Probiotics and Prebiotics in Subclinical Hypothyroidism of pregnancy with Small Intestinal Bacterial Overgrowth

Objective: Evaluating efficacy of probiotics combined with prebiotics in small intestinal bacterial overgrowth (SIBO) in subclinical hypothyroidism (SCH) in the second trimester. Methods: : We collected data from 78 pregnant women with SCH(SCH group)and 74 normal pregnant women(Control group) in second trimester，compare the differences in high sensitivity C-reactive protein (hsCRP), result of lactulose methane-hydrogen breath test and gastrointestinal symptoms assessed by GSRS scale between two groups.In SCH group, 32 patients with SIBO were selected as Intervention group. Treatment with probiotics + prebiotics for 21 days; The differences of lipid metabolism, hsCRP, thyroid function level, methane-hydrogen breath test results and GSRS scores before and after treatment were compared to evaluate the therapeutic effect. Results: 1. The positive rate of SIBO and methane，hsCRP levels in SCH group were higher than those in control group(P <0.05),the total score of GSRS scale, mean score of indigestion and constipation syndrome in SCH group were higher (P <0.05).2. The mean abundance of hydrogen and methane were higher in SCH group 3.After treatment, serum levels of thyrotropin (TSH), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and hsCRP in intervention group were decreased , and high-density lipoprotein (HDL) was increased compared with before treatment (P<0.05).4.After treatment, Methane positive rate, total score of GSRS scale, mean score of diarrhea syndrome, dyspepsia syndrome and constipation syndrome were decreased. (P < 0.05)5. The average abundance of methane and hydrogen were lower. Conclusion: Probiotics combined with prebiotics are effective in the treatment of SIBO in pregnant SCH patients . Clinical Trial Registration Number: ChiCTR1900026326