Could surgeon's expertise resolve the debate about surgery effectiveness in treatment of endometriosis-related infertility?

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This study found that infertile patients treated by a specialized endometriosis surgeon had higher spontaneous pregnancy and lower ectopic pregnancy rates compared to those treated by a skilled surgeon.

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This observational cohort study enrolled women with pelvic endometriosis-related infertility undergoing laparoscopic surgery, comparing two large groups treated by different surgeons: a skilled surgeon (Group A) versus a surgeon dedicated to endometriosis-related infertility (Group B). The study assessed perioperative surgical outcomes and subsequent fertility outcomes, including spontaneous/assisted pregnancy rates, obstetrical outcomes, and live birth rates. Group B had a significantly higher spontaneous fertility rate (especially within the first year) and a lower ectopic pregnancy rate, while ART success rates and perioperative/obstetrical outcomes were similar between groups; the authors explicitly frame expectant versus surgical management as depending on the estimated likelihood of natural conception. This paper is centrally about endometriosis-related infertility—showing how surgeon expertise and specialized laparoscopic “pelvic cleanout” affect spontaneous fertility after surgery in pelvic endometriosis.

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Abstract

PURPOSE: Restoring the anatomical relationship and preserving the function of pelvic organs represent the ideal outcome of surgical intervention in patients suffering from endometriosis-related infertility. The aim of the study was to compare two large cohorts (Group A and Group B) of infertile patients in terms of postsurgical spontaneous/assisted fertility and perioperative surgical outcomes. The surgical treatment was performed by a skilled surgeon (Group A) and a surgeon dedicated to endometriosis-related infertility (Group B). METHODS: An observational cohort study on women affected by pelvic endometriosis who underwent laparoscopic treatment (to restore/improve their fertility) was conducted. A comparison, between Group A and Group B, in terms of perioperative surgical outcomes, clinical/ongoing pregnancy and live birth rates, spontaneous pregnancy rate and obstetrical outcome was performed. RESULTS: A significantly higher spontaneous fertility rate (particularly in the first year after surgery) and lower ectopic pregnancy rate were found in Group B. ART success rates were not affected by different surgical approaches. Perioperative and obstetrical outcomes were similar in both groups. CONCLUSION: In patients affected by endometriosis, the choice between expectant management versus intervention should be personalized: when the estimated probability of natural conception is low, surgery may be considered as a second-line treatment. Conversely, in all other cases surgery should be offered early (as a first-line approach) as it improves the chance of spontaneous conception. The laparoscopic treatment of infertility due to endometriosis must be performed by a skilled specialized surgeon to ensure a complete "pelvic cleanout" while respecting the anatomical structures and reducing the risk of fertility impairment due to surgical procedures.
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Abstract

Purpose Restoring the anatomical relationship and preserving the function of pelvic organs represent the ideal outcome of surgical intervention in patients suffering from endometriosis-related infertility. The aim of the study was to compare two large cohorts (Group A and Group B) of infertile patients in terms of postsurgical spontaneous/assisted fertility and perioperative surgical outcomes. The surgical treatment was performed by a skilled surgeon (Group A) and a surgeon dedicated to endometriosis-related infertility (Group B).

Methods

An observational cohort study on women affected by pelvic endometriosis who underwent laparoscopic treatment (to restore/improve their fertility) was conducted. A comparison, between Group A and Group B, in terms of perioperative surgical outcomes, clinical/ongoing pregnancy and live birth rates, spontaneous pregnancy rate and obstetrical outcome was performed.

Results

A significantly higher spontaneous fertility rate (particularly in the first year after surgery) and lower ectopic pregnancy rate were found in Group B. ART success rates were not affected by different surgical approaches. Perioperative and obstetrical outcomes were similar in both groups.

Conclusion

In patients affected by endometriosis, the choice between expectant management versus intervention should be personalized: when the estimated probability of natural conception is low, surgery may be considered as a second-line treatment. Conversely, in all other cases surgery should be offered early (as a first-line approach) as it improves the chance of spontaneous conception. The laparoscopic treatment of infertility due to endometriosis must be performed by a skilled specialized surgeon to ensure a complete “pelvic cleanout” while respecting the anatomical structures and reducing the risk of fertility impairment due to surgical procedures. Similar content being viewed by others

