. Availability of data and materials ： The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. Competing interests ： The authors declare that they have no competing interests. Funding ： The authors have not received any funding from any company. Authors' contributions: Xuan Cai is responsible for gathering, analyzing and interpreting the patient data regarding the acute appendicitis before and after the pandemic, was a major contributor in writing the manuscript. Jingtao Bi, Zhixue Zheng and Yaqi Liu participated in treatment and performed surgery for those patients. All authors read and approved the final manuscript. Author’s information: The authors of this study are working in general surgery, a department of Beijing Jishuitan hospital, as a team being responsible for emergency surgery. Xuan Cai, Zhixue Zheng and Yaqi Liu are attending doctors, Jingtao Bi is a Chief Physician who are experienced surgeon(more than 10 years length of serve) and capable of perform emergency surgery including appendicectomy . Since the outbreak of COVID-19, the region where they are working has been hit by the pandemic several times. Beijing Jishuitan Hospital is a large comprehensive medical institution located in Beijing, the capital of China. It mainly serves two mega communities which has a population of over 400000 respectively. Meanwhile, Clinical activities have been carried out under regular epidemic prevention and control, which is a fact we must accept at present. Emergency surgeons are facing unprecedented challenges in this situation. We have witnessed the pandemic has been under control in china through the effective pandemic prevention policy, though we observed some changes in decision-making for both patients and medical personnel along with the treatment outcomes. References Cheeyandira A. The effects of COVID-19 pandemic on the provision of urgent surgery: a perspective from the USA. J Surg Case Rep. 2020. 2020(4): rjaa109. Stewart B , Khanduri P , McCord C, et al. Global disease burden of conditions requiring emergency surgery . Br J Surg . 2014 . 101 ( 1 ): e9-22 . Hardin DM Jr . 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A closer look at neoplasm rates in adult patients undergoing interval appendectomy after complicated appendicitis . Surg Endosc . 2021 . 35 ( 7 ): 3855–3860 . Tang S , Mao Y , Jones RM, et al. Aerosol transmission of SARS-CoV-2? Evidence, prevention and control . Environ Int . 2020 . 144 : 106039 . Quah GS , Eslick GD , Cox MR . Laparoscopic appendicectomy is superior to open surgery for complicated appendicitis . Surg Endosc . 2019 . 33 ( 7 ): 2072–2082 . Güler Y , Karabulut Z , Çali? H , ?engül S . Comparison of laparoscopic and open appendectomy on wound infection and healing in complicated appendicitis . Int Wound J . 2020 . 17 ( 4 ): 957–965 . Emile SH , Elfallal AH , Elbaz SA , Elmetwally AM . Development and validation of risk prediction score for incisional surgical site infection after appendectomy . Updates Surg . 2021 . 73 ( 6 ): 2189–2197 . Markides G , Subar D , Riyad K . Laparoscopic versus open appendectomy in adults with complicated appendicitis: systematic review and meta-analysis . World J Surg . 2010 . 34 ( 9 ): 2026-40 . Tables Table 1 Comparison of treatment before and after the pandemic Pre-pandemic group Post-pandemic group P-value Cases 1582 409 Age 0.304 60years 286（18.1%） 83（20.29%） Appendiceal fecalith 0.247 Yes 361（22.82%） 105（27.87%） No 1221（77.18%） 304（72.13%） Gender 0.359 Male 864(54.61%) 213(52.08%) Female 718(45.39%) 196(47.92%) Treatment 0.022 * Operation 238（15.04%） 57（13.94%） Non-operation 1293（81.73%） 318（77.75%） Failure of non-operation a 51（3.22%） 34（8.31%） *: P＜0.05, statistically significant a: The criteria of non-operative management failure were based on worsening of the signs and symptoms of patients who were treated by a non-surgical approach first followed by a surgical approach. Table 2 Long-term outcomes of non-operation before and after the pandemic Pre-pandemic group Post-pandemic group P-value Non-operation 1293 318 outcomes （ 8 months ） 0.003 * Interval appendectomy 166(12.84%) 20（6.29%） No recurrence 940（72.7%） 224（70.44%） recurrence 187（14.46%） 74（23.27%） Outcomes of recurrence 187 74 0.035 * Operation 74（39.57%） 19（25.68%） Non-operation 113（60.43%） 55（74.32%） *: P＜0.05, statistically significant Table 3 Comparison of operative treatment before and after the pandemic Pre-pandemic group Post-pandemic group P - value Cases 289 91 Age 0.373 60years 37（12.8%） 15（16.48%） Gender 0.288 Male 180（62.28%） 51（56.04%） Female 109（37.72%） 40（43.96%） Appendiceal fecalith 0.194 Yes 185（64.01%） 65（71.43%） No 104(35.99%） 26（28.57%） Fever （ >37.5°C ） 0.259 Yes 29（10.03%） 13（14.29%） No 260（89.97%） 78（85.71%） Jaundice 0.505 Yes 129（44.64%） 37（40.66%） No 160（55.36%） 54（59.34%） Anesthesia 0.005 * Lumbar anesthesia 84（29.07%） 41（45.25%） General anesthesia 205（70.93%） 50（54.95%） Surgery OA 89（30.8%） 49（53.85%） 0.007 * LA 200（69.2） 42（46.15%） Conversion to open surgery 1 0 Length of onset before presenting to ED （ h ） 20.91±17.06 21.01±26.45 0.972 White cell count(10 9 /L) 14.14±3.88 15.08±3.51 0.096 Pathology 0.016* Gangrene 79(27.34%) 37(40.66%) Non-gangrene 210(72.66%) 54(59.34%) Complications 0.037 * Yes 12（4.15%） 9（9.89%） No 277（95.85%） 82（90.11%） Length of stay （ days ） 4.73 5.14 0.467 *: P＜0.05, statistically significant Abbreviations: emergency department (ED); novel coronavirus (COVID-19); open appendectomy (OA); laparoscopic appendectomy (LA) Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Major revision 25 Aug, 2022 Reviews received at journal 07 Aug, 2022 Reviewers agreed at journal 02 Aug, 2022 Reviewers invited by journal 01 Aug, 2022 Editor assigned by journal 01 Aug, 2022 Editor invited by journal 01 Aug, 2022 Submission checks completed at journal 01 Aug, 2022 First submitted to journal 07 May, 2022 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1633362","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":125549572,"identity":"f157fad2-2ecb-4b6b-b78b-a623f9d18250","order_by":0,"name":"Xuan cai","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA/0lEQVRIiWNgGAWjYFACxvYPCQYSPGzMjI2Pf1QABZiZGwhoYT7G8KHAQo6PvfmwMcMZkAAjIS1saYwzPlQYy/EcS5NmbAPbi18L/4wcs8c8BhKJbRI5BtKF82qj+duBWn5UbMOpReLMGXNjmBbjmduO5844zNjA2HPmNk4tBuw9BtIwLQm8247lNgC1MDO24dHCzIPQcoB3zrHc+QS1sLelSc4wkDBm4zmW2MzbUJO7gZAWiTOHDxt8MJCQYwMGMuOMYwdyNwK1HMTnF/4ZiY0PEv7U8cg3M7b/+FBTlzvv/OGDD35U4NaCDg6DyQNEqweCOlIUj4JRMApGwQgBAOS6W4BtisFDAAAAAElFTkSuQmCC","orcid":"","institution":"Beijing