The Systematic Analysis of lncRNA Expression in Ebola-infected Human Macrophages

Abstract Ebola is a dangerous virus which causes severe headache, muscle pain, hemorrhagic fever, and multi-organ failure. The underlying mechanism of Ebola-human interaction at the molecular level remains unexplored. The recently reported research revealed that lncRNA are known to be important in the pathogenesis of viruses. The study carried out the comprehensive analysis of lncRNA identification in EBOLA, LPS and RESTV infected MDMs. In EBOLA, the total number of known lncRNA is EBOLA 555 in, in RESTV 476, in LPS 550 and the novel lncRNAs in EBOLA 142, RESTV 127, in LPS 136 identified. Also, differentially expressed lncRNAs and neighbourhood genes of each lncRNA about 100kb identified for analysis.The study reported the known and novel lncRNA in EBOLA, LPS and RESTV infected cells of MDMs. The results of the study may help to understand the immune response further.