Index of Subjects

AAV-2. see Adeno-associated virus-2 Aβ42, augmented levels exacerbate IBM pathology, skeletal muscle (mouse), 1986 AD. see Alzheimer's disease Adeno-associated virus-2, causes trophoblast dysfunction and preeclampsia, 1951 Adipocytes, autoamplification of TNF-α (mouse), 435 ADP-ribosylation factor-3, in kidney and retinal development (mouse), 1288 Adrenomedullin lethal endotoxemia prevented by UCN and, septic shock (mouse), 1921 regulates tumor and mast cell functions, 280 Age/aging decreased collagen production, skin, 1861 effect of myostatin blockade, limb-girdle MD (mouse), 1975 AIDS, LPS enhanced cardiomyopathy, role of macrophages and TLR4 (mouse), 727 Airway inflammation, Ag and LPS in effector phase (mouse), 1425 Akt, IFN-γ induces Fas trafficking and apoptosis sensitivity via PI3-K and, SMCs, 2054 Alcohol, abuse of, exacerbates HIVE (mouse), 1335 Alexander disease, plectin regulates GFAP organization, 888 Alkaline phosphatase, increased during elastin calcification (rat), 490 Allografts, renal, C4 in rejection (mouse), 1241 Alport syndrome, sequential type IV collagen expression in testes (dog), 1587 ALX, in LXA 4 response to acid injury, bronchial epithelial cells, 1064 Alzheimer's disease ApoE4 effects on amyloid pathology in brain (double- and triple-transgenic mouse), 245 caspase-mediated GFAP cleavage in astrocytes, 936 intracellular and extracellular Aβ pools (mouse), 184 tauopathy, dissociation of neuronal loss and neurofibrillary pathology (mouse), 1598 AM. see Adrenomedullin American Journal of Pathology, readership and (editorial), 1 Amyloid β, MnSOD nitration mediated by (mouse), 1608 Amyloid-β peptide, intracellular and extracellular pools (mouse), 184 Amyloidosis, transmission into offspring (mouse with AApoAII amyloidosis), 898 Anaplastic anemias, angiogenesis and VEGF in BM, 123 Androgen receptors, 113 CAG knock-in mice, germ and Sertoli cell abnormalities (mouse), 195 Ang II. see Angiotensin II Angiogenesis endometriosis, noninvasive model for anti-angiogenic therapy (mouse), 2074 evaluation in BM, anaplastic anemia, 123 Pax2 in apoptosis and, TECs, 706 VEGF165-mediated, modulated by plasmin, wound healing (mouse), 670 Angiotensin-converting enzyme-2, ANG II-dependent glomerulosclerosis development following loss of, 1808 Angiotensin II glomerulosclerosis dependent on, development following ACE2 loss, 1808 induces podocyte permselective dysfunction, 1073 Animal models alcohol abuse exacerbates HIVE (mouse), 1335 cancer, mortalin-based cytoplasmic sequestration of p53 (soft shell clams), 1526 EGF blockade prevents nerve disruption in grade I neurofibromas (mouse), 1686 Emery-Dreifuss muscular dystrophy (emerin-deficient mouse), 907 endometriosis, noninvasive model for anti-angiogenic therapy (mouse), 2074 Ret C620R mutation in Hirschprung's disease (mouse), 1262 skeletal muscle into neuromuscular therapeutics, commentary, 1775 Anterior subcapsular cataract, MMPI2/9 suppress TGF-β induction of (rat), 69 Antibody arrays, protein profiling with, bladder cancer, 93 Antigens, in effector phase of airway inflammation (mouse), 1425 Aortic abdominal aneurysms, markers for mural thrombus renewal (human/rat), 1022 Apigenin, pro- or anti-inflammatory agent?, letter, 1762 ApoE4. see Apolipoprotein E4 Apolipoprotein E4, effects on amyloid pathology in brain (double- and triple-transgenic mouse), 245 Apoptosis ERK1/2, Bclx L and Bax in inflammation (rat), 33 hepatic SEC, prevented by Bad phosphorylation (rat), 1097 inhibited by gelsolin, Fas Ab-induced liver failure (mouse), 778 lipid raft cholesterol levels and sensitivity to, breast and prostate cancer, 1107 Pax2 in angiogenesis and, TECs, 706 stress-induced, role of ASK1, neurons (mouse), 261 Apoptosis signal-regulating kinase 1, in stress-induced apoptosis, neural cells (mouse), 261 AQP1. see Aquaporin 1 Aquaporin 1, overexpression in lung cancers, 1345 Arl3. see ADP-ribosylation factor-3 ASC. see Anterior subcapsular cataract ASK1. see Apoptosis signal-regulating kinase 1 Aspartic proteinase-like gene, in stratified epithelia and SSC, skin (mouse), 1354 Asthma airway inflammation, Ag and LPS in effector phase (mouse), 1425 allergen-specific T cells cause maternal transmission of (mouse), 1931 Astrocytes caspase-mediated GFAP cleavage in, AD, 936 osteopontin marks progression in ENU-induced gliomas (rat), 1676 Astroglia, CK2 in, normal and neovascularized retinas, 1722 Atherogenesis KC/GRO-α in progression and macrophage accumulation (mouse), 1385 MET, HGF/SF and, 340 Atherosclerosis hepatic VLDL receptor overexpression induces plaque regression (LDLR-deficient mouse), 2064 ionizing radiation induced lesions (ApoE -/- mouse), 649 lesions, sources of CRP (letter), 1054 Autophagy, in mutant fibrinogen clearance, 1299 Autosomal-dominant polycystic kidney disease, linked to Pkd1 expression (mouse), 205 Avian influenza, Virchow's reminder (commentary), 6 B cells Brk expression and oncogenic role, 1631 CD40 ligation triggers inflammation mediated by, liver (mouse), 786 CD19 modulates Th1/Th2 cytokine balance, inhibits EAE (mouse), 812 decreased by BR3-Fc, peripheral blood and lymphoid tissue (cynomolgus monkey), 476 Bad, phosphorylation, prevents apoptosis, hepatic SEC (rat), 1097 Basement membrane, in cancer progression and metastasis (commentary), 715 Bax, in acute inflammation (rat), 33 Bcl-X L in acute inflammation (rat), 33 p21 Cip1 mediates cytoprotection