Paternity in male kidney transplant recipients: A French national survey, the PATeRNAL study.

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Annabel Boyer, Thierry Lobbedez, Mohamed Ouethrani, Angélique Thuillier Lecouf, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-52614/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 16 Nov, 2020 Read the published version in BMC Nephrology → Version 2 posted 4 You are reading this latest preprint version Show more versions Abstract Background : There is concern about the impact of immunosuppressive agents taken by male kidney transplant (KT) recipients on the risk of foetal malformations. The aim of our survey was to estimate the paternity rate and the outcomes of pregnancies fathered by kidney transplanted males. Methods : This survey analysed 1332 male KT recipients older than 18 years, followed in 13 centres in France. A self-reported questionnaire was used to collect data on the patients, treatments at the time of conception and the pregnancy outcomes. Results : The study included data on 349 children from 404 pregnancies fathered by 232 male KT recipients. The paternity rate was 17% (95% CI [15–20]). There were 37 (9%, 95% CI [7–12]) spontaneous abortions, 12 (3%, 95% CI [2–5]) therapeutic abortions, 2 (0.5%, 95% CI [0.1–1]) still births, and 13 (4%, 95% CI [2–6]) malformations reported. Compared to the general population, there was no difference in the proportion of congenital malformations nor unwanted outcomes whether the father was exposed or not to immunosuppressive agents. Conclusions : This survey does not provide any warning signal that pregnancies fathered by male patients exposed to immunosuppressive agents, notably the debated MMF/MPA, have more complications than pregnancies in the general population. Urology & Nephrology Paternity kidney transplant pregnancy congenital malformation immunosuppression. Figures Figure 1 Background The first child of a kidney transplant recipient was born in 1958. Pregnancy is currently considered one of the benefits accorded to women by kidney transplantation [1]. Despite early concerns about the teratogenicity of immunosuppressive medication, thousands of solid organ transplant recipients worldwide have had successful pregnancies after transplantation [2-9]. In 1991, the National Transplantation Pregnancy Registry (NTPR) was created to collect information on the outcomes of pregnancies among transplant recipients in North America [10]. Pregnancy in transplanted patients remains a challenge because of the increased risk of adverse maternal complications and adverse foetal outcomes [2-4,7-9,11]. In addition, immunosuppressive medications, such as sirolimus and mycophenolate mofetil/mycophenolic acid (MMF/MPA), have been associated with an increased incidence of foetal malformations [5,6,12-16]. A specific pattern of malformation has been described with MMF/MPA exposure during pregnancy, including microtia, cleft lip and palate, and congenital heart defects [4,6,13-17]. These data led the Food and Drug Administration to change the pregnancy category of MMF/MPA from C to D (positive evidence of human foetal risk, potential benefits may warrant its use despite the potential risk) in October 2007 [18]. There are guidelines for female kidney transplant (KT) recipients regarding the timing of pregnancy and the management of immunosuppressive therapy. MMF/MPA and sirolimus should be discontinued and replaced by another drug at least six weeks prior to conception [5,7,12,19-21]. Information on fertility and the outcomes of pregnancies fathered by male KT recipients is sparse [4,5,22-24]. Some clinicians have expressed concern about the effect of immunosuppressive agents taken by the father at the time of conception on the risk of foetal malformation. Data from the NTPR are reassuring since the outcomes of pregnancies fathered by male KT recipients were similar to those from the general population [5,22]. No pattern of malformation was observed in the offspring of 152 male recipients who were on MMF/MPA at the time of conception [4,22]. In two population-based studies conducted in Norway, the risk of malformation was not increased when the father was on MMF/MPA at the time of conception [23,24]. There is a lack of data regarding the fertility rate in men under immunosuppressive therapy after a kidney transplantation. A higher incidence of infertility in transplanted patients on sirolimus has been observed [4,25-29]. Based on in vitro studies [30], the European medicines Agency (EMA), and hence the French Agence Nationale de la Santé et des Médicaments (ANSM), have recommended since October 2015 that sexually active men treated with MMF/MPA must use effective contraception until at least 90 days after the cessation of MMF/MPA [31-33]. It was initially recommended that their female partners also use effective contraception during the same period. Since 2017, it is no longer advocated that both partners use contraception [34]. This recommendation is a matter of concern for the transplant teams and for the transplanted patients as planned fatherhood would require changing MMF/MPA for another immunosuppressive agent, which could increase the risk of rejection. It also raises the question of pregnancy termination in cases of paternal exposure to MMF/MPA. In the absence of scientific evidence, some authors urged the EMA to reconsider their position, or provide data to support it [35-37]. The current information in the literature is insufficient to allow institutions to make evidence-based decisions and thus additional studies are needed. In the absence of reliable data, we aimed to conduct a nationwide survey of male transplanted patients followed in 13 centres in France. This survey was carried out to determine the paternity rate of male transplanted patients and to estimate the outcomes of pregnancies fathered by male KT recipients under immunosuppressive therapy at the time of conception. Methods Study population This national survey was conducted by the Spiesser transplant group in France, which was created in 1997 and includes 13 of the 31 adult transplant centres in order to develop research protocols and share experiences in the field of renal transplantation. All male adults older than 18 years who lived in France and had received at least one kidney transplant in one of the participating centres between the January 1, 2005, and December 31, 2014, were included. Patients older than 60 years at the time of first transplantation, under guardianship, multi-organ transplanted or those who refused to participate were excluded from the survey. Objectives The survey was carried out to seek for a signal of increased adverse pregnancy outcomes across male KT participants. Thus, the main objective was to determine the paternity rate in our population. The secondary objectives were to describe the outcome of pregnancies fathered by KT recipients under immunosuppressive therapy at the time of conception, and to investigate a possible future desire to father a child. Method The survey was distributed by post between January 2018 and February 2019, with a pre-stamped return envelope, to male transplanted patients included in the study. A second dispatch was sent out to increase the number of responders. Two months after the first and second dispatches, a relaunch was sent to patients who had not responded, to maximise the number of participants. A self-reported questionnaire, developed for this survey and adapted with authorization from the NTPR questionnaire, was used [38]. The questionnaire was divided into four sections and contained 32 items (Supplementary data, Figure S1). The collected data included global information on the patient: age, reference centre and year of kidney transplantation, number of children, and number of children after transplantation. If the patient did not have children, we collected information on the reasons why: anxiety, infertility, no desire. If the patient had children after transplantation, the collected data included: the year of pregnancy, the immunosuppressive agents taken at the time of conception and the pregnancy outcomes (miscarriage, stillbirth, livebirth, birth term, birth weight, congenital malformation, cognitive impairment). The last section of our questionnaire collected data on a possible future desire to father a child. Statistical analysis Continuous variables are described by their median and interquartile range (IQR). Categorical variables are described by frequencies, percentage and their 95% confidence interval (95% CI). Missing data on our primary objective were less than 5% and were considered missing at random. Missing data on the other variables were as follow: less than 5% on patients’ characteristics, treatment at the time of conception and pregnancy outcomes (living birth, spontaneous abortion, therapeutic abortion, stillbirth, malformation); and 8%, 11% and 12% on the birth weight, gestational age and year of pregnancy respectively. Analyses were performed with R 3.4.3 (R Foundation for Statistical Computing, Vienna, Austria). The study was approved by the ethics committee of CHU de Caen and was conducted according to the declaration of Helsinki. Results Participants characteristics Of the 3321 eligible male KT recipients, there were 413 (12%) missing addresses. Among the 2908 subjects who received the questionnaire, 1332 completed the survey (46% respond rate) (Figure 1). Supplementary data Table S1 details the number of participants per centre. Participants with and without children were distributed equally across the 13 centres. Our population median age was of 55 years old [IQR 46-62]. The participants’ characteristics are described in Supplementary data Table S2. Paternity rate With 232 participants having at least one child after transplantation, the paternity rate in our population was 17% (95% CI [15–20]), with on average 2 children after renal transplantation. Of these, 62 (27%, 95% CI [21–33]) male KT recipients had experienced fertility issues that were solved with medically assisted reproduction. A total of 1100 (83%, 95% CI [80–85]) participants did not have a child after renal transplantation: 330 (25%, 95% CI [22–27]) never had a child at all, and 770 (58%, 95% CI [55–60]) had children before transplantation only. Participants without children after transplantation Of the 330 participants who never had a child, 105 (32%, 95% CI [27–37]) declared that they did not want to conceive after transplantation, 6 (2%, 95% CI [0.7–4]) male KT recipients were concerned about the risk of transmission of polycystic kidney disease (PKD), whereas 55 (17%, 95% CI [13–21]) suffered from infertility (Table 1). Childless participants seemed to be younger than the ones who had fathered children before KT only, with a median age of 50 years [IQR 39-59] and 59 years [IQR 53-64] respectively (Table 1). Table 1 Description of participants without children Covariate Childless patients (n = 330) Age, median (IQR), years 50 (39–59) Year of first transplantation, median (IQR) 2009 (2005–2012) Reason, n (%, [95% CI]) No desire to father a child 105 (32%, [ 27 – 37 ]) Infertility 55 (17%, [ 13 – 21 ]) Erectile dysfunction 5 (1%, [0.5-4]) Spermatogenesis disorders 33 (10%, [ 7 – 14 ]) Other 17 (5%, [ 3 – 8 ]) Anxiety 37 (11%, [ 8 – 15 ]) Other Age 7 (2%, [ 1 – 4 ]) Celibacy 75 (23%, [ 18 – 28 ]) Genetic PKD 6 (2%, [0.7-4]) Genetic disease other than PKD 11 (3%, [ 2 – 6 ]) Intellectual disability 4 (1%, [0.3-3]) Partner's infertility 3 (1%, [0.2-3]) Missing 27 (8%, [ 5 – 12 ]) Ongoing pregnancy, n (%, [95% CI]) 4 (1%, [0.3-3]) IQR: interquartile range; PKD: polycystic kidney disease Outcome of pregnancies fathered by male kidney transplant recipients under immunosuppressive therapy at the time of conception There were 349 children from 404 pregnancies fathered by 232 male KT recipients, including twin pregnancies. Unwanted outcomes occurred in the 404 pregnancies as follows: 37 (9%, 95% CI [7–12]) spontaneous abortions, 12 (3%, 95% CI [2–5]) therapeutic abortions, and 2 (0.5%, 95% CI [0.1–1]) still births. There were 10 (2%, 95% CI [1–5]) ongoing pregnancies at the time of the survey. Of the 349 living births, the median gestational age was 41 weeks (IQR [39–41]), with only 30 (9%, 95% CI [6–12]) pre-term deliveries. The median birth weight was 3.4 Kg (IQR [3–3.7]). There were 13 (4%, 95% CI [2–6]) congenital malformations reported (Table 2). Table 2 Description and outcomes of pregnancies fathered by male kidney transplant patients Covariate All pregnancies n = 404 First pregnancy n = 245 Second pregnancy n = 115 Third pregnancy n = 35 Fourth pregnancy n = 9 Age, median (IQR), years 41 (36–48) 41 (36–48) 42 (37–48) 43 (37.5–49) 48 (44–52) Age at conception, median (IQR), years 34 (30–37) 33 (21–36) 35 (31–39) 37 (34–40) 41 (40–44) Year of first transplantation, median (IQR) 2006 (1999–2010) 2006 (1999–2010) 2006 (1996–2008) 2005 (1994–2007) 1994 (1986–2002) Transplant to conception time in years, median (IQR) 5 (2–8) 4 (1.5-7) 7 (4–10) 8 (6–11) 16 (13–19) Immunosuppressive co-medication at the time of conception § Corticosteroids 298 (74%, [69–78]) 176 (72%, [66–77]) 84 (73%, [64–81]) 29 (83%, [66–93]) 9 (100%, [66–100]) Azathioprine 59 (15%, [ 11 – 18 ]) 44 (18%, [ 13 – 23 ]) 13 (11%, [ 6 – 19 ]) 1 (3%, [0.7–15]) 1 (11%, [0.3–50]) MMF/MPA 313 (77%, [73–81]) 190 (78%, [72–83]) 92 (80%, [72–87]) 26 (74%, [57–88]) 5 (56%, [21–86]) Tacrolimus 255 (63%, [58–68]) 156 (64%, [57–70]) 70 (61%, [51–70]) 22 (63%, [45–79]) 7 (78%, [40–97]) Cyclosporine 152 (38%, [ 33 – 43 ]) 94 (38%, [ 32 – 45 ]) 43 (37%, [ 29 – 47 ]) 13 (37%, [21–55]) 2 (22%, [3–60]) Everolimus 5 (1%, [0.5-3]) 3 (1%, [0.3-4]) 2 (2%, [0.2-6]) 0 (0%, [0–10]) 0 (0%, [0–33]) Sirolimus 7 (2%, [ 1 – 4 ]) 5 (2%, [0.7-5]) 2 (2%, [0.2-6]) 0 (0%, [0–10]) 0 (0%, [0–33]) Belatacept 6 (1%, [0.5-3]) 4 (2%, [0.4-4]) 1 (1%, [0.1-5]) 1 (3%, [0.7–15]) 0 (0%, [0–33]) Other §§ 40 (10%, [ 7 – 13 ]) 18 (7%, [ 4 – 11 ]) 16 (14%, [ 8 – 22 ]) 5 (14%, [ 5 – 30 ]) 1 (11%, [0.3–50]) Rejection episode before or during pregnancy 80 (20%, [ 16 – 24 ]) 40 (16%, [ 12 – 22 ]) 29 (25%, [ 18 – 34 ]) 8 (23%, [ 10 – 40 ]) 3 (33%, [7–70]) Pregnancy outcomes Live births, including 6 twin pregnancies 349 (86%, [83–90]) 222 (91%, [86–94]) 94 (82%, [73–88]) 26 (74%, [57–88]) 7 (78%, [40–97]) Twin pregnancy 7 (2%, [0.5-3]) 5 (2%, [0.7-5]) 1 (1%, [0.1-5])* 1 (3%, [0.7–15]) 0 (0%, [0–33]) Spontaneous abortion 37 (9%, [ 7 – 12 ]) 18 (7%, [ 4 – 11 ]) 14 (12%, [ 7 – 20 ]) 4 (11%, [ 3 – 27 ]) 1 (11%, [0.3–50]) Therapeutic abortion 12 (3%, [ 2 – 5 ]) 6 (2%, [0.9-5]) 2 (2%, [0.2-6]) 3 (9%, [ 2 – 23 ]) 1 (11%, [0.3–50]) Still births 2 (0.5%, [0.1-1]) 0 (0%, [0-0.1]) 0 (0%, [0–3]) 2 (6%, [ 1 – 19 ]) 0 (0%, [0–33]) Ongoing pregnancy 10 (2%, [ 1 – 5 ]) 4 (2%, [0.4-4]) 5 (4%, [ 1 – 10 ]) 1 (3%, [0.7–15]) 0 (0%, [0–33]) Live births, including twin pregnancies 349 222 94 26 7 Gestational age in weeks, median (IQR) 41 (39–41) 41 (38–41) 41 (39–41) 41 (39–41) 41 (39–41) Pre-term delivery (< 37 weeks) 30 (9%, [ 6 – 12 ]) 23 (10%, [ 7 – 15 ]) 5 (5%, [ 2 – 12 ]) 2 (8%, [ 1 – 25 ]) 0 (0%, [0–41]) Birthweight (Kg), median (IQR) 3.4 (3-3.7) 3.3 (3-3.7) 3.4 (3-3.8) 3.5 (3-3.6) 3.5 (3.2–3.8) Low birthweight (< 2.5 Kg) 20 (6%, [ 4 – 9 ]) 16 (7%, [ 4 – 11 ]) 3 (3%, [ 1 – 9 ]) 1 (4%, [0.1–20]) 0 (0%, [0–41]) Sex (male) 193 (55%, [50–61]) 127 (57%, [50–64]) 47 (50%, [40–60]) 16 (62%, [41–80]) 3 (43%, [10–82]) Intellectual disability 3 (1%, [0.2-3]) 3 (1%, [0.3-4]) 0 (0%, [0–4]) 0 (%, [0–13]) 0 (0%, [0–41]) Congenital malformation 13 (4%, [ 2 – 6 ]) 10 (5%, [ 2 – 8 ]) 3 (3%, [ 1 – 9 ]) 0 (%, [0–13]) 0 (0%, [0–41]) Values are presented as numbers and percentages [95% CI] unless otherwise specified. IQR: interquartile range; MMF/MPA: mycophenolate mofetil/mycophenolic acid; Kg: Kilograms § Immunosuppressive agents of the father at the time of conception, more than one co-medication possible §§ Other: Immunosuppression