Jishuitan Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Xuan","middleName":"","lastName":"cai","suffix":""},{"id":125549573,"identity":"1613ac1c-11e9-420f-b090-7d18fd27c847","order_by":1,"name":"Jingtao Bi","email":"","orcid":"","institution":"Beijing Jishuitan Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jingtao","middleName":"","lastName":"Bi","suffix":""},{"id":125549575,"identity":"bbcce7c4-44b2-47a0-b08d-418f9b958bec","order_by":2,"name":"Zhixue Zheng","email":"","orcid":"","institution":"Beijing Jishuitan Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zhixue","middleName":"","lastName":"Zheng","suffix":""},{"id":125549577,"identity":"a54f5511-ca4d-4613-a18c-69c11ba3ecbc","order_by":3,"name":"Yaqi Liu","email":"","orcid":"","institution":"Beijing Jishuitan Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yaqi","middleName":"","lastName":"Liu","suffix":""}],"badges":[],"createdAt":"2022-05-07 14:44:02","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-1633362/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-1633362/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":24741510,"identity":"0ecbfcf8-0240-4254-b3a1-eb0fa0f2131a","added_by":"auto","created_at":"2022-08-03 18:15:49","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":132906,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eAlgorithm for diagnosis and treatment of adult patients with suspected acute appendicitis\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"Figure1.png","url":"https://assets-eu.researchsquare.com/files/rs-1633362/v1/76f3e48c5b331201322410fb.png"},{"id":24741511,"identity":"52be4608-ca32-4630-9c1a-9c2379f49b5c","added_by":"auto","created_at":"2022-08-03 18:15:49","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":60887,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eVisits of patients with acute appendicitis from February to December in 2017, 2018, 2019, and 2020\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"Figure2.png","url":"https://assets-eu.researchsquare.com/files/rs-1633362/v1/0b14210c26a7615180eeff23.png"},{"id":24741512,"identity":"a600a3b5-0c85-47a9-8dcd-44d25f25d806","added_by":"auto","created_at":"2022-08-03 18:15:52","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":563878,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1633362/v1/bc9bf76e-8179-4ba0-9290-34294454f7a8.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Decision-making changes for patients and medical personnel in the management of acute appendicitis during the COVID-19 pandemic","fulltext":[{"header":"Background","content":"\u003cp\u003eThe first case of the novel coronavirus (COVID-19) was confirmed in December 2019 in Wuhan, China. COVID-19 has eventually turned into a global pandemic that is still spreading around\u0026nbsp;the world. Several measures were implemented in various countries and regions to effectively contain the outbreak, and they were regularly altered as the pandemic changed. In China, this disease was specified as a Class B infectious disease by the Law of the People\u0026rsquo;s Republic of China on the Prevention and Treatment of Infectious Diseases and was regarded as class A infectious disease to warrant anti-epidemic measures. All these indeed blocked the spread of the virus, especially in China, but it also resulted in a change in the overall healthcare strategy with a\u0026nbsp;tremendous\u0026nbsp;impact on the healthcare system.\u0026nbsp;There is little doubt that emergency surgeons are facing\u0026nbsp;unprecedented challenges\u0026nbsp;in this situation\u003csup\u003e[1]\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eAcute appendicitis is a common disease in acute surgical conditions with a lifetime incidence rate as high as 7-8%\u003csup\u003e[2, 3]\u003c/sup\u003e. While numerous studies demonstrate that non-operative management with antibiotic therapy is a safe option for people with acute uncomplicated appendicitis\u003csup\u003e[4, 5]\u003c/sup\u003e, appendicectomy is still the primary management option\u003csup\u003e[6, 7]\u003c/sup\u003e. There have been multiple studies that reveal and share the experience of performing general surgery, including appendicectomy, as part of regular epidemic prevention and control. The related anti-epidemic process is\u0026nbsp;becoming increasingly mature\u003csup\u003e[8-10]\u003c/sup\u003e. Beijing Jishuitan Hospital is a large comprehensive medical institution located in Beijing, the capital of China, which has been hit by this outbreak several times, since February 2020. Clinical activities have been carried out under regular epidemic prevention and control, which is a fact we must accept at present.\u003c/p\u003e\n\u003cp\u003eThere have been some investigations about the changes in treatment behavior of people with acute appendicitis\u003csup\u003e[8, 11, 12]\u003c/sup\u003e. However, to improve therapy in the post-pandemic era, we still need to discover and collect additional information, particularly about some of the effects on decision-making by both patients and medical personnel in the course of managing acute appendicitis. This study attempted to review and gather the information and data of patients diagnosed with acute appendicitis and treated in Beijing Jishuitan Hospital. Detecting and investigating this effect will help direct practices for the rest of the COVID-19 epidemic and possibly beyond.\u003c/p\u003e"},{"header":"Materials And Methods","content":"\u003cp\u003eAfter the COVID-19 breakout in Wuhan, China, several epidemic prevention policies were established and implemented immediately in our hospital. According to the policy, every patient of the emergency department (ED) with fever or epidemiological\u0026nbsp;contact\u0026nbsp;history has to undergo scanning for COVID-19. If the patient was required to be treated in emergency observation wards by a doctor, a Novel Coronavirus nucleic acid test must be done. Patients who were scheduled for emergency surgery were also administered a low-dose lung CT scan and a Novel Coronavirus antibody test. The patient would subsequently be treated under the appropriate pandemic protection level based on the results of these tests. Acute appendicitis was considered present when the appendiceal diameter exceeded 6 mm with wall thickening and at least one of the following was present: 1) abnormal contrast enhancement of the appendiceal wall,\u0026nbsp;2) inflammatory edema, or\u0026nbsp;3) fluid collections around the appendix\u003csup\u003e[13, 14]\u003c/sup\u003e. There have been numerous studies and guidelines that have concluded that non-operative treatment with antibiotics as the initial treatment for patients with uncomplicated acute appendicitis is a feasible\u0026nbsp;alternative. Our hospital, on the other hand, adhered to the traditional principle and recommended an appendectomy as the primary treatment for patients showing symptoms for\u0026nbsp;less than 72 hours, though this was not mandatory. Meanwhile, patients with at least one of the following symptoms or signs were strongly recommended to undergo surgery：fever, shiver, perforation, or diffuse peritonitis. The non-operative approach was used when patients explicitly refused surgery. In this situation, the patient was observed in the emergency ward and critically assessed repeatedly every 6-8 hours. Once the patient\u0026rsquo;s condition progressed, laparotomy was performed immediately. The criteria included aggravation of abdomen signs or symptoms, white cell count, or temperature rise. Patients with most of the acute inflammation resolved were also advised to have an interval appendectomy 6\u0026ndash;8 weeks later.