against hypoxia via, 1838 Bile ducts lithocholic acid-induced obstruction (mouse), 410 loss prevented by UDCA and TUDCA, cholestasis (rat), 398 Bladder cancers, protein profiling with antibody arrays, 93 Blood-retinal barrier breakdown suppressed by ephrinA1, 331 preservation by cannabidiol, experimental diabetes (rat), 235 BM. see Bone marrow BMP-2. see Bone morphogenetic protein-2 BMSC. see Bone marrow stromal cells Bone microenvironment, cancer interaction with, review, 1405 OPN-independent tumor growth (OPN-deficient mouse), 551 Bone marrow, angiogenesis and VEGF in, anaplastic anemia, 123 Bone marrow stromal cells, autologous, cranial reconstruction using (dog), 542 Bone morphogenetic protein-2, proinflammmatory effect, coronary arterial EC (rat), 629 BR3-Fc, decreases B cells, peripheral blood and lymphoid tissue (cynomolgus monkey), 476 Brain, glia, inflammatory responses triggered by gangliosides via TLR4 (rat), 1619 BRB. see Blood-retinal barrier Breast cancer AM regulates functions, 280 apoptosis sensitivity and lipid raft cholesterol levels, 1107 Cav-1 in mammary acinar development (Cav-1 deficient mouse), 292 Cav-1 mutations associated with ERα status, 1998 metastases promoted by mammary involution (rat), 608 Brk, expression and oncogenic role, T and B cells, 1631 Bronchial epithelial cells, human, nACHR modulates intracellular calcium during wound repair, 55 Bruch's membrane, HSC in repair function following rupture (mouse), 1031 Buruli ulcers, painlessness and M. ulcerans inflicted nerve damage (mouse), 805 C/EBP homology protein, in adhesion, podocytes, 20 c-Jun N-terminal kinase, in unstable human carotid plaques, 1004 C-reactive protein, sources in atherosclerotic lesions (letter), 1054 Cadherin-11, induces FLS to form lining layers, RA, 1486 Calcium, intracellular, nACHR modulates during wound repair, HBEC, 55 Cancers HUIV26 cryptic collagen epitope regulates metastases, 1576 interaction with bone microenvironment, review, 1405 progression and metastasis, role of type IV collagen and BM (commentary), 715 Cannabidiol, neuroprotective and BRB-preserving effects, experimental diabetes (rat), 235 Carcinoembryonic antigen-related cell adhesion molecule-1, in CRH-modulated trophoblast invasion, 141 Carcinogenesis, metastasis and, third dimension (commentary), 363 Cardiomyocytes, G-CSF prevents autophagic death (cardiomyopathic hamsters), 386 Cardiomyopathy G-CSF prevents autophagic cardiomyocyte death (cardiomyopathic hamsters), 386 LPS enhanced, role of macrophages and TLR4, AIDS (mouse), 727 Carotid plaques, human, protein expression in unstable regions of, 1004 Caseating granulomas, role of TDM and lipid in pathogenesis (mouse), 1249 Caspases caspase-9 in unstable human carotid plaques, 1004 mediate GFAP cleavage in astrocytes, AD, 936 Cat S. see Cathepsin S Catagen p75NTR and, 221 role of prolactin, HF, 748 Cathepsin S, integrin α v β3 and, in SMC migration, 685 Cav-1. see Caveolin-1 Caveolin-1 in mammary acinar development (Cav-1 deficient mouse), 292 mutations associated with ERα status, breast cancer, 1998 CCL2. see MCP-1 CD19, inhibits EAE progression (mouse), 812 CD34, marker for LECs, tumors, 1045 CD40, ligation triggers B cell-mediated inflammation, liver (mouse), 786 CD163, identifies perivascular macrophages, HIV and SIV encephalitis, 822 CEACAM1. see Carcinoembryonic antigen-related cell adhesion molecule-1 Cell cycles, p21Cip1 and p27Kip1 levels, tauopathy (transgenic mouse), 878 Cellular stress response 1, suppresses tumor growth and metastasis, prostate cancer, 597 Chemokine receptors, CXCR4,TNF-α and SDF-1 regulate ICC migration, 1155 Cholangitis, lithocholic acid-induced (mouse), 410 Cholestasis, cytoprotective effects of UDCA and TUDCA, biliary epithelium (rat), 398 Cholesterol, lipid raft levels, affect sensitivity to apoptosis, breast and prostate cancers, 1107 Chondrosarcomas, Hedgehog signaling and proliferation (human/mouse), 321 CHOP. see C/EBP homology protein Choroidal neovascularization, model using HSC for Bruch's membrane repair (mouse), 1031 Chromatin, GBM-associated fragments of, from apoptotic intraglomerular cells (mouse), 1779 Chrondocytes, effect of TGF-β2 on hypertrophy, OA, 131 CK2, in astroglial cells, normal and neovascularized retinas, 1722 Clusterin, secreted as marker for VHL protein, 574 CMV. see Cytomegalovirus Colitis, DC accumulation of Foxp3-expressing CD103 Treg cells (mouse), 1898 Collagen decreased production, aging skin, 1861 HUIV26 cryptic epitope, regulates metastases, 1576 type IV, in cancer progression and metastasis (commentary), 715 type IV, loss of expression of α5 and α6 chains and hypermethylation, colorectal cancer, 856 type IV, sequential expression in testes (dog), 1587 Colorectal cancer, hypermethylation and loss of expression of type IV collagen α5 and α6 chains, 856 Complement, C4, in renal allograft rejection (mouse), 1241 Connective tissue growth factor, induced by DEX, renal tubular epithelial cells (mouse/human), 737 Copper, accumulation in liver ( Atp7b -/- mouse), 423 Core binding factor-α-1 , increased during elastin calcification (rat), 490 Corticotropin-releasing hormone, modulates trophoblast invasion via CEACAM1, 141 Coxsackievirus B3, myocarditis induced by, association with immunoproteasome activity (mouse), 1542 Cranium, reconstruction using autologous BMSC (dog), 542 Creutzfeldt-Jakob disease detection and localization of PrP Sc , skeletal