Identification and Characterization of Exosomes in the Pathogenisis of Endometriosis

Endometriosis, the deposition of ectopic endometrial tissue in the peritoneal cavity, is an enigmatic, benign, estrogen dependent disease coupled with infertility and pain.The symptoms of endometriosis generally include dysmenorrhea, infertility, irregular menses, and pain with intercourse, bowel movements and /or urination.When subjected to ovarian hormones, Mature miRNAs are short, non-coding RNAs that play key roles in the regulation of gene expression at the post -transcriptional level.Mature miRNAs are involved in a wide range of biological processes such as cell cycle control, apoptosis and angiogenesis.We isolated miRNA from exosomes.Deep sequencing revealed differential expression levels of miR-21 and miR-126 in case and control exosomes, and was confirmed by real -time PCR.