EVALUATION OF THE ENDOMETRIAL CHANGES IN FEMALES DIAGNOSED WITH THE UTERINE LEIOMYOMAS

Aakarsh Sinha, Kumar Amit
In: International Journal of Medical and Biomedical Studies · 2020 · vol. 4(3) · doi:10.32553/ijmbs.v4i5.1149 · W3033623066
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This study examined endometrial changes in uteri with leiomyomas, finding dilated/distorted glands, atrophy, and polyposis associated with leiomyoma presence and submucosal location.

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The paper studied endometrial histopathological changes in 50 females diagnosed with uterine leiomyomas, examining uterine features such as size, weight, fibroid location, and the presence of endometrial polyps. Using gross assessment and 5-micron hematoxylin-and-eosin stained tissue sections, the authors evaluated endometrium from multiple sites including the fundic region and areas adjacent to submucosal leiomyoma. They found statistically significant endometrial patterns consistent with mechanical or hormonal influences, including dilated/distorted glands, specific gland orientations, muscle-separated glands, focal total or subtotal glandular atrophy, and polyposis. The study found that total and subtotal endometrial glandular atrophy were significantly associated with submucosal leiomyoma. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The female genital tract includes the uterine corpus and cervix. The uterus consists of the endometrium and myometrium which are continuously stimulated by hormones, denuded monthly of its endometrial mucosa and inhabited periodically by foetuses. Together with the lesions that affect the cervix, the lesions of the corpus of the uterus and the endometrium account for most patient visits to gynaecologists. Many treatment options are available nowadays including medical and conservative surgical procedures. Hence based on above findings the present study was planned for Evaluation of the Endometrial Changes in Females Diagnosed with the Uterine Leiomyomas. The present study was planned in Department of Obstetrics and Gynaecology, Madhubani Medical College and Hospital, Madhubani, Bihar. In the present study 50 cases of the females diagnosed with the uterine leiomyomas were enrolled. Gross examination was performed with respect to size and weight of uterus, location of fibroids and endometrial polyp if any was noted. Tissue bits from the fundic endometrium, tissue from both sides of endometrial canal & endometrium subjacent to sub mucosal leiomyoma were taken for histopathological examination, processed and sections of 5 micron thickness stained with haematoxylin and eosin.The data generated from the present study concludes that Different patterns are seen in the endometrium of leiomyomatous uteri as a result of mechanical or hormonal factors such as dilated/ distorted glands, glands parallel to long axis of myometrium, glands separated by muscle fibres, focal total or subtotal glandular atrophy and polyposis which are statistically significant in identifying uterine leiomyoma. Further, total and subtotal endometrial glandular atrophy showed significant association with submucosal leiomyoma. Keywords: Leiomyoma, Endometrium, Menorrhagia, etc.
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EVALUATION OF THE ENDOMETRIAL CHANGES IN FEMALES DIAGNOSED WITH THE UTERINE LEIOMYOMAS DOI: https://doi.org/10.32553/ijmbs.v4i5.1149Abstract The female genital tract includes the uterine corpus and cervix. The uterus consists of the endometrium and myometrium which are continuously stimulated by hormones, denuded monthly of its endometrial mucosa and inhabited periodically by foetuses. Together with the lesions that affect the cervix, the lesions of the corpus of the uterus and the endometrium account for most patient visits to gynaecologists. Many treatment options are available nowadays including medical and conservative surgical procedures. Hence based on above findings the present study was planned for Evaluation of the Endometrial Changes in Females Diagnosed with the Uterine Leiomyomas. The present study was planned in Department of Obstetrics and Gynaecology, Madhubani Medical College and Hospital, Madhubani, Bihar. In the present study 50 cases of the females diagnosed with the uterine leiomyomas were enrolled. Gross examination was performed with respect to size and weight of uterus, location of fibroids and endometrial polyp if any was noted. Tissue bits from the fundic endometrium, tissue from both sides of endometrial canal & endometrium subjacent to sub mucosal leiomyoma were taken for histopathological examination, processed and sections of 5 micron thickness stained with haematoxylin and eosin.The data generated from the present study concludes that Different patterns are seen in the endometrium of leiomyomatous uteri as a result of mechanical or hormonal factors such as dilated/ distorted glands, glands parallel to long axis of myometrium, glands separated by muscle fibres, focal total or subtotal glandular atrophy and polyposis which are statistically significant in identifying uterine leiomyoma. Further, total and subtotal endometrial glandular atrophy showed significant association with submucosal leiomyoma. Keywords: Leiomyoma, Endometrium, Menorrhagia, etc.

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