muscle, 927 detection of type 1 PrP Sc (human/bovine), 151 CRH. see Corticotropin-releasing hormone Cryptococcosis, pulmonary, CD4 T cell compartmentalization during (mouse), 847 Cryptococcus neoformans , CD4 T cell compartmentalization during pulmonary infection (mouse), 847 CSR1. see Cellular stress response 1 CTGF. see Connective tissue growth factor CXLC2. see MIP-2 Cyclic stretch regulation of pulmonary endothelial monolayer integrity by, 1749 TR3 prevents proliferation induced by, venous SMCs, 2027 Cyclooxygenase-2, defensive roles, gut and lung (commentary), 1060 Cytokeratin, salivary gland carcinoma development via K- ras driven by K5 promoter (mouse), 1654 Cytokine profiles, in severe sepsis, lung DCs (mouse), 1940 Cytomegalovirus, human, maternal Abs influence infection via FcRn-mediated transcytosis, 1210 Danon disease, LAMP-2 defect in, 1309 DDR1. see Discoidin domain receptor 1 Decidual cells, MCP-1 regulated by TNF-α and IL-1β, first trimester decidual cells, 445 Demyelination coronavirus infection and, oligodendroglia (mouse), 796 EAE model of, IFN-γ in, (mouse), 1464 Dendritic cells accumulation of Foxp3-expressing CD103 Treg cells, colitis (mouse), 1898 cytokine profiles in severe sepsis, lung (mouse), 1940 SEMA6A induced by IFN-γ, 453 Dermatopathic lymphadenitis, LC, IFN-γ induces SEMA6A, 453 Desferroxamine, injury induced by, attenuation by SUMOylation, salivary epithelial cells, 1452 DEX. see Dexamethasone Dexamethasone, induces CTGF, renal tubular epithelial cells (mouse/human), 737 Diabetes nephropathy, role of midkine (mouse), 9 neuroprotective and BRB-preserving effects of cannabidiol (rat), 235 TNF-α and InsR in wound healing ( ob/ob mouse), 765 TNF-α mediates apoptosis and impairs healing (mouse), 757 Diazoxide, prevents I/R spinal cord injury (rabbit), 1443 Discoidin domain receptor 1, in lung fibroblast survival, IPF, 866 Doxycycline, alters vascular SMC adhesion and migration, 1697 Duchenne muscular dystrophy, NF-κB in muscle degeneration ( mdx mouse), 918 Dystrophin, deficiency, sarcolemmal damage via excess NO, dystrophin deficiency (mouse), 1276 EAE. see Experimental autoimmune encephalomyelitis EGF. see Epidermal growth factor Elastin, calcification and gene expression (rat), 490 Emery-Dreifuss muscular dystrophy, minimal motor and cardiac dysfunctions (emerin-deficient mouse), 907 Encephalitis HIV-1 associated, exacerbated by alcohol abuse (mouse), 1335 HIV and SIV, CD163 identifies perivascular macrophages, 822 Endometriosis, noninvasive model for modeling anti-angiogenic therapy (mouse), 2074 Endoplasmic reticulum-associated protein, in mutant fibrinogen clearance from ER, 1299 Endothelial cells bFGF enhances leukocyte recruitment via adhesion molecule stimulation (rat), 835 coronary artery, proinflammatory effect of BMP-2 (rat), 629 MAPK activation by LysoPC-induced mitochondrial ROS, 1737 pulmonary artery adventitial fibroblasts with, in regulating vasa vasorum neovascularization, 1793 renal tumor-derived, role of Pax2 in apoptosis and angiogenesis, TECs, 706 Endothelial progenitor cells, myeloid origin of (mouse and human), 1710 Endothelin-1, in regulating vasa vasorum neovascularization, 1793 Endotoxemia, lethal, prevented by UCN and AM, septic shock (mouse), 1921 Eosinophilin, modulated by CD8 T cells, Pneumocystis pneumonia (B-cell-deficient mouse), 466 EphrinA1, inhibits VEGF-induced signaling and retinal neovascularization, 331 Epidermal growth factor blockade of, prevents nerve disruption in grade I neurofibromas (mouse), 1686 with laminin α2 chain in vessel invasion, lung neuroendocrine carcinomas, 991 Epithelial cells bronchial, LXA 4 regulates acid injury responses, 1064 salivary, SUMOylation attenuates hypoxia- or desferroxamine-induced injury, 1452 sensitivity to PyMT (mouse), 310 ERAD. see Endoplasmic reticulum-associated protein ERK1/2. see Extracellular regulated kinase 1/2 Estrogen, effects of neonatal exposure on prostate gland (estrogen-deficient mouse), 1869 Estrogen receptor α, Cav-1 mutations associated with status of, breast cancer, 1998 Ethanol impairs intestinal barrier (rat/mouse), 1148 infusion into coronary arteries, myocardial FAEE synthesis following (pig), 1435 Experimental autoimmune encephalomyelitis effect of VIP (mouse), 1179 interaction of CNS-specific T cells with TNF-α, MCP-1 and MIP-2 (mouse), 1200 model of demyelination, IFN-γ in, (mouse), 1464 progression inhibited by CD19 (mouse), 812 UCP2 protective function during (mouse), 1570 Extracellular regulated kinase 1/2, in acute inflammation (rat), 33 FAEE. see Fatty acid ethyl ester Fas FasL and, essential for NK cell induced psoriasis (mouse), 170 trafficking, induced by IFN-γ via PI3-K and Akt, SMCs, 2054 Fatty acid ethyl ester, myocardial synthesis following coronary artery ethanol infusion (pig), 1435 Fc receptor, neonatal, mediates maternal Abs effect on CMV infection via transcytosis, 1210 FcRn. see Fc receptor Fetal growth restriction, idiopathic, decreased HLX1 expression, 511 FGR. see Fetal growth restriction Fibrinogen, mutant, cleared from ER via ERAD and autophagy, 1299 Fibroblast growth factor basic, enhances leukocyte recruitment to EC via adhesion molecule stimulation (rats), 835 glioma glypican-1 enhances signaling by, 2014 Fibroblast-like synoviocytes, cadherin-11 induces formation of lining layers, RA, 1486 Fibroblasts adventitial, pulmonary artery, with ECs in regulating vasa vasorum