Gonadal Dysfunction in Wolfram Syndrome: A Prospective Study

Gonadal Dysfunction in Wolfram Syndrome: A Prospective Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Gonadal Dysfunction in Wolfram Syndrome: A Prospective Study Gema Esteban-Bueno, Juan Luis Fernández-Martínez This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6403130/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Wolfram syndrome (WFS), also known as DIDMOAD, is a rare monogenic neurodegenerative disorder characterized by 4 key components: non-autoimmune insulin-dependent diabetes mellitus (DM), optic atrophy, sensorineural hearing loss, and diabetes insipidus. Although it significantly affects quality of life, gonadal dysfunction, particularly hypogonadism, remains underrecognized. Methods: 45 patients (25 men, 20 women) with genetically confirmed WFS from a single tertiary care center were prospectively followed to assess gonadal function. Men underwent hormonal evaluations, semen analysis, imaging tests, and testicular biopsies. In women, data on age at menarche, menstrual irregularities, and age at menopause were recorded. Hormonal analyses, including anti-Müllerian hormone (AMH) levels, and imaging tests were also conducted. Results: Hypogonadism was identified in 17 men, predominantly hypergonadotropic. Testicular biopsies showed seminiferous tubule damage, Sertoli cell predominance, and reduced Leydig cells. Azoospermia was observed in 12 patients, whereas others presented with oligozoospermia, teratozoospermia, or asthenozoospermia. Most patients exhibited low testosterone levels along with elevated LH and FSH, suggesting primary testicular failure, except for 2 cases of hypogonadotropic hypogonadism. In women, menstrual irregularities were universal, with 20% experiencing premature menopause. 4 patients had low AMH levels, with ovarian atrophy in 3 and a postmenopausal uterus in 2, indicating early hypogonadism risk. Conclusions: Gonadal dysfunction is a significant yet overlooked feature of WFS, requiring systematic evaluation during puberty and beyond. Proper management is essential to mitigate metabolic disturbances and psychological impacts, including infertility distress, relationship challenges, and quality of life concerns. Addressing sexual health is crucial as WFS patients live longer and aspire to establish relationships or start families. Wolfram syndrome Gonadal failure Hypogonadism DIDMOAD Quality of life DIDMOAD INTRODUCTION Wolfram syndrome (WS), also known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), is a rare monogenic neurodegenerative disorder that is inherited in an autosomal recessive pattern, affecting multiple organ systems. Its estimated prevalence is 1 in 770,000 individuals in the United Kingdom and approximately 1 in 1 million in Spain [1,2,3]. WS is primarily characterized by the early onset of non-autoimmune, insulin-dependent diabetes mellitus and optic atrophy, followed by diabetes insipidus and sensorineural hearing loss [4,5,6, 7] However, other clinical manifestations, such as gonadal dysfunction, remain understudied despite their significant impact on patients’ quality of life [8]. Recent studies suggest that gonadal dysfunction could serve as a relevant diagnostic criterion for WS, particularly in pediatric patients, underscoring the need for systematic screening and early intervention [9,10]. Hypogonadism in WS can manifest as either hypogonadotropic or hypergonadotropic hypogonadism, affecting both males and females. In males, primary testicular dysfunction is the predominant form, characterized by low testosterone levels and histological abnormalities such as seminiferous tubule hyalinization and Leydig cell deficiencies [11]. Hypogonadism in males with WS can be classified into two primary types: primary (hypergonadotropic) hypogonadism and secondary (hypogonadotropic) hypogonadism. Primary hypogonadism is characterized by low testosterone levels accompanied by elevated luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which indicates testicular failure [12,13]. In contrast, secondary hypogonadism is defined by low testosterone levels with inappropriately low or normal LH and FSH levels, suggesting dysfunction at the hypothalamic or pituitary level [14,15]. Diagnostic criteria for hypogonadism in males include low total testosterone levels, typically below 300 ng/dL (10.4 nmol/L), measured in the morning when levels peak [15]. Low free testosterone should also be considered if alterations in sex hormone-binding