Association of TP53 gene codon 72 polymorphism with endometriosis risk\nin Isfahan

Background: Endometriosis is a female health disorder that occurs when\ncells from the lining of the uterus grow in other areas of the body.\nThe cause of endometriosis is unknown. Objective: The purpose of this\nstudy was to investigate TP53 gene codon 72 polymorphism in women with\nendometriosis and compared it with healthy samples in Isfahan.\nMaterials and Methods: We undertook a case-control study to examine the\npossible association of the TP53 gene codon 72 polymorphism with the\nrisk of endometriosis in Isfahan. Ninety whole blood specimens from\nnormal people as controls and ninety endometriosis specimens were\nanalyzed. p53 codon 72 genotypes were identified using allele-specific\npolymerase chain reaction. Results: Frequency of genotype Arg/Arg\n(Arginine/Arginine) in the samples of endometriosis was 28.9% and in\nhealthy samples 42.2%. Frequency of genotype Pro/Pro (Proline/Proline)\nin the samples of endometriosis was 15.6% and in healthy ones.\nFrequency of heterozygote's Arg/Pro was 55.6% in endometriosis samples\nand 54.45% in healthy ones 3.3%. By comparing statistical genotype\nPro/Pro with two other genotypes in both groups there was a statistical\nmeaningful difference between control group and endometriosis group.\n[p=0.009, CI=95%, OR=5.34 (1047-19.29)]. Conclusion: Recent research\nshows that genotype Pro/Pro codon72 exon4 TP53 gene may be one\npredisposing genetic factor for endometriosis in Isfahan.