neovascularization, 1793 dermal, integrin αvβ5 induces myofibroblastic differentiation, 499 lung, DDR1 and survival, IPF, 866 species-specific, and invasiveness of transformed keratinocytes, 1889 Fibrosarcoma, liposarcoma phenotype induced by FUS-DDIT3 fusion oncogene, transfected human fibrosarcoma cells, 1642 Fibrosis bleomycin-induced, TAFI attenuates, lung (mouse), 1086 liver, attenuated by HGF (mouse), 1500 FLS. see Fibroblast-like synoviocytes Folic acid, nephropathies induced by, attenuation of (PAFR-deficient mouse), 1413 Foxp3, CD103 Treg cells expressing, accumulation in DC aggregates, colitis (mouse), 1898 FUS-DDIT3 fusion oncogene, induce liposarcoma phenotype, transfected human fibrosarcoma cells, 1642 G-CSF. see Granulocyte colony-stimulating factor G-protein-coupled receptor kinase-interacting protein, in unstable human carotid plaques, 1004 GADD153. see C/EBP homology protein Galectin-3 correlates with apoptosis of tumor-associated T cells, melanomas, 1666 regulatory role in immunity in T. gondii infection (mouse), 1910 Gangliosides, trigger inflammatory responses via TLR4, brain glia (rat), 1619 GBM. see Glomerular basement membranes Gelsolin, anti-apoptopic function, Fas Ab-induced liver failure (mouse), 778 Germ cells, testes, maturational abnormalities (AR113Q mouse), 195 GFAP. see Glial fibrillary acidic protein Glia, inflammatory responses triggered by gangliosides via TLR4 (rat), 1619 Glial fibrillary acidic protein caspase-mediated cleavage in astrocytes, AD, 936 plectin regulates organization, Alexander disease, 888 Gliomas ENU-induced, astrocytes expression of osteopontin marks progression in (rat), 1676 glypican-1 enhances FGF signaling, 2014 Glomerular basement membranes, associated chromatin fragments from apoptotic intraglomerular cells (mouse), 1779 Glomerulonephritis, HCV-associated, role of TLR3, 370 Glomerulosclerosis ANG II-dependent, development following ACE2 loss, 1808 podocyte numbers and (rat), 42 Glypican-1, gliomas, enhances FGF signaling, 2014 Granulocyte colony-stimulating factor, prevents autophagic cardiomyocyte death (cardiomyopathic hamsters), 386 Gut, defensive role of COX-2 (commentary), 1060 Hair, formation of, matriptase in (mouse), 1513 Hair follicles human, multipotent adult stem cell isolation, 1879 Musashi expression during development, 80 p75NTR and regression, 221 prolactin in regression, 748 SGK3, in morphogenesis and homeostasis (mouse), 1119 Hairy cell leukemia, IFN-α regulates RhoGTPases and p53, 562 HBEC. see Bronchial epithelial cells HCL. see Hairy cell leukemia HCV. see Hepatitis C virus Heart, myocardial FAEE synthesis following coronary artery ethanol infusion (pig), 1435 Heat shock proteins p38 and, in ischemic preconditioning of steatotic liver (rat), 1474 ubiquitin and HSP90 in α-synuclein inclusions, α- synucleinopathies, 947 Hedgehog, in chondrosarcoma proliferation (human/mouse), 321 Hemangiomas, infantile, myeloid cells in, 621 Hematopoietic stem cells, provide repair functions, Bruch's membrane rupture (mouse), 1031 Hepatitis collateral damage in liver (commentary), 1057 Kupffer cell-dependent, influenza infection, 1169 Hepatitis C virus, glomerulonephritis associated with, role of TLR3, 370 Hepatocellular carcinomas, epigenetic and chromosomal instability, 1375 Hepatocyte growth factor attenuates liver fibrosis (mouse), 1500 MET and, in arterial repair and atherogenesis, 340 HF. see Hair follicles Hirschsprung's disease, Ret C620R mutation affects renal and ENS development (mouse), 1262 HIVE. see Human immunodeficiency virus-1 encephalitis HLX1, in idiopathic human FGR, 511 H5N1, influenza A virus, causes systemic disease (cats), 176 HSC. see Stem cells Hsp90. see Heat shock proteins Human immunodeficiency virus, encephalitis, CD163 identifies perivascular macrophages, 822 Human immunodeficiency virus-1 encephalitis, exacerbated by alcohol abuse (mouse), 1335 Hypermethylation, COL4A5/COL4A6 promoter, colorectal cancer, 856 Hypersensitivity, intestinal, stress and (commentary), 3 Hypoxia injury induced by, attenuation by SUMOylation, salivary epithelial cells, 1452 p21 Cip1 mediates cytoprotection against, Bcl-X L in, 1838 in regulating vasa vasorum neovascularization, 1793 Hypoxic pulmonary hypertension, vascular remodeling and monocyte/macrophage recruitment (rat/calf), 659 I/R injury. see Ischemia/reperfusion injury IBM. see Inclusion body myositis ICC. see Intrahepatic cholangiocarcinomas Idiopathic pulmonary fibrosis, DDR1 and fibroblast survival, lung, 866 IL-1β. see Interleukin 1β Inclusion body myositis, augmented Aβ42 levels exacerbate pathology, skeletal muscle (mouse), 1986 Indian Hedgehog, in chondrosarcoma proliferation (human/mouse), 321 Infantile hemangiomas, myeloid cells in, 621 Inflammation acute, ERK1/2, Bcl-x L and Bax in resolution (rat), 33 apigenin as pro- or anti-inflammatory agent?, letter, 1762 pulmonary, SSAO-mediated deamination (mouse), 718 triggered by gangliosides via TLR4, brain glia (rat), 1619 Influenza virus H5N1 subtype, causes systemic disease (cats), 176 Kupffer cell-dependent hepatitis, 1169 Virchow's reminder (commentary), 6 Insulin receptors, TNF-α and, in wound healing, diabetes ( ob/ob mouse), 765 Integrins αvβ5, induce myofibroblastic differentiation, dermal fibroblasts, 499 α v β3 and Cat S, in SMC migration, 685 Intercellular adhesion molecule-1 cannabidol decreases levels, experimental diabetes (rat), 235 enhanced by