Low Adherence to and Low Sustainability of Weight Loss Among Patients with Non-alcoholic Fatty Liver Disease

Low Adherence to and Low Sustainability of Weight Loss Among Patients with Non-alcoholic Fatty Liver Disease | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Low Adherence to and Low Sustainability of Weight Loss Among Patients with Non-alcoholic Fatty Liver Disease Joseph Nino Espino, Ann Margaret C. Navarroza, Alvin Brian C. Velasco, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3963969/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Weight loss, though difficult to attain and sustain over time, remains the cornerstone of non-alcoholic fatty liver disease (NAFLD) treatment. We aimed to describe weight changes among NAFLD patients. Methods: This was a retrospective, cohort study of consecutively-identified NAFLD patients with >2 clinic visits from March2007–April2018. Weight changes from baseline were categorized into weight gain, weight loss, and no change. Baseline liver and metabolic biochemistries and non invasive liver fibrosis tests were correlated with the final weight changes. Succeeding weight changes after the initial follow-up visits were used to determine sustainability of weight loss. Results: Of the 240 patients included, 123 (51.2%), 93 (38.8%), and 24 (10%) had weight gain, weight loss, and no change, respectively. Only 12.5% had >5% weight loss. Duration of follow-up was significantly longer for patients with weight loss (p<0.001). None of the baseline demographic and laboratory data were associated with weight loss. Patients with weight loss also did not have significant changes to their biochemistries and non-invasive liver fibrosis tests compared to patients with weight gain/no change. Compared to patients with weight gain after the initial follow-up, where only 11.8% were able to lose weight on the final visit, 73.1% of patients who lost weight after the initial follow-up were able to sustain their weight loss on the final visit. Conclusions: Weight loss is achieved in only a third of NAFLD patients. Although 73% of patients who lost weight initially were able to sustain it, patients who gained weight after the 1st follow-up were unlikely to lose weight on further follow-up. Gastroenterology & Hepatology Non-alcoholic fatty liver disease weight loss sustainability Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3963969","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":273381235,"identity":"41537e18-bc00-43e4-a6f3-d88a75b90b82","order_by":0,"name":"Joseph Nino Espino","email":"","orcid":"","institution":"University of Santo Tomas Hospital","correspondingAuthor":false,"prefix":"","firstName":"Joseph","middleName":"Nino","lastName":"Espino","suffix":""},{"id":273381236,"identity":"e6c9e45b-5466-4f61-8a1a-38d2dbb011bc","order_by":1,"name":"Ann Margaret C. Navarroza","email":"","orcid":"","institution":"University of Santo Tomas Hospital","correspondingAuthor":false,"prefix":"","firstName":"Ann","middleName":"Margaret C.","lastName":"Navarroza","suffix":""},{"id":273381237,"identity":"33826343-394b-44e8-9f10-e04e2d30e723","order_by":2,"name":"Alvin Brian C. Velasco","email":"","orcid":"","institution":"University of Santo Tomas Hospital","correspondingAuthor":false,"prefix":"","firstName":"Alvin","middleName":"Brian C.","lastName":"Velasco","suffix":""},{"id":273381238,"identity":"457d294e-ef7a-48b3-8df2-f0f2d069d1c7","order_by":3,"name":"Rommel Romano","email":"","orcid":"","institution":"University of Santo Tomas Hospital","correspondingAuthor":false,"prefix":"","firstName":"Rommel","middleName":"","lastName":"Romano","suffix":""},{"id":273381239,"identity":"572c07e2-a4bd-429b-b4c1-88499dd1b49a","order_by":4,"name":"Carmelita C. Dalupang","email":"","orcid":"","institution":"University of Santo Tomas Hospital","correspondingAuthor":false,"prefix":"","firstName":"Carmelita","middleName":"C.","lastName":"Dalupang","suffix":""},{"id":273381240,"identity":"c42c381d-d39e-49b7-b51e-96bca64a6fdb","order_by":5,"name":"Frederick T. Dy","email":"","orcid":"","institution":"University of Santo Tomas Hospital","correspondingAuthor":false,"prefix":"","firstName":"Frederick","middleName":"T.","lastName":"Dy","suffix":""},{"id":273381241,"identity":"0d8e5cf2-1c09-42b3-9c2d-ab01329be109","order_by":6,"name":"Stephen