Association between 25-hydroxyvitamin D and abdominal aortic calcification in US adults: Findings From NHANES 2013-2014

Aims: : This study aimed to explore the correlation of 25-hydroxyvitamin D and abdominal aortic calcification. Methods: : In this cross-sectional study, the data were collected from NHANES (National Health and Nutrition Examination Survey) 2013–2014. Multivariable logistic regression was performed to determine the association of 25-hydroxyvitamin D and AAC. The non-linear relationship was analyzed using smooth curve fitting. Results: : 3,040 participants with compete data were included for data analysis. The fully-adjusted model showed serum calcium and HDL levels were correlated with the severity of AAC, and 25-hydroxyvitamin D was closely correlated with plasma calcium and HDL levels. Furthermore, either a low or high level of 25-hydroxyvitamin D was positively correlated with an increased risk of severe AAC, and a U-shaped dose-response relationship (inflection point: 45.8ng/mL and 146ng/mL) was indicated. Conclusions: : Either a high or low level of 25-hydroxyvitamin D was positively associated with an increased risk of severe AAC. It was suggested that clinicians should be cautious when prescribing 25-hydroxyvitamin D supplementation, and the mechanism underlying the correlation of 25-hydroxyvitamin D and AAC remains to be further confirmed.