References

Benschop L, Farquhar C, van der Poel N, Heineman MJ (2010) Interventions for women with endometrioma prior to assisted reproductive technology. Cochrane Database Syst Rev (11):CD008571 Harb HM, Gallos ID, Chu J, Harb M, Coomarasamy A (2013) The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis. BJOG 120(11):1308–1320 Hart RJ, Hickey M, Maouris P, Buckett W (2008) Excisional surgery versus ablative surgery for ovarian endometriomata. Cochrane Database Syst Rev (2):CD004992 Saccardi C, Cosmi E, Borghero A, Tregnaghi A, Dessole S, Litta P (2012) Comparison between transvaginal sonography, saline contrast sonovaginography and magnetic resonance imaging in the diagnosis of posterior deep infiltrating endometriosis. Ultrasound Obstet Gynecol 40(4):464–469 Kaplan CR, Eddy CA, Olive DL, Schenken RS (1989) Effect of ovarian endometriosis on ovulation in rabbits. Am J Obstet Gynecol 160:40–44 Kyama CM, Overbergh L, Mihalyi A, Meuleman C, Mwenda JM, Mathieu C, D’Hooghe TM (2008) Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis. Fertil Steril 89:301–310 de Ziegler D, Borghese B, Chapron C (2010) Endometriosis and infertility: pathophysiology and management. Lancet 376:730–738 Gizzo S, Capuzzo D, Zicchina C, Di Gangi S, Coronella ML, Andrisani A, Gangemi M, Nardelli GB (2014) Could empirical low-dose-aspirin administration during IVF cycle affect both the oocytes and embryos quality via COX 1-2 activity inhibition? J Assist Reprod Genet 31(3):261–268 Lo Vasco VR, Leopizzi M, Chiappetta C, Businaro R, Polonia P, Della Rocca C, Litta P (2012) Expression of phosphoinositide-specific phospholipase C enzymes in normal endometrium and in endometriosis. Fertil Steril 98(2):410–414 Jones CJ, Inuwa IM, Nardo LG, Litta P, Fazleabas AT (2009) Eutopic endometrium from women with endometriosis shows altered ultrastructure and glycosylation compared to that from healthy controls—a pilot observational study. Reprod Sci. 16(6):559–572 Pfeifer S, Fritz M, Goldberg J, McClure R, Lobo R, Thomas M, Widra E, Schattman G, Licht M, Collins J, Cedars M, Racowsky C, Vernon M, Davis O, Barnhart K, Gracia C, Catherino W, Rebar R, Barbera AL (2012) Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility: a committee opinion. Fertil Steril 98(3):591–598 Gupta S, Agarwal A, Agarwal R, Loret de Mola JR (2006) Impact of ovarian endometrioma on assisted reproduction outcomes. Reprod Biomed Online 13:349–360 Barnhart K, Dunsmoor-Su R, Coutifaris C (2002) Effect of endometriosis on in vitro fertilization. Fertil Steril 77:1148–1155 Johnson NP, Hummelshoj L (2013) World Endometriosis Society Montpellier Consortium. Consensus on current management of endometriosis. Hum Reprod 28(6):1552–1568 Gizzo S, Andrisani A, Esposito F, Oliva A, Zicchina C, Capuzzo D, Gangemi M, Nardelli GB (2014) Ovarian reserve test: an impartial means to resolve the mismatch between chronological and biological age in the assessment of female reproductive chances. Reprod Sci 21(5):632–639 Gizzo S, Patrelli TS, Rossanese M, Noventa M, Berretta R, Di Gangi S, Bertin M, Gangemi M, Nardelli GB (2013) An update on diabetic women obstetrical outcomes linked to preconception and pregnancy glycemic profile: a systematic literature review. Sci World J 6(2013):254901 Saccardi C, Conte L, Fabris A, De Marchi F, Borghero A, Gizzo S, Litta P (2013) Hysteroscopic enucleation in toto of submucous type 2 myomas: long-term follow-up in women affected by Menorrhagia. J Minim Invasive Gynecol 21(3):426–430 Litta P, Cosmi E, Saccardi C, Esposito C, Rui R, Ambrosini G (2008) Outpatient operative polypectomy using a 5 mm-hysteroscope without anaesthesia and/or analgesia: advantages and limits. Eur J Obstet Gynecol Reprod Biol 139(2):210–214 (1997) Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 67(5):817–821 Uncu G, Kasapoglu I, Ozerkan K, Seyhan A, Oral Yilmaztepe A, Ata B (2013) Prospective assessment of the impact of endometriomas and their removal on ovarian reserve and determinants of the rate of decline in ovarian reserve. Hum Reprod 28(8):2140–2145 Vercellini P, Somigliana E, Viganò P, Abbiati A, Barbara G, Crosignani PG (2009) Surgery for endometriosis-associated infertility: a pragmatic approach. Hum Reprod 24(2):254–269 Tsolakidis D, Pados G, Vavilis D, Athanatos D, Tsalikis T, Giannakou A, Tarlatzis BC (2010) The impact on ovarian reserve after laparoscopic ovarian cystectomy versus three-stage management in patients with endometriomas: a prospective randomized study. Fertil Steril 94(1):71–77 