\u003c/p\u003e\n\u003cp\u003eWe retrospectively collected clinical data of all patients who were diagnosed with acute appendicitis and were treated in Beijing Jishuitan hospital during two time periods, one from January 1, 2017 to December 31, 2019 and second from February 1, 2020 to December 31, 2020. Inclusion criteria: 1. The diagnosis of acute appendicitis was confirmed by a CT scan of the abdomen; 2. Age of patients was at least 18 years; 3. Patients without any serious complications, ASA classification I or II. \u003ca href=\"javascript%3A;\"\u003eExclusion\u003c/a\u003e \u003ca href=\"javascript%3A;\"\u003ecriteria\u003c/a\u003e: 1. Patients with age less than 18 years; 2. Patients undergoing other surgery during the appendectomy; 3. Pregnant females with the appendix. There were 1740 reported cases of appendicitis from the period between January 1, 2017 and December 31, 2019, and 436 cases were included in this study from February 1, 2020 to December 31, 2020. The variation in the pattern of patient visits who were diagnosed as having acute appendicitis in ED is depicted in Figure 2. To obtain the information and details about the treatment during the acute phase of the appendix, all these visitors were followed up after 8 months by telephonic\u0026nbsp;interview. This follow-up also facilitated analysis of recurrence, interval surgery, and outcomes of recurrence for patients who received non-operation treatment. Finally, there were 1582 cases with complete\u0026nbsp;follow-up data during the period between January 1, 2017 and December 31, 2019. The success rate was 90.92%, and 289 underwent an appendectomy. For the data of 409 cases, collected between February 1, 2020 and December 31, 2020, the success rate was 93.81%. Ninety-one patients out of them were treated by surgery. There were two surgical\u0026nbsp;options in this study, laparoscopic and traditional open methods.\u003c/p\u003e\n\u003cp\u003eThe above cases with the integrity of data were divided into two groups. One was the post-pandemic group, which consisted of 409 cases from the period between February 1, 2020 and December 31, 2020. The other was the pre-pandemic group, which consisted of 1582 cases over 3 years (2017-2019). Patients\u0026rsquo; medical records including gender, age, imaging, laboratory results, appendiceal fecalith, operative details, and pathology results were extracted from the chart. Meanwhile, we also gathered details of the treatment process through telephonic follow-up (Table 1). The criteria of non-operative management failure were based on worsening of the signs and symptoms of patients who were treated by a non-surgical approach first followed by a surgical approach. The long-term prognosis of patients who were cured by antibiotics in their acute phase is shown in Table 2. There were 380 patients treated by appendectomy, and 91 of them were from the post-pandemic surgery group, while 289 were from the pre-pandemic group. We gathered data on the operation for these patients, including time of onset before visit, white blood cell count, temperature, liver function, operation method, anesthesia mode, time of stay in the hospital, pathology, and complications as shown in Table 3.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe used SPSS software version 19.0 (IBM Statistics) to analyze the data. Between-group comparisons for continuous variables were performed with Student\u0026rsquo;s t-test or Welch\u0026rsquo;s t-test, the latter if the variances differed significantly. Categorical variables were compared using Pearson\u0026chi;\u003csup\u003e2\u003c/sup\u003e test or Fisher\u0026rsquo;s exact test. Two-tailed P-values of 0.05 or less were considered statistically significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003ePost-pandemic, the number of visits to the ED of Beijing Jishuitan hospital dropped significantly. The overall reduction was about 19.8% compared to previous years. However, compared to pre-pandemic years, the number of patients who underwent an appendectomy in the acute phase showed no remarkable change (dropped by roughly 5%). There were no significant differences in gender, age, and appendiceal fecalith before and after the pandemic (P\u0026gt;0.05). However, the treatment (P=0.022) and the outcomes of non-operative therapy (P=0.003) had changed significantly (P\u0026lt;0.05). The number of patients who experienced failure of non-operative treatment had increased significantly compared to that in the pre-pandemic period (after pandemic 8.31% vs. before pandemic 3.22%). The overall rate of non-operation approach getting converted to surgery was 8.31%. We also observed that fewer patients with a successful non-operation treatment were willing to opt for an interval appendectomy in the post-pandemic period (before pandemic 12.84% vs. after pandemic 6.89%, P\u0026lt;0.05). However, there was an increased recurrence rate in those patients (14.46% vs 23.27%), and the preference for appendectomy as the preferred treatment in the acute setting was lower in patients with increased recurrence than in patients before the outbreak (39.57% vs. 25.68%, P\u0026lt;0.05). While comparing the baseline characteristics and outcomes of the patients who underwent surgery in the ED before and after the pandemic, we found no statistical differences in age, gender, fever, appendiceal fecalith, jaundice, length of onset before presenting to ED, white cell count, and length of stay (P\u0026gt;0.05). There were significant differences in the way of anesthesia and surgery, pathology, and complications (P\u0026lt;0.05). The incidence rate of lumbar anesthesia and open appendectomy after the outbreak was higher than before. The complication rate in the post-pandemic group was also significantly higher than before (4.15% vs. 9.89% P\u0026lt;0.05). All cases of post-operation complications were surgical site infections except one case of deep vein thrombosis of the lower extremity in the pre-pandemic group.