Beneficial effects of danazol on symptoms and laboratory changes in cholinergic urticaria

E Wong, Elizabeth Wong, N Eftekhari, Malcolm W. Greaves, M W Greaves, A. Milford Ward, A M Ward
The British journal of dermatology · 1987 · vol. 116(4) , pp. 553–556 · doi:10.1111/j.1365-2133.1987.tb05877.x · PMID:3555598 · W2070969637
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Danazol effectively reduced exercise-induced weals in cholinergic urticaria and significantly increased protease inhibitors, including antichymotrypsin.

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Abstract

In a double-blind placebo-controlled study, danazol, an attenuated androgen, was effective in reducing exercise-induced weals in cholinergic urticaria. Danazol treatment also caused significant elevations of several protease inhibitors, particularly antichymotrypsin which has been reported previously to be low in cholinergic urticaria.

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MeSH descriptors

Danazol Pregnadienes Urticaria Adolescent Adult Cholinergic Fibers Cholinergic Fibers Clinical Trials as Topic Danazol Double-Blind Method Humans Male Pregnadienes Protease Inhibitors Protease Inhibitors Random Allocation Urticaria Urticaria

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