N. Wong","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAxklEQVRIiWNgGAWjYPACGwjFA8QGRGpJY2BgI1HLYRK0yM/uMXxc8Ot84vz5DYwP3rYx5JkT0mJw54yx8cy+24kbjjEwG85tYyi2bCCkRSJ3mzRvD1ALGwObNG8bQ+KGA4QcNgOs5Vzi/DYG9t9EaWG4AdTC8+NAYsMxBjZmorQY3Mj/bMzbkGy84Vhis+SccxLFBoQdlpb4mOePnez85sMHP7wps8kjqAUMGNvAZAOQkEggRgMQ/EEwidUyCkbBKBgFIwgAAFUOQYH3gCr4AAAAAElFTkSuQmCC","orcid":"","institution":"University of Santo Tomas Hospital","correspondingAuthor":true,"prefix":"","firstName":"Stephen","middleName":"N.","lastName":"Wong","suffix":""}],"badges":[],"createdAt":"2024-02-17 11:53:57","currentVersionCode":1,"declarations":{"humanSubjects":true,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":true,"humanSubjectConsent":true,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-3963969/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3963969/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":51380048,"identity":"d5909db6-aca7-4ce1-bc6c-65c4d92a5752","added_by":"auto","created_at":"2024-02-20 15:23:15","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":280195,"visible":true,"origin":"","legend":"","description":"","filename":"nafldwtloss.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3963969/v1_covered_0466c553-6f88-4cf9-9da5-51e2b4dbf447.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003eLow Adherence to and Low Sustainability of Weight Loss Among Patients with Non-alcoholic Fatty Liver Disease\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Non-alcoholic fatty liver disease, weight loss, sustainability","lastPublishedDoi":"10.21203/rs.3.rs-3963969/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3963969/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Weight loss, though difficult to attain and sustain over time, remains the cornerstone of non-alcoholic fatty liver disease (NAFLD) treatment. We aimed to \tdescribe weight changes among NAFLD patients.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e This was a retrospective, cohort study of consecutively-identified NAFLD patients with \u0026gt;2 clinic visits from March2007–April2018. Weight changes from baseline were categorized into weight gain, weight loss, and no change. Baseline liver and metabolic biochemistries and non invasive liver fibrosis tests were correlated with the final weight changes. Succeeding weight changes after the initial follow-up visits were used to determine sustainability of weight loss. \u003cstrong\u003eResults:\u003c/strong\u003e Of the 240 patients included, 123 (51.2%), 93 (38.8%), and 24 \t(10%) had weight gain, weight loss, and no change, respectively. Only 12.5% had \u0026gt;5% weight loss. Duration of follow-up was significantly longer for patients with weight loss (p\u0026lt;0.001). None of the baseline demographic and laboratory data were associated with weight loss. Patients with weight loss also did not have significant changes to their biochemistries and non-invasive liver fibrosis tests compared to patients with weight gain/no change. Compared to patients with weight gain after the initial follow-up, \twhere only 11.8% were able to lose weight on the final visit, 73.1% of patients who lost weight after the initial follow-up were able to sustain their weight loss on the final visit.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions:\u003c/strong\u003e Weight loss is \u0026nbsp;achieved in only a third of NAFLD patients. Although 73% of patients who lost weight initially were able to sustain it, patients who gained weight after the 1st follow-up were unlikely to lose weight on further follow-up.\u003c/p\u003e","manuscriptTitle":"Low Adherence to and Low Sustainability of Weight Loss Among Patients with Non-alcoholic Fatty Liver Disease","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-02-20 15:15:05","doi":"10.21203/rs.3.rs-3963969/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"56427ef2-3495-4daf-91e7-69e6c3346aea","owner":[],"postedDate":"February 20th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":28816315,"name":"Gastroenterology \u0026 Hepatology"}],"tags":[],"updatedAt":"2024-02-20T15:15:06+00:00","versionOfRecord":[],"versionCreatedAt":"2024-02-20 15:15:05","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3963969","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3963969","identity":"rs-3963969","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}