including one of the following treatments before or at the time of conception: Cyclophosphamide, Intravenous immunoglobulin, Plasma exchange, Rituximab * The twin pregnancy was still ongoing at the time of the study The outcomes of pregnancies fathered by male KT recipients according to the father’s immunosuppressive medication at the time of conception are described in Tables 3.1 and 3.2. The immunosuppressive agents and the malformations or therapeutic abortions are displayed in Table 4. Since before the pregnancies the male patients were exposed to co-medication, outcomes can be declared in several columns. Of the 5 pregnancies within the partnerships of the participants treated by everolimus, there was one therapeutic abortion due to multiple malformations. The proportion of therapeutic abortions and malformations according to the immunosuppressive agents taken by the father were: 6 of 59 (10%, 95% CI [4–21]) pregnancies for azathioprine (AZA), 18 of 255 (7%, 95% CI [4–11]) pregnancies for tacrolimus, 19 of 298 (6%, 95% CI [4–10]) pregnancies for corticosteroid (CTC), 17 of 313 (5%, 95% CI [3–9]) pregnancies for MMF/MPA, and 6 of 152 (4%, 95% CI [1–8]) pregnancies for cyclosporine. The most common treatment associations were: CTC – MMF/MPA – tacrolimus (159 pregnancies conceived by 103 patients) and CTC – MMF/MPA – cyclosporine (72 pregnancies conceived by 45 patients), with a malformation rate of 3.7% (95% CI [1.5–8]) and 1.4% (95% CI [0.7–8.5]) respectively. Table 3.1. Description and outcomes of pregnancies fathered after kidney transplantation according to the fathers’ immunosuppressive medication at the time of conception Covariate MMF/MPA n=313 CTC n=298 Tacrolimus n=255 Cyclosporine n=152 Number of recipients 195 177 166 94 Age, median (IQR), years 40 (36-45) 43 (37-50) 40 (35-45) 46 (38-52) Age at conception, median (IQR), years 34 (30-38) 34 (31-38) 35 (31-38) 33 (29-37) Transplant to conception time § , median (IQR) 5 (2-9) 5 (3-10) 5 (7-10) 4 (2-7.5) Pregnancy outcomes Live births, including 6 twin pregnancies 268 (86%, [81-89]) 257 (86%, [82-90]) 219 (86%, [81-90]) 136 (89%, [83-94]) Twin pregnancy 6 (2%, [0.7-4])* 6 (2%, [0.7-4])* 5 (2%, [0.6-5]) 2 (1%, [0.2-5])* Spontaneous abortion 32 (10%, [7-14]) 29 (10%, [7-14]) 23 (9%, [6-13]) 12 (8%, [4-13]) Therapeutic abortion 8 (3%, [1-5]) 10 (3%, [2-6]) 8 (3%, [1-6]) 2 (1%, [0.2-5]) Still births 2 (1%, [0.1-2])** 2 (0.7%, [0.1-2])** 2 (0.8%, [0-3])** 0 (0%, [0-2]) Ongoing pregnancy 8 (3%, [1-5]) 5 (2%, [0.5-4]) 8 (3%, [1-6]) 3 (2%, [0.4-6]) Live births, including twins 268 257 219 136 Gestational age in weeks, median (IQR) 41 (39-41) 41 (39-41) 41 (39-41) 41 (39-41) Pre-term delivery (<37 weeks) 24 (9%, [6-13]) 22 (9%, [5-13]) 16 (7%, [4-12]) 16 (12%, [7-18]) Birthweight (Kg), median (IQR) 3.3 (3-3.7) 3.4 (3-3.7) 3.4 (3-3.7) 3.3 (2.9-3.7) Low birthweight (<2.5 Kg) 18 (7%, [4-10]) 10 (4%, [2-7]) 12 (5%, [3-9]) 9 (7%, [3-12]) Sex (male) 142 (53%, [47-59]) 143 (56%, [49-62]) 119 (54%, [47-61]) 76 (56%, [47-64]) Intellectual disability 1 (0.4%, [0-2]) 2 (0.8%, [0-3]) 1 (0.5%, [0-3]) 1 (0.7%, [0-4]) Congenital malformation 9 (3%, [1-6]) 9 (4%, [2-7]) 10 (5%, [2-8]) 4 (3%, [1-7]) Values are presented as numbers and percentages [95% CI] unless otherwise specified . As before the pregnancies the male patients were exposed to co-medication, one outcome can be declared in several columns. MMF: Mycophelonate mofetil; CTC: corticosteroid; IQR: interquartile range § Transplant to conception time, in years * One of the twin pregnancy was still ongoing at the time of the study ** In both stillbirths, from a twin pregnancy, a pulmonary malformation was discovered Table 3.2. Description and outcomes of pregnancies fathered after kidney transplantation according to the fathers’ immunosuppressive medication at the time of conception Covariate Azathioprine n=59 Sirolimus n=7* Belatacept n=6* Everolimus n=5* Number of recipients 46 7 4 5 Age, median (IQR), years 51 (44-56) 40 (38-48) 39 (35-42) 55 (37-62) Age at conception, median (IQR), years 34 (29-36) 34 (29-36) 38 (35-39) 37 (34-40) Transplant to conception time § , median (IQR) 5 (2-9.5) 4 (1.5-12) 6 (5-8) 7 (4-10.8) Pregnancy outcomes Live births, including 6 twin pregnancies 55 (93%, [84-98]) 5 4 5 Twin pregnancy 1 (2%, [0-9]) 0 0 1 Spontaneous abortion 2 (3%, [0.5-11]) 2 2 0 Therapeutic abortion 2 (3%, [0.5-11]) 0 0 1 Still births 0 (0%, [0-6]) 0 0 0 Ongoing pregnancy 1 (2%, [0-9]) 0 0 0 Live births, including twins 55 5 4 5 Gestational age in weeks, median (IQR) 41 (39-41) 39 (38-40) 38 (38-39) 39 (36-41) Pre-term delivery (<37 weeks) 5 (9%, [3-20]) 0 0 2 Birthweight (Kg), median (IQR) 3.5 (3.1-3.6) 3 (2.4-3.3) 3.1 (2.9-3.2) 3.2 (2.9-3.6) Low birthweight (<2.5 Kg) 1 (2%, [0.1-10]) 1 0 0 Sex (male) 33 (60%, [46-73]) 3 2 3 Intellectual disability 2 (4%, [0.5-13]) 0 0 0 Congenital malformation 4 (7%, [2-17]) 0 0 0 Values are presented as numbers and percentages [95% CI] unless otherwise specified . As before the pregnancies the male patients were exposed to co-medication, one outcome can be declared in several columns. MMF: Mycophelonate mofetil; IQR: interquartile range § Transplant to conception time, in years * Due to the small number of events, percentages are not presented Table 4 List of therapeutic abortions and congenital malformations identified among 25 offspring of male kidney transplant recipients exposed to immunosuppressive medication Therapeutic abortion, n = 12 Year of pregnancy Year of transplant Paternal age* Medical reason for abortion Male KT recipients’ medication regimen at the time of conception 1986 1981 NA Genetic disorder AZA, prednisone NA 1994 NA Trisomy 21 MMF/MPA, tacrolimus, prednisone 2005 1979 31 Spina bifida and Arnold Chiari AZA, prednisone 2012 2006 48 Ectopic pregnancy MMF/MPA, cyclosporine 2013 2007 34 Trisomy 21 MMF/MPA, cyclosporine 2014 2010 36 missing MMF/MPA, tacrolimus, prednisone 2015 2006 34 missing MMF/MPA, tacrolimus, prednisone 2016 2009 40 missing MMF/MPA, tacrolimus, prednisone 2016 2008 35 missing Tacrolimus, prednisone 2016 2011 35 Multiple malformations Tacrolimus, everolimus, prednisone 2018 2014 33 missing MMF/MPA, tacrolimus, prednisone 2018 2013 43 missing MMF/MPA, tacrolimus, prednisone Congenital malformation, n = 13 Year of birth Year of transplant Paternal age* Congenital malformation Male KT recipients’ medication regimen at the time of conception 1998 1996 33 Cleft lip and palate AZA, cyclosporine 2000 NA NA Deafness AZA, cyclosporine, prednisone 2001 1998 32 Congenital phimosis MMF/MPA, cyclosporine, tacrolimus, prednisone 2001 2000 NA Cleft lip and palate AZA, tacrolimus, prednisone 2002 1989 41 Complex cardio-facial syndrome AZA, tacrolimus, prednisone 2005 2004 34 Left thumb's agenesis MMF/MPA, tacrolimus, prednisone 2006 1992 25 Pyloric stenosis MMF/MPA, tacrolimus, prednisone 2009 2007 21 Renal hypoplasia MMF/MPA, tacrolimus 2012 2007 30 Hypospadias MMF/MPA, cyclosporine 2015 2011 26 Hypoplastic toes MMF/MPA, tacrolimus, prednisone 2015 2013 32 Urinary tract malformation MMF/MPA, tacrolimus 2016 2010 32 Plagiocephaly MMF/MPA, tacrolimus, prednisone 2017 2006 38 Wolff Parkinson White syndrome MMF/MPA, tacrolimus, prednisone MMF/MPA: Mycophelonate mofetil/Mycophenolic acid; AZA: Azathioprine * Age at conception of the pregnancy, in years Willingness of having a child in male transplanted patients under immunosuppressive therapy In the cohort, 175 (13%, 95% CI [11–15]) participants reported having a desire to father a child in the future, while 140 (11%, 95% CI [9–12]) felt anxious about fathering a child while taking immunosuppressive medications. Of these 175 subjects, 50 (4%, 95% CI [3–5]) patients have had treatment modifications linked to their willingness to conceive. Table 5 describes the patients’ feelings regarding a future pregnancy according to their fatherhood status. Table 5 Participants’ feelings regarding a future pregnancy according to their fatherhood status Covariate All patients (n = 1332) Patients without children after KT (n = 1100) Patients having fathered after KT (n = 232) Future desire to father a child, n (%, [95% CI]) 175 (13%, [ 11 – 15 ]) 119 (11%, [ 9 – 13 ]) 56 (24%, [ 19 – 30 ]) Anxiety regarding a future pregnancy, n (%, [95% CI]) 140 (11%, [ 9 – 12 ]) 106 (10%, [ 8 – 12 ]) 34 (15%, [ 10 – 20 ]) Treatment modification to prepare for pregnancy, n (%, [95% CI]) 50 (4%, [ 3 – 5 ]) 34 (3%, [ 2 – 4 ]) 16 (7%, [ 4 – 11 ]) KT: kidney transplant Discussion Successful transplantation improves reproductive function, permitting male KT recipients to father children [22,39,40]. The impact of immunosuppressive medication on the fertility of male KT recipients and their offspring is however unknown, since data related to paternal exposure at the time of conception are sparse. We hereby provide an estimation, based on a survey, of the proportion of male KT recipients having fathered children, and the outcome of the pregnancies. We report a paternity rate in our population of 17%, a majority of the participants did not have children after renal transplantation. Infertility issues The reported infertility rate in our childless population has been estimated at 17% mainly because of spermatogenesis disorders, higher than that in the general population (Table 1). In France, among 10–15% of couples who suffer from infertility, approximately 20–30% have a male origin [42]. It is generally assumed that approximately 6–7% of men face fertility problems [43-45]. Immunosuppressive agents, notably sirolimus, have been associated with impaired fertility after transplant [25,27-29]. In a study from Zuber et al. [29], the proportion of patients who had fathered after KT was significantly lower in patients treated with sirolimus, with abnormalities in sperm analysis. Our results highlight that 27% of patients who had fathered a child after KT needed medically assisted reproduction, with an equal proportion in each group of immunosuppressive agents. The issue of male fertility in kidney transplant recipients requires additional studies. Outcome of pregnancies fathered by male kidney transplant recipients under immunosuppressive therapy at the time of conception This is to date one of the largest cohorts, apart from the NTPR reports, regarding paternity in transplanted patients [4,5,22]. In our population, 86%, 9%, 3% and 0.5% of respectively livebirths, spontaneous abortions, therapeutic abortions and stillbirths, occurred. The higher occurrence of unwanted outcomes observed in pregnancies fathered by patients treated with everolimus, sirolimus and belatacept should be interpreted with caution as only a few patients were exposed to these agents. Of note, the occurrence of spontaneous abortion in the general population varies between 12–15% of pregnancies [46]. In France, authorizations for therapeutic abortion are delivered in approximately 0.93% of pregnancies [47], a lower rate than the one observed in our population. The general population stillbirth rate varies from 0.9% to 0.4% [48], which is similar to our results. In our study, among the 349 livebirths, only 9% were pre-term delivered, 6% had low birth-weights <2.5 Kg, and 4% had malformations. It should be noted that there was a higher rate of pre-term delivery in pregnancies fathered by patients treated with everolimus, and a higher rate of low birth-weight in pregnancies fathered by patients treated with sirolimus. These results should be interpreted very cautiously as only 5 and 7 patients were treated with everolimus and sirolimus, respectively. In the general population, the pre-term delivery and low birth-weight rates are 7.5%, and birth defects occur in approximately 2–3% of newborns [49,50]. Our study shows that there was no difference in the proportion of congenital malformations whether the father was exposed or not to immunosuppressive agents. Reports and analyses from the NTPR concluded that the outcomes of pregnancies fathered by male transplant recipients were similar to those of the general population. In 2010, Coscia et al. [5] reported 902 pregnancies fathered by 591 male KT recipients, with 93% livebirths but birth defects were not described. A Norwegian study reported 474 children born after transplantation, and no increased risk was found for any pregnancy outcomes compared with the general population, with a malformation rate of 1.9% [23]. Of the 13 congenital malformations in our population, 3 (one congenital phimosis, one pyloric stenosis and one Wolf Parkinson White syndrome) are well known malformations that have never been associated with any medication [51-53]. Paternal exposure to MMF/MPA at the time of conception There has been increasing concern since the EMA recommendations on the precautions male KT recipients should take while being treated with MMF/MPA [32,33,35-37]. These recommendations rely on the theoretical potential of chromosomal damage due to the transfer of MMF/MPA through seminal fluid [30,35]. In our study, pregnancies were mostly conceived under the following medications: CTC, MMF/MPA and tacrolimus, which is currently the most common post-transplant combination worldwide [24]. The malformation rates were 4%, 3% and 5% respectively, without highlighting any over-representation of malformations under MMF. The highest malformation rate (10%) was observed with azathioprine exposure. Jones et al. [22] identified 205 pregnancies fathered by male KT recipients exposed to MMF/MPA at the time of conception, and among 194 livebirths, the rate of malformations and prematurity were 3.1% and 11%, respectively. No specific pattern of malformation was identified [22]. Recently, Midtvedt et al. [24] retrospectively compared outcomes in pregnancies fathered by male KT recipients either exposed to MMF/MPA or not at the time of conception. There were 112 patients who fathered 155 children under MMF/MPA, and 133 patients who fathered 195 children without MMF/MPA exposure. They found no difference in malformations nor pre-term deliveries in children fathered by MMF/MPA exposed compared to KT recipients not exposed [24]. The outcomes of pregnancies fathered by male transplant recipients appear similar to those of the general population and MPA embryopathies have not been noted in pregnancies fathered by those patients [21,54]. Our results add to the available data in the literature, that pregnancies fathered by patients under MMF/MPA at the time of conception do not seem to have more complications than pregnancies in the general population Anxiety issues To our knowledge, patient anxiety about the impact of immunosuppressive drugs on pregnancies and children has never been previously studied. Our survey reveals a signal of increased anxiety in this population, which is important to take into account to improve patient’s quality of life. Among participants who never had children, one-third did not have a desire to father children, without any differences across the centres. It remained a common feeling among men who wanted children after transplantation, as the childless patients reported feeling anxious about exposure to immunosuppressive drugs (Table 5). The design of the survey did not inquire about the reasons of this anxiety, nor its care. Our findings will require further qualitative studies, to better describe the sources of anxiety. A multidisciplinary transplant team, to help KT patients medically as well as psychologically, seems necessary in the light of our findings. Limitation of the survey This study has several limitations, most notably the limited response rate which was less than 50% despite several relaunches to improve participation. Our population may not be representative of the experiences of all male KT recipients. Participation was voluntary and was thus subject to reporting and selection biases. Although the response rate may limit the generalizability of our results, this survey represents to our knowledge one of the largest sampling of pregnancies