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThere are no signs that the pandemic is \u0026quot;winding down,\u0026quot; but\u0026nbsp;the healthcare system or\u0026nbsp;hospitals are now\u0026nbsp;prepared for such events. While measures and bills have been put in place to protect the surgical workforce\u0026nbsp;from nosocomial infections by following current local guidelines, the \u0026quot;war\u0026quot; against this virus is expected to be long drawn. We know that the pandemic has not only affected the process of treatment for acute appendicitis deeply but has also changed the treatment decision-making leading to different outcomes. There is no report on the effect of the pandemic on the treatment of acute appendicitis. By comparing data before and after the outbreak, we found that the number of visits of appendicitis patients (roughly 19.8% drop) and the rate of interval appendectomy (pre-pandemic 12.84% vs. post-pandemic 6.29%) significantly declined, but the number of patients who underwent an emergency appendectomy and those who were pre-registered showed no remarkable change (dropped by roughly 5%). The failure rate of non-operation was increased (3.22% vs. 8.31%). Several other studies have also reported similar results of a decrease in visits by patients diagnosed with acute appendicitis during this outbreak. However, long-term follow-up data are not available\u003csup\u003e[15, 16]\u003c/sup\u003e. When we focused on patients who underwent an emergency appendectomy, the data showed that the length of onset before presenting to ED (20.91\u0026plusmn;17.06 h vs. 21.01\u0026plusmn;26.45 h) was similar to the length of onset before the breakout. Therefore, we speculated that there must be a certain number of patients experiencing uncomplicated appendicitis and who opted to stay at home with or without antibiotics, those patients significantly contributed to the decrease in the number of visits. Due to no change of emergency operation numbers and the length of onset, most of them might have eventually recovered. This might have led to a significant increase in the percentage of cases of gangrenous perforative appendicitis (Table.3). This result further confirmed that the non-operation approach can be used as a safe and effective alternative for acute uncomplicated appendicitis. A new meta-analysis in the setting of COVID-19 from Professor \u003ca href=\"https://pubmed.ncbi.nlm.nih.gov/?term=Emile+SH\u0026cauthor_id=33772399\"\u003eSameh Hany Emile\u003c/a\u003e also provided the same result, and the study by professor Vishal K. Patel even included some complicated cases\u003csup\u003e[17, 18]\u003c/sup\u003e. However, the failure rate of non-operation significantly increased in our study, and there might have been a few patients with acute complicated appendicitis who refused the surgery on the first instance and were treated by non-operative management. Therefore, our view remains conservative and that non-operation treatment should be used only in uncomplicated acute appendicitis. There is certainly more scope to further define conservative treatment during this pandemic.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eIn addition, People have concerns about contracting COVID-19 by visiting hospitals, and more or less some fear, anxiety and stresses by strictly screening and repeated epidemic. To reduce the probability of exposure to this virus, people avoided coming to the hospital or being hospitalized and prefer to take a wait-and-see attitude toward interval appendectomy. Therefore, we could find that the number of visits for interval appendectomy was lower in the post-pandemic period than the pre-pandemic period (12.84% vs. 6.29%), and the rate of emergency surgery for recurrences was also lower than before (39.57% vs. 25.68%, P\u0026lt;0.05) in our study. Meanwhile, that also showed a remarkably increased recurrence rate (23.27% vs. 14.46%) in patients with acute appendicitis 8 months after the treatment with the non-operation approach. But, under the effective pandemic prevention policy, there was actually no reported case of nosocomial infection from our hospital during the pandemic. In any case, we did\u0026nbsp;not anticipate an ideal outcome. The above results also confirmed that the pandemic influenced the decision-making of patients and created an obstacle between hospitals and patients. Despite many studies favoring non-operative management, recent studies have shown that the increase in recurrence rate within 1 year after the first non-surgical treatment for acute appendicitis cannot be ignored. The five-year follow-up result from the famous APPAC trial showed that in the non-operative treatment group, the recurrence rate reached up to 32.8%, and most of these cases emerged during the period within one year after initial treatment\u003csup\u003e[19-21]\u003c/sup\u003e. However,\u0026nbsp;whether\u0026nbsp;an\u0026nbsp;interval\u0026nbsp;appendectomy\u0026nbsp;after\u0026nbsp;effective\u0026nbsp;non-operative\u0026nbsp;therapy\u0026nbsp;could\u0026nbsp;be\u0026nbsp;considered\u0026nbsp;routine\u0026nbsp;has\u0026nbsp;sparked\u0026nbsp;heated\u0026nbsp;controversy. Routine interval surgery is preferred after non-operative management for acute appendicitis, and this treatment applies only to patients with recurrent symptoms\u003csup\u003e[7, 22, 23]\u003c/sup\u003e. Acute appendicitis is fatal and should not be overlooked. Our recommendations should not exacerbate the dangerous situation in which patients with the highest recurrence risk are in a worse situation. For patients with recurrence, conservative treatment has repeatedly aggravated the economic burden and increased the health risk. Since the outbreak of COVID-19, the current anti-pandemic policy and measures have already shown their value for the guaranteed running of medical institutions. We should focus on strengthening the healthcare system for patients after their initial treatment. By optimizing the medical processes, we can dispel the fear of this infection and increase patients\u0026rsquo; confidence about staying protected from the pandemic.