Comprehensive Analysis of Heart Failure: Characteristics, Treatment, and Outcomes in a Reduced Ejection Fraction Patient Cohort from SIDIAP database, Catalonia, Spain.

Comprehensive Analysis of Heart Failure: Characteristics, Treatment, and Outcomes in a Reduced Ejection Fraction Patient Cohort from SIDIAP database, Catalonia, Spain. | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 10 November 2025 V1 Latest version Share on Comprehensive Analysis of Heart Failure: Characteristics, Treatment, and Outcomes in a Reduced Ejection Fraction Patient Cohort from SIDIAP database, Catalonia, Spain. Authors : Maria Giner-Soriano 0000-0003-3750-9233 [email protected] , Ramon Monfà 0000-0002-1324-3971 , Roser Vives , Silvia Fernández-García , Carles Vilaplana-Carnerero , Antoni Vallano , and Rosa Morros Authors Info & Affiliations https://doi.org/10.22541/au.176274557.73176005/v1 Published Atención Primaria Version of record Peer review timeline 198 views 92 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Introduction: Despite evidence on reduction of morbidity and mortality of the recommended drug treatment in heart failure with reduced ejection fraction, a gap persists in our comprehension of the management of the disease in Primary Care. We aimed to describe sociodemographic and clinical characteristics, treatments, and incidence of hospital admission and all-cause mortality within a cohort of patients diagnosed with heart failure with reduced ejection fraction who are followed-up in Primary Care. Methods: Population-based cohort study including adults with a diagnostic code of heart failure with reduced ejection fraction in 2018-2022. Data source: Information System for the Development of Research in Primary Care (SIDIAP). We analyzed socio-demographic and clinical characteristics, drug exposure, hospitalizations due to heart failure and all-cause mortality. Results: We included 17,169 patients; 59.5% men and 40.5% women. We found differences between men and women in clinical characteristics and in drug combinations, and suboptimal use to recommended therapies, being better for men than for women. Women had higher hospitalization (44.6% vs 42.1%) and all-cause mortality rates (27.2% vs 25.3%). Hazard ratio of hospitalization was higher in older than 60, with increasing NYHA, diabetic patients and in previously hospitalized. Conclusions: We observed sex disparities in baseline characteristics, in drug use for heart failure, and in adherence to treatment recommendations. Women had higher rates of hospital admissions and all-cause mortality, although the hazard ratio for hospitalization risk was similar between sexes. Age over 60, increasing NHYA, diabetes and prior heart-failure hospitalization resulted in higher risk of hospital admission. These findings highlight the importance of tailoring treatment strategies according to clinical conditions. Supplementary Material File (pds-25-0942-file001.docx) Download 377.43 KB Information & Authors Information Version history V1 Version 1 10 November 2025 Peer review timeline Published Atención Primaria Version of Record 1 Aug 2026 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords electronic health records heart failure heart failure with reduced ejection fraction left ventricular ejection fraction primary health care Authors Affiliations Maria Giner-Soriano 0000-0003-3750-9233 [email protected] Institut de Recerca en Atencio Primaria Jordi Gol View all articles by this author Ramon Monfà 0000-0002-1324-3971 Institut de Recerca en Atencio Primaria Jordi Gol View all articles by this author Roser Vives Universitat Autònoma de Barcelona View all articles by this author Silvia Fernández-García Institut de Recerca en Atencio Primaria Jordi Gol View all articles by this author Carles Vilaplana-Carnerero Universitat de Barcelona View all articles by this author Antoni Vallano Universitat Autònoma de Barcelona View all articles by this author Rosa Morros Institut de Recerca en Atencio Primaria Jordi Gol View all articles by this author Metrics & Citations Metrics Article Usage 198 views 92 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Maria Giner-Soriano, Ramon Monfà, Roser Vives, et al. Comprehensive Analysis of Heart Failure: Characteristics, Treatment, and Outcomes in a Reduced Ejection Fraction Patient Cohort from SIDIAP database, Catalonia, Spain.. Authorea . 10 November 2025. DOI: https://doi.org/10.22541/au.176274557.73176005/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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