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by claude@2026-07, 2026-07-09
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This study evaluated pregnancy, delivery, and newborn outcomes in women surgically treated for bowel endometriosis compared to controls, finding higher IVF/ET rates in the endometriosis group.
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by claude@2026-07, 2026-07-09
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This seven-year single-centre retrospective matched cohort study examined pregnancy, delivery, and newborn adverse outcomes in 71 pregnancies among women diagnosed with bowel endometriosis and treated with laparoscopic-assisted surgery, matched 1:3 by a Cox proportional hazards approach to 213 pregnancies without endometriosis. Compared with controls, the bowel endometriosis group had higher use of IVF/ET and increased risks for labor abnormalities, non-cephalic fetal presentation, cesarean section (including emergent cesarean), and several maternal complications including placenta previa, second-trimester hemorrhage, postpartum hemorrhage, and transfusion during labor. Neonatal outcomes were also worse, with increased neonatal intensive care unit admissions. The authors note that additional prospective and comparative studies are needed to validate these retrospective findings. This paper is centrally about endometriosis — specifically pregnancy and neonatal outcomes after laparoscopic-assisted surgery for bowel (colorectal) endometriosis.
Abstract
Deep infiltrating endometriosis has been linked to worsened maternal and neonatal outcomes. However, reports regarding bowel endometriosis are still scanty. We aimed to evaluate pregnancy, delivery, and newborn adverse outcomes in women after laparoscopicassisted surgery for bowel endometriosis. Methods: A single-center retrospective cohort study was conducted at a tertiary-care university hospital. From January 2015 to December 2021, pregnant women who were diagnosed and treated for bowel endometriosis were matched using a 1:3 ratio with pregnant women with no history of endometriosis. Patients were matched using the Cox proportional hazards model to determine parity, age, BMI and gestational age-adjusted relative risk (aRR) with a 95% confidence interval (CI). Co-primary outcomes were the incidence of labor abnormalities and cesarean section (CS) rate. Co-secondary outcomes were incidence of complications related to pregnancy, delivery, and newborn. Results: A total of 71 pregnancies among women treated for bowel endometriosis and 213 from healthy controls were included. Patients requiring IVF/ET for getting pregnant were in the bowel endometriosis group relative to controls (43.7% vs. 11.7%
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| Naslov: | Pregnancy and neonatal outcomes in women treated for bowel endometriosis : a seven-year single-centre retrospective matched cohort study |
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| Avtorji: | ID Šalamun, Vesna (Avtor) ID Riemma, Gaetano (Avtor) ID Sirc, Tina (Avtor) ID Vrtačnik-Bokal, Eda (Avtor) ID Ban Frangež, Helena (Avtor) |
| Datoteke: | PDF - Predstavitvena datoteka, prenos (221,32 KB) MD5: FC305DCC3C97E88650C3057D66289C6C
URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2077-0383/13/19/5956
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Deep infiltrating endometriosis has been linked to worsened maternal and neonatal outcomes. However, reports regarding bowel endometriosis are still scanty. We aimed to evaluate pregnancy, delivery, and newborn adverse outcomes in women after laparoscopicassisted surgery for bowel endometriosis. Methods: A single-center retrospective cohort study was conducted at a tertiary-care university hospital. From January 2015 to December 2021, pregnant women who were diagnosed and treated for bowel endometriosis were matched using a 1:3 ratio with pregnant women with no history of endometriosis. Patients were matched using the Cox proportional hazards model to determine parity, age, BMI and gestational age-adjusted relative risk (aRR) with a 95% confidence interval (CI). Co-primary outcomes were the incidence of labor abnormalities and cesarean section (CS) rate. Co-secondary outcomes were incidence of complications related to pregnancy, delivery, and newborn. Results: A total of 71 pregnancies among women treated for bowel endometriosis and 213 from healthy controls were included. Patients requiring IVF/ET for getting pregnant were in the bowel endometriosis group relative to controls (43.7% vs. 11.7%; p < 0.001). Increased risk of labor abnormalities was present for bowel endometriosis relative to controls (21.1% vs. 17.4%; p = 0.040; aRR 1.39 [95% CI 1.06–2.05]). Risk of non-cephalic fetal presentation (14.1% vs. 6.1%; p = 0.016; aRR 3.08 [95% CI 2.03–4.68]), CS rate (43.7% vs. 24.9%; p = 0.003; aRR 1.75 [95% CI 1.23– 2.49]), and emergent CS rate (19.7% vs. 8.5%; p = 0.009; aRR 2.21 [95% CI 1.55–3.16]) were significantly higher in women treated for colorectal endometriosis compared with controls. Moreover, placenta previa (9.9% vs. 0.0%; p < 0.001; aRR 21.82 [95% CI 2.19–116.40]), second-trimester hemorrhage (5.6% vs. 0.9%; p = 0.017; aRR 6.00 [95% CI 1.12–32.06]), postpartum hemorrhage (15.5% vs. 3.3%; p < 0.001; aRR 4.71 [95% CI 1.90–11.70]), and the need for transfusion during labor (5.6% vs. 0.5%; p = 0.004; aRR 12.00 [95% CI 1.36–105.60]) were increased in treatments vs. controls. Concerning neonatal outcomes, an increased risk for neonatal intensive care unit admission was seen in postsurgical endometriotic women relative to healthy controls (26.0% vs. 6.9%; p < 0.001; aRR 3.75 [2.04–3.86]). Conclusions: Women treated for bowel endometriosis seem more exposed to adverse pregnancy and neonatal outcomes relative to healthy controls. However, additional prospective and comparative studies are needed to validate the available evidence. |
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| Ključne besede: | endometriosis, colorectal endometriosis, surgery, pregnancy outcomes, in-vitro fertilization |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | str. 1-11 |
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| Številčenje: | Vol. , iss. [v tisku], [article no.] |
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| PID: | 20.500.12556/DiRROS-30017 |
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| UDK: | 61 |
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| ISSN pri članku: | 2077-0383 |
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| DOI: | 10.3390/jcm13195956 |
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| COBISS.SI-ID: | 211411971 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 14. 10. 2024;
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| Datum objave v DiRROS: | 11.06.2026 |
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| Število ogledov: | 183 |
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| Število prenosov: | 115 |
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| Metapodatki: | |
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