Nucleolar organizer regions activity in women with ovarian endometriosis and infertility

M. S. Kachurina, Л. Ф. Зайнетдинова, Е. Л. Куренков, Т.N. Shamaeva, S. V. Kvyatkovskaya
In: Voprosy ginekologii, akušerstva i perinatologii · 2021 · vol. 20(1) , pp. 71–78 · doi:10.20953/1726-1678-2021-1-71-78 · W3157685969
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In women with ovarian endometriosis and infertility, low melatonin levels were associated with increased ribosomal synthesis activity in endometriotic cells compared to those without infertility.

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This study investigated the relationship between melatonin levels and nucleolar organizer region activity in ovarian tissue from women with endometriosis. Researchers analyzed urine samples for melatonin metabolites and assessed ribosomal synthesis activity in endometriotic lesions from two groups: those with infertility and those without. The results showed that patients with both ovarian endometriosis and infertility had significantly lower melatonin levels and increased ribosomal synthesis within the endometriotic cells compared to those without infertility. This paper is centrally about endometriosis — specifically examining cellular changes in ovarian endometriotic lesions associated with infertility status.

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Abstract

Objective. To determine the activity of ribosomal synthesis and its connection with the level of melatonin in women with ovarian endometriosis and infertility. Patients and methods. The study included 49 women with ovarian endometriosis, who were divided into 2 groups: group 1 – 22 women with ovarian endometriosis and infertility, group 2 – 27 women with ovarian endometriosis without infertility. Medical history was collected from all women, who underwent therapeutic and diagnostic laparoscopy, the chronobiological type, the level of 6-sulfatoxymelatonin (aMT6s) in a first morning urine sample and the activity of nucleolar organizer regions in the foci of endometrioid heterotopias of the ovaries were determined. Results. It was found that the level of urinary 6-sulfatoxymelatonin was significantly reduced in patients with ovarian endometriosis and infertility compared to patients with endometriosis without infertility. In group 1, its level was 40.29 ± 7.25 ng/mL, in group 2 – 78.46 ± 15.46 ng/mL (p = 0.044). In patients with ovarian endometriosis and infertility, there was a moderate increase in the activity of ribosomal synthesis due to an increase in the number of intranucleolar inclusions against the background of decreased level of melatonin. In patients of group 2, with a decrease in the level of melatonin, ribosomal synthesis was activated by increasing the number of extranucleolar inclusions. This characterizes the high activity of ribosome synthesis in the cell. Conclusion. In women with ovarian endometriosis and infertility, against the background of low melatonin level, there was an increase in the activity of ribosomal synthesis in the cells of ovarian endometriotic formations. Key words: nucleolar organizer regions activity, melatonin, ovarian endometriosis
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Nucleolar organizer regions activity in women with ovarian endometriosis and infertility Maria S. Kachurina / Larisa F. Zainetdinova / Evgeniy L. Kurenkov / Tatyana N. Shamaeva / Svetlana V. Kvyatkovskaya / Objective. To determine the activity of ribosomal synthesis and its connection with the level of melatonin in women with ovarian endometriosis and infertility. Patients and methods. The study included 49 women with ovarian endometriosis, who were divided into 2 groups: group 1 – 22 women with ovarian endometriosis and infertility, group 2 – 27 women with ovarian endometriosis without infertility. Medical history was collected from all women, who underwent therapeutic and diagnostic laparoscopy, the chronobiological type, the level of 6-sulfatoxymelatonin (aMT6s) in a first morning urine sample and the activity of nucleolar organizer regions in the foci of endometrioid heterotopias of the ovaries were determined. Results. It was found that the level of urinary 6-sulfatoxymelatonin was significantly reduced in patients with ovarian endometriosis and infertility compared to patients with endometriosis without infertility. In group 1, its level was 40.29 ± 7.25 ng/mL, in group 2 – 78.46 ± 15.46 ng/mL (p = 0.044). In patients with ovarian endometriosis and infertility, there was a moderate increase in the activity of ribosomal synthesis due to an increase in the number of intranucleolar inclusions against the background of decreased level of melatonin. In patients of group 2, with a decrease in the level of melatonin, ribosomal synthesis was activated by increasing the number of extranucleolar inclusions. This characterizes the high activity of ribosome synthesis in the cell. Conclusion. In women with ovarian endometriosis and infertility, against the background of low melatonin level, there was an increase in the activity of ribosomal synthesis in the cells of ovarian endometriotic formations. Key words: nucleolar organizer regions activity, melatonin, ovarian endometriosis For citation: Kachurina M.S., Zainetdinova L.F., Kurenkov E.L., Shamaeva T.N., Kvyatkovskaya S.V. Nucleolar organizer regions activity in women with ovarian endometriosis and infertility. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2021; 20(1): 71–78. DOI: 10.20953/1726-1678-2021-1-71-78

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