bFGF, EC leukocyte recruitment (rat), 835 Interferon, type I, induced by pristane, tertiary lymphoid tissue (mouse), 1227 Interferon-α, regulates RhoGTPases and p53, HCL, 562 Interferon-γ in coronavirus clearance, oligodendroglia (mouse), 796 in EAE model of demyelination (mouse), 1464 induces Fas trafficking and apoptosis sensitivity via PI3-K and Akt, SMCs, 2054 induces SEMA6A, Langerhans cells, 453 Interleukin 1, modulates arterial neointima formation (mouse), 1396 Interleukin 1β modulates arterial neointima formation (mouse), 1396 regulates MCP-1, first trimester decidual cells, 445 Interleukin 27R. see T-cell cytokine receptor Intrahepatic cholangiocarcinomas, migration regulation via CXCR4 interaction with TNF-α and SDF-1, 1155 IPF. see Idiopathic pulmonary fibrosis Ischemia/reperfusion injury role of VEGF (mouse), 695 spinal cord, prevented by diazoxide (rabbit), 1443 Ischemic ocular disease, role of ephrinA1, 331 Ischemic preconditioning, p38 and HSP in, steatotic liver (rat), 1474 Junctional adhesion molecule-1, in unstable human carotid plaques, 1004 K- ras , salivary gland carcinoma development via, driven by K5 promoter (mouse), 1654 KC/GRO-α, in progession and macrophage accumulation, atherogenesis (mouse), 1385 Kennedy disease, germ cell and Sertoli cell abnormalities (AR113Q mouse), 195 Keratinocytes hypermotility/growth-arrest response involving laminin 5 and p16 INK4A , wound healing, 1821 transformed, species-specific fibroblasts and invasiveness of, 1889 Kidneys Arl3 in development (mouse), 1288 attenuation of folic acid-induced nephropathy (PAFR-deficient mouse), 1413 C4 in renal allograft rejection (mouse), 1241 DEX induces CTGF in renal tubular epithelial cells (mouse/human), 737 GBM-associated chromatin fragments from apoptotic intraglomerular cells (mouse), 1779 midkine in diabetic nephropathy (mouse), 9 pathophysiological implications of reduced podocyte number (rat), 42 Kupffer cells, hepatitis dependent on, influenza infection, 1169 Laminin, α2 chain, with EGF in vessel invasion, lung neuroendocrine carcinomas, 991 Laminin 5, p16 INK4A and, keratinocyte hypermotility/growth-arrest response involving, wound healing, 1821 Langerhans cells, IFN-γ induces SEMA6A, 453 LEC. see Lymphatic endothelial cells Leishmania donovani , enhanced resistance to (TCCR-deficient mouse), 158 Lentiviral encephalitis, macrophage infection in (SIV-infected CD8 T cell-depleted macaque), 1552 Leukocytes, bFGF enhances recruitment to EC via adhesion molecule stimulation (rat), 835 Lipid rafts, cholesterol levels and apoptosis sensitivity, breast and prostate cancer, 1107 Lipids, peroxidation, inhibition affects NF-κB functions ( mdx mouse), 918 Lipopolysaccharide, in effector phase of airway inflammation (mouse), 1425 Liposarcomas, phenotype induced by FUS-DDIT3 fusion oncogene, transfected human fibrosarcoma cells, 1642 Lipoxin A 4 , regulates acid injury responses via ALX, bronchial epithelial cells, 1064 Lithocholic acid, induces bile duct obstruction and cholangitis (mouse), 410 Liver CD40 ligation triggers B cell-mediated inflammation (mouse), 786 copper accumulation ( Atp7b -/- mouse), 423 Fas Ab-induced failure, anti-apoptopic gelsolin function (mouse), 778 HGF attenuates fibrosis of (mouse), 1500 steatotic, HSP and p38 in ischemic preconditioning (rat), 1474 systemic viral infections and collateral damage (commentary), 1057 VEGF in I/R injury (mouse), 695 VLDL receptor overexpression induces atherosclerotic plaque regression (LDLR-deficient mouse), 2064 LOXL1. see Lysyl oxidase-like-1 Lung cancers AM regulates function, 280 AQP1 overexpression in, 1345 Lungs defensive role of COX-2 (commentary), 1060 regulation of pulmonary endothelial monolayer integrity by cyclic stretch, 1749 severe sepsis, cytokine profiles in DCs (mouse), 1940 TAFI attenuates fibrosis, lung (mouse), 1086 Lupus nephritis, GBM-associated chromatin fragments from apoptotic intraglomerular cells (mouse), 1779 LXA 4 . see Lipoxin A 4 Lymphatic endothelial cells, CD34 as marker for, tumors, 1045 Lymphoid tissue, pristane-induced neogenesis, IFN-I production (mouse), 1227 Lysosome-associated membrane protein-2, defect in Danon disease, 1309 Lysyl oxidase-like-1, in elastic fiber homeostasis, pelvic floor disorders (mouse), 519 Macrophages infection, lentiviral encephalitis (SIV-infected CD8 T cell-depleted macaque), 1552 KC/GRO-α influences accumulation, atherogenesis, 1385 in LPS-enhanced cardiomyopathy, AIDS (mouse), 727 monocytes and, in neovascularization and tissue repair (mouse), 529 perivascular, identified by CD163, HIV and SIV encephalitis, 822 Mammary tumors involution after lactation promotes metastases, breast cancer (rat), 608 MMPs in regression (mouse), 270 Notch1 and Notch3 in development and tumor induction (transgenic mouse), 973 TGFα induction by, potentiated by PRL (transgenic mouse), 1356 Manganese superoxide dismutase, β-amyloid mediated nitration of (mouse), 1608 Mast cells activation by ethanol (rat/mouse), 1148 AM regulates functions, human carcinogenesis, 280 Matriptase, in barrier function, hair formation and SCC (mouse), 1513 Matrix metalloproteinases in hormone-induced mammary tumor regression (mouse), 270 increased during elastin calcification (rat), 490 inhibitors MMPI2/9 suppress TGF-β-induced ASC (rat), 69 MCP-1, interactions with TNF-α, MIP-2 and CNS-specific T cells, EAE (mouse), 1200 Melanoma, Gal-3 correlates with tumor-associated