\u003c/p\u003e\n\u003cp\u003eThe same strategy was applied to medical workers. After analyzing the data of patients who underwent an appendectomy in our hospital before and after the outbreak, the result showed that there were significant differences in anesthesia method, surgery procedure, and complications. According to the measures of our hospital for COVID-19 control and prevention, every in-patient is needed to undergo a Novel Coronavirus nucleic acid test or antibody test and low dose lung CT scan before admission. Based on the test results and patient histories, we determined the protective class for the surgery. It is up to the surgeon and anesthesiologist to decide whether or not to open the airway during surgery. The number of lumbar anesthesia cases steeply increased. However, there was no positive COVID-19 case, and all patients who were admitted to the hospital were mandatorily ruled out for COVID-19. This result reflected that anesthesiologists preferred lumbar anesthesia over general anesthesia during the pandemic period as chances\u0026nbsp;of viral exposure\u0026nbsp;are considerably higher in the case of airway opening. The literature also supports the importance of aerosol transmission of infectious diseases\u003csup\u003e[24]\u003c/sup\u003e. Therefore, these factors could have led to a significant decrease in the number of laparoscopic appendectomies. After comparing the treatment outcome of the two periods, the rate of postoperative complications was significantly higher than that before the outbreak (4.5% vs. 9.89%; P\u0026lt;0.05). With the development and popularization of laparoscopic technique, several guidelines and \u003ca href=\"javascript%3A;\"\u003especialist\u003c/a\u003es\u0026nbsp;have recommended laparoscopic appendectomy as the primary treatment for acute appendicitis\u003csup\u003e[7]\u003c/sup\u003e. Many studies pointed out that compared to an open appendectomy, laparoscopic surgery leads to a desirable outcome, lower rate of complications, shorter postoperative recovery time, less postoperative pain, and scarring. There was no effect on the operation time\u003csup\u003e[25, 26]\u003c/sup\u003e. In our study, only one patient had to be converted to open surgery during LA. The number of patients who underwent open surgery increased in the post-pandemic era, and the rate of postoperative complications was also significantly higher than before, particularly the rate of surgical site infections. Of course, The increase in gangrenous perforative appendicitis (Table 3) also contributed to these negative outcomes\u003csup\u003e[27]\u003c/sup\u003e. Therefore, we could not conclude that the significant decrease in the number of laparoscopic appendectomies results in an increased incidence of complications, but it is at least a risk factor. Moreover, as seen with our previous analyses, the incidence of gangrenous perforative appendicitis also increased in the post-pandemic era. Meanwhile, professor Georgios Markides and Gaik S Quah report that LA is superior to open surgery for complicated appendicitis\u003csup\u003e[25, 28]\u003c/sup\u003e. As a result, given the current anti-pandemic environment, we should make use of laparoscopy to improve treatment outcomes and promote laparoscopic surgery as the first line of treatment for acute appendicitis. The safe and effective pandemic prevention and its influence on the decision of medical personnel is conflicted. More research on anti-pandemic methods will further enhance medical personnel\u0026rsquo;s confidence and increase the use of general anesthesia.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eIn conclusion, the non-operative approach could be an option for acute appendicitis, which is now verified as a flexible and secure treatment approach. However, a thorough clinical examination is necessary to ensure that the surgical intervention may be completed quickly. COVID-19 has spread rapidly to transform into a pandemic and has affected not only our lifestyle but also the decision-making of patients and medical workers. Although these changes did not significantly increase the incidence of serious adverse events related to acute appendicitis, the increased recurrence rate and complications with decreased rates of surgery in patients with recurrent episodes will eventually lift the burden on the whole healthcare system. Under the current anti-pandemic policy, we should work to strengthen the faith and reduce the fear for people. Certainly, the increased vaccination coverage might improve the situation. Further studies on this topic should be pursued. In the context of anti-pandemic efforts, we need to obtain more comprehensive information regarding treatment strategies to ensure patient safety.\u003c/p\u003e\n"},{"header":"Abbreviations","content":"\u003cp\u003eemergency department (ED); novel coronavirus (COVID-19); open appendectomy (OA); laparoscopic appendectomy (LA)\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics:\u0026nbsp;\u003c/strong\u003eEthics approval and consent to participate Ethical approval was waived by the local Ethics Committee of Beijing Jishuitan Hospital in view of\u0026nbsp;\u003c/p\u003e\n\u003cp\u003ethe retrospective nature of the research and all the procedures being performed were part of the routine care.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatement of Informed Consent:\u0026nbsp;\u003c/strong\u003eInformed consent was obtained from all individual participants included in the study.The participant has consented to the submission of article to the journal.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003cstrong\u003e：\u003c/strong\u003eThe datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003cstrong\u003e：\u003c/strong\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003cstrong\u003e：\u003c/strong\u003eThe authors have not received any funding from any company.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions:\u003c/strong\u003e Xuan Cai is responsible for gathering, analyzing and interpreting the patient data regarding the acute appendicitis before and after the pandemic, was a major contributor in writing the manuscript. Jingtao Bi, Zhixue Zheng and Yaqi Liu participated in treatment and performed surgery for those patients. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor’s information:\u0026nbsp;\u003c/strong\u003eThe authors of this study are working in general surgery, a department of Beijing Jishuitan hospital, as a team being responsible for emergency surgery. Xuan Cai, Zhixue Zheng and Yaqi Liu are attending doctors, Jingtao Bi is a Chief Physician who are experienced surgeon(more than 10 years length of serve) and capable of perform emergency surgery including appendicectomy . Since the outbreak of COVID-19, the region where they are working has been hit by the pandemic several times. Beijing Jishuitan Hospital is a large comprehensive medical institution located in Beijing, the capital of China. It mainly serves two mega communities which has a population of over 400000 respectively. 