Clinical value of GnRH-a and low-dose estrogen reverse addition therapy on endometriosis after the operation

Objective To investigate the clinical value of GnRH-a and low-dose estrogen reverse addition therapy on endometriosis after operation. Methods Ninety-eight patients with endometriosis were selected. According to the random number table method, the 98 patients were divided into observation group and control group, with 49 cases in each group. The control group were treated with gonadotropin releasing hormone agonist (GnRH-a), while the observation group was treated with GnRH-a combined with low-dose estrogen reverse addition therapy. The levels of sex hormones and CA125, VAS score, Kupperman scores and adverse reactions were compared between the two groups before and after treatment. Results After treatment, the levels of FSH, E2, LH and CA125 were significantly decreased in the two groups, and the level of E2 in the observation group was significantly higher than that in the control group (P 0.05). In the observation group, the incidences of hot flashes, emotional instability and decreased libido were significantly higher than those in the control group (P 0.05). Conclusions The use of GnRH-a combined with estrogen after the operation of endometriosis can significantly improve the symptoms of low hormones, reduce the incidence of adverse reactions, and it is worthy promotion. Key words: Endometriosis; Gonadotropin releasing hormone agonist; Estrogen; Reverse addition therapy