fathered by male KT recipients. It should also be noted that surveys may accentuate the concerns of a minority of responders, further limiting generalizability. The use of a questionnaire to collect past events could introduce memory bias. Participants needed to recall events that could have happened over 10-15 years back in time, which could question the validity of the collected data. Additionally, in addition to immunosuppressive agents, KT recipients are treated with multiple other medications, and thus exposures to various other agents cannot be excluded. As previously discussed, our spontaneous abortion rate is probably under-estimated due to a misunderstanding of the questionnaire by some patients. Information about immunosuppressive drugs of patients who did not father children after KT was not collected, which limits the interpretation of our infertility rate. Moreover, our study lacks information on the graft function, which also influences male KT recipients’ ability to conceive. Finally, because of the design of the study, medical information about the mother as well as her potential treatments were not available, even though the mothers’ exposure can have a major impact when studying pregnancy outcomes. Conclusion In conclusion, our survey adds further information on the proportion of malformations in the offspring of transplanted men exposed to immunosuppressive drugs, which remains a crucial issue that has lacked evidence to date. Despite the limited response rate, this survey does not provide any warning signal that pregnancies fathered by male patients exposed to immunosuppressive agents, notably the debated MMF/MPA, have more complications than pregnancies in the general population; which is consistent with previous studies. Even more data will be needed in the future; and health care providers are encouraged to report the outcomes of such pregnancies in the literature. Abbreviations 95% CI, 95% confidence interval ANSM, Agence Nationale de la Santé et des Médicaments AZA, Azathioprine CTC, corticosteroid EMA, European medicines Agency IQR, interquartile range Kg, kilogram KT, kidney transplant MMF/MPA, mycophenolate mofetil/mycophenolic acid NA, non-applicable NTPR, National Transplantation Pregnancy Registry PKD, polycystic kidney disease Declarations Ethics approval and consent to participate The study was approved by the ethics committee of CHU de Caen (France) and was conducted according to the declaration of Helsinki. Informed and written consent to participate in the study was obtained from participants. Consent for publication Not applicable. Availability of data and materials All data generated or analysed during this study are available from the corresponding author on reasonable request. Competing interests The authors declare that they have no competing interests. Funding This study was funded by a grant from “L’Agence de la Biomédecine”. The “Agence de la Biomédecine” reviewed and accepted the study design. The funding financed the postal costs and personnel costs for data collection and data management. Authors’ contributions AB, MD: study conception, methodology, data collection and analysis, and writing of the manuscript. TL, MD: writing of the manuscript. MO, MSc: data collection and analysis. ATL, MD: manuscript revision. NB, MD-PhD: manuscript revision. VC, MD-PhD: study conception, methodology and writing of the manuscript. BHL, MD-PhD: study conception, methodology and writing of the manuscript. All authors have read and approved the manuscript. Acknowledgments The authors thank the participating centres of the Spiesser transplant group and the Cristal Registry: Pierre-François Weestel (CHU Amiens, France), Jean-François Augusto (CHU Angers, France), Yann Le Meur (CHU Brest, France), Cyril Garrouste (CHU Clermont-Ferrand, France), Jean-Philippe Rérolle (CHU Limoges, France), Eric Thervet (Hôpital Européen Georges-Pompidou, France), Dany Anglicheau (Hôpital Necker AP-HP, France), Antoine Thierry (CHU Poitiers, France), Charlotte Colosio (CHU Reims, France), Joseph Rivalan (CHU Rennes, France), Isabelle Etienne (CHU Rouen, France), Sophie Caillard (CHU Strasbourg, France), and Mathias Büchler (CHU Tours, France). Questionnaire adapted from the National Transplantation Pregnancy Registry. References Murray JE, Reid DE, Harrison JH, Merrill JP. Successful pregnancies after human renal transplantation. N Engl J Med. 1963;269:341-3. Deshpande NA, James NT, Kucirka LM, Boyarsky BJ, Garonzik-Wang JM, Montgomery RA, et al. Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis. Am J Transplant. 2011;11:2388-404. Sibanda N, Briggs JD, Davison JM, Johnson RJ, Rudge CJ. Pregnancy after organ transplantation: a report from the UK transplant pregnancy registry. Transplantation. 2007;83:1301-7. Armenti VT, Constantinescu S, Moritz MJ, Davison JM. Pregnancy after transplantation. Transplant Rev. 2008;22:223-40. Coscia LA, Constantinescu S, Moritz MJ, Frank AM, Ramirez CB, Maley WR, et al. Report from the national transplantation pregnancy registry (NTPR): outcomes of pregnancy after transplantation. Clin Transpl. 2010:65-85. Coscia LA, Constantinescu S, Davison JM, Moritz MJ, Armenti VT. Immunosuppressive drugs and fetal outcome. Best Pract Res Clin Obstet Gynaecol. 2014;28:1174-87. McKay DB, Josephson MA. Pregnancy in recipients of solid organs--effects on mother and child. N Engl J Med. 2006;354:1281-93. Davison JM, Bailey DJ. Pregnancy following renal transplantation. 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Tondolo V, Citterio F, Panocchia N, Nanni G, Favi E, Brescia A, et al. Gonadal function and immunosuppressive therapy after renal transplantation. Transplant Proc. 2005;37:1915-7. Skrzypek J, Krause W. Azoospermia in a renal transplant recipient during sirolimus (rapamycin) treatment. Andrologia. 2007;39:198-9. Zuber J, Anglicheau D, Elie C, Bererhi L, Timsit M-O, Mamzer-Bruneel M-F, et al. Sirolimus may reduce fertility in male renal transplant recipients. Am J Transplant. 2008;8:1471-9. Scialli AR, Bailey G, Beyer BK, Bøgh IB, Breslin WJ, Chen CL, et al. Potential seminal transport of pharmaceuticals to the conceptus. Reprod Toxicol. 2015;58:213-21. Roche. Mycophenolate mofetil (CellCept): serious risk of teratogenicity - important new pregnancy prevention advice for women and men. https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=2ahUKEwiovqix_froAhWyZDUKHfZiDGkQFjAAegQIARAB&url=https%3A%2F%2Fwww.hpra.ie%2Fdocs%2Fdefault-source%2Fdefault-document-library%2Fimportant-safety-information---cellcept-(mycophenolate-mofetil).pdf%3Fsfvrsn%3D0&usg=AOvVaw3LM_4Orwhg4O51nfbRVwLA. Published 2015. Accessed May 7, 2020. European Medicines Agency. EMA recommends additional measures to prevent use of mycophenolate in pregnancy. http://www.ema.europa.eu/ema/index.jsp?curl=pages/. Published 2015. Accessed May 7, 2020. ANSM. 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Midtvedt K, Asberg A. Mycophenolate acid and balancing the risk for male allograft recipients. Transplantation. 2017;101:e39. Kuypers DR, Van Mieghem T, Meijers B, Claes K. Updated manufacturer and European medicines agency recommendations on the use of mycophenolate acid: balancing the risks for male allograft recipients. Transplantation. 2016;100:e50-51. Transplant Pregnancy Registry International. A division of gift of life institute. https://www.transplantpregnancyregistry.org/participation/. Accessed May 7, 2020. Holdsworth S, Atkins RC, de Kretser DM. The pituitary-testicular axis in men with chronic renal failure. N Engl J Med. 1977;296:1245-9. Handelsman DJ, McDowell IF, Caterson ID, Tiller DJ, Hall BM, Turtle JR. Testicular function after renal transplantation: comparison of Cyclosporin A with azathioprine and prednisone combination regimes. Clin Nephrol. 1984;22:144-8. Couchoud C, Lassalle M. Rapport annuel REIN 2017. https://www.agence-biomedecine.fr/IMG/pdf/rapportrein2017.pdf. Accessed May 7, 2020. INSERM. Infertilité, des difficultés à concevoir d’origines multiples. https://www.inserm.fr/information-en-sante/dossiers-information/infertilite. Accessed May 7, 2020. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015;13:37. Okutman O, Rhouma MB, Benkhalifa M, Muller J, Viville S. Genetic evaluation of patients with non-syndromic male infertility. J Assist Reprod Genet. 2018;35:1939-1951. Krausz C. Male infertility: pathogenesis and clinical diagnosis. Best Pract Res Clin Endocrinol Metab. 2011;25:271-85. Delabaere A, Huchon C, Deffieux X, Beucher G, Gallot V, Nedellec S, et al. Epidemiology of loss pregnancy. J Gynecol Obstet Biol Reprod. 2014;43:764-75. Agence de la Biomédecine. Rapport d’activité annuel des centres pluridisciplinaires de diagnostic prénatal 2015. https://www.agence-biomedecine.fr/annexes/bilan2016/donnees/diag-prenat/02-centres/pdf/cpdpn.pdf. Accessed May 7, 2020. Blondel B, Cuttini M, Hindori-Mohangoo AD, Gissler M, Loghi M, Prunet C, et al. How do late terminations of pregnancy affect comparisons of stillbirth rates in Europe? Analyses of aggregated routine data from the Euro-Peristat Project. Bjog. 2018;125:226-34. INSERM et DRESS. Enquête nationale périnatale Rapport 2016. Les naissances et les établissements Situation et évolution depuis 2010. http://www.xn--epop-inserm-ebb.fr/wp-content/uploads/2017/10/ENP2016_rapport_complet.pdf. Published 2017. Accessed May 7, 2020. Morris JK, Springett AL, Greenlees R, Loane M, Addor M-C, Arriola L, et al. Trends in congenital anomalies in Europe from 1980 to 2012. PLoS One. 2018;13:e0194986. Galea R, Said E. Infantile hypertrophic pyloric stenosis: an epidemiological review. Neonatal Netw. 2018;37:197-204. Bréaud J, Guys JM. Phimosis: medical treatment or circumcision? Arch Pediatrie. 2005;12:1424-32. Chhabra L, Goyal A, Benham M. Wolff Parkinson White Syndrome (WPW). Treasure Island, FL: StatPearls Publishing; 2020. Coscia LA, Armenti DP, King RW, Sifontis NM, Constantinescu S, Moritz MJ. Update on the teratogenicity of maternal mycophenolate mofetil. J Pediatr Genet. 2015;4:42-55. Supplementary Files PaternalBMCNephrolSupplementarydata.docx Cite Share Download PDF Status: Published Journal Publication published 16 Nov, 2020 Read the published version in BMC Nephrology → Version 2 posted Editorial decision: Accept 20 Oct, 2020 Editor assigned by journal 16 Oct, 2020 Submission checks completed at journal 15 Oct, 2020 Editor invited by journal 15 Oct, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-52614","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":3610198,"identity":"7db0a469-1171-4e00-9a86-d03635bfd41f","order_by":0,"name":"Annabel 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1958. Pregnancy is currently considered one of the benefits accorded to women by kidney transplantation [1]. Despite early concerns about the teratogenicity of immunosuppressive medication, thousands of solid organ transplant recipients worldwide have had successful pregnancies after transplantation [2-9]. In 1991, the National Transplantation Pregnancy Registry (NTPR) was created to collect information on the outcomes of pregnancies among transplant recipients in North America [10].\u003c/p\u003e\n\u003cp\u003ePregnancy in transplanted patients remains a challenge because of the increased risk of adverse maternal complications and adverse foetal outcomes [2-4,7-9,11]. In addition, immunosuppressive medications, such as sirolimus and mycophenolate mofetil/mycophenolic acid (MMF/MPA), have been associated with an increased incidence of foetal malformations [5,6,12-16]. A specific pattern of malformation has been described with MMF/MPA exposure during pregnancy, including microtia, cleft lip and palate, and congenital heart defects [4,6,13-17]. These data led the Food and Drug Administration to change the pregnancy category of MMF/MPA from C to D (positive evidence of human foetal risk, potential benefits may warrant its use despite the potential risk) in October 2007 [18]. There are guidelines for female kidney transplant (KT) recipients regarding the timing of pregnancy and the management of immunosuppressive therapy. MMF/MPA and sirolimus should be discontinued and replaced by another drug at least six weeks prior to conception [5,7,12,19-21].\u003c/p\u003e\n\u003cp\u003eInformation on fertility and the outcomes of pregnancies fathered by male KT recipients is sparse [4,5,22-24]. Some clinicians have expressed concern about the effect of immunosuppressive agents taken by the father at the time of conception on the risk of foetal malformation. Data from the NTPR are reassuring since the outcomes of pregnancies fathered by male KT recipients were similar to those from the general population [5,22]. No pattern of malformation was observed in the offspring of 152 male recipients who were on MMF/MPA at the time of conception [4,22]. In two population-based studies conducted in Norway, the risk of malformation was not increased when the father was on MMF/MPA at the time of conception [23,24]. There is a lack of data regarding the fertility rate in men under immunosuppressive therapy after a kidney transplantation. A higher incidence of infertility in transplanted patients on sirolimus has been observed [4,25-29].\u003c/p\u003e\n\u003cp\u003eBased on in vitro studies [30], the European medicines Agency (EMA), and hence the French Agence Nationale de la Sant\u0026eacute; et des M\u0026eacute;dicaments (ANSM), have recommended since October 2015 that sexually active men treated with MMF/MPA must use effective contraception until at least 90 days after the cessation of MMF/MPA [31-33]. It was initially recommended that their female partners also use effective contraception during the same period. Since 2017, it is no longer advocated that both partners use contraception [34]. This recommendation is a matter of concern for the transplant teams and for the transplanted patients as planned fatherhood would require changing MMF/MPA for another immunosuppressive agent, which could increase the risk of rejection. It also raises the question of pregnancy termination in cases of paternal exposure to MMF/MPA. In the absence of scientific evidence, some authors urged the EMA to reconsider their position, or provide data to support it [35-37]. The current information in the literature is insufficient to allow institutions to make evidence-based decisions and thus additional studies are needed.\u003c/p\u003e\n\u003cp\u003eIn the absence of reliable data, we aimed to conduct a nationwide survey of male transplanted patients followed in 13 centres in France. This survey was carried out to determine the paternity rate of male transplanted patients and to estimate the outcomes of pregnancies fathered by male KT recipients under immunosuppressive therapy at the time of conception.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003eStudy population\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis national survey was conducted by the Spiesser transplant group in France, which was created in 1997 and includes 13 of the 31 adult transplant centres in order to develop research protocols and share experiences in the field of renal transplantation. All male adults older than 18 years who lived in France and had received at least one kidney transplant in one of the participating centres between the January 1, 2005, and December 31, 2014, were included. Patients older than 60 years at the time of first transplantation, under guardianship, multi-organ transplanted or those who refused to participate were excluded from the survey.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eObjectives\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe survey was carried out to seek for a signal of increased adverse pregnancy outcomes across male KT participants. Thus, the main objective was to determine the paternity rate in our population. The secondary objectives were to describe the outcome of pregnancies fathered by KT recipients under immunosuppressive therapy at the time of conception, and to investigate a possible future desire to father a child.