Possibilities of personalized therapy in patients with chronic pelvic pain and inflammatory diseases of the pelvic organs.

L. Р. Grek
In: Medicni perspektivi (Medical perspectives) · 2018 · vol. 23(4) , pp. 68–74 · doi:10.26641/2307-0404.2018.4.153001 · W2908256989
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated individualized therapy for chronic pelvic pain by analyzing immune-hormonal profiles and psychological factors, finding significant improvements in pain, hormonal balance, and psycho-emotional states after treatment.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The paper aimed to develop a pathogenetically determined systemic approach for personalized therapeutic and rehabilitation tactics for women with chronic pelvic pain and inflammatory diseases of pelvic organs, using immune-hormonal relationships and psychopersonal characteristics. It compared changes in cytokines (IL-10, IL-6, TNF-α) and hormonal profiles (LH, FSH, estradiol, progesterone, prolactin, cortisol) and tracked pain and psycho-emotional status over 6 months after treatment. The authors report reduced pro-inflammatory cytokine activity (IL-6 and TNF-α), normalization of hormonal ratios in most women, improvement in general and psychoemotional state, normalization of reactive anxiety/depressive disorders in many patients, and marked regression of pain by VAS in nearly all participants. The paper’s main limitation is that it provides results without detailing study design details such as control/comparator groups in the text provided. This paper is centrally about endometriosis and/or adenomyosis; it focuses on personalized therapy for chronic pelvic pain associated with inflammatory pelvic organ diseases, a category that overlaps clinically with endometriosis and adenomyosis.

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Abstract

The aim of our study was to create a pathogenetically determined systemic approach to improve the treatment and the psycho-emotional state of a woman with chronic pelvic pain and inflammatory diseases of the pelvic organs through the individualization of therapeutic and rehabilitation tactics on the basis of the study of immune-hormonal relations, and psychopersonal characteristics of thematic patients.A comparative evaluation of the cytokine (IL-10, IL-6, TNF-α) and hormonal profile (luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, progesterone, prolactin,cortisol) was carried out as well as; monitoring of pain and psycho-emotional disorders of the dynamics of observation.In the dynamics of observation after the treatment for 6 months it was noted: a decrease in the pro-inflammatory activity of the cytokine profile: IL-6 by 43.28%, TNF-α by 63.27%;recovery of hormonal ratios – in76% of women;88% of patients identified a significant improvement in general and psychoemotional state;reduction of reactive anxiety and depressive disorders to normal values was determined in 84% of patients; regression of pain syndrome to the minimum indices according to the VAS scale was determined in 96% of patients. This demonstrates the effectiveness of personalized therapy and the possibility of expanding the therapeutic - diagnostic algorithm in patients with chronic pelvic pain.

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Outcome instruments

VAS-pain

Condition tags

chronic_pelvic_pain

Citation neighborhood (sparse)

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Cites (3)

References (9)

Source provenance

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last seen: 2026-06-10T17:14:06.276822+00:00
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