The Role of Probiotic in Psoriasis Treatment: A Meta-Analysis of Randomized Controlled Clinical Trials

Abstract Backgrounds: The body of knowledge about the pathogenesis and treatment of psoriasis is expanding. Several recent studies have suggested a link between dysbiosis in the gut microbiome and the occurrence of psoriasis. Probiotics are thought to treat gut microbiome dysbiosis. Methods: The literature included randomized control trials (RCT) studies published between January 2003 and June 2022 and found in three databases. Review Manager 5.4 software was used for statistical analysis. Results:This meta-analysis study included 4 RCT articles involving 212 adults. This study’s RCTs all compared oral probiotics to a placebo. For the clinical improvement outcome, this study showed that the probiotic group had 1.82 times higher risk of recovery than the placebo group (P < 0.05). C-reactive Protein levels were found to be 1.25 times lower in patients who received probiotic supplementation (P < 0.05). Meanwhile, a study on Interleukin 6 (IL-6) levels found that probiotic supplementation reduced serum IL-6 levels by 1.28 times, but this was not statistically significant (P= 0.35). Conclusion: Oral probiotic supplementation may be beneficial for psoriasis treatment because it reduces clinical severity and inflammation.