Application of mifepristone in the treatment of adenomyosis during menopausal transitional period

Objective To assess the clinical effects of mifepristone in the treatment of adenomyosis during menopausal transitional period. Methods Mifepristone were taken 10mg qd for 3 months continuously by 36 patients older than 40 years old with adenomyosis at menopausal transition. After treatment,the symptoms,uterine size and CA 125 were compared. Results At three months after treatment,all clinical symptoms of 36 patients relieved.Amenorrhea was induced in 8 patients; bleeding amount immediately decreased in 28 patients ( P 0 01).Dysmenorrhea completely disappeared in 27 patients,significantly alleviated in 6 and the other 3 recurred.The uterine shrunk significantly; CA 125 was decreased.After 6 months,amenorrhea was induced in 5 patients,bleeding amount reduced significantly in 21 patients; yet the other 10 were as the same as that before treatment.Dysmenorrhea completely disappeared in 14 patients,significantly alleviated in 20 and the other 2 recurred. Conclusions Mifepristone is effect in the treatment of adenomyosis during menopausal transitional period.