T cell apoptosis, 1666 MET, HGF/SF and, in arterial repair and atherogenesis, 340 Metastases, regulated by HUIV26 cryptic collagen epitope, 1576 Microflora, enteric, effect of ethanol (rat/mouse), 1148 Midkine, in diabetic nephropathy (mouse), 9 Migration role of CXCR4, TNF-α and SDF-1, ICC, 1155 SMC, role of Cat S/integrin α v β3 surface co-localization, 685 MIP-2, interactions with TNF-α, MCP-1 and CNS-specific T cells, EAE (mouse), 1200 Mitogen activated protein kinase, activation by LysoPC-induced mitochondrial ROS, 1737 MMPs. see Matrix metalloproteinases MnSOD. see Manganese superoxide dismutase Monocyte chemoattractant protein-1, regulated by TNF-α and IL-1β, first trimester decidual cells, 445 Monocytes macrpohages and, in neovascularization and tissue repair (mouse), 529 p21 Cip1 in development of, RA (mouse), 1531 Mortalin, cytoplasmic sequestration of p53 based on (soft shell clams), 1526 Multifunctional protein-2, peroxisomal, deficiency causes neurological lesions, CNS (mouse), 1321 Mural thrombus, markers for renewal, aortic abdominal aneurysms (human/rat), 1022 Musashi, in hair follicles, 80 Muscular dystrophy, limb-girdle, age-dependent effect of myostatin blockade (mouse), 1975 Mycobacterium ulcerans , nerve damage inflicted by, Buruli ulcers (mouse), 805 Myeloid cells, detection in infantile hemangiomas, 621 Myocarditis, CVB3-induced, association with immunoproteasome activity (mouse), 1542 Myostatin, age-dependent effects of blockade, limb-girdle MD (mouse), 1975 nACHR. see α3α5β2-Nicotinic acetylcholine receptor Natural killer cells, Fas/FasL in psoriasis induction by (mouse), 170 Neointima, arterial, formation modulated by IL-β and IL-1 (mouse), 1396 Neovascularization choroidal, model using HSC for Bruch's membrane repair (mouse), 1031 normal and neovascularized retinas, CK2 expression, astroglial cells, 1722 ocular, PDGF B signaling inhibition enhances anti-VEGF therapy (mouse), 2036 role of monocytes/macrophages (mouse), 529 vasa vasorum, pulmonary artery adventitial fibroblasts with ECs in regulation of, 1793 Nephritis, GBM-associated chromatin fragments from apoptotic intraglomerular cells (mouse), 1779 Nerves, damaged by M. ulcerans , Buruli ulcers (mouse), 805 Neuroendocrine carcinomas, lung, laminin α2 chain and EGF in vessel invasion and metastasis, 991 Neurofibromas, grade I, EGF-blockade prevents nerve disruption in (mouse), 1686 Neurons ASK1 and stress-induced apoptosis (mouse), 261 loss of, dissociation of neurofibrillary pathology and, tauopathy (mouse), 1598 α3α5β2-Nicotinic acetylcholine receptor, modulates intracellular calcium during wound repair, HBEC, 55 Nitric oxidase synthase, inducible, mediates PGHS-2 nitration (mouse), 349 Nitric oxide, in sarcolemmal damage, dystrophin deficiency (mouse), 1276 NK cells. see Natural killer cells Notch proteins, Notch1 and Notch3, in development and tumor induction, mammary gland (transgenic mouse), 973 Nrf2 transcription factor, multiorgan immune effects (mouse deficient in), 1960 Nuclear factor-κB, oxidative stress inhibition affects cellular functions ( mdx mouse), 918 Obesity, TNF-α autoamplification in adipocytes (mouse), 435 Oligodendroglia, IFN−γ in coronavirus clearance and demyelination (mouse), 796 Oncogenesis, Brk and, T and B cells, 1631 Osteoarthritis, effect of TGF-β2 on collagen cleavage, 131 Osteopontin astrocyte, marks progression in ENU-induced gliomas (rat), 1676 increased during elastin calcification (rat), 490 metastatic bone tumor growth independent of (OPN-deficient mouse), 551 Oxidative stress, inhibition affects NF-κB functions ( mdx mouse), 918 p16 INK4A , laminin 5 and, keratinocyte hypermotility/growth-arrest response involving, wound healing, 1821 p21 Cip1 levels in tauopathy (transgenic mouse), 878 mediates cytoprotection against hypoxia through Bcl-X L , 1838 in monocyte development and response to RA (mouse), 1531 p27Kip1, levels in tauopathy (transgenic mouse), 878 p38, HSP and, in ischemic preconditioning of steatotic liver (rat), 1474 p53 mortalin-based cytoplasmic sequestration of (soft shell clams), 1526 regulated by IFN-α, HCL, 562 p75 neurotrophin receptor, signaling and hair follicle regression, 221 Pancreatic adenomas, Src inhibition reduces progression and metastasis (nude mouse), 962 Pancreatitis, activated polyamine catabolism (human/rat), 115 PAR 2 . see Protease-activated receptor-2 Pax2, in apoptosis and angiogenesis, TECs, 706 Pelvic floor disorders, elastic fiber homeostasis and LOXL1 (mouse), 519 Periodontitis, PAR 2 in pathogenesis (mouse), 1179 Peroxisomes, MFP-2 deficiency, causes neurological lesions, CNS (mouse), 1321 Pheochromocytomas, clusterin as secreted marker for VHL protein, 574 Phosphatidylinositol 3 kinase, IFN-γ induces Fas trafficking and apoptosis sensitivity via Akt and, SMCs, 2054 Pkd1 gene, linked to ADPKD (mouse), 205 Placenta, maternal Abs affect CMV infection via FcRn-mediated transcytosis, 1210 Plasmin, modulates VEGF165-mediated angiogenesis, wound healing (mouse), 670 Platelet-activating factor receptor, deficiency of, attenuation of folic acid-induced nephropathies (mouse), 1413 Platelet-derived growth factor B, signaling inhibition enhances anti-VEGF therapy, ocular neovascularization (mouse), 2036 Plectin, regulates GFAP organization, Alexander disease, 888 Pneumocystis pneumonia, CD4 T cell and eosinophil effects modulated by CD8 T cells (B-cell-deficient mouse), 466 