Involution of IgE sensitisation to House Dust Mite allergen molecules by age

Involution of IgE sensitisation to House Dust Mite allergen molecules by age | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 9 February 2026 V1 Latest version Share on Involution of IgE sensitisation to House Dust Mite allergen molecules by age Authors : Filipa Semedo 0000-0003-2762-9354 [email protected] , Yulia Dorofeeva , Catarina Martins , Ana Paula Pires , Filipe Inácio , Luis Taborda Barata 0000-0001-6649-8890 , and Rudolf Valenta 0000-0001-5944-3365 Authors Info & Affiliations https://doi.org/10.22541/au.177067244.46279589/v1 119 views 105 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: The evolution of mite sensitisation profiles from childhood to adulthood is associated with distinct clinical outcomes. Longitudinal sensitisation trajectories have never been addressed across two generations over an extended time frame. Using molecular diagnosis, we aimed to investigate how the evolution of mite sensitisation relates to the expression of rhinitis and asthma in adult versus paediatric patients over a 20-year period. Methods: Specific IgE (sIgE) to mite molecular allergens was determined using MeDALL allergen chip (Der p 1, 2, 4, 5, 7, 10, 11, 14, 15, clone 16, 18, 21 and 23; Der f 1, Der f 2, Lep d 2, Blot t 5). Assessment was made in adult (n=21), adolescent (n=11) and paediatric patients (n=19) with rhinitis and/or asthma, in T1 (20-years-ago) and in T2 (current time). Results: After the 20-year-period, the adult cohort significantly decreased the number of sIgE responses to mite components - T1: 7 [3-9] versus T2: 4 [2-6], median [IQR], p=0.0040. A strong negative correlation was observed between age and the 20-year variation of sensitisation count (r = - 0.5305; p<0.0001). In adults, the reduction in mite molecular IgE responses was associated with improvement in rhinitis (p=0.0010) and asthma (p=0.0020), reflecting disease progression patterns not observed in the paediatric cohort. Conclusions: This is the first analysis to show that molecular mite sensitisation declines with ageing, and this reduction may relate to decreased asthma and rhinitis symptoms and severity. This age-associated decline highlights the importance of careful clinical interpretation in older adults to avoid overtreatment and missed diagnoses. Title: Involution of IgE sensitisation to House Dust Mite allergen molecules by age Full name of authors: Filipa Matos Semedo 1-4 , Yulia Dorofeeva 5 , Catarina Martins 3,6 , Ana Paula Pires 1 , Filipe Inácio 1 , Luís Taborda-Barata 4,7 , Rudolf Valenta 5,8,9,10 Institutional affiliation of authors: 1. Allergy and Immunology Department, São Bernardo Hospital, Centro Hospitalar de Setúbal E.P.E., Portugal 2. Present address: Hospital da Luz Setúbal, Grupo Luz Saúde, Setúbal, Portugal 3. Department of Immunology, Nova Medical School, NOVA University Lisbon, Lisbon, Portugal 4. RISE–Health, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal 5. Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria 6. Comprehensive Health Research Centre (CHRC), NOVA Medical School, Nova University of Lisbon, Lisbon, Portugal; 7. Department of Allergy & Clinical Immunology, Cova da Beira University Hospital, Covilhã, Portugal 8. Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia 9. Life Improvement by Future Technologies (LIFT) Center, Moscow, Russia 10. Center for Molecular Allergology, Karl Landsteiner University for Healthcare Sciences, Krems, Austria Running title: Involution of mite sensitisation by age Corresponding author: Filipa Matos Semedo, MD, PhD Avenida Bento Gonçalves, nº 33, 3º esquerdo, 2910-433 Setúbal, Portugal +351 927 297 534 [email protected] ; [email protected] Word count: 3489 words ; Tables: 1; Figures: 5 Electronic repository: Tables: 3; Figures: 8 Supplementary Material File (main text file.docx) Download 189.16 KB Information & Authors Information Version history V1 Version 1 09 February 2026 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Filipa Semedo 0000-0003-2762-9354 [email protected] Centro Hospitalar de Setubal EPE View all articles by this author Yulia Dorofeeva Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie View all articles by this author Catarina Martins Universidade Nova de Lisboa Medical School View all articles by this author Ana Paula Pires Centro Hospitalar de Setubal EPE View all articles by this author Filipe Inácio Centro Hospitalar de Setubal EPE View all articles by this author Luis Taborda Barata 0000-0001-6649-8890 Universidade da Beira Interior Faculdade de Ciencias da Saude View all articles by this author Rudolf Valenta 0000-0001-5944-3365 Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie View all articles by this author Metrics & Citations Metrics Article Usage 119 views 105 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Filipa Semedo, Yulia Dorofeeva, Catarina Martins, et al. 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