globulin (SHBG) are suspected to affect bioavailability [16]. Clinical symptoms commonly associated with hypogonadism include reduced libido, erectile dysfunction, decreased muscle mass, fatigue, and osteoporosis [16]. Additionally, altered levels of LH and FSH may help distinguish primary from secondary hypogonadism, although they are not diagnostic on their own [12]. In females, gonadal dysfunction in WS can present as either primary (hypergonadotropic) or secondary (hypogonadotropic) hypogonadism [17]. However, its diagnosis is particularly challenging due to the limited number of studies evaluating ovarian function in WS. Unlike in males, where testosterone, LH, and FSH levels allow for a clear distinction between primary and secondary hypogonadism, hormonal monitoring in women with WS is rarely performed [10,18,19]. Alternative markers, such as anti-Müllerian hormone (AMH) levels and ovarian imaging, have been suggested to assess ovarian insufficiency in WS [18]. However, despite its clinical significance, female hypogonadism in WS remains significantly underdiagnosed. Some researchers suggest that gonadal dysfunction, like urinary dysfunction, should be considered a relevant diagnostic feature of WS to ensure early recognition and appropriate management, including hormone therapy [9,17]. The lack of systematic studies on female hypogonadism in WS highlights a critical gap in knowledge, as current research largely relies on male-centered diagnostic criteria. Given the increasing recognition of reproductive dysfunction in WS, further studies are needed to improve diagnosis and management in affected females [21]. Gonadal dysfunction in WS has far-reaching consequences beyond fertility, impacting metabolic health, bone density, and psychological well-being. Hypogonadism can lead to symptoms such as fatigue, muscle weakness, and osteoporosis, as well as mood disturbances, cognitive impairments, and an increased risk of anxiety and depression [22,23]. Recognizing its impact across multiple health domains highlights the necessity of a proactive approach to screening and management. While previous studies have reported hypogonadism in WS, it remains an underdiagnosed and often overlooked feature, necessitating more structured diagnostic and therapeutic strategies [24]. MATERIALS AND METHODS Patients and Variables : This study included a cohort of 45 patients diagnosed with Wolfram syndrome (WS) between 1999 and 2024, consisting of 25 males and 20 females. Ten patients had passed away during this period, leaving 35 survivors with a mean age of 26.23 years (SD: 9.61). All patients were genetically confirmed with WFS1 mutations. Inclusion Criteria: Diagnosis of Wolfram syndrome based on clinical criteria and confirmed by genetic testing of the WFS1 gene. Exclusion Criteria: Failure to meet the inclusion criteria. This research focuses on hypogonadism in WS, with gonadal function assessments conducted in all patients. Given that diabetes mellitus and optic atrophy are clinical diagnostic criteria for WS, the presence of these conditions was recorded in all individuals. For diabetes mellitus, particular attention was given to the absence of diabetes-associated autoantibodies, including islet cell antibodies (ICA), insulin autoantibodies (IAA), glutamic acid decarboxylase antibodies (GADA), and anti-tyrosine phosphatase 2 antibodies (IA-2A), as this is a defining characteristic of WS-related diabetes. For the assessment of hypogonadism, males underwent comprehensive hormonal assessments, including total testosterone, free testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), inhibin B, sex hormone-binding globulin (SHBG), and albumin levels. Semen analysis was performed to assess sperm concentration, motility, and morphology, categorizing findings into azoospermia, oligozoospermia, asthenozoospermia, and teratozoospermia. Testicular imaging was conducted to detect structural abnormalities, and testicular biopsies were analyzed to assess seminiferous tubule integrity, Sertoli cell predominance, and Leydig cell presence. In females, recorded variables included age at menarche, presence of menstrual irregularities or dysmenorrhea, and age at menopause, given the frequent association with ovarian dysfunction. Hormonal analysis included anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol levels to assess ovarian reserve [17]. Pelvic imaging was performed to evaluate ovarian atrophy and uterine morphology. Additionally, hypogonadism was classified as primary (hypergonadotropic) or secondary (hypogonadotropic), based on gonadotropin levels. Hypergonadotropic hypogonadism suggested primary testicular or ovarian failure, whereas hypogonadotropic hypogonadism indicated hypothalamic or pituitary dysfunction. Testicular volume was measured using orchidometry or ultrasound to further assess testicular development and function. Data Collection Patients were recruited from different regions of Spain and Portugal. Some attended multidisciplinary evaluations in person, while others were visited at home by the principal investigator. STUDY DESIGN, COMPLIANCE WITH ETHICAL STANDARDS, AND DATA ANALYSIS This study was a quantitative, observational, descriptive, and cross-sectional analysis conducted in genetically confirmed WS patients from Spain, with the inclusion of 2 additional patients from Portugal. The study received approval from the Research Ethics Committee of the Province of Almería (Approval No. AP-0009-2020-C1-F2 , Internal Study Code: 2/2021 ) and was conducted in compliance with the Declaration of Helsinki and applicable national ethical guidelines. Prior to study inclusion, written informed consent was obtained from all participants or their legal guardians. For participants under 18 years of age or those unable to provide informed consent, consent was obtained from a parent or legal guardian. Confidentiality and data protection were ensured in accordance with Spanish Organic Law, 3/2018, December 5th, on the Protection of Personal Data and Guarantee of Digital Rights. Data anaysis Statistical analyses were performed using Python’s statistical libraries, including SciPy and Pandas, ensuring robust and reproducible computations. Descriptive statistics were applied to all variables, with continuous variables summarized as means ± standard deviations (SD) for normally distributed data and medians with interquartile ranges for non-normally distributed data. Categorical variables were expressed as frequencies and percentages. Correlation analyses were conducted to assess relationships between hormonal and metabolic biomarkers, identifying statistically significant associations (p < 0.05) CONFLICT OF INTEREST STATEMENT The authors declare that they have no conflicts of interest related to this study. Results General Findings: In all cases except for one patient with autosomal dominant Wolfram syndrome (WFS1-related disorder), diabetes mellitus was present. Among those with diabetes, the onset occurred before the age of 16 years. In 100% of cases, diabetes mellitus had an insidious onset, and none tested positive for islet cell antibodies (ICA), insulin autoantibodies (IAA), glutamic acid decarboxylase antibodies (GADA), or anti-tyrosine phosphatase 2 antibodies (IA-2A), confirming the absence of an autoimmune component. Additionally, all patients presented with optic atrophy before the age of 16 years, which was thoroughly evaluated and documented by an ophthalmologist. The patient with the autosomal dominant form of WFS1-related disorder, due to his young age (13 years), did not show any signs of hypogonadism at the time of evaluation. Male Patients The hormonal values in the sample of 24 male patients were as follows: luteinizing hormone (LH) had an average of 12.40 IU/L with a standard deviation (SD) of 6.90 and a mean of 5.99 IU/L; follicle-stimulating hormone (FSH) had an average of 18.47 IU/L (SD, 13.21) with a mean of 19.72 IU/L; total testosterone levels averaged 9.88 nmol/L (SD, 7.056) with a mean of 5.99 nmol/L; and free testosterone showed an average of 0.13 IU/L (SD, 0.07) with a mean of 0.11 IU/L. Population with hypogonadism: 17 male patients met the criteria for hypogonadism. The condition typically begins at an average age of 18.35 years, ranging from 15 to 29 years, with most cases starting during adolescence. The majority of cases are classified as severe. The average total testosterone level is 6.36 ng/dL, with significant variability ranging from 2.76 to 19.06 ng/dL, while the average free testosterone level is 0.091 ng/dL, indicating consistently low values. The mean luteinizing hormone (LH) value is 14.37 IU/mL, with a range from 1.2 to 25 IU/mL, demonstrating variability in hormonal regulation. Blood albumin levels average 4.05 g/dL, remaining within expected reference ranges. Sex hormone-binding globulin (SHBG) levels exhibit a wide range from 5.69 to 147, reflecting differences in testosterone bioavailability. Testicular volume is less than 12 mL in all 17 cases. Testicular biopsies were