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Evidence, prevention and control\u003c/em\u003e. \u003cem\u003eEnviron Int\u003c/em\u003e. \u003cem\u003e2020\u003c/em\u003e. \u003cem\u003e144\u003c/em\u003e: \u003cem\u003e106039\u003c/em\u003e.\u003c/span\u003e\u003c/li\u003e\n \u003cli\u003e\u003cspan\u003e\u003cem\u003eQuah GS\u003c/em\u003e, \u003cem\u003eEslick GD\u003c/em\u003e, \u003cem\u003eCox MR\u003c/em\u003e. \u003cem\u003eLaparoscopic appendicectomy is superior to open surgery for complicated appendicitis\u003c/em\u003e. \u003cem\u003eSurg Endosc\u003c/em\u003e. \u003cem\u003e2019\u003c/em\u003e. \u003cem\u003e33\u003c/em\u003e(\u003cem\u003e7\u003c/em\u003e): \u003cem\u003e2072\u0026ndash;2082\u003c/em\u003e.\u003c/span\u003e\u003c/li\u003e\n \u003cli\u003e\u003cspan\u003e\u003cem\u003eG\u0026uuml;ler Y\u003c/em\u003e, \u003cem\u003eKarabulut Z\u003c/em\u003e, \u003cem\u003e\u0026Ccedil;ali? H\u003c/em\u003e, \u003cem\u003e?eng\u0026uuml;l S\u003c/em\u003e. \u003cem\u003eComparison of laparoscopic and open appendectomy on wound infection and healing in complicated appendicitis\u003c/em\u003e. \u003cem\u003eInt Wound J\u003c/em\u003e. \u003cem\u003e2020\u003c/em\u003e. \u003cem\u003e17\u003c/em\u003e(\u003cem\u003e4\u003c/em\u003e): \u003cem\u003e957\u0026ndash;965\u003c/em\u003e.\u003c/span\u003e\u003c/li\u003e\n \u003cli\u003e\u003cspan\u003e\u003cem\u003eEmile SH\u003c/em\u003e, \u003cem\u003eElfallal AH\u003c/em\u003e, \u003cem\u003eElbaz SA\u003c/em\u003e, \u003cem\u003eElmetwally AM\u003c/em\u003e. \u003cem\u003eDevelopment and validation of risk prediction score for incisional surgical site infection after appendectomy\u003c/em\u003e. \u003cem\u003eUpdates Surg\u003c/em\u003e. \u003cem\u003e2021\u003c/em\u003e. \u003cem\u003e73\u003c/em\u003e(\u003cem\u003e6\u003c/em\u003e): \u003cem\u003e2189\u0026ndash;2197\u003c/em\u003e.\u003c/span\u003e\u003c/li\u003e\n \u003cli\u003e\u003cspan\u003e\u003cem\u003eMarkides G\u003c/em\u003e, \u003cem\u003eSubar D\u003c/em\u003e, \u003cem\u003eRiyad K\u003c/em\u003e. \u003cem\u003eLaparoscopic versus open appendectomy in adults with complicated appendicitis: systematic review and meta-analysis\u003c/em\u003e. \u003cem\u003eWorld J Surg\u003c/em\u003e. \u003cem\u003e2010\u003c/em\u003e. \u003cem\u003e34\u003c/em\u003e(\u003cem\u003e9\u003c/em\u003e): \u003cem\u003e2026-40\u003c/em\u003e.\u003c/span\u003e\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cstrong\u003eTable 1 Comparison of treatment before and after the pandemic\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" width=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e\u003cstrong\u003ePre-pandemic group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e\u003cstrong\u003ePost-pandemic group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u003cstrong\u003eP-value\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003e\u003cstrong\u003eCases\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e1582\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e409\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAge\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e0.304\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003e\u0026lt;60years\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e1296（81.9%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e326（79.71%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003e\u0026gt;60years\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e286（18.1%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e83（20.29%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAppendiceal fecalith\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e0.247\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e361（22.82%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e105（27.87%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e1221（77.18%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e304（72.13%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003e\u003cstrong\u003eGender\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e0.359\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e864(54.61%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e213(52.08%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e718(45.39%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e196(47.92%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003e\u003cstrong\u003eTreatment\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e0.022\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003e\u0026nbsp; \u0026nbsp;Operation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e238（15.04%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e57（13.94%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003eNon-operation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e1293（81.73%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e318（77.75%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"25.996533795493935%\"\u003e\n \u003cp\u003eFailure of non-operation\u003csup\u003ea\u003c/sup\u003e\u0026nbsp; \u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.7157712305026%\"\u003e\n \u003cp\u003e51（3.22%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e34（8.31%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e*: P＜0.05, statistically significant\u003c/p\u003e\n\u003cp\u003ea: The criteria of non-operative management failure were based on worsening of the signs and symptoms of patients who were treated by a non-surgical approach first followed by a surgical approach.