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eMethod\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe survey was distributed by post between January 2018 and February 2019, with a pre-stamped return envelope, to male transplanted patients included in the study. A second dispatch was sent out to increase the number of responders. Two months after the first and second dispatches, a relaunch was sent to patients who had not responded, to maximise the number of participants.\u003c/p\u003e\n\u003cp\u003eA self-reported questionnaire, developed for this survey and adapted with authorization from the NTPR questionnaire, was used [38]. The questionnaire was divided into four sections and contained 32 items (Supplementary data, Figure S1). The collected data included global information on the patient: age, reference centre and year of kidney transplantation, number of children, and number of children after transplantation. If the patient did not have children, we collected information on the reasons why: anxiety, infertility, no desire. If the patient had children after transplantation, the collected data included: the year of pregnancy, the immunosuppressive agents taken at the time of conception and the pregnancy outcomes (miscarriage, stillbirth, livebirth, birth term, birth weight, congenital malformation, cognitive impairment). The last section of our questionnaire collected data on a possible future desire to father a child.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eStatistical analysis\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eContinuous variables are described by their median and interquartile range (IQR). Categorical variables are described by frequencies, percentage and their 95% confidence interval (95% CI). Missing data on our primary objective were less than 5% and were considered missing at random. Missing data on the other variables were as follow: less than 5% on patients\u0026rsquo; characteristics, treatment at the time of conception and pregnancy outcomes (living birth, spontaneous abortion, therapeutic abortion, stillbirth, malformation); and 8%, 11% and 12% on the birth weight, gestational age and year of pregnancy respectively. Analyses were performed with R 3.4.3 (R Foundation for Statistical Computing, Vienna, Austria).\u003c/p\u003e\n\u003cp\u003eThe study was approved by the ethics committee of CHU de Caen and was conducted according to the declaration of Helsinki.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003eParticipants characteristics\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eOf the 3321 eligible male KT recipients, there were 413 (12%) missing addresses. Among the 2908 subjects who received the questionnaire, 1332 completed the survey (46% respond rate) (Figure 1). Supplementary data Table S1 details the number of participants per centre. Participants with and without children were distributed equally across the 13 centres. Our population median age was of 55 years old [IQR 46-62]. The participants\u0026rsquo; characteristics are described in Supplementary data Table S2.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePaternity rate\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWith 232 participants having at least one child after transplantation, the paternity rate in our population was 17% (95% CI [15\u0026ndash;20]), with on average 2 children after renal transplantation. Of these, 62 (27%, 95% CI [21\u0026ndash;33]) male KT recipients had experienced fertility issues that were solved with medically assisted reproduction. A total of 1100 (83%, 95% CI [80\u0026ndash;85]) participants did not have a child after renal transplantation: 330 (25%, 95% CI [22\u0026ndash;27]) never had a child at all, and 770 (58%, 95% CI [55\u0026ndash;60]) had children before transplantation only.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eParticipants without children after transplantation\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eOf the 330 participants who never had a child, 105 (32%, 95% CI [27\u0026ndash;37]) declared that they did not want to conceive after transplantation, 6 (2%, 95% CI [0.7\u0026ndash;4]) male KT recipients were concerned about the risk of transmission of polycystic kidney disease (PKD), whereas 55 (17%, 95% CI [13\u0026ndash;21]) suffered from infertility (Table 1). Childless participants seemed to be younger than the ones who had fathered children before KT only, with a median age of 50 years [IQR 39-59] and 59 years [IQR 53-64] respectively (Table 1).\u003c/p\u003e\u003ctable border=\"1\" data-mce-selected=\"1\" style=\"outline: black solid 1px; resize: none; color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;\"\u003e\n \u003ccaption\u003e\n \u003cdiv class=\"CaptionNumber\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; font-size: 15px;\"\u003eTable 1\u003c/span\u003e\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eDescription of participants without children\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCovariate\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eChildless patients\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e(n\u0026thinsp;=\u0026thinsp;330)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAge, median (IQR), years\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e50 (39\u0026ndash;59)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eYear of first transplantation, median (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2009 (2005\u0026ndash;2012)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eReason, n (%, [95% CI])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eNo desire to father a child\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e105 (32%, [\u003cspan class=\"CitationRef\"\u003e27\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e37\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eInfertility\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e55 (17%, [\u003cspan class=\"CitationRef\"\u003e13\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e21\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eErectile dysfunction\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (1%, [0.5-4])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eSpermatogenesis disorders\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e33 (10%, [\u003cspan class=\"CitationRef\"\u003e7\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e14\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eOther\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e17 (5%, [\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e8\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAnxiety\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e37 (11%, [\u003cspan class=\"CitationRef\"\u003e8\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e15\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eOther\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAge\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7 (2%, [\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCelibacy\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e75 (23%, [\u003cspan class=\"CitationRef\"\u003e18\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e28\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eGenetic PKD\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e6 (2%, [0.7-4])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eGenetic disease other than PKD\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e11 (3%, [\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e6\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eIntellectual disability\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e4 (1%, [0.3-3])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePartner\u0026apos;s infertility\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (1%, [0.2-3])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMissing\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e27 (8%, [\u003cspan class=\"CitationRef\"\u003e5\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e12\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eOngoing pregnancy, n (%, [95% CI])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e4 (1%, [0.3-3])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003ctfoot\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eIQR: interquartile range; PKD: polycystic kidney disease\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tfoot\u003e\n\u003c/table\u003e\n\u003cbr\u003e\u003cp\u003e\u003cstrong\u003e\u003cem\u003eOutcome of pregnancies fathered by male kidney transplant recipients under immunosuppressive therapy at the time of conception\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThere were 349 children from 404 pregnancies fathered by 232 male KT recipients, including twin pregnancies. Unwanted outcomes occurred in the 404 pregnancies as follows: 37 (9%, 95% CI [7\u0026ndash;12]) spontaneous abortions, 12 (3%, 95% CI [2\u0026ndash;5]) therapeutic abortions, and 2 (0.5%, 95% CI [0.1\u0026ndash;1]) still births. There were 10 (2%, 95% CI [1\u0026ndash;5]) ongoing pregnancies at the time of the survey. Of the 349 living births, the median gestational age was 41 weeks (IQR [39\u0026ndash;41]), with only 30 (9%, 95% CI [6\u0026ndash;12]) pre-term deliveries. The median birth weight was 3.4 Kg (IQR [3\u0026ndash;3.7]). There were 13 (4%, 95% CI [2\u0026ndash;6]) congenital malformations reported (Table 2).\u003c/p\u003e\u003ctable border=\"1\" data-mce-selected=\"1\" style=\"outline: black solid 1px; resize: none; color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;\"\u003e\n \u003ccaption\u003e\n \u003cdiv class=\"CaptionNumber\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTable 2\u003c/span\u003e\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eDescription and outcomes of pregnancies fathered by male kidney transplant patients\u003c/span\u003e\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCovariate\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAll pregnancies\u003c/span\u003e\u003c/p\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003en\u0026thinsp;=\u0026thinsp;404\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eFirst pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003en\u0026thinsp;=\u0026thinsp;245\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eSecond pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003en\u0026thinsp;=\u0026thinsp;115\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eThird pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003en\u0026thinsp;=\u0026thinsp;35\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eFourth pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003en\u0026thinsp;=\u0026thinsp;9\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAge, median (IQR), years\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e41 (36\u0026ndash;48)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e41 (36\u0026ndash;48)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e42 (37\u0026ndash;48)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e43 (37.5\u0026ndash;49)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e48 (44\u0026ndash;52)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAge at conception, median (IQR), years\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e34 (30\u0026ndash;37)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e33 (21\u0026ndash;36)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e35 (31\u0026ndash;39)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e37 (34\u0026ndash;40)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e41 (40\u0026ndash;44)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eYear of first transplantation, median (IQR)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2006 (1999\u0026ndash;2010)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2006 (1999\u0026ndash;2010)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2006 (1996\u0026ndash;2008)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2005 (1994\u0026ndash;2007)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1994 (1986\u0026ndash;2002)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTransplant to conception time in years, median (IQR)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (2\u0026ndash;8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e4 (1.5-7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7 (4\u0026ndash;10)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e8 (6\u0026ndash;11)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e16 (13\u0026ndash;19)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eImmunosuppressive co-medication at the time of conception\u003csup\u003e\u0026sect;\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCorticosteroids\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e298 (74%, [69\u0026ndash;78])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e176 (72%, [66\u0026ndash;77])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e84 (73%, [64\u0026ndash;81])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e29 (83%, [66\u0026ndash;93])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e9 (100%, [66\u0026ndash;100])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAzathioprine\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e59 (15%, [\u003cspan class=\"CitationRef\"\u003e11\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e18\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e44 (18%, [\u003cspan class=\"CitationRef\"\u003e13\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e23\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e13 (11%, [\u003cspan class=\"CitationRef\"\u003e6\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e19\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (3%, [0.7\u0026ndash;15])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (11%, [0.3\u0026ndash;50])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e313 (77%, [73\u0026ndash;81])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e190 (78%, [72\u0026ndash;83])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e92 (80%, [72\u0026ndash;87])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e26 (74%, [57\u0026ndash;88])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (56%, [21\u0026ndash;86])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTacrolimus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e255 (63%, [58\u0026ndash;68])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e156 (64%, [57\u0026ndash;70])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e70 (61%, [51\u0026ndash;70])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e22 (63%, [45\u0026ndash;79])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7 (78%, [40\u0026ndash;97])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCyclosporine\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e152 (38%, [\u003cspan class=\"CitationRef\"\u003e33\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e43\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e94 (38%, [\u003cspan class=\"CitationRef\"\u003e32\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e45\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e43 (37%, [\u003cspan class=\"CitationRef\"\u003e29\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e47\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e13 (37%, [21\u0026ndash;55])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2 (22%, [3\u0026ndash;60])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eEverolimus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (1%, [0.5-3])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (1%, [0.3-4])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2 (2%, [0.2-6])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;10])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;33])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eSirolimus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7 (2%, [\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (2%, [0.7-5])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2 (2%, [0.2-6])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;10])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;33])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eBelatacept\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e6 (1%, [0.5-3])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e4 (2%, [0.4-4])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (1%, [0.1-5])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (3%, [0.7\u0026ndash;15])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;33])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eOther\u003csup\u003e\u0026sect;\u0026sect;\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e40 (10%, [\u003cspan class=\"CitationRef\"\u003e7\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e13\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e18 (7%, [\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e11\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e16 (14%, [\u003cspan class=\"CitationRef\"\u003e8\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e22\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (14%, [\u003cspan class=\"CitationRef\"\u003e5\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e30\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (11%, [0.3\u0026ndash;50])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eRejection episode before or during pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e80 (20%, [\u003cspan class=\"CitationRef\"\u003e16\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e24\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e40 (16%, [\u003cspan class=\"CitationRef\"\u003e12\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e22\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e29 (25%, [\u003cspan class=\"CitationRef\"\u003e18\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e34\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e8 (23%, [\u003cspan class=\"CitationRef\"\u003e10\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e40\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (33%, [7\u0026ndash;70])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePregnancy outcomes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eLive births, including 6 twin pregnancies\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e349 (86%, [83\u0026ndash;90])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e222 (91%, [86\u0026ndash;94])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e94 (82%, [73\u0026ndash;88])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e26 (74%, [57\u0026ndash;88])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7 (78%, [40\u0026ndash;97])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTwin pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7 (2%, [0.5-3])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (2%, [0.7-5])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (1%, [0.1-5])*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (3%, [0.7\u0026ndash;15])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;33])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eSpontaneous abortion\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e37 (9%, [\u003cspan class=\"CitationRef\"\u003e7\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e12\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e18 (7%, [\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e11\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e14 (12%, [\u003cspan class=\"CitationRef\"\u003e7\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e20\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e4 (11%, [\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e27\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (11%, [0.3\u0026ndash;50])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTherapeutic abortion\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e12 (3%, [\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e5\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e6 (2%, [0.9-5])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2 (2%, [0.2-6])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (9%, [\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e23\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (11%, [0.3\u0026ndash;50])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eStill births\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2 (0.5%, [0.1-1])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0-0.1])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;3])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2 (6%, [\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e19\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;33])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eOngoing pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e10 (2%, [\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e5\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e4 (2%, [0.4-4])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (4%, [\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e10\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (3%, [0.7\u0026ndash;15])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;33])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eLive births, including twin pregnancies\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e349\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e222\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e94\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eGestational age in weeks, median (IQR)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e41 (39\u0026ndash;41)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e41 (38\u0026ndash;41)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e41 (39\u0026ndash;41)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e41 (39\u0026ndash;41)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e41 (39\u0026ndash;41)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePre-term delivery (\u0026lt;\u0026thinsp;37 weeks)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e30 (9%, [\u003cspan class=\"CitationRef\"\u003e6\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e12\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e23 (10%, [\u003cspan class=\"CitationRef\"\u003e7\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e15\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e5 (5%, [\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e12\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2 (8%, [\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e25\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;41])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eBirthweight (Kg), median (IQR)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.4 (3-3.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.3 (3-3.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.4 (3-3.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.5 (3-3.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3.5 (3.2\u0026ndash;3.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eLow birthweight (\u0026lt;\u0026thinsp;2.5 Kg)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e20 (6%, [\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e16 (7%, [\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e11\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (3%, [\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1 (4%, [0.1\u0026ndash;20])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;41])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eSex (male)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e193 (55%, [50\u0026ndash;61])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e127 (57%, [50\u0026ndash;64])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e47 (50%, [40\u0026ndash;60])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e16 (62%, [41\u0026ndash;80])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (43%, [10\u0026ndash;82])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eIntellectual disability\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (1%, [0.2-3])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (1%, [0.3-4])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;4])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (%, [0\u0026ndash;13])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;41])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCongenital malformation\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e13 (4%, [\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e6\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e10 (5%, [\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e8\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e3 (3%, [\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (%, [0\u0026ndash;13])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e0 (0%, [0\u0026ndash;41])\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003ctfoot\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eValues are presented as numbers and percentages [95% CI] unless otherwise specified.\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eIQR: interquartile range; MMF/MPA: mycophenolate mofetil/mycophenolic acid; Kg: Kilograms\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026sect; Immunosuppressive agents of the father at the time of conception, more than one co-medication possible\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026sect;\u0026sect; Other: Immunosuppression including one of the following treatments before or at the time of conception: Cyclophosphamide, Intravenous immunoglobulin, Plasma exchange, Rituximab\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e* The twin pregnancy was still ongoing at the time of the study\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tfoot\u003e\n\u003c/table\u003e\u003cbr\u003e\u003cp\u003eThe outcomes of pregnancies fathered by male KT recipients according to the father\u0026rsquo;s immunosuppressive medication at the time of conception are described in Tables 3.1 and 3.2. The immunosuppressive agents and the malformations or therapeutic abortions are displayed in Table 4. Since before the pregnancies the male patients were exposed to co-medication, outcomes can be declared in several columns. Of the 5 pregnancies within the partnerships of the participants treated by everolimus, there was one therapeutic abortion due to multiple malformations. The proportion of therapeutic abortions and malformations according to the immunosuppressive agents taken by the father were: 6 of 59 (10%, 95% CI [4\u0026ndash;21]) pregnancies for azathioprine (AZA), 18 of 255 (7%, 95% CI [4\u0026ndash;11]) pregnancies for tacrolimus, 19 of 298 (6%, 95% CI [4\u0026ndash;10]) pregnancies for corticosteroid (CTC), 17 of 313 (5%, 95% CI [3\u0026ndash;9]) pregnancies for MMF/MPA, and 6 of 152 (4%, 95% CI [1\u0026ndash;8]) pregnancies for cyclosporine. The most common treatment associations were: CTC \u0026ndash; MMF/MPA \u0026ndash; tacrolimus (159 pregnancies conceived by 103 patients) and CTC \u0026ndash; MMF/MPA \u0026ndash; cyclosporine (72 pregnancies conceived by 45 patients), with a malformation rate of 3.7% (95% CI [1.5\u0026ndash;8]) and 1.4% (95% CI [0.7\u0026ndash;8.5]) respectively.\u003c/p\u003e\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in; text-align: center;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"font-size: 13px; line-height: 200%; font-family: Helvetica;\" style=\"font-size: 15px; line-height: 26px; font-family: Calibri, sans-serif;\"\u003eTable 3.1. \u003cbr\u003e\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%;\" style=\"line-height: 26px;\"\u003eDescription and outcomes of pregnancies fathered after kidney transplantation according to the fathers\u0026rsquo; immunosuppressive medication at the time of conception\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable class=\"mce-item-table\" data-mce-style=\"width: 6.5e+2pt; border: none; border-collapse: collapse;\" style=\"border: none; color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; width: 650pt; border-collapse: collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; background: #BDD7EE; padding: 0in 0in 0in 0in; height: 27.4pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 212.65pt; background: rgb(189, 215, 238); padding: 0in; height: 27.4pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eCovariate\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; background: #BDD7EE; padding: 0in 0in 0in 0in; height: 27.4pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 109.85pt; background: rgb(189, 215, 238); padding: 0in; height: 27.4pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eMMF/MPA\u003cbr\u003e\u0026nbsp;n=313\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; background: #BDD7EE; padding: 0in 0in 0in 0in; height: 27.4pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; background: rgb(189, 215, 238); padding: 0in; height: 27.4pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eCTC\u003cbr\u003e\u0026nbsp;n=298\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; background: #BDD7EE; padding: 0in 0in 0in 0in; height: 27.4pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; background: rgb(189, 215, 238); padding: 0in; height: 27.4pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eTacrolimus\u003cbr\u003e\u0026nbsp;n=255\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; background: #BDD7EE; padding: 0in 0in 0in 0in; height: 27.4pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; background: rgb(189, 215, 238); padding: 0in; height: 27.4pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eCyclosporine\u003cbr\u003e\u0026nbsp;n=152\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; border: none; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: none; width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eNumber of recipients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: none; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e195\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e177\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e166\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e94\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eAge, median (IQR), years\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e40 (36-45)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e43 (37-50)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e40 (35-45)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e46 (38-52)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eAge at conception, median (IQR), years\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e34 (30-38)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e34 (31-38)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e35 (31-38)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e33 (29-37)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eTransplant to conception time\u003csup\u003e\u0026sect;\u003c/sup\u003e, median (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5 (2-9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5 (3-10)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5 (7-10)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e4 (2-7.