What are the effects of drug resistance on the global spread of malaria? A systematic literature review

What are the effects of drug resistance on the global spread of malaria? A systematic literature review | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 9 January 2025 V1 Latest version Share on What are the effects of drug resistance on the global spread of malaria? A systematic literature review Author : ASHENAFI WOIME 0009-0001-0643-0736 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.173641983.31939886/v1 274 views 131 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Malaria remains one of the most significant global health challenges, particularly in tropical and subtropical regions, with sub-Saharan Africa bearing the highest burden. Advances in malaria control, including insecticide-treated nets (ITNs), indoor residual spraying, and artemisinin-based combination therapies (ACTs), have reduced malaria cases and deaths. However, the emergence and spread of antimalarial drug resistance, especially to artemisinin, present a growing threat to malaria control and elimination efforts. Resistance to ACTs, characterized by delayed parasite clearance due to kelch13 mutations, is most prevalent in Southeast Asia and is beginning to emerge in Africa. This systematic literature review examines the global impact of drug resistance on malaria transmission, treatment efficacy, and control strategies. Findings reveal that drug resistance undermines treatment effectiveness, increases transmission potential, and imposes significant operational and economic challenges. Resistance hotspots in Southeast Asia, sub-Saharan Africa, and South Asia are expanding, driven by human migration and inadequate surveillance systems. The review highlights the need for strengthened molecular surveillance, the development of triple ACT therapies, and region-specific interventions to address resistance patterns. Without coordinated global efforts, drug resistance will continue to undermine progress toward malaria elimination, exacerbating the disease’s global burden. This review underscores the urgent need for innovative treatment strategies, improved surveillance systems, and international collaboration to contain the spread of drug-resistant malaria and ensure the sustainability of malaria control programs worldwide. Supplementary Material File (what are the effects of drug resistance on the global spread of malaria.docx) Download 78.15 KB Information & Authors Information Version history V1 Version 1 09 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords and molecular surveillance artemisinin-based combination therapies (acts) drug resistance Authors Affiliations ASHENAFI WOIME 0009-0001-0643-0736 [email protected] Hossana College of Health Sciences View all articles by this author Metrics & Citations Metrics Article Usage 274 views 131 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation ASHENAFI WOIME. What are the effects of drug resistance on the global spread of malaria? A systematic literature review. Authorea . 09 January 2025. DOI: https://doi.org/10.22541/au.173641983.31939886/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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