Faculty Opinions recommendation of Hypoxia and its possible relationship with endometrial receptivity in adenomyosis: a preliminary study.

Moamar Al‐Jefout
In: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2021 · doi:10.3410/f.739336953.793581796 · W4211059915
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This study investigated the relationship between hypoxia and endometrial receptivity markers HOXA10 and HOXA11 in adenomyosis, finding that inhibiting HIF-2 in a mouse model altered these markers.

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Abstract

Background: Adenomyosis (AM) is an important cause of female infertility. However, the underlying mechanism remains unclear. This report describes a preliminary study of hypoxia and its possible association with endometrial receptivity in AM. Methods: The study was divided into in vitro and in vivo experiments. In vitro, expression levels of the endometrial receptivity markers HOXA10 and HOXA11 in the implantation period were examined using real-time PCR and western blotting. Endometrial expression of hypoxia-inducible factor (HIF)-1, HIF-2, and HIF-3 was determined using immunohistochemistry. In vivo, using an AM mouse model established by oral administration of tamoxifen, we inhibited expression of HIF-2 using an HIF-2 antagonist (PT2399; 30 mg/kg body weight, twice daily by oral gavage for 2 days) and then examined expression levels of Hoxa10 and Hoxa11 using real-time PCR and western blotting.

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Condition tags

adenomyosisinfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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