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003ePregnancy outcomes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Live births,\u003csup\u003e\u0026nbsp;\u003c/sup\u003eincluding 6 twin pregnancies\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e268 (86%, [81-89])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e257 (86%, [82-90])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e219 (86%, [81-90])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e136 (89%, [83-94])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Twin pregnancy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e6 (2%, [0.7-4])*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e6 (2%, [0.7-4])*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5 (2%, [0.6-5])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2 (1%, [0.2-5])*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Spontaneous abortion\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e32 (10%, [7-14])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e29 (10%, [7-14])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e23 (9%, [6-13])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e12 (8%, [4-13])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Therapeutic abortion\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e8 (3%, [1-5])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e10 (3%, [2-6])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e8 (3%, [1-6])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2 (1%, [0.2-5])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Still births\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2 (1%, [0.1-2])**\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2 (0.7%, [0.1-2])**\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2 (0.8%, [0-3])**\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0 (0%, [0-2])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Ongoing pregnancy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e8 (3%, [1-5])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5 (2%, [0.5-4])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e8 (3%, [1-6])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3 (2%, [0.4-6])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eLive births, including twins\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e268\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e257\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e219\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e136\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Gestational age in weeks, median (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e41 (39-41)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e41 (39-41)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e41 (39-41)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e41 (39-41)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Pre-term delivery\u003csup\u003e\u0026nbsp;\u003c/sup\u003e(\u0026lt;37 weeks)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e24 (9%, [6-13])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e22 (9%, [5-13])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e16 (7%, [4-12])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e16 (12%, [7-18])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Birthweight (Kg), median (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3.3 (3-3.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3.4 (3-3.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3.4 (3-3.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3.3 (2.9-3.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Low birthweight\u003csup\u003e\u0026nbsp;\u003c/sup\u003e(\u0026lt;2.5 Kg)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e18 (7%, [4-10])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e10 (4%, [2-7])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e12 (5%, [3-9])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e9 (7%, [3-12])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Sex (male)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e142 (53%, [47-59])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e143 (56%, [49-62])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e119 (54%, [47-61])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e76 (56%, [47-64])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Intellectual disability\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e1 (0.4%, [0-2])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2 (0.8%, [0-3])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e1 (0.5%, [0-3])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e1 (0.7%, [0-4])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in; height: 14.15pt; vertical-align: bottom;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: none; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 212.65pt; padding: 0in; height: 14.15pt; vertical-align: bottom;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Congenital malformation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: none; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e9 (3%, [1-6])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: none; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e9 (4%, [2-7])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: none; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e10 (5%, [2-8])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: none; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e4 (3%, [1-7])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%;\" style=\"line-height: 26px;\"\u003eValues are presented as numbers and percentages [95% CI] unless otherwise specified\u003c/span\u003e\u003cspan data-mce-style=\"line-height: 200%; color: black;\" style=\"line-height: 26px; color: black;\"\u003e.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%;\" style=\"line-height: 26px;\"\u003eAs before the pregnancies the male patients were exposed to co-medication, one outcome can be declared in several columns.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%; color: black;\" style=\"line-height: 26px; color: black;\"\u003eMMF: Mycophelonate mofetil; CTC: corticosteroid; IQR: interquartile range\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%; color: black;\" style=\"line-height: 26px; color: black;\"\u003e\u0026sect; Transplant to conception time, in years\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%; color: black;\" style=\"line-height: 26px; color: black;\"\u003e* One of the twin pregnancy was still ongoing at the time of the study\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in 0in 8.0pt 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in 0in 8pt;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%; color: black;\" style=\"line-height: 26px; color: black;\"\u003e** In both stillbirths, from a twin pregnancy, a pulmonary malformation was discovered\u003c/span\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in; text-align: center;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in; text-align: center;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"line-height: 200%;\" style=\"line-height: 26px;\"\u003eTable 3.2.\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in; text-align: center;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in; text-align: center;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%;\" style=\"line-height: 26px;\"\u003eDescription and outcomes of pregnancies fathered after kidney transplantation according to the fathers\u0026rsquo; immunosuppressive medication at the time of conception\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable class=\"mce-item-table\" data-mce-style=\"width: 6.5e+2pt; border: none; border-collapse: collapse;\" style=\"border: none; color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; width: 650pt; border-collapse: collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; background: #BDD7EE; padding: 0in 0in 0in 0in; height: 27.4pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 212.65pt; background: rgb(189, 215, 238); padding: 0in; height: 27.4pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eCovariate\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; background: #BDD7EE; padding: 0in 0in 0in 0in; height: 27.4pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; background: rgb(189, 215, 238); padding: 0in; height: 27.4pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eAzathioprine\u003cbr\u003e\u0026nbsp;n=59\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; background: #BDD7EE; padding: 0in 0in 0in 0in; height: 27.4pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 109.85pt; background: rgb(189, 215, 238); padding: 0in; height: 27.4pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eSirolimus\u003cbr\u003e\u0026nbsp;n=7*\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; background: #BDD7EE; padding: 0in 0in 0in 0in; height: 27.4pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; background: rgb(189, 215, 238); padding: 0in; height: 27.4pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eBelatacept\u003cbr\u003e\u0026nbsp;n=6*\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; background: #BDD7EE; padding: 0in 0in 0in 0in; height: 27.4pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; background: rgb(189, 215, 238); padding: 0in; height: 27.4pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eEverolimus\u003cbr\u003e\u0026nbsp;n=5*\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; border: none; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: none; width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eNumber of recipients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: 1pt solid windowtext; border-right: none; border-bottom: none; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eAge, median (IQR), years\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e51 (44-56)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e40 (38-48)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e39 (35-42)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e55 (37-62)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eAge at conception, median (IQR), years\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e34 (29-36)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e34 (29-36)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e38 (35-39)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e37 (34-40)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eTransplant to conception time\u003csup\u003e\u0026sect;\u003c/sup\u003e, median (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5 (2-9.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e4 (1.5-12)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e6 (5-8)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e7 (4-10.8)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003ePregnancy outcomes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Live births,\u003csup\u003e\u0026nbsp;\u003c/sup\u003eincluding 6 twin pregnancies\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e55 (93%, [84-98])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Twin pregnancy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e1 (2%, [0-9])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Spontaneous abortion\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2 (3%, [0.5-11])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Therapeutic abortion\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2 (3%, [0.5-11])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Still births\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0 (0%, [0-6])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Ongoing pregnancy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e1 (2%, [0-9])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003eLive births, including twins\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Gestational age in weeks, median (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e41 (39-41)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e39 (38-40)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e38 (38-39)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e39 (36-41)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Pre-term delivery\u003csup\u003e\u0026nbsp;\u003c/sup\u003e(\u0026lt;37 weeks)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e5 (9%, [3-20])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Birthweight (Kg), median (IQR)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3.5 (3.1-3.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3\u0026nbsp;\u003c/span\u003e(2.4-3.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3.1 (2.9-3.2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3.2 (2.9-3.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Low birthweight\u003csup\u003e\u0026nbsp;\u003c/sup\u003e(\u0026lt;2.5 Kg)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e1 (2%, [0.1-10])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Sex (male)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e33 (60%, [46-73])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 212.65pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Intellectual disability\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e2 (4%, [0.5-13])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border: 1px dashed rgb(187, 187, 187); width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd data-mce-style=\"width: 212.65pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in; height: 14.15pt; vertical-align: bottom;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: none; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 212.65pt; padding: 0in; height: 14.15pt; vertical-align: bottom;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e\u0026nbsp; \u0026nbsp;Congenital malformation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: none; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e4 (7%, [2-17])\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: none; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: none; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd data-mce-style=\"width: 109.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 0in 0in 0in; height: 14.15pt;\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; border-top: none; border-right: none; border-bottom: 1pt solid windowtext; border-left: none; border-image: initial; width: 109.85pt; padding: 0in; height: 14.15pt;\"\u003e\n \u003cp data-mce-style=\"line-height: normal; font-size: 15px; font-family: 'Calibri',sans-serif; text-align: center; margin: 0in;\" style=\"line-height: normal; font-size: 15px; font-family: Calibri, sans-serif; text-align: center; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"color: black;\" style=\"color: black;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%;\" style=\"line-height: 26px;\"\u003eValues are presented as numbers and percentages [95% CI]\u0026nbsp;unless otherwise specified\u003c/span\u003e\u003cspan data-mce-style=\"line-height: 200%; color: black;\" style=\"line-height: 26px; color: black;\"\u003e.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%;\" style=\"line-height: 26px;\"\u003eAs before the pregnancies the male patients were exposed to co-medication, one outcome can be declared in several columns.