Increased exercise intensity is associated with reduced risk of death in patients with COPD: a study from the 2007-2012 NHANES database

Increased exercise intensity is associated with reduced risk of death in patients with COPD: a study from the 2007-2012 NHANES database | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Increased exercise intensity is associated with reduced risk of death in patients with COPD: a study from the 2007-2012 NHANES database Rong Zhang, Xueyu Lu, Liyuan Pang, Yongjuan Zhao, Kan He This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4268335/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Chronic obstructive pulmonary disease (COPD) is a common chronic disease, and its harm to people's health is on the rise in recent years. With the increasing incidence and mortality of COPD, its prevention and the care of patients with the disease are becoming increasingly important in order to improve the life expectancy of patients and reduce the mortality rate. COPD patients often do not dare to exercise because of breathing difficulties and weakness, which is not conducive to the maintenance and improvement of their heart and lung function, and will worsen their condition. Our aim was to investigate the association between exercise and the risk of death in patients with COPD. The study included 6,723 participants aged > 40 years with complete data on COPD prevalence and physical activity from the 2007–2012 National Health and Nutrition Examination Survey (NHANES). Multivariate COX regression analysis was used to establish three model analyses with the exercise intensity of the groups as independent variables, taking full account of various covariates (demographic factors, prevalence of underlying diseases, and detection of biochemical indicators), respectively, to analyze the expected death risk of patients. The restricted cubic spline (RCS) was used to fit the relationship between exercise intensity and the risk of death in COPD patients, and the exercise intensity at critical risk of death was obtained. Our findings suggest that moderate, high-intensity exercise contributes to a reduction in the risk of death in patients with COPD. Within a certain range, the greater the intensity of exercise, the lower the risk of death. These findings suggest that moderate physical activity can be beneficial to the health of people with COPD and can extend their life expectancy, especially if there are underlying conditions. It is necessary for COPD patients to increase their exercise and doctors to give them appropriate exercise guidance and rehabilitation programs. physical exercise COPD NHANES Multivariate Cox regression analysis Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4268335","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":293949757,"identity":"9e4f5df0-c5fc-49cf-83e7-44fb91f8f5ae","order_by":0,"name":"Rong Zhang","email":"","orcid":"","institution":"The First Bethune Hospital of Jilin University","correspondingAuthor":false,"prefix":"","firstName":"Rong","middleName":"","lastName":"Zhang","suffix":""},{"id":293949765,"identity":"f6b34308-75a9-4454-9626-79b5879e0fa0","order_by":1,"name":"Xueyu Lu","email":"","orcid":"","institution":"Jilin University","correspondingAuthor":false,"prefix":"","firstName":"Xueyu","middleName":"","lastName":"Lu","suffix":""},{"id":293949766,"identity":"bc5b196e-0a0d-48ba-8a2d-48f5d9129316","order_by":2,"name":"Liyuan Pang","email":"","orcid":"","institution":"Jilin University","correspondingAuthor":false,"prefix":"","firstName":"Liyuan","middleName":"","lastName":"Pang","suffix":""},{"id":293949767,"identity":"870d1b26-1c40-4aec-a3d9-c07a6e64b7fd","order_by":3,"name":"Yongjuan Zhao","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA2klEQVRIie3QIQ7CMBSA4dc0meoyZNV2hS1ILvMWxMxIUGRypMlmOEATuAQ3aFOBWaYRiB0AMYkhsIGnw5HQX1W8L++lAC7Xb4aqLx4hqce3N42kWjZ0TsQXhBq/omlJp5JIYmdY42VCsBj6jYFgX34mRCLqQ8FW24EQ2RrgF2W5iiOqa8NfhPqVgZjjZ+KNxK/ijIzkPoWwgWi/QnwRMoVw1uHwySrZCm+td23G+NlCojpf9n2hoqQWx+62WYSBtBCY5e+JpARQ46WW+aHgpN7r7KMul8v1rz0Bxj5Gfm1P3zkAAAAASUVORK5CYII=","orcid":"","institution":"Jilin University","correspondingAuthor":true,"prefix":"","firstName":"Yongjuan","middleName":"","lastName":"Zhao","suffix":""},{"id":293949768,"identity":"6658448a-4eec-4166-a43d-0d38e1cef735","order_by":4,"name":"Kan He","email":"","orcid":"","institution":"Jilin University","correspondingAuthor":false,"prefix":"","firstName":"Kan","middleName":"","lastName":"He","suffix":""}],"badges":[],"createdAt":"2024-04-15 08:33:13","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4268335/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4268335/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":74860955,"identity":"018d273e-4506-4d2b-9a55-9240de7b9811","added_by":"auto","created_at":"2025-01-27 16:31:41","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":847720,"visible":true,"origin":"","legend":"","description":"","filename":"IncreasedexerciseintensityisassociatedwithreducedriskofdeathinpatientswithCOPD.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4268335/v1_covered_294e9ffa-7946-44d0-b55b-da47e53e9ee4.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Increased exercise intensity is associated with reduced risk of death in patients with COPD: a study from the 2007-2012 NHANES database","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"physical exercise, COPD, NHANES, Multivariate Cox regression analysis","lastPublishedDoi":"10.21203/rs.3.rs-4268335/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4268335/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eChronic obstructive pulmonary disease (COPD) is a common chronic disease, and its harm to people's health is on the rise in recent years. With the increasing incidence and mortality of COPD, its prevention and the care of patients with the disease are becoming increasingly important in order to improve the life expectancy of patients and reduce the mortality rate. COPD patients often do not dare to exercise because of breathing difficulties and weakness, which is not conducive to the maintenance and improvement of their heart and lung function, and will worsen their condition. Our aim was to investigate the association between exercise and the risk of death in patients with COPD. The study included 6,723 participants aged\u0026thinsp;\u0026gt;\u0026thinsp;40 years with complete data on COPD prevalence and physical activity from the 2007\u0026ndash;2012 National Health and Nutrition Examination Survey (NHANES). Multivariate COX regression analysis was used to establish three model analyses with the exercise intensity of the groups as independent variables, taking full account of various covariates (demographic factors, prevalence of underlying diseases, and detection of biochemical indicators), respectively, to analyze the expected death risk of patients. The restricted cubic spline (RCS) was used to fit the relationship between exercise intensity and the risk of death in COPD patients, and the exercise intensity at critical risk of death was obtained. Our findings suggest that moderate, high-intensity exercise contributes to a reduction in the risk of death in patients with COPD. Within a certain range, the greater the intensity of exercise, the lower the risk of death. These findings suggest that moderate physical activity can be beneficial to the health of people with COPD and can extend their life expectancy, especially if there are underlying conditions. 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