Insulin resistance, left atrium enlargement, and recurrence in patients with atrial fibrillation undergoing radiofrequency ablation

Insulin resistance, left atrium enlargement, and recurrence in patients with atrial fibrillation undergoing radiofrequency ablation | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Insulin resistance, left atrium enlargement, and recurrence in patients with atrial fibrillation undergoing radiofrequency ablation Yan Luo, Shujuan Qin, Wenchao Huang, Guoshu Yang, Duan Luo, Huaxin Sun, and 9 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4637985/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Aims: To investigate the association between insulin resistance (IR), left atrial enlargement, and atrial fibrillation (AF) recurrence in AF patients undergoing radiofrequency catheter ablation (RFCA). Methods: 910 AF patients were evaluated for IR using TyG-BMI and left atrial enlargement using LAD. Various analytical methods were employed to study the relationship between TyG-BMI, LAD, and AF recurrence. Results: Over a median 12-month follow-up period, 189 (20.77%) cases of AF recurrence were observed. The likelihood of AF recurrence rose with elevated TyG-BMI and LAD levels. After adjusting for multiple factors, both TyG-BMI and LAD were significant predictors of AF recurrence. Both TyG-BMI and LAD demonstrated a positive dose-response relationship with AF recurrence. The areas under the ROC curves for TyG-BMI and LAD in predicting AF recurrence were 0.634 and 0.639, respectively. Notably, LAD partly mediated the association between TyG-BMI and AF recurrence, accounting for an 19.23% proportion. Conclusion: Elevated baseline TyG-BMI and LAD were associated with a higher risk of AF recurrence in patients undergoing RFCA. Furthermore, the enlargement of the left atrium partially mediated the relationship between IR and AF recurrence. Ameliorating IR may serve as a potential upstream therapy for the comprehensive management of AF in clinical practice. Health sciences/Cardiology Health sciences/Cardiology/Interventional cardiology atrial fibrillation catheter ablation left atrium insulin resistance clinical prognosis Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementalMaterials.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4637985","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":328837157,"identity":"38081da9-d3c9-4632-bdb7-bb9a632171c5","order_by":0,"name":"Yan Luo","email":"","orcid":"","institution":"The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University","correspondingAuthor":false,"prefix":"","firstName":"Yan","middleName":"","lastName":"Luo","suffix":""},{"id":328837158,"identity":"218819f1-690b-4ccb-9d9b-bfe34ca9dd1a","order_by":1,"name":"Shujuan Qin","email":"","orcid":"","institution":"The Third People's 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Xiong","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAwklEQVRIiWNgGAWjYDACZhBRYMHDwN7Y+PAD8VoMJHgYeA43G0sQb5UBUK1EepsAD1GKjzMfe/jFQELG4ObDNgYJBjs53QYCWiSb2dKNZYAOM7id2PaggCHZ2OwAAS38zDxm0hIQLe1A9x1I3EZICxtcy82DbcBAIEILyBbJDyAtNxiJ1AL0S5o0KJAlzyQCA9mACL8YnD98TPJHhY093/HjDx9+qLCTI6gFBJgR0WFAhHIQYPxBpMJRMApGwSgYoQAAebY3m9aBfYwAAAAASUVORK5CYII=","orcid":"","institution":"The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University","correspondingAuthor":true,"prefix":"","firstName":"Shiqiang","middleName":"","lastName":"Xiong","suffix":""}],"badges":[],"createdAt":"2024-06-25 16:58:33","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4637985/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4637985/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":65267320,"identity":"932ec63a-27cd-4ed7-9c00-b85f62282798","added_by":"auto","created_at":"2024-09-25 12:17:02","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":483935,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4637985/v1_covered_b48ed0af-8a0a-40a0-ae54-177e3d4b4037.pdf"},{"id":60653535,"identity":"0babcd06-2ec6-442b-91db-77aa4420e05c","added_by":"auto","created_at":"2024-07-19 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ablation","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"atrial fibrillation, catheter ablation, left atrium, insulin resistance, clinical prognosis","lastPublishedDoi":"10.21203/rs.3.rs-4637985/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4637985/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eAims: \u003c/strong\u003eTo investigate the association between insulin resistance (IR), left atrial enlargement, and atrial fibrillation (AF) recurrence in AF patients undergoing radiofrequency catheter ablation (RFCA).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003e910 AF patients were evaluated for IR using TyG-BMI and left atrial enlargement using LAD. Various analytical methods were employed to study the relationship between TyG-BMI, LAD, and AF recurrence.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eOver a median 12-month follow-up period, 189 (20.77%) cases of AF recurrence were observed. The likelihood of AF recurrence rose with elevated TyG-BMI and LAD levels. After adjusting for multiple factors, both TyG-BMI and LAD were significant predictors of AF recurrence. Both TyG-BMI and LAD demonstrated a positive dose-response relationship with AF recurrence. The areas under the ROC curves for TyG-BMI and LAD in predicting AF recurrence were 0.634 and 0.639, respectively. Notably, LAD partly mediated the association between TyG-BMI and AF recurrence, accounting for an 19.23% proportion.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eElevated baseline TyG-BMI and LAD were associated with a higher risk of AF recurrence in patients undergoing RFCA. Furthermore, the enlargement of the left atrium partially mediated the relationship between IR and AF recurrence. Ameliorating IR may serve as a potential upstream therapy for the comprehensive management of AF in clinical practice.\u003c/p\u003e","manuscriptTitle":"Insulin resistance, left atrium enlargement, and recurrence in patients with atrial fibrillation undergoing radiofrequency ablation","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-07-19 07:01:12","doi":"10.21203/rs.3.rs-4637985/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c69cbea5-72f3-4acf-8125-c16ba3ea2c78","owner":[],"postedDate":"July 19th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":34809587,"name":"Health sciences/Cardiology"},{"id":34809588,"name":"Health sciences/Cardiology/Interventional cardiology"}],"tags":[],"updatedAt":"2024-09-25T12:08:49+00:00","versionOfRecord":[],"versionCreatedAt":"2024-07-19 07:01:12","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4637985","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4637985","identity":"rs-4637985","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}