What evidence describes clear cell adenocarcinoma of the omentum or other extra-ovarian sites arising after bladder urothelial/transitional cell carcinoma or endometriosis, and what pathological evidence supports each proposed origin?

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This paper reviews evidence linking clear cell adenocarcinoma of the omentum to endometriosis through case reports, while noting that data connecting bladder urothelial carcinoma to this cancer remain limited.

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This paper reviews the limited indirect evidence linking clear cell adenocarcinoma of the omentum or extra-ovarian sites to prior bladder urothelial carcinoma or endometriosis. It examines pathological evidence supporting proposed origins, noting that existing data primarily highlight endometrial transformation in cases associated with endometriosis. The authors emphasize that further research is required to clarify the links between bladder urothelial carcinoma and these extra-ovarian tumors. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

Limited indirect evidence links clear cell adenocarcinoma to endometriosis, with case reports highlighting endometrial transformation. Further research is required to explore links between bladder urothelial carcinoma and extra-ovarian clear cell adenocarcinoma, as existing data primarily address endometriosis-related origins.
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Published October 1, 2026 | Version v1 Other Open What evidence describes clear cell adenocarcinoma of the omentum or other extra-ovarian sites arising after bladder urothelial/transitional cell carcinoma or endometriosis, and what pathological evidence supports each proposed origin? Description Limited indirect evidence links clear cell adenocarcinoma to endometriosis, with case reports highlighting endometrial transformation. Further research is required to explore links between bladder urothelial carcinoma and extra-ovarian clear cell adenocarcinoma, as existing data primarily address endometriosis-related origins. Files 969d7b4e-b9c2-4e19-862d-654c3c12f48f.pdf Files (18.6 kB) | Name | Size | Download all | |---|---|---| | md5:9a7829002bd543dd39792f19d35d70ca | 18.6 kB | Preview Download |

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last seen: 2026-10-06T06:07:52.081803+00:00
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