Possibilities of personalized therapy in patients with chronic pelvic pain and inflammatory diseases of the pelvic organs.

Possibilities of personalized therapy in patients with chronic pelvic pain and inflammatory diseases of the pelvic organs. DOI: https://doi.org/10.26641/2307-0404.2018.4.153001Keywords: chronic pelvic pain, inflammatory diseases of the pelvic organs, interleukins, personalized therapyAbstract The aim of our study was to create a pathogenetically determined systemic approach to improve the treatment and the psycho-emotional state of a woman with chronic pelvic pain and inflammatory diseases of the pelvic organs through the individualization of therapeutic and rehabilitation tactics on the basis of the study of immune-hormonal relations, and psychopersonal characteristics of thematic patients.A comparative evaluation of the cytokine (IL-10, IL-6, TNF-α) and hormonal profile (luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, progesterone, prolactin,cortisol) was carried out as well as; monitoring of pain and psycho-emotional disorders of the dynamics of observation.In the dynamics of observation after the treatment for 6 months it was noted: a decrease in the pro-inflammatory activity of the cytokine profile: IL-6 by 43.28%, TNF-α by 63.27%;recovery of hormonal ratios – in76% of women;88% of patients identified a significant improvement in general and psychoemotional state;reduction of reactive anxiety and depressive disorders to normal values was determined in 84% of patients; regression of pain syndrome to the minimum indices according to the VAS scale was determined in 96% of patients. 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