p75NTR. see p75 neurotrophin receptor Podocytes Ang II induces permselective dysfunction, 1073 CHOP in adhesion, 20 reduction, proteinuria and glomerulosclerosis (rat), 42 Polyamines α-methylated analogues, prevent pancreatitis mortality (rat), 115 activated catabolism, acute pancreatitis (human/rat), 115 Polyomavirus middle T oncogene, sensitivity of epithelial tissues to (mouse), 310 Porphyromonas gingivalis, PAR 2 in pathogenesis (mouse), 1189 Preeclampsia, AAV-2 causes trophoblast dysfunction and, 1951 Pregnancy maternal Abs affect CMV infection via FcRn-mediated transcytosis, 1210 MCP-1 regulated by TNF-α and IL-1β, first trimester decidual cells, 445 Prion proteins PrP Sc , localization in skeletal muscle, Creutzfeldt-Jakob disease, 927 type 1, detection on Creutzfeldt-Jakob disease (human/bovine), 151 Pristane, IFN-I production induced by, tertiary lymphoid tissue (mouse), 1227 PRL. see Prolactin Prolactin in apoptosis-driven regression, HF, 748 potentiates TGFα mammary cancer induction (transgenic mouse), 1365 Prostaglandin E 2 , effect of TGF-β2 on production, OA, 131 Prostaglandin H 2 synthase, iNOS mediates nitration (mouse), 349 Prostate cancers apoptosis sensitivity and lipid raft cholesterol levels, 1107 CSR1 suppresses growth and metastasis, 597 Prostate gland, effects of neonatal estrogen exposure (estrogen-deficient mouse), 1869 Protease-activated receptor-2, in porphyromonas gingivalis infection (mouse), 1179 Protein profiling, with antibody arrays, bladder cancers, 93 Proteinuria, podocyte numbers and (rat), 42 Psoriasis, Fas/FasL in NK cell induction (mouse), 170 Pulmonary arteries adventitial fibroblasts, with ECs in regulating vasa vasorum neovascularization, 1793 adventitia,monocyte/macrophage recruitment during remodeling, hypoxic pulmonary hypertension (rat/calf), 659 Pulmonary inflammation, LPS-induced, SSAO-mediated deamination (mouse), 718 PyMT. see Polyomavirus middle T oncogene Radiation, ionizing, induces atherosclerotic lesions (ApoE -/- mouse), 649 Rap1GAP, inhibits oropharyngeal SCC growth (nude mouse), 585 Reactive oxygen species CHOP and, in podocyte adhesion, 20 LysoPC-induced mitochondrial, MAPK activation by, ECs, 1737 Ret gene, Ret C620R mutation in Hirschprung's disease (mouse), 1262 Retina Arl3 in development (mouse), 1288 normal and neovascularized, CK2 expression, astroglial cells, 1722 Rheumatoid arthritis cadherin-11 induces FLS to form lining layers, 1486 p21 Cip1 in monocyte development and response to (mouse), 1531 RhoGTPases, regulated by IFN-α, HCL, 562 Salivary gland carcinoma, development via K- ras driven by K5 promoter (mouse), 1654 Sarcolemma, damage via excess NO, dystrophin deficiency (mouse), 1276 Scatter factor. see Hepatocyte growth factor Scleroderma, dermal fibroblasts, integrin αvβ5 induces myofibroblastic differentiation, 499 SDF-1. see Stromal-derived factor-1 SEC. see Sinusoidal endothelial cells Selectins, E and P, enhanced by bFGF, EC leukocyte recruitment (rat), 835 SEMA6A, induced by IFN-γ, Langerhans cells, 453 Semanophorins, SEMA6A, induced by IFN-γ, Langerhans cells, 453 Semicarbazide-sensitive amine oxidase, mediates deamination, LPS-induced pulmonary inflammation (mouse), 718 Sepsis, severe, cytokine profiles in lung DCs (mouse), 1940 Septic shock, lethal endotoxemia prevented by AM and UCN (mouse), 1921 Sertoli cells, cytoskeletal abnormalities (AR113Q mouse), 195 Serum/glucocorticoid-regulated kinase, in morphogenesis and homeostasis, hair follicles (mouse), 1119 SF. see Hepatocyte growth factor SGK. see Serum/glucocorticoid-regulated kinase Simian immunodeficiency virus encephalitis, CD163 identifies perivascular macrophages, 822 macrophage infection in lentiviral encephalitis (CD8 T cell-depleted macaque), 1552 Sinusoidal endothelial cells, hepatic, apoptosis prevented by Bad phosphorylation (rat), 1097 Skeletal muscle Aβ42 augmented levels exacerbate IBM pathology (mouse), 1986 neuromuscular therapeutics, commentary, 1775 Skin aging, decreased collagen production, 1861 TNF-α and InsR in wound healing, diabetes ( ob/ob mouse), 765 SMC. see Smooth muscle cells Smooth muscle cells Cat S/integrin α v β3 surface co-localization in migration, 685 IFN-γ induces Fas trafficking and apoptosis sensitivity via PI3-K and Akt, 2054 vascular, doxycycline alters adhesion and migration of, 1697 venous, TR3 prevents CS-induced proliferation, 2027 Spinal cord, I/R injury prevented by diazoxide (rabbit), 1443 Squamous cell carcinomas matriptase in (mouse), 1513 oropharyngeal, Rap1GAP inhibits growth (nude mouse), 585 Taps gene expression in stratified epithelia and (mouse), 1354 Src, inhibition reduces progression and metastasis, pancreatic adenomas (nude mouse), 962 SSAO. see Semicarbazide-sensitive amine oxidase SSC. see Squamous cell carcinomas Stem cells hematopoietic, provide repair functions, Bruch's membrane rupture (mouse), 1031 multipotent adult, human hair follicles, 1879 Stress apoptosis-induced, role of ASK1, neurons (mouse), 261 induces intestinal sensitization to luminal Ags (rats), 104 intestinal hypersensitivity and (commentary), 3 Stromal-derived factor-1, in ICC migration, 1155 SUMOylation, attenuates hypoxia- or desferroxamine-induced injury, salivary epithelial cells, 1452 α-Synucleinopathies, Hsp90 and ubiquitin in α-synuclein inclusions (human/mouse), 947 T-cell cytokine receptor, mice-deficient in, L.donovani infection (mouse), 158 T cells allergen-specific, cause