performed in 5 patients, revealing seminiferous tubule hyalinization, Sertoli cell predominance, and reduced Leydig cells. Semen analysis demonstrated azoospermia in 12 patients and oligozoospermia in 2, with associated teratozoospermia and asthenozoospermia. A correlation matrix between these biomarkers for the population with hypogonadism is presented in Table 1. Table 1. Correlation matrix between biomarkers for the population with hypogonadism Population without hypogonadism: The population without hypogonadism showed higher hormonal values compared to the hypogonadism group. The mean total testosterone level was 18.08 ng/dL, significantly higher than the 6.36 ng/dL observed in the hypogonadism group. The mean free testosterone level was 0.234 ng/dL, also markedly higher compared to 0.091 ng/dL in the hypogonadism group. The mean luteinizing hormone (LH) level in this group was 7.35 IU/mL, with a range from 2.8 to 14.2 IU/mL, which is considerably lower than the hypogonadism group’s mean of 14.37 IU/mL, suggesting differences in hormonal regulation or feedback mechanisms. The mean albumin level was 4.63 g/dL, slightly higher than the 4.05 g/dL observed in the hypogonadism group. The mean sex hormone-binding globulin (SHBG) level was 61.93, slightly higher than the hypogonadism group’s mean of 57.80, though the difference was not substantial. A correlation matrix between these biomarkers for the population without hypogonadism is presented in Table 2. Table 2. Correlation matrix between biomarkers for the population without hypogonadism The group without hypogonadism exhibits higher total and free testosterone levels compared to the hypogonadism group. In accordance with a functional hypothalamic-pituitary-gonadal axis, LH levels are significantly lower in this group, reflecting appropriate negative feedback regulation. While albumin and SHBG levels are slightly higher, these differences are minor compared to the variations observed in testosterone and LH and are unlikely to have a clinically significant impact on testosterone bioavailability. Testosterone and SHBG have a strong positive relationship, while Free Testosterone and SHBG show a moderate negative relationship, which could suggest different regulatory mechanisms for the bound vs. free forms of testosterone. LH and Albumin have a strong positive correlation, which may suggest they are regulated similarly. SHBG and Free Testosterone show a moderate negative correlation, suggesting a potential relationship between SHBG levels and the bioavailability of testosterone. Conversely, in the group with hypogonadism the strongest relationships are between Testosterone and Free Testosterone and Testosterone and SHBG, both showing strong positive correlations. LH shows weak correlations with most variables, suggesting less direct interaction with testosterone and SHBG, but a moderate negative correlation with SHBG. Albumin has weak positive correlations with both testosterone and free testosterone, but it does not show a strong connection to the other variables. Female Patients All 20 female patients experienced menstrual irregularities, requiring hormonal therapy. The mean age of menarche was 14 years (SD: 1.57). 4 patients entered menopause at a mean age of 35 years (SD: 5.56), with the earliest case at 27 years. Only one woman had given birth at the age of 25. Menstrual irregularities were common, and 20% experienced premature menopause. 4 women exhibited low AMH levels (≤0.53 ng/mL). The mean AMH level was 0.30 ng/mL (SD 0.21), with a median of 0.35 ng/mL. The average age of the women was 23 years (SD 4.32), with a median age of 24 years. Notably, the woman with the highest AMH level was 17 years old, with a value of 0.5 ng/mL, while the woman with the lowest AMH level was 29 years old, with a value of 0.01 ng/mL., with ultrasound evidence of ovarian atrophy in 3 cases and a uterus compatible with a menopausal state in 2 of them. Notably, the woman with an AMH level of 0.01 ng/mL, after 1 year and 2 months of hormonal treatment to achieve an adequate endometrial thickness, successfully achieved embryo implantation using a donor oocyte. These findings suggest an increased predisposition to hypogonadism, or an earlier onset compared to the general population. Discussion Our study demonstrates a high prevalence of hypogonadism among patients with Wolfram Syndrome (WS), particularly in males. Hypogonadism was present in 79.1% of male patients, with 89.47% of them exhibiting hypergonadotropic