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%; color: black;\" style=\"line-height: 26px; color: black;\"\u003eMMF: Mycophelonate mofetil; IQR: interquartile range\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp data-mce-style=\"line-height: 200%; font-size: 15px; font-family: 'Calibri',sans-serif; margin: 0in;\" style=\"color: rgb(0, 0, 0); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial; line-height: 30px; font-size: 15px; font-family: Calibri, sans-serif; margin: 0in;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cspan data-mce-style=\"line-height: 200%; color: black;\" style=\"line-height: 26px; color: black;\"\u003e\u0026sect; Transplant to\u0026nbsp;\u003c/span\u003e\u003cspan data-mce-style=\"line-height: 200%;\" style=\"line-height: 26px;\"\u003econception time, in years\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;\"\u003e\u003cspan data-mce-style=\"font-size: 13px; line-height: 107%; font-family: Helvetica;\" style=\"font-size: 15px; line-height: 13.91px; font-family: Calibri, sans-serif;\"\u003e* Due to the small number of events, percentages are not presented\u003c/span\u003e\u003c/p\u003e\u003cbr\u003e\u003ctable border=\"1\" data-mce-selected=\"1\" style=\"outline: black solid 1px; resize: none; color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;\"\u003e\n \u003ccaption\u003e\n \u003cdiv class=\"CaptionNumber\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; font-size: 15px;\"\u003eTable 4\u003c/span\u003e\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eList of therapeutic abortions and congenital malformations identified among 25 offspring of male kidney transplant recipients exposed to immunosuppressive medication\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\" colspan=\"6\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTherapeutic abortion, n\u0026thinsp;=\u0026thinsp;12\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eYear of pregnancy\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eYear of transplant\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePaternal age*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMedical reason for abortion\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMale KT recipients\u0026rsquo; medication regimen at the time of conception\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1986\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1981\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eGenetic disorder\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAZA, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1994\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTrisomy 21\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2005\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1979\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e31\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eSpina bifida and Arnold Chiari\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAZA, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2012\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2006\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e48\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eEctopic pregnancy\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, cyclosporine\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2013\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2007\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e34\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTrisomy 21\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, cyclosporine\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2014\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2010\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e36\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003emissing\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2015\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2006\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e34\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003emissing\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2016\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2009\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e40\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003emissing\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2016\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2008\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003emissing\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2016\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2011\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMultiple malformations\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTacrolimus, everolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2018\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2014\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e33\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003emissing\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2018\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2013\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003emissing\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"6\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e\u003cstrong\u003eCongenital malformation, n\u0026thinsp;=\u0026thinsp;13\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eYear of birth\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eYear of transplant\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePaternal age*\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCongenital malformation\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMale KT recipients\u0026rsquo; medication regimen at the time of conception\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1998\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1996\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e33\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCleft lip and palate\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAZA, cyclosporine\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eDeafness\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAZA, cyclosporine, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1998\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCongenital phimosis\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, cyclosporine, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCleft lip and palate\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAZA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2002\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1989\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e41\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eComplex cardio-facial syndrome\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAZA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2005\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2004\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e34\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eLeft thumb\u0026apos;s agenesis\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2006\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e1992\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e25\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePyloric stenosis\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2009\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2007\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e21\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eRenal hypoplasia\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2012\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2007\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e30\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eHypospadias\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, cyclosporine\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2015\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2011\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e26\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eHypoplastic toes\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2015\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2013\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eUrinary tract malformation\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2016\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2010\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePlagiocephaly\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2017\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e2006\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e38\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eWolff Parkinson White syndrome\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA, tacrolimus, prednisone\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003ctfoot\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-size: 15px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eMMF/MPA: Mycophelonate mofetil/Mycophenolic acid; AZA: Azathioprine\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; font-size: 15px;\"\u003e* Age at conception of the pregnancy, in years\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tfoot\u003e\n\u003c/table\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003e\u003cem\u003eWillingness of having a child in male transplanted patients under immunosuppressive therapy\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn the cohort, 175 (13%, 95% CI [11\u0026ndash;15]) participants reported having a desire to father a child in the future, while 140 (11%, 95% CI [9\u0026ndash;12]) felt anxious about fathering a child while taking immunosuppressive medications. Of these 175 subjects, 50 (4%, 95% CI [3\u0026ndash;5]) patients have had treatment modifications linked to their willingness to conceive. Table 5 describes the patients\u0026rsquo; feelings regarding a future pregnancy according to their fatherhood status.\u003c/p\u003e\u003ctable border=\"1\" style=\"color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;\"\u003e\n \u003ccaption\u003e\n \u003cdiv class=\"CaptionNumber\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; font-size: 16px;\"\u003eTable 5\u003c/span\u003e\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eParticipants\u0026rsquo; feelings regarding a future pregnancy according to their fatherhood status\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eCovariate\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAll patients\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e(n\u0026thinsp;=\u0026thinsp;1332)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePatients without children after KT\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e(n\u0026thinsp;=\u0026thinsp;1100)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003ePatients having fathered after KT\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e(n\u0026thinsp;=\u0026thinsp;232)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eFuture desire to father a child, n (%, [95% CI])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e175 (13%, [\u003cspan class=\"CitationRef\"\u003e11\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e15\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e119 (11%, [\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e13\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e56 (24%, [\u003cspan class=\"CitationRef\"\u003e19\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e30\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eAnxiety regarding a future pregnancy, n (%, [95% CI])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e140 (11%, [\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e12\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e106 (10%, [\u003cspan class=\"CitationRef\"\u003e8\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e12\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e34 (15%, [\u003cspan class=\"CitationRef\"\u003e10\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e20\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eTreatment modification to prepare for pregnancy, n (%, [95% CI])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e50 (4%, [\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e5\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e34 (3%, [\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\n \u003cp\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003e16 (7%, [\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e11\u003c/span\u003e])\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003ctfoot\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif;\"\u003eKT: kidney transplant\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tfoot\u003e\n\u003c/table\u003e\n\u003cp style=\"color: rgb(0, 0, 0); font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; font-size: 16px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eSuccessful transplantation improves reproductive function, permitting male KT recipients to father children [22,39,40]. The impact of immunosuppressive medication on the fertility of male KT recipients and their offspring is however unknown, since data related to paternal exposure at the time of conception are sparse. We hereby provide an estimation, based on a survey, of the proportion of male KT recipients having fathered children, and the outcome of the pregnancies.\u003c/p\u003e\n\u003cp\u003eWe report a paternity rate in our population of 17%, a majority of the participants did not have children after renal transplantation.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eInfertility issues\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe reported infertility rate in our childless population has been estimated at 17% mainly because of spermatogenesis disorders, higher than that in the general population (Table 1). In France, among 10\u0026ndash;15% of couples who suffer from infertility, approximately 20\u0026ndash;30% have a male origin [42]. It is generally assumed that approximately 6\u0026ndash;7% of men face fertility problems [43-45]. Immunosuppressive agents, notably sirolimus, have been associated with impaired fertility after transplant [25,27-29]. In a study from Zuber et al. [29], the proportion of patients who had fathered after KT was significantly lower in patients treated with sirolimus, with abnormalities in sperm analysis. Our results highlight that 27% of patients who had fathered a child after KT needed medically assisted reproduction, with an equal proportion in each group of immunosuppressive agents. The issue of male fertility in kidney transplant recipients requires additional studies.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eOutcome of pregnancies fathered by male kidney transplant recipients under immunosuppressive therapy at the time of conception\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis is to date one of the largest cohorts, apart from the NTPR reports, regarding paternity in transplanted patients [4,5,22]. In our population, 86%, 9%, 3% and 0.5% of respectively livebirths, spontaneous abortions, therapeutic abortions and stillbirths, occurred. The higher occurrence of unwanted outcomes observed in pregnancies fathered by patients treated with everolimus, sirolimus and belatacept should be interpreted with caution as only a few patients were exposed to these agents. Of note, the occurrence of spontaneous abortion in the general population varies between 12\u0026ndash;15% of pregnancies [46]. In France, authorizations for therapeutic abortion are delivered in approximately 0.93% of pregnancies [47], a lower rate than the one observed in our population. The general population stillbirth rate varies from 0.9% to 0.4% [48], which is similar to our results.\u003c/p\u003e\n\u003cp\u003eIn our study, among the 349 livebirths, only 9% were pre-term delivered, 6% had low birth-weights \u0026lt;2.5 Kg, and 4% had malformations. It should be noted that there was a higher rate of pre-term delivery in pregnancies fathered by patients treated with everolimus, and a higher rate of low birth-weight in pregnancies fathered by patients treated with sirolimus. These results should be interpreted very cautiously as only 5 and 7 patients were treated with everolimus and sirolimus, respectively. In the general population, the pre-term delivery and low birth-weight rates are 7.5%, and birth defects occur in approximately 2\u0026ndash;3% of newborns [49,50].