maternal transmission of asthma (mouse), 1931 Brk expression and oncogenic role, 1631 CD4, compartmentalization during pulmonary cryptococcosis (mouse), 847 CD4, modulated by CD8 T cells, Pneumocystis pneumonia (B-cell-deficient mouse), 466 CD8, modulate CD4 Tcell and eosinophilin-mediated Pneumocystis pneumonia (B-cell-deficient mouse), 466 CNS-specific, role of TNF-α, MCP-1 and MIP-2, EAE (mouse), 1200 Foxp3-expressing, CD103 regulatory, accumulation in DC aggregates, colitis (mouse), 1898 tumor-associated, Gal-3 correlates with apoptosis of, melanomas, 1666 TAFI. see Thrombin-activatable fibrinolysis inhibitor Tauopathy cell-cycle markers in (transgenic mouse), 878 dissociation of neuronal loss and neurofibrillary pathology (mouse), 1598 Tauroursodeoxycholic acid, cytoprotective effect in cholestasis (rat), 398 TCCR. see T-cell cytokine receptor TDM. see Trehalose 6,6′-dimycolate TECs. see Endothelial cells Testes, sequential type IV collagen expression in (dog), 1587 2,6,10,14-Tetramethyl-pentadecane, IFN-I production induced by, tertiary lymphoid tissue (mouse), 1227 TGF-β. see Transforming growth factor-β TGF-β2. see Transforming growth factor-β2 TGFα. see Transforming growth factor-α Thrombin-activatable fibrinolysis inhibitor, deficiency attenuates fibrosis, lung (mouse), 1086 TLR3. see Toll-like receptors, TLR3 TNF-α. see Tumor necrosis factor-α Toll-like receptors TLR4, gangliosides trigger inflammatory responses via, brain glia (rat), 1619 TLR4, in LPS-enhanced cardiomyopathy, AIDS (mouse), 727 TLR3 in HCV-associated glomerulonephritis, 370 Topoisomerase-II-α, in unstable human carotid plaques, 1004 Toxoplasma gondii , regulatory role of Gal-3 in immunity in infection (mouse), 1910 TR3, prevents CS-induced proliferation, venous SMCs, 2027 TRAF4, in unstable human carotid plaques, 1004 Transforming growth factor-α, mammary cancer induction by, potentiated by PRL (transgenic mouse), 1365 Transforming growth factor-β integrin αvβ5 in signaling, dermal fibroblasts, 499 MMPI2/9 suppresses ACS induced by (rat), 69 response mediated by, potentiated by TNF-α loss, wound healing (mouse), 1848 Transforming growth factor-β1, increased during elastin calcification (rat), 490 Transforming growth factor-β2, suppresses collagen cleavage, OA, 131 Trehalose 6,6′-dimycolate, in pathogenesis of caseating granulomas (mouse), 1249 Trophoblasts AAV-2 causes dysfunction and preeclampsia, 1951 invasion modulated by CRH via CEACAM1, 141 Wnt/TCF activation promotes invasiveness, 1134 Tuberculosis, TDM and lipid in caseating granulomas (mouse), 1249 Tumor-associated T cells, gal-3 correlates with apoptosis of, melanomas, 1666 Tumor microenvironment, bone, cancer interaction with, review, 1405 Tumor necrosis factor-α autoamplification in adipocytes (mouse), 435 cannabidiol decreases levels, experimental diabetes (rat), 235 in ICC migration, 1155 InsR and, in wound healing, diabetes ( ob/ob mouse), 765 interactions with MCP-1, MIP-2 and CNS-specific T cells, EAE (mouse), 1200 loss potentiates TGF-β-mediated response, wound healing (mouse), 1848 mediates diabetes-enhanced apoptosis during healing (mouse), 757 regulates MCP-1, first trimester decidual cells, 445 Tumors AM regulates functions, human carcinogenesis, 280 CD34 marker for LECs, 1045 mammary, Notch1 and Notch3 in induction (transgenic mouse), 973 OPN-independent tumor growth in bone (OPN-deficient mouse), 551 Ubiquitin, Hsp90 and, in α-synuclein inclusions, α- synucleinopathies, 947 UCDA. see Ursodeoxycholic acid UCN. see Urocortin UCP2. see Uncoupling protein 2 Uncoupling protein 2, protective function during EAE (mouse), 1570 Urocortin, lethal endotoxemia prevented by AM and, septic shock (mouse), 1921 Ursodeoxycholic acid, cytoprotective effect in cholestasis (rat), 398 Vascular adhesion protein-1. see Semicarbazide-sensitive amine oxidase Vascular endothelial growth factor antibody therapy, enhanced by PDGF B signaling inhibition, ocular neovascularization (mouse), 2036 in BM, anaplastic anemia, 123 cannabidiol decreases levels, experimental diabetes (rat), 235 ephrinA1 inhibits intracellular signaling by, 331 in liver I/R injury (mouse), 695 localization in adult tissues (mouse), 639 Vascular endothelial growth factor-A, VEGF165 isoform, plasmin modulates angiogenesis induction, wound healing (mouse), 670 Vasoactive intestinal peptide, effect on EAE (mouse), 1179 VEGF. see Vascular endothelial growth factor Very low-density lipoprotein receptor, hepatic overexpression induces atherosclerotic plaque regression (LDLR-deficient mouse), 2064 VHL. see von Hippel-Lindau protein VIP. see Vasoactive intestinal peptide Viral infections, systemic, collateral damage in liver (commentary), 1057 von Hippel-Lindau gene, tumor suppressor product and metastasis (commentary), 367 von Hippel-Lindau protein, clusterin secreted marker for, 574 Wilson disease, copper accumulation in liver ( Atp7b -/- mouse), 423 Wingless/T-cell factor, activation promotes trophoblast invasion, 1134 Wnt/TCF. see Wingless/T-cell factor Wound healing keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16 INK4A , 1821 nACHR in, HBEC, 55 plasmin modulates VEGF165-mediated angiogenesis (mouse), 670 TNF-α and InsR in, diabetes ( ob/ob mouse), 765 TNF-α loss potentiates TGF-β-mediated response (mouse), 1848 TNF-α mediates diabetes-enhanced apoptosis during (mouse), 757 ZO-1, in Ang II-induced podocyte dysfunction, 1073