Monitoring therapy with a gonadotropin-releasing hormone analog: utility of MR imaging.

Zawin M, Marlene Zawin, M Zawin, S Mccarthy, McCarthy S, Shirley McCarthy, Leslie M. Scoutt, Scoutt L, L Scoutt, Lange R, R Lange, Gad Lavy, Lavy G, G Lavy, Vulte J, J Vulte, Florence Comite, F Comite
Radiology · 1990 · vol. 175(2) , pp. 503–506 · doi:10.1148/radiology.175.2.2109336 · PMID:2109336 · W1990429782
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MR imaging can assess GnRH analog therapy response by showing reduced fibroid volumes, decreased vessel conspicuity, fewer visible endometriomas, and poorer ovarian identifiability.

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Abstract

The utility of magnetic resonance (MR) imaging in assessing response to therapy with a gonadotropin-releasing hormone (GnRH) analog was assessed in 19 women with uterine leiomyomas and 19 women with endometriosis. There was a significant reduction in individual fibroid volumes at 3 months (P less than .05) and at 6 months (P less than .005) in the drug group, whereas there was no significant change in the placebo group. Vessel conspicuity significantly decreased at 3 months (P less than .02) and at 6 months (P less than .01) in the drug group but not in the placebo group. In the patients with endometriosis, there was a significant decrease (P less than .0006) in the number of endometriomas visualized. Significant changes were also noted in the pelvis in women who were receiving the GnRH analog. After 6 months of therapy, the identifiability of the ovaries was significantly poorer (P less than .05). The authors conclude that the utility of conservative therapy with a GnRH analog can be quantitatively assessed with MR imaging.

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Condition tags

endometriosis

MeSH descriptors

Antineoplastic Agents Endometriosis Gonadotropin-Releasing Hormone Leiomyoma Magnetic Resonance Imaging Uterine Neoplasms Abdominal Neoplasms Abdominal Neoplasms Abdominal Neoplasms Adult Antineoplastic Agents Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Leiomyoma Leiomyoma Leuprolide

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