The Prevalence of Post Stroke Delirium and associated risk factors a multicenter prospective study in hospitalized patients at Tikur Anbessa specialized Hospital, Yekatit 12 Hospital and Yehulshet specialty Clinic, Addis Ababa, Ethiopia.

The Prevalence of Post Stroke Delirium and associated risk factors a multicenter prospective study in hospitalized patients at Tikur Anbessa specialized Hospital, Yekatit 12 Hospital and Yehulshet specialty Clinic, Addis Ababa, Ethiopia. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The Prevalence of Post Stroke Delirium and associated risk factors a multicenter prospective study in hospitalized patients at Tikur Anbessa specialized Hospital, Yekatit 12 Hospital and Yehulshet specialty Clinic, Addis Ababa, Ethiopia. Beruk Ketema, Getahun Mengistu, Dereje Melka, Yared Zenebe, Mehila Zebenegus, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4370680/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Post-stroke delirium, a frequent and significant complication of stroke, manifests as a sudden onset of confusion, altered consciousness, and cognitive decline. Various factors contribute to its occurrence, including old age, multiple comorbidity, electrolyte abnormalities and infections. The impact of post-stroke delirium on stroke recovery is substantial. It leads to prolonged hospital stays, heightened risk of institutionalization, increased dependence, and elevated mortality rates. As a result, early identification and prompt treatment of post-stroke delirium are imperative for optimizing outcomes in stroke patients. Objective: The objective of this study is to determine the Prevalence of Post Stroke Delirium and associated risk factors in hospitalized patients at TASH, Y12HMC and YSC, Addis Ababa, Ethiopia from August to December, 2023 G.c. Method: We performed a prospective observational cross sectional study, including all the stroke patients admitted to the respective study areas during the study period from August to December, 2023 G.c. A total of 101 participants who fulfilled the inclusion criteria were involved in this study. Data was collected using interviewer administered Questionnaire with well tested and validated tool, Patients were assessed for Delirium within 48 hour of admission and subsequently screened every 12 hours. A Descriptive statistics was used to summarize the data in terms of frequency, proportion, mean and standard deviation. Bivariate and multivariate logistic regression analysis were carried out to identify associated factors. Statistical significance was considered when the p value is below 0.05. Results: Out of 101 patients 26(25.7%) had Post stroke Delirium. Majority 56 (55.4%) of the patients were females. The mean (SD) age of the study participants was 56.05 ± 15.38 years, the mean time in day’s until the occurrence of delirium is 3 ± 1 days. Multivariable logistic regression analysis showed that, Age Greater than 60(AOR=19.1, 95% CI (1.7-211) p=0.016, Presence of Sepsis (AOR=8.3, 95% CI (1.2-56) P=0.029, Presence of Polypharmacy (AOR=157, 95% CI (10.2-244) P=0.0001, Presence of Electrolyte Derangement (AOR=65.2, 95% CI (3.4-124.1) P=0.005 were statistically significant risk factors. Conclusion: Our Study showed that Post Stroke Delirium occurs in a quarter of patients admitted with Diagnosis of Acute Stroke, and the Identified risk factors were Age greater than 60, Polypharmacy, Presence of Sepsis and Electrolyte Derangement, Medical professionals responsible for caring for acute stroke patients should be vigilant in identifying those at higher risk of developing post-stroke delirium. Additionally, they should focus on preventing and treating possible precipitating factors such as infections or electrolyte abnormalities. Incorporating delirium screening into routine patient assessments is crucial. Neurology Delirium Stroke Tikur Anbessa Specialized Hospital Yekatit 12 Hospital and Medical College Yehulshet Specialty Clinic Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4370680","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":299028170,"identity":"90bd4a4d-c6a3-4524-bf4a-e36d9dc89021","order_by":0,"name":"Beruk 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Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Delirium, Stroke, Tikur Anbessa Specialized Hospital, Yekatit 12 Hospital and Medical College, Yehulshet Specialty Clinic","lastPublishedDoi":"10.21203/rs.3.rs-4370680/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4370680/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Post-stroke delirium, a frequent and significant complication of stroke, manifests as a sudden onset of confusion, altered consciousness, and cognitive decline. Various factors contribute to its occurrence, including old age, multiple comorbidity, electrolyte abnormalities and infections. The impact of post-stroke delirium on stroke recovery is substantial. It leads to prolonged hospital stays, heightened risk of institutionalization, increased dependence, and elevated mortality rates. As a result, early identification and prompt treatment of post-stroke delirium are imperative for optimizing outcomes in stroke patients.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eObjective:\u003c/strong\u003e The objective of this study is to determine the Prevalence of Post Stroke Delirium and associated risk factors in hospitalized patients at TASH, Y12HMC and YSC, Addis Ababa, Ethiopia from August to December, 2023 G.c.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod:\u003c/strong\u003e We performed a prospective observational cross sectional study, including all the stroke patients admitted to the respective study areas during the study period from August to December, 2023 G.c.\u003c/p\u003e\n\u003cp\u003eA total of 101 participants who fulfilled the inclusion criteria were involved in this study. Data was collected using interviewer administered Questionnaire with well tested and validated tool, Patients were assessed for Delirium within 48 hour of admission and subsequently screened every 12 hours. A Descriptive statistics was used to summarize the data in terms of frequency, proportion, mean and standard deviation. Bivariate and multivariate logistic regression analysis were carried out to identify associated factors. Statistical significance was considered when the p value is below 0.05.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e Out of 101 patients 26(25.7%) had Post stroke Delirium. Majority 56 (55.4%) of the patients were females. The mean (SD) age of the study participants was 56.05 ± 15.38 years, the mean time in day’s until the occurrence of delirium is 3 ± 1 days. Multivariable logistic regression analysis showed that, Age Greater than 60(AOR=19.1, 95% CI (1.7-211) p=0.016, Presence of Sepsis (AOR=8.3, 95% CI (1.2-56) P=0.029, Presence of Polypharmacy (AOR=157, 95% CI (10.2-244) P=0.0001, Presence of Electrolyte Derangement (AOR=65.2, 95% CI (3.4-124.1) P=0.005 were statistically significant risk factors.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e Our Study showed that Post Stroke Delirium occurs in a quarter of patients admitted with Diagnosis of Acute Stroke, and the Identified risk factors were Age greater than 60, Polypharmacy, Presence of Sepsis and Electrolyte Derangement, Medical professionals responsible for caring for acute stroke patients should be vigilant in identifying those at higher risk of developing post-stroke delirium. Additionally, they should focus on preventing and treating possible precipitating factors such as infections or electrolyte abnormalities. 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