环氧合酶-2、芳香酶与子宫内膜异位症
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Abstract
子宫内膜异位症(endometriosis，EM)是雌激素依赖性疾病，任何与雌激素合成代谢有关的因素均可能影响异位内膜的生长或萎缩。芳香酶(P450arom)是雌激素合成的限速酶，前列腺素E2(PGE2)为芳香酶的强诱导剂；环氧合酶-2(COX-2)是前列腺素(PG)合成的限速酶，故两种酶活性的高低、mRNA的过度表达以及两者间的相互作用均与EM的病理生理过程密切相关。芳香酶抑制剂能降低雌激素水平而使异位内膜萎缩。笔者主要从COX-2、芳香酶的生物学特性及其与EM的关系以及芳香酶抑制剂在EM中作用的分子机制及临床应用等予以综述。
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
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