Garcia-Velasco JA, Somigliana E (2009) Management of endometriomas in women requiring IVF: to touch or not to touch. Hum Reprod 24(3):496–501 Patrelli TS, Franchi L, Gizzo S, Salvati MA, Berretta R, Piantelli G, Modena AB (2013) Can the impact of pelvic inflammatory disease on fertility be prevented? Epidemiology, clinical features and surgical treatment: evolution over 8 years. J Reprod Med 58(9–10):425-433 Lee HJ, Lee JE, Ku SY, Kim SH, Kim JG, Moon SY, Choi YM (2013) Natural conception rate following laparoscopic surgery in infertile women with endometriosis. Clin Exp Reprod Med 40(1):29–32 Raffi F, Metwally M, Amer S (2012) The impact of excision of ovarian endometrioma on ovarian reserve: a systematic review and meta-analysis. J Clin Endocrinol Metab 97(9):3146–3154 Somigliana E, Berlanda N, Benaglia L, Viganò P, Vercellini P, Fedele L (2012) Surgical excision of endometriomas and ovarian reserve: a systematic review on serum antimüllerian hormone level modifications. Fertil Steril 98(6):1531–1538 Sugita A, Iwase A, Goto M, Nakahara T, Nakamura T, Kondo M, Osuka S, Mori M, Saito A, Kikkawa F (2013) One-year follow-up of serum antimüllerian hormone levels in patients with cystectomy: are different sequential changes due to different mechanisms causing damage to the ovarian reserve? Fertil Steril 100(2):516–522 Littman E, Giudice L, Lathi R, Berker B, Milki A, Nezhat C (2005) Role of laparoscopic treatment of endometriosis in patients with failed in vitro fertilization cycles. Fertil Steril 84(6):1574–1578 Jacobson TZ, Duffy JM, Barlow D, Farquhar C, Koninckx PR, Olive D (2010) Laparoscopic surgery for subfertility associated with endometriosis. Cochrane Database Syst Rev (1):CD001398 Parazzini F (1999) Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell’Endometriosi. Hum Reprod 14(5):1332–1334 Marcoux S, Maheux R, Bérubé S (1997) Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis. N Engl J Med 337(4):217–222 Alborzi S, Momtahan M, Parsanezhad ME, Dehbashi S, Zolghadri J, Alborzi S (2004) A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas. Fertil Steril 82:1633–1700 Beretta P, Franchi M, Ghezzi F, Busacca M, Zupi E, Bolis P (1998) Randomized clinical trial of two laparoscopic treatments of endometriomata: cystectomy versus drainage and coagulation. Fertil Ster 70:1176–1180 Vercellini P, Fedele L, Aimi G, De Giorgi O, Consonni D, Crosignani PG (2006) Reproductive performance, pain recurrence and disease relapse after conservative surgical treatment for endometriosis: the predictive value of the current classification system. Hum Reprod 21:2679–2685 Litta P, D’Agostino G, Conte L, Saccardi C, Cela V, Angioni S, Plebani M (2013) Anti-Müllerian hormone trend after laparoscopic surgery in women with ovarian endometrioma. Gynecol Endocrinol 29(5):452–454 Patrelli TS, Berretta R, Gizzo S, Pezzuto A, Franchi L, Lukanovic A, Nardelli GB, Modena AB (2011) CA 125 serum values in surgically treated endometriosis patients and its relationships with anatomic sites of endometriosis and pregnancy rate. Fertil Steril 95(1):393–396 Franchi L, Patrelli TS, Berretta R, Rolla M, Gizzo S, Gramellini D, Bacchi Modena A, Nardelli GB (2010) Role of d-dimer testing in severe pelvic inflammatory disease: a new usable marker to assess the need for fertility-impairing surgery? Fertil Steril 94(6):2372–2375 Patrelli TS, Gizzo S, Sianesi N, Levati L, Pezzuto A, Ferrari B, Bacchi Modena A (2012) Anti-Müllerian hormone serum values and ovarian reserve: can it predict a decrease in fertility after ovarian stimulation by ART cycles? PLoS One 7(9):e44571 Acknowledgments The authors would like to thank equip of the Gynecologic and Obstetric Clinic of Padua. All authors declare that they have no funding. Conflict of interest All authors declare no conflicts of interest. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Gizzo, S., Conte, L., Di Gangi, S. et al. Could surgeon’s expertise resolve the debate about surgery effectiveness in treatment of endometriosis-related infertility?. Arch Gynecol Obstet 292, 217–223 (2015). https://doi.org/10.1007/s00404-014-3591-z Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-014-3591-z

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Laparoscopy Surgeons Adult Cohort Studies Endometriosis Endometriosis Female Fertility Humans Infertility, Female Infertility, Female Laparoscopy Pregnancy Pregnancy, Ectopic Pregnancy, Ectopic Pregnancy Rate Surgeons

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