Effects of endocrinal therapy on the treatment of endometriosis after laparoscopy

Objective To study necessity and side effects of endocrinal therapy in patients with mid- or severe endometriosis after laparoscopy. Methods The postoperative women with mid- or severe endometriosis were divided into three groups, 19 without endocrinal therapy (Group A), 19 treated with synthesis progesterone (Group B) and 18 with ganodotropin releasing hormone-analogue (Group C). The recurrence, following pregnancy rate and side effects were compared. Results In Group A, B and C, the recurrent rates were 15 8%, 26 3% and 17 0%, respectively. There was no significant difference in recurrence rates or pregnency rates among the three groups. No significant difference was observed in menstrual recovery between Group B and C. The most severe side-effects of Group B was hyper-androgen syndrome, and menopause syndrome in Group C. Conclusions For women with endometriosis and infertility, who are willing to bear babies, endocrinal therapy can be suspended if completely cystectomy can be insured. Endocrinal therapy and fertility assistant therapy can be applied if persistent infertility after 6-12 months. The side effects must be noticed, especially in women of specifical profession.