Impact of levonorgestrel-releasing intrauterine device on amenorrhea rates after endometrial resection or ablation in women with abnormal uterine bleeding.

ObjectiveTo evaluate the impact of adjunctive levonorgestrel-releasing intrauterine device (LNG-IUD) placement on amenorrhea rates and hysterectomy risk following endometrial resection or ablation in women with abnormal uterine bleeding (AUB).MethodsA retrospective cohort study was conducted involving 385 premenopausal women undergoing surgery for AUB. Patients were divided into surgery-only (n = 238) and surgery + LNG-IUD (n = 147) groups. Amenorrhea and hysterectomy rates were assessed at 12 months postoperatively. Multivariate logistic regression analyses were performed to examine the association of adjunctive LNG-IUD use with the risks of amenorrhea and hysterectomy, adjusting for potential confounders.ResultsThe surgery + LNG-IUD group demonstrated a significantly higher amenorrhea rate compared to the surgery-only group (61.2% vs. 24.4%, p < 0.01) and a lower hysterectomy rate (10.2% vs. 20.2%, p < 0.01). Multivariate logistic regression showed that adjunctive LNG-IUD use independently increased the odds of amenorrhea (adjusted OR = 4.89, 95% CI: 3.07-7.78, p < 0.01) and decreased the risk of hysterectomy (adjusted OR = 0.45, 95% CI: 0.24-0.85, p = 0.01).ConclusionAdjunctive LNG-IUD placement significantly improves amenorrhea rates and reduces the risk of hysterectomy after endometrial surgery in women with AUB.