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2 Long-term outcomes of non-operation before and after the pandemic\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" width=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.1421143847487%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"23.570190641247834%\"\u003e\n \u003cp\u003e\u003cstrong\u003ePre-pandemic group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e\u003cstrong\u003ePost-pandemic group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u003cstrong\u003eP-value\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.1421143847487%\"\u003e\n \u003cp\u003e\u003cstrong\u003eNon-operation\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"23.570190641247834%\"\u003e\n \u003cp\u003e1293\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e318\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.1421143847487%\"\u003e\n \u003cp\u003e\u003cstrong\u003eoutcomes\u003c/strong\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e8 months\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"23.570190641247834%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e0.003\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.1421143847487%\"\u003e\n \u003cp\u003eInterval appendectomy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"23.570190641247834%\"\u003e\n \u003cp\u003e166(12.84%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e20（6.29%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.1421143847487%\"\u003e\n \u003cp\u003eNo recurrence\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"23.570190641247834%\"\u003e\n \u003cp\u003e940（72.7%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e224（70.44%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.1421143847487%\"\u003e\n \u003cp\u003erecurrence\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"23.570190641247834%\"\u003e\n \u003cp\u003e187（14.46%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e74（23.27%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.1421143847487%\"\u003e\n \u003cp\u003e\u003cstrong\u003eOutcomes of recurrence\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"23.570190641247834%\"\u003e\n \u003cp\u003e187\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e0.035\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.1421143847487%\"\u003e\n \u003cp\u003e\u0026nbsp;Operation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"23.570190641247834%\"\u003e\n \u003cp\u003e74（39.57%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e19（25.68%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.1421143847487%\"\u003e\n \u003cp\u003eNon-operation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"23.570190641247834%\"\u003e\n \u003cp\u003e113（60.43%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"28.942807625649912%\"\u003e\n \u003cp\u003e55（74.32%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.344887348353552%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e*: P＜0.05, statistically significant\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3 Comparison of operative treatment before and after the pandemic\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" width=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e\u003cstrong\u003ePre-pandemic group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e\u003cstrong\u003ePost-pandemic group\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u003cstrong\u003eP\u003cem\u003e-\u003c/em\u003evalue\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eCases\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e289\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAge\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.373\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u0026lt;60years\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e252（87.2%%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e76（83.52%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u0026gt;60years\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e37（12.8%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e15（16.48%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eGender\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.288\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e180（62.28%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e51（56.04%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e109（37.72%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e40（43.96%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAppendiceal fecalith\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.194\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e185（64.01%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e65（71.43%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e104(35.99%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e26（28.57%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eFever\u003c/strong\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e\u0026gt;37.5\u0026deg;C\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.259\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e29（10.03%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e13（14.29%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e260（89.97%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e78（85.71%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eJaundice\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.505\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e129（44.64%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e37（40.66%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e160（55.36%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e54（59.34%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eAnesthesia\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.005\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eLumbar anesthesia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e84（29.07%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e41（45.25%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eGeneral anesthesia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e205（70.93%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e50（54.95%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eSurgery\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;OA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e89（30.8%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e49（53.85%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.007\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;LA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e200（69.2）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e42（46.15%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eConversion to open surgery\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eLength of onset before presenting to ED\u003c/strong\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003eh\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e20.91\u0026plusmn;17.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e21.01\u0026plusmn;26.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.972\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eWhite cell count(10\u003csup\u003e9\u003c/sup\u003e/L)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e14.14\u0026plusmn;3.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e15.08\u0026plusmn;3.