Effects of CGP049090 treatment on fibrosis in a mouse endometriosis model.

Sachiko Matsuzaki (405488), Claude Darcha (405489)
2015 · doi:10.1371/journal.pone.0076808.g005 · W6904291155
other OA: green CC0
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This study investigated the therapeutic potential of CGP049090, a Wnt/β-Catenin signaling inhibitor, in reducing fibrosis within a murine model of endometriosis. Researchers administered the compound to mice at specific intervals following the induction of endometriotic implants and assessed fibrotic changes using Sirius Red and Masson Trichrome staining over time points ranging from day 7 to day 28. The results demonstrated that treatment with CGP049090 significantly reduced fibrotic markers compared to vehicle-treated controls, indicating an inhibition of fibrosis development. This paper is centrally about endometriosis — specifically the evaluation of pharmacological interventions targeting fibrotic pathways in ectopic endometrial tissue.

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Abstract

A-D: Staining score for Sirius Red (A, B) or Masson Trichrome (C, D) staining in a time course study of fibrosis development (on days 0, 7, 14, 21, and 28) (A, C) and vehicle-treated and CGP049090 (2 mg/kg)-treated mice (Groups I and II: treated once a day between days 7 and 21 for 14 days; Groups III and IV: treated once a day between days 14 and 28 for 14 days) (B, D).\n*: p<.05 versus endometrium on day 0 and endometriotic implants on day 7.\n**: p<.05 versus vehicle-treated mice.\nDay 0 (endometrium) (n=10), Days 7 (n=10), 14 (n=10), 21 (n=10), or 28 (n=10).\nV: vehicle-treated mice; T: CGP049090 (2 mg/kg)-treated mice.\nG1: Group I (n=10), GII: Group II (n=10), GIII: Group III (n=10), GIV: Group IV (n=10).\nE-G: Representative photomicrographs of the endometrium stained with hematoxylin and eosin, Sirius Red, or Masson Trichrome on day 0 (E), or of endometriotic implants of mice treated for 14 days with vehicle alone (F) or with CGP049090 (G) at day 21. Scale bars (a-c, g-i, m-o: 200 μm; d-f, j-l, p-r: 50 μm).
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Involvement of the Wnt/β-Catenin Signaling Pathway in the Cellular and Molecular Mechanisms of Fibrosis in Endometriosis Figure 5 Effects of CGP049090 treatment on fibrosis in a mouse endometriosis model. A-D: Staining score for Sirius Red (A, B) or Masson Trichrome (C, D) staining in a time course study of fibrosis development (on days 0, 7, 14, 21, and 28) (A, C) and vehicle-treated and CGP049090 (2 mg/kg)-treated mice (Groups I and II: treated once a day between days 7 and 21 for 14 days; Groups III and IV: treated once a day between days 14 and 28 for 14 days) (B, D). *: p<.05 versus endometrium on day 0 and endometriotic implants on day 7. **: p<.05 versus vehicle-treated mice. Day 0 (endometrium) (n=10), Days 7 (n=10), 14 (n=10), 21 (n=10), or 28 (n=10). V: vehicle-treated mice; T: CGP049090 (2 mg/kg)-treated mice. G1: Group I (n=10), GII: Group II (n=10), GIII: Group III (n=10), GIV: Group IV (n=10). E-G: Representative photomicrographs of the endometrium stained with hematoxylin and eosin, Sirius Red, or Masson Trichrome on day 0 (E), or of endometriotic implants of mice treated for 14 days with vehicle alone (F) or with CGP049090 (G) at day 21. Scale bars (a-c, g-i, m-o: 200 μm; d-f, j-l, p-r: 50 μm).

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