Uterine Arterial Methotrexate Infusion and Embolization in the Treatment of Uterine Adenomyosis

Objective To investigate the therapeutic effects of transcatheter local infusion of methotrexate(MTX) combined with uterine arterial embolization under guidance of digital subtraction angiography on uterine adenomyosis.Methods Total 18 patients with uterine adenomyosis according to clinical symptoms and color Doppler were enrolled in the trial.Super-selective uterine arterial catheterization was performed with Seldinger methods.The patients were then treated with uterine arterial local infusion 50 mg MTX and embolization with PVA microsphere(diameter 350-560 um),individually.Finally,we observed in menstruation volumes,the degree of dysmenorrheal,uterine sizes,and sex hormone levels changes.Results The uterine arterial local infusion combined with embolization showed no chemotherapeutic side effects.In all cases,there were decrease of menstruation amount,alleviated dysmenorrheal,reduction of uterine size(P0.05),while no difference was found in levels of sex hormones(P0.05).Conclusion Micro-invasive interventional technique combined with drug therapy has stable efficacy,and provide a new method for clinical treatment of uterine adenomyosis.