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.096\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003ePathology\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.016*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eGangrene\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e79(27.34%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e37(40.66%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eNon-gangrene\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e210(72.66%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e54(59.34%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eComplications\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.037\u003csup\u003e*\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e12（4.15%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e9（9.89%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e277（95.85%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e82（90.11%）\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"34.08695652173913%\"\u003e\n \u003cp\u003e\u003cstrong\u003eLength of stay\u003c/strong\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003edays\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.434782608695652%\"\u003e\n \u003cp\u003e4.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"26.782608695652176%\"\u003e\n \u003cp\u003e5.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.695652173913043%\"\u003e\n \u003cp\u003e0.467\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e*: P＜0.05, statistically significant\u003c/p\u003e\n\u003cp\u003eAbbreviations: emergency department (ED); novel coronavirus (COVID-19); open appendectomy (OA); laparoscopic appendectomy (LA)\u003c/p\u003e\n"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-emergency-medicine","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"emmd","sideBox":"Learn more about [BMC Emergency Medicine](http://bmcemergmed.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/emmd","title":"BMC Emergency Medicine","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"COVID-19, Acute Appendicitis, Emergency Treatment, Decision-Making, Laparoscopic Surgery","lastPublishedDoi":"10.21203/rs.3.rs-1633362/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1633362/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Acute appendicitis is the most common cause of acute abdomen. During the pandemic, to contain the spread of COVID-19, there were some integral changes in the medical processes based on the pandemic prevention policy, especially about emergency surgery.This study was conducted to investigate whether thi\u003cu\u003es pandemic\u003c/u\u003e had also an impact on the decision-making for both patients and medical personnel along with the treatment outcomes. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e Patients of age 18 years or older who were diagnosed radiologically with acute appendicitis between Jan 1, 2017 and Dec 31, 2020 were reviewed. The data of 1991 cases were collected and used for this study. Two groups were formed, one group before and the other group after the outbreak.The gathered data included gender, age, appendiceal fecalith, outcomes of treatment, and long-term outcomes of non-operation (8 months follow-up). We also collected details of surgical cases from above two groups. This data also included age, gender, appendiceal fecalith, fever, jaundice, length of onset before presenting to an emergency department (ED), anesthesia, surgery, white cell count, pathology, complications, and length of stay. We compared above data respectively, and analyzed the differences.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e Compared to the period before the outbreak, patient visits for acute appendicitis remarkably dropped (19.8%), but surgical cases showed no change (dropped by roughly 5%). There were significant differences (P\u0026lt;0.05) in failure of non-operation(after pandemic 8.31% vs. before pandemic 3.22%), interval appendectomy(after pandemic 6.29% vs. before pandemic 12.84%), recurrence , and outcomes of recurrence. There was a significant difference (P\u0026lt;0.05) in anesthesia method , surgery way, and complications( before pandemic 4.15% vs. after pandemic9.89% P\u0026lt;0.05) in patients who underwent the surgery. There was no statistical difference (P\u0026gt;0.05) with respect to age, gender, fever, jaundice, appendiceal fecalith, white cell count, and length of onset before presenting to the ED.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions:\u003c/strong\u003e Non-operation is a flexible and secure\u0026nbsp;treatment option. Laparoscopic appendectomy might be a better choice than open surgery. The current pandemic prevention policy is very effective, but it affected the decision-making process of patients and medical personnel along with some treatment outcomes.\u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Decision-making changes for patients and medical personnel in the management of acute appendicitis during the COVID-19 pandemic","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2022-08-03 18:15:47","doi":"10.21203/rs.3.rs-1633362/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2022-08-25T06:34:11+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2022-08-07T10:05:27+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"741f4710-6494-47b5-87e7-339fc04c7942","date":"2022-08-03T01:26:50+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2022-08-01T16:24:39+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2022-08-01T16:22:30+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2022-08-01T13:37:28+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2022-08-01T13:32:29+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Emergency Medicine","date":"2022-05-07T14:36:55+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-emergency-medicine","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"emmd","sideBox":"Learn more about [BMC Emergency Medicine](http://bmcemergmed.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/emmd","title":"BMC Emergency Medicine","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"31b637aa-6001-401b-9bca-4bfb17588a86","owner":[],"postedDate":"August 3rd, 2022","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2022-09-28T07:14:30+00:00","versionOfRecord":[],"versionCreatedAt":"2022-08-03 18:15:47","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-1633362","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1633362","identity":"rs-1633362","version":["v1"]},"buildId":"369fNeqWncA4NS6XSWjrt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}