Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma

Zhiwei Yin; Stephen Peters; Ravi Chokshi; Ravi J. Chokshi; Debra S. Heller

doi:10.1177/1066896918763547

Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma

Zhiwei Yin, Stephen Peters, Ravi Chokshi, Ravi J. Chokshi, Debra S. Heller

International journal of surgical pathology · 2018 · vol. 26(6) , pp. 578–580 · doi:10.1177/1066896918763547 · PMID:29551085 · W2792545468

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case report describes an ovarian clear cell adenofibroma exhibiting benign, borderline, and invasive components, supporting the theory that borderline clear cell tumors can precede clear cell adenocarcinomas.

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Abstract

Ovarian clear cell adenofibroma is uncommon, and borderline clear cell adenofibroma (low malignant potential) is extremely rare. Borderline clear cell adenofibromas may represent the precursor lesion of clear cell adenocarcinoma of the ovary, but this has not been established. We present a case of a woman in her mid-50s with a clear cell adenofibroma ranging from benign to borderline to frankly invasive. While some clear cell adenocarcinomas are thought to arise from endometriosis, this range of findings supports the theory that some ovarian clear cell adenocarcinomas originate from borderline tumors.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Adenofibroma Colon, Sigmoid Ovarian Neoplasms Sigmoid Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenofibroma Adenofibroma Adenofibroma Cell Transformation, Neoplastic Colectomy Colon, Sigmoid Colon, Sigmoid Colon, Sigmoid Female Gastrointestinal Hemorrhage Gastrointestinal Hemorrhage

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

References (5)

Clear Cell Adenocarcinoma Arising from Adenofibroma in a Patient with Endometriosis of the Ovary via openalex
Pathogenesis of Ovarian Clear Cell Adenofibroma, Atypical Proliferative (Borderline) Tumor, and Carcinoma: Clinicopathologic Features of Tumors with Endometriosis or Adenofibromatous Components Support Two Related Pathways of Tumor Development via openalex
W1986693994 via openalex
W2087074511 via openalex
W6633764179 via openalex

Source provenance

europepmc: last seen: 2026-06-13T06:22:48.782012+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-05-13T22:19:55.107525+00:00

License: CC0 · commercial use OK

[1] Pathogenesis of Ovarian Clear Cell Adenofibroma, Atypical Proliferative (Borderline) Tumor, and Carcinoma: Clinicopathologic Features of Tumors with Endometriosis or Adenofibromatous Components Support Two Related Pathways of Tumor Development 2011

[2] Clear Cell Adenocarcinoma Arising from Adenofibroma in a Patient with Endometriosis of the Ovary 2015