hypogonadism, characterized by elevated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels accompanied by low total and free testosterone levels. These findings suggest that primary testicular failure is the predominant mechanism of gonadal dysfunction in most cases [9,10,25]. Semen analyses conducted in hypogonadal patients revealed azoospermia in 12 cases and oligozoospermia in 2 cases, frequently associated with teratozoospermia and asthenozoospermia [5,13]. Additionally, testicular biopsies demonstrated seminiferous tubule hyalinization, Sertoli cell predominance, and reduced Leydig cell populations, findings consistent with primary testicular failure. These histological features align with previous reports describing testicular dysfunction in patients with WS [5]. In female patients, the prevalence of hypogonadism is less clearly defined due to the widespread use of hormonal contraceptives, which may obscure underlying ovarian insufficiency [11]. However, low anti-Müllerian hormone (AMH) levels were identified in 20% of female patients, with ultrasonographic evidence of ovarian atrophy in 3 cases [17,18]. These findings suggest a significant reduction in ovarian reserve, which may remain undetected due to hormonal therapy masking the condition [16,18]. The comparative analysis between patients with and without hypogonadism reveals essential differences. Patients without hypogonadism exhibited significantly higher total and free testosterone levels, along with lower LH levels, reflecting appropriate negative feedback mechanisms. In contrast, patients with hypogonadism displayed elevated LH levels concomitant with low testosterone levels, supporting the diagnosis of primary testicular failure in the majority of cases [5,10,13]. Our study highlights the substantial impact of gonadal dysfunction on patient quality of life, further emphasizing the necessity of comprehensive management protocols. Male patients with hypogonadism reported erectile dysfunction and difficulties in romantic relationships, illustrating the emotional burden of the condition. Considering that hypogonadism can adversely affect both physical and psychological health, implementing multidisciplinary strategies involving endocrinologists, reproductive specialists, and mental health professionals is critical [1, 5, 10]. Findings in female patients warrant special attention due to the paucity of literature addressing ovarian insufficiency in WS. Although 20% of female patients exhibited premature menopause, the actual prevalence of ovarian insufficiency may be higher [17]. This discrepancy may be attributed to the use of hormonal contraceptives, which can suppress ovarian function and mask underlying insufficiency. Furthermore, the low fertility rate observed in our cohort, with only one woman achieving pregnancy using donor oocytes after prolonged hormonal therapy, highlights the need for tailored reproductive counseling and management. Although clinical guidelines such as the French National Diagnostic and Care Protocol for Wolfram Syndrome (PNDS) [22] and the Clinical Practice Guideline for Wolfram Syndrome (DIDMOAD) [23] are available, no standardized protocol currently exists that addresses systematic gonadal function evaluation in both sexes and its impact on quality of life. Based on our study, it is essential to produce scientific articles that thoroughly address genetic counseling for individuals affected by WS and their families. Given the genetic nature of this disease, providing clear, evidence-based guidance is crucial to improve patient care and support informed decision-making. Notably, we have only identified one recent scientific work specifically focusing on genetic counseling for WS, authored by the principal investigator of this study. This publication provides a robust foundation for our recommendations and underscores the critical importance of interdisciplinary collaboration in the management of WS [23]. As noted by other authors and supported by our results, the need to implement early screening protocols in WS patients becomes evident. These protocols should include periodic hormonal assessments (total testosterone, free testosterone, LH, FSH, and inhibin B) and semen analysis in males starting at the age of 14, particularly in those presenting with delayed puberty or clinical signs of hypogonadism. In females, AMH measurement should be initiated during early adolescence, even if menstrual cycles appear normal, to detect early ovarian insufficiency [17,18]. Such an approach