ATP level (A), mtDNA copies (B), and ΔΨm(C) of HTF-control group and groups cultured with peritoneal fluid from patients with endometriosis (PF-E) and those without endometriosis (PF-control) at different phases.

Jing Shu (304108), Lili Xing (502138), Guolian Ding (502139), Qiong Luo (502140), Xinmei Liu (502141), Qingfeng Yan (7397), Jianzhong Sheng (502142), Hefeng Huang (419748)
2015 · doi:10.1371/journal.pone.0082334.g003 · W6922837777
Lab / animal OA: green CC0
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This figure compares ATP levels, mitochondrial DNA copies, and mitochondrial membrane potential between a healthy control group and groups cultured with peritoneal fluid from patients with endometriosis versus those without.

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This study investigated how peritoneal fluid from patients with endometriosis affects mitochondrial function and early development in mouse embryos compared to control groups. Researchers measured ATP levels, mitochondrial DNA copies, and mitochondrial membrane potential across different culture phases using fluid from women with and without the disease. The results indicated significant alterations in these mitochondrial parameters when embryos were exposed to endometriosis-associated peritoneal fluid relative to controls. This paper is centrally about endometriosis — specifically examining its impact on embryonic mitochondrial health via peritoneal fluid analysis.

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Abstract

a Indicates a significant difference between the given group and HTF-control group. bIndicates a significant difference between the PF-control and PF-E groups.
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The Effect of Peritoneal Fluid from Patients with Endometriosis on Mitochondrial Function and Development of Early Mouse Embryos Figure 3 ATP level (A), mtDNA copies (B), and ΔΨm(C) of HTF-control group and groups cultured with peritoneal fluid from patients with endometriosis (PF-E) and those without endometriosis (PF-control) at different phases. a Indicates a significant difference between the given group and HTF-control group. bIndicates a significant difference between the PF-control and PF-E groups.

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endometriosis

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