Clinical Research of the Therapeutic Effects of Mifepristone on Endometriosis

Objective:To research the therapeutic effects and side effects of mifepristone on endometriosis.Methods:94 patients with ovarian endometriosis were selected and divided randomly into mifepristone group(Group M)and gestrinone group (Group G).46 cases were in Group M and 48 in Group G.All of them were detected by t and x~2 test.Results:The effective rate of Group M and G was 91.3% and 85.42% respectively.The differences of the effective rate between the groups M and G did not have any statistic significance(P＞0.05).Whereas the side effects of Group M were obviously lower than that of Group G.The weight gain rate of Group M and Group G was 15.00% and 43.75% respectively,with an obviously statistic difference(P＜0.01). Besides,compared with 25.00% of the Group G,only 4.40% of the Group M had abnormal glutamic pyruvic transaminase.The differences between them also had obvious statistic significance(P＜0.05).Conclusion:Mifepritone is similar to Gestrinone in the therapeutic effects on ovarian endometriosis,but mifepristone has fewer side effects than gestrinone.