would not only facilitate early diagnosis of gonadal dysfunction but also enable timely therapeutic interventions aimed at improving quality of life and potentially preserving fertility. Conclusion This study confirms that gonadal dysfunction is a prevalent and significant feature of Wolfram syndrome (WS), predominantly manifesting as hypergonadotropic hypogonadism. Among males, 17 of 25 patients (68%) exhibited hypogonadism, including 12 cases of azoospermia and 2 cases of oligozoospermia. The mean total testosterone level in affected males was 6.36 ng/dL, significantly lower than that of the non-hypogonadal group (18.08 ng/dL). In females, 20% experienced premature menopause, and 4 patients exhibited AMH levels ≤0.5 ng/mL; ovarian atrophy was detected in 3 of these cases. These findings indicate that primary gonadal dysfunction predominates, although 2 cases of hypogonadotropic hypogonadism suggest hypothalamic-pituitary axis involvement. The high prevalence of primary gonadal failure, particularly in males, and the reduced ovarian reserve detected in female patients underscore the need for standardized protocols for gonadal function assessment. Early detection through hormonal evaluations — specifically testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and inhibin B — and semen analysis in boys from age 14, as well as anti-Müllerian hormone (AMH) measurement and ovarian imaging in girls during preadolescence, is critical for timely diagnosis and intervention. Additionally, considering the emotional and psychological burden associated with hypogonadism, particularly its impact on fertility and interpersonal relationships, implementing psychological support as part of comprehensive care is essential. Furthermore, the lack of standardized reproductive health guidelines for WS management necessitates the incorporation of routine gonadal function evaluations into clinical practice. Genetic counseling should be systematically provided to patients and their families, given the hereditary nature of WS, to support informed decision-making and enhance overall well-being. Future studies should also explore fertility preservation strategies to improve long-term reproductive outcomes and quality of life for individuals affected by WS. Declarations COMPLIANCE WITH ETHICAL STANDARDS Ethical Approval: This study was approved by the Research Ethics Committee of the Province of Almería (Approval No. AP-0009-2020-C1-F2, Internal Study Code: 2/2021) and was conducted in accordance with the principles outlined in the Declaration of Helsinki and national ethical guidelines. Informed Consent: Written informed consent was obtained from all participants or their legal guardians before inclusion in the study. For participants under 18 years of age or those unable to provide informed consent, consent was obtained from a parent or legal guardian. Data Protection and Confidentiality: Patient confidentiality was ensured, and the study complied with the Spanish Organic Law, 3/2018, December 5th, on the Protection of Personal Data and Guarantee of Digital Rights. Conflict of Interest Statement: The authors declare that they have no conflicts of interest related to this study. ACKNOWLEDGMENTS We sincerely thank the families affected by Wolfram syndrome for their invaluable participation in this study, as well as the Spanish Association for Research and Support for Wolfram Syndrome for their continuous support and collaboration. We would like to acknowledge the work of the Spanish Wolfram Syndrome Clinical Team, which has been evaluating patients since 2011. In particular, we highlight the contributions of the specialties involved in this article, urology and endocrinology, with the participation of Dr. José Ignacio Abad Vivas-Pérez (urologist) and Dr. Manuel Romero Muñoz (endocrinologist), who have played a key role in patient assessment. Additionally, we recognize the incorporation of Dr. Pedro Mezquita Raya (endocrinologist) in recent years, further strengthening the team and contributing to the specialized evaluation of these clinical aspects. FUNDING: We acknowledge the Andalusian Regional Ministry of Health (Consejería de Salud de Andalucía) for supporting this project through the AP-0009-2020-C1-F2 FPS 2020 - Research Call for Primary Care, Regional Hospitals, and CHARES. Additionally, we thank the Consejería de Salud de Andalucía for its support through the “SAS 2024 - Refuerzo con Recursos Humanos de la Actividad Investigadora en las Unidades Clínicas del Servicio Andaluz de Salud”; which has provided dedicated time for scientific investigation and contributed to the development of this study. References Esteban Bueno G, Romero Muñoz M, Navarro Cabrero M, Fernández P, López J, García A, et al. Clinical Practice Guideline for Wolfram Syndrome (DIDMOAD). Soria, Spain: CEASGA-Publishing; 2020. 