The role of stress echocardiography in patients with anomalous aortic origin of coronary arteries: two tertiary cardiac centres’ experience

The role of stress echocardiography in patients with anomalous aortic origin of coronary arteries: two tertiary cardiac centres’ experience | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 13 October 2025 V1 Latest version Share on The role of stress echocardiography in patients with anomalous aortic origin of coronary arteries: two tertiary cardiac centres’ experience Authors : Oleksandr Danylenko [email protected] , Myo Thidar Lwin , Ioannis Kasouridis , Abigail Masding , Katherine Von Klemperer , Rebecca Macrae , Ricardo Prista Monteiro , Roxy Senior , and Wei Li Authors Info & Affiliations https://doi.org/10.22541/au.176035666.67267539/v1 Published Echocardiography Version of record Peer review timeline 157 views 107 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Aims: The objective of our study was to establish the prevalence of ischaemia during exercise stress echocardiography (ESE) in patients with anomalous aortic origin of coronary arteries (AAOCA). Methods and results: a cohort of 46 patients with AAOCA was retrospectively included in this study. Treadmill/bike exercise stress echo tests for ischaemia assessment were performed and analysed according to ESC guidelines. Computed tomography coronary angiography (CTCA), cardiac magnetic resonance (CMR), myocardial perfusion scintigraphy and invasive angiography with intravascular ultrasound (IVUS) if needed were used for coronary artery (CA) morphology and myocardial perfusion assessment. Most patients (70%) were overall symptomatic at rest, 57% reported chest pains and 2% had cardiac arrest before the ESE. By contrast, only 2% of patients reported chest pains during ESE. CTCA revealed that 70% of patients had an interarterial course, 17% were found to have an intramural course and 24% had a slit-like ostium of their anomalous CA. Other high-risk features were less frequent findings. All myocardial perfusion studies were negative and only one patient with AAOCA developed ischaemia during ESE. Following investigations, four patients were eligible for surgical interventions and were operated while the remaining patients were followed up for a median of 3 years with no adverse cardiovascular events. Conclusions: incidence of ischaemia on exercise stress echo is extremely low in AAOCA patients despite symptoms at rest and malignant anatomical features. A good short-term outcome in unoperated AAOCA patients following negative exercise stress echocardiography has been shown. Supplementary Material File (figure legends.docx) Download 1.77 MB File (manuscript.docx) Download 44.61 KB File (tables.docx) Download 19.68 KB Information & Authors Information Version history V1 Version 1 13 October 2025 Peer review timeline Published Echocardiography Version of Record 15 Dec 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords congenital coronary artery abnormalities multimodality imaging stress echocardiography surgical correction and outcome in congenital coronary artery abnormalities Authors Affiliations Oleksandr Danylenko [email protected] Royal Brompton Hospital View all articles by this author Myo Thidar Lwin Barts Health NHS Trust View all articles by this author Ioannis Kasouridis Royal Brompton Hospital View all articles by this author Abigail Masding Barts Health NHS Trust View all articles by this author Katherine Von Klemperer Barts Health NHS Trust View all articles by this author Rebecca Macrae Barts Health NHS Trust View all articles by this author Ricardo Prista Monteiro Barts Health NHS Trust View all articles by this author Roxy Senior Royal Brompton Hospital View all articles by this author Wei Li Royal Brompton Hospital View all articles by this author Metrics & Citations Metrics Article Usage 157 views 107 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Oleksandr Danylenko, Myo Thidar Lwin, Ioannis Kasouridis, et al. The role of stress echocardiography in patients with anomalous aortic origin of coronary arteries: two tertiary cardiac centres’ experience. Authorea . 13 October 2025. DOI: https://doi.org/10.22541/au.176035666.67267539/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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