ARYL SULFONAMIDES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR
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This patent describes aryl sulfonamide compounds that modulate the progesterone receptor and their methods of use for treating or preventing endometriosis, fibroids, uterine leiomyomata, and other reproductive conditions.
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Abstract
In one embodiment, compounds of the following structure are described, wherein R1 to R7 are described herein. Formula (I): Also provided are methods for preparing these compounds and methods of contraception; treating or preventing fibroids; treating or preventing uterine leiomyomata; treating or preventing endometriosis, dysfunctional bleeding, and polycystic ovary syndrome; treating or preventing hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms using the compounds described herein.
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- europepmc
- last seen: 2026-10-12T06:17:10.165071+00:00