\u003c/p\u003e\n\u003cp\u003eOur study shows that there was no difference in the proportion of congenital malformations whether the father was exposed or not to immunosuppressive agents. Reports and analyses from the NTPR concluded that the outcomes of pregnancies fathered by male transplant recipients were similar to those of the general population. In 2010, Coscia et al. [5] reported 902 pregnancies fathered by 591 male KT recipients, with 93% livebirths but birth defects were not described. A Norwegian study reported 474 children born after transplantation, and no increased risk was found for any pregnancy outcomes compared with the general population, with a malformation rate of 1.9% [23]. Of the 13 congenital malformations in our population, 3 (one congenital phimosis, one pyloric stenosis and one Wolf Parkinson White syndrome) are well known malformations that have never been associated with any medication [51-53].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePaternal exposure to MMF/MPA at the time of conception\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThere has been increasing concern since the EMA recommendations on the precautions male KT recipients should take while being treated with MMF/MPA [32,33,35-37]. These recommendations rely on the theoretical potential of chromosomal damage due to the transfer of MMF/MPA through seminal fluid [30,35]. In our study, pregnancies were mostly conceived under the following medications: CTC, MMF/MPA and tacrolimus, which is currently the most common post-transplant combination worldwide [24]. The malformation rates were 4%, 3% and 5% respectively, without highlighting any over-representation of malformations under MMF. The highest malformation rate (10%) was observed with azathioprine exposure. Jones et al. [22] identified 205 pregnancies fathered by male KT recipients exposed to MMF/MPA at the time of conception, and among 194 livebirths, the rate of malformations and prematurity were 3.1% and 11%, respectively. No specific pattern of malformation was identified [22]. Recently, Midtvedt et al. [24] retrospectively compared outcomes in pregnancies fathered by male KT recipients either exposed to MMF/MPA or not at the time of conception. There were 112 patients who fathered 155 children under MMF/MPA, and 133 patients who fathered 195 children without MMF/MPA exposure. They found no difference in malformations nor pre-term deliveries in children fathered by MMF/MPA exposed compared to KT recipients not exposed [24]. The outcomes of pregnancies fathered by male transplant recipients appear similar to those of the general population and MPA embryopathies have not been noted in pregnancies fathered by those patients [21,54]. Our results add to the available data in the literature, that pregnancies fathered by patients under MMF/MPA at the time of conception do not seem to have more complications than pregnancies in the general population \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAnxiety issues\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo our knowledge, patient anxiety about the impact of immunosuppressive drugs on pregnancies and children has never been previously studied. Our survey reveals a signal of increased anxiety in this population, which is important to take into account to improve patient\u0026rsquo;s quality of life. Among participants who never had children, one-third did not have a desire to father children, without any differences across the centres. It remained a common feeling among men who wanted children after transplantation, as the childless patients reported feeling anxious about exposure to immunosuppressive drugs (Table 5). The design of the survey did not inquire about the reasons of this anxiety, nor its care. Our findings will require further qualitative studies, to better describe the sources of anxiety. A multidisciplinary transplant team, to help KT patients medically as well as psychologically, seems necessary in the light of our findings.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eLimitation of the survey\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study has several limitations, most notably the limited response rate which was less than 50% despite several relaunches to improve participation. Our population may not be representative of the experiences of all male KT recipients. Participation was voluntary and was thus subject to reporting and selection biases. Although the response rate may limit the generalizability of our results, this survey represents to our knowledge one of the largest sampling of pregnancies fathered by male KT recipients. It should also be noted that surveys may accentuate the concerns of a minority of responders, further limiting generalizability.\u003c/p\u003e\n\u003cp\u003eThe use of a questionnaire to collect past events could introduce memory bias. Participants needed to recall events that could have happened over 10-15 years back in time, which could question the validity of the collected data.\u003c/p\u003e\n\u003cp\u003eAdditionally, in addition to immunosuppressive agents, KT recipients are treated with multiple other medications, and thus exposures to various other agents cannot be excluded. As previously discussed, our spontaneous abortion rate is probably under-estimated due to a misunderstanding of the questionnaire by some patients. Information about immunosuppressive drugs of patients who did not father children after KT was not collected, which limits the interpretation of our infertility rate. Moreover, our study lacks information on the graft function, which also influences male KT recipients\u0026rsquo; ability to conceive. Finally, because of the design of the study, medical information about the mother as well as her potential treatments were not available, even though the mothers\u0026rsquo; exposure can have a major impact when studying pregnancy outcomes.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn conclusion, our survey adds further information on the proportion of malformations in the offspring of transplanted men exposed to immunosuppressive drugs, which remains a crucial issue that has lacked evidence to date. Despite the limited response rate, this survey does not provide any warning signal that pregnancies fathered by male patients exposed to immunosuppressive agents, notably the debated MMF/MPA, have more complications than pregnancies in the general population; which is consistent with previous studies.\u003c/p\u003e\n\u003cp\u003eEven more data will be needed in the future; and health care providers are encouraged to report the outcomes of such pregnancies in the literature.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003e95% CI, 95% confidence interval\u003c/p\u003e\n\u003cp\u003eANSM, Agence Nationale de la Sant\u0026eacute; et des M\u0026eacute;dicaments\u003c/p\u003e\n\u003cp\u003eAZA, Azathioprine\u003c/p\u003e\n\u003cp\u003eCTC, corticosteroid\u003c/p\u003e\n\u003cp\u003eEMA, European medicines Agency\u003c/p\u003e\n\u003cp\u003eIQR, interquartile range\u003c/p\u003e\n\u003cp\u003eKg, kilogram\u003c/p\u003e\n\u003cp\u003eKT, kidney transplant\u003c/p\u003e\n\u003cp\u003eMMF/MPA, mycophenolate mofetil/mycophenolic acid\u003c/p\u003e\n\u003cp\u003eNA, non-applicable\u003c/p\u003e\n\u003cp\u003eNTPR, National Transplantation Pregnancy Registry\u003c/p\u003e\n\u003cp\u003ePKD, polycystic kidney disease\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was approved by the ethics committee of CHU de Caen (France) and was conducted according to the declaration of Helsinki. Informed and written consent to participate in the study was obtained from participants.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll data generated or analysed during this study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was funded by a grant from \u0026ldquo;L\u0026rsquo;Agence de la Biom\u0026eacute;decine\u0026rdquo;. The \u0026ldquo;Agence de la Biom\u0026eacute;decine\u0026rdquo; reviewed and accepted the study design. The funding financed the postal costs and personnel costs for data collection and data management.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAB, MD: study conception, methodology, data collection and analysis, and writing of the manuscript.\u003c/p\u003e\n\u003cp\u003eTL, MD: writing of the manuscript.\u003c/p\u003e\n\u003cp\u003eMO, MSc: data collection and analysis.\u003c/p\u003e\n\u003cp\u003eATL, MD: manuscript revision.\u003c/p\u003e\n\u003cp\u003eNB, MD-PhD: manuscript revision.\u003c/p\u003e\n\u003cp\u003eVC, MD-PhD:\u0026nbsp; study conception, methodology and writing of the manuscript.\u003c/p\u003e\n\u003cp\u003eBHL, MD-PhD: study conception, methodology and writing of the manuscript.\u003c/p\u003e\n\u003cp\u003eAll authors have read and approved the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors thank the participating centres of the Spiesser transplant group and the Cristal Registry: Pierre-Fran\u0026ccedil;ois Weestel (CHU Amiens, France), Jean-Fran\u0026ccedil;ois Augusto (CHU Angers, France), Yann Le Meur (CHU Brest, France), Cyril Garrouste (CHU Clermont-Ferrand, France), Jean-Philippe R\u0026eacute;rolle (CHU Limoges, France), Eric Thervet (H\u0026ocirc;pital Europ\u0026eacute;en Georges-Pompidou, France), Dany Anglicheau (H\u0026ocirc;pital Necker AP-HP, France), Antoine Thierry (CHU Poitiers, France), Charlotte Colosio (CHU Reims, France), Joseph Rivalan (CHU Rennes, France), Isabelle Etienne (CHU Rouen, France), Sophie Caillard (CHU Strasbourg, France), and Mathias B\u0026uuml;chler (CHU Tours, France).\u003c/p\u003e\n\u003cp\u003eQuestionnaire adapted from the National Transplantation Pregnancy Registry.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eMurray JE, Reid DE, Harrison JH, Merrill JP. 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Analyses of aggregated routine data from the Euro-Peristat Project. Bjog. 2018;125:226-34.\u003c/li\u003e\n\u003cli\u003eINSERM et DRESS. Enqu\u0026ecirc;te nationale p\u0026eacute;rinatale Rapport 2016. Les naissances et les \u0026eacute;tablissements Situation et \u0026eacute;volution depuis 2010. http://www.xn--epop-inserm-ebb.fr/wp-content/uploads/2017/10/ENP2016_rapport_complet.pdf. Published 2017. Accessed May 7, 2020.\u003c/li\u003e\n\u003cli\u003eMorris JK, Springett AL, Greenlees R, Loane M, Addor M-C, Arriola L, et al. Trends in congenital anomalies in Europe from 1980 to 2012. PLoS One. 2018;13:e0194986.\u003c/li\u003e\n\u003cli\u003eGalea R, Said E. Infantile hypertrophic pyloric stenosis: an epidemiological review. Neonatal Netw. 2018;37:197-204.\u003c/li\u003e\n\u003cli\u003eBr\u0026eacute;aud J, Guys JM. Phimosis: medical treatment or circumcision? Arch Pediatrie. 2005;12:1424-32.\u003c/li\u003e\n\u003cli\u003eChhabra L, Goyal A, Benham M. Wolff Parkinson White Syndrome (WPW). Treasure Island, FL: StatPearls Publishing; 2020.\u003c/li\u003e\n\u003cli\u003eCoscia LA, Armenti DP, King RW, Sifontis NM, Constantinescu S, Moritz MJ. Update on the teratogenicity of maternal mycophenolate mofetil. J Pediatr Genet. 2015;4:42-55.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-nephrology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bnep","sideBox":"Learn more about [BMC Nephrology](http://bmcnephrol.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bnep/default.aspx","title":"BMC Nephrology","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Paternity, kidney transplant, pregnancy, congenital malformation, immunosuppression.","lastPublishedDoi":"10.21203/rs.3.rs-52614/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-52614/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003eBackground\u003c/em\u003e\u003c/strong\u003e: There is concern about the impact of immunosuppressive agents taken by male kidney transplant (KT) recipients on the risk of foetal malformations. The aim of our survey was to estimate the paternity rate and the outcomes of pregnancies fathered by kidney transplanted males. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003e\u003cem\u003eMethods\u003c/em\u003e\u003c/strong\u003e: This survey analysed 1332 male KT recipients older than 18 years, followed in 13 centres in France. A self-reported questionnaire was used to collect data on the patients, treatments at the time of conception and the pregnancy outcomes.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003e\u003cem\u003eResults\u003c/em\u003e\u003c/strong\u003e: The study included data on 349 children from 404 pregnancies fathered by 232 male KT recipients. The paternity rate was 17% (95% CI [15–20]). There were 37 (9%, 95% CI [7–12]) spontaneous abortions, 12 (3%, 95% CI [2–5]) therapeutic abortions, 2 (0.5%, 95% CI [0.1–1]) still births, and 13 (4%, 95% CI [2–6]) malformations reported. Compared to the general population, there was no difference in the proportion of congenital malformations nor unwanted outcomes whether the father was exposed or not to immunosuppressive agents.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003e\u003cem\u003eConclusions\u003c/em\u003e\u003c/strong\u003e: This survey does not provide any warning signal that pregnancies fathered by male patients exposed to immunosuppressive agents, notably the debated MMF/MPA, have more complications than pregnancies in the general population.\u003c/p\u003e","manuscriptTitle":"Paternity in male kidney transplant recipients: A French national survey, the PATeRNAL study.","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-10-21 15:26:24","doi":"10.21203/rs.3.rs-52614/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Accept","date":"2020-10-20T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-10-16T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-10-15T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-10-15T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-nephrology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bnep","sideBox":"Learn more about [BMC Nephrology](http://bmcnephrol.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bnep/default.aspx","title":"BMC Nephrology","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-09-08 19:05:02","doi":"10.21203/rs.3.rs-52614/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2020-10-10T12:00:00+00:00","index":1,"fulltext":"Recommendation: Reviewer's comments unavailable pending editorial decision\n"},{"type":"reviewerAgreed","content":"","date":"2020-09-25T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-25T12:00:00+00:00","index":2,"fulltext":"Recommendation: Reviewer's comments unavailable pending editorial decision\n"},{"type":"reviewerAgreed","content":"","date":"2020-09-20T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-09-07T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-09-01T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-08-31T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-08-31T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-nephrology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bnep","sideBox":"Learn more about [BMC Nephrology](http://bmcnephrol.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bnep/default.aspx","title":"BMC Nephrology","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"f5956b2b-dc8b-43aa-88bc-b417b95e343a","owner":[],"postedDate":"October 21st, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":464183,"name":"Urology \u0026 Nephrology"}],"tags":[],"updatedAt":"2020-11-22T15:01:59+00:00","versionOfRecord":{"articleIdentity":"rs-52614","link":"https://doi.org/10.1186/s12882-020-02115-x","journal":{"identity":"bmc-nephrology","isVorOnly":false,"title":"BMC Nephrology"},"publishedOn":"2020-11-16 15:00:46","publishedOnDateReadable":"November 16th, 2020"},"versionCreatedAt":"2020-10-21 15:26:24","video":"","vorDoi":"10.1186/s12882-020-02115-x","vorDoiUrl":"https://doi.org/10.1186/s12882-020-02115-x","workflowStages":[]},"version":"v2","identity":"rs-52614","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-52614","identity":"rs-52614","version":["v2"]},"buildId":"369fNeqWncA4NS6XSWjrt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}