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Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment. Nat Rev Endocrinol . 2015;11(9):547–564. doi: 10.1038/nrendo.2015.112. Ramasamy R, Armstrong JM, Lipshultz LI. Preserving fertility in the hypogonadal patient: an update. Asian J Androl . 2015;17(2):197–200. doi: 10.4103/1008-682X.142772. Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, et al. The physiology and clinical utility of anti-Mullerian hormone in women. Hum Reprod Update . 2014 May-Jun;20(3):370–385. doi: 10.1093/humupd/dmt062. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6403130","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":440078356,"identity":"9648b855-6628-46b4-a457-ee697e3af13a","order_by":0,"name":"Gema Esteban-Bueno","email":"data:image/png;base64,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","orcid":"","institution":"Unidad de gestión clínica Almería Periferia- Distrito Sanitario Almería. Servicio Andaluz de Salud.","correspondingAuthor":true,"prefix":"","firstName":"Gema","middleName":"","lastName":"Esteban-Bueno","suffix":""},{"id":440078357,"identity":"90b0a523-6cd6-41bd-96e4-e79560c65dad","order_by":1,"name":"Juan Luis Fernández-Martínez","email":"","orcid":"","institution":"Group of Inverse, Optimization and Machine Learning Problems. University of Oviedo. Spain","correspondingAuthor":false,"prefix":"","firstName":"Juan","middleName":"Luis","lastName":"Fernández-Martínez","suffix":""}],"badges":[],"createdAt":"2025-04-08 12:08:12","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6403130/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6403130/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":81903890,"identity":"63bdb7b3-bcb2-46f5-9bfa-cedc894d8424","added_by":"auto","created_at":"2025-05-04 10:31:22","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":463887,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6403130/v1/c00611f4-fa32-43a6-8f5d-2668b322976d.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"\u003cp\u003eGonadal Dysfunction in Wolfram Syndrome: A Prospective Study\u003c/p\u003e","fulltext":[{"header":"INTRODUCTION","content":"\u003cp\u003eWolfram syndrome (WS), also known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), is a rare monogenic neurodegenerative disorder that is inherited in an autosomal recessive pattern, affecting multiple organ systems. Its estimated prevalence is 1 in 770,000 individuals in the United Kingdom and approximately 1 in 1\u0026nbsp;million in Spain [1,2,3]. WS is primarily characterized by the early onset of non-autoimmune, insulin-dependent diabetes mellitus and optic atrophy, followed by diabetes insipidus and sensorineural hearing loss [4,5,6, 7] However, other clinical manifestations, such as gonadal dysfunction, remain understudied despite their significant impact on patients\u0026rsquo; quality of life [8].\u003c/p\u003e \u003cp\u003eRecent studies suggest that gonadal dysfunction could serve as a relevant diagnostic criterion for WS, particularly in pediatric patients, underscoring the need for systematic screening and early intervention [9,10]. Hypogonadism in WS can manifest as either hypogonadotropic or hypergonadotropic hypogonadism, affecting both males and females. In males, primary testicular dysfunction is the predominant form, characterized by low testosterone levels and histological abnormalities such as seminiferous tubule hyalinization and Leydig cell deficiencies [11].\u003c/p\u003e \u003cp\u003eHypogonadism in males with WS can be classified into two primary types: primary (hypergonadotropic) hypogonadism and secondary (hypogonadotropic) hypogonadism. Primary hypogonadism is characterized by low testosterone levels accompanied by elevated luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which indicates testicular failure [12,13]. In contrast, secondary hypogonadism is defined by low testosterone levels with inappropriately low or normal LH and FSH levels, suggesting dysfunction at the hypothalamic or pituitary level [14,15].\u003c/p\u003e \u003cp\u003eDiagnostic criteria for hypogonadism in males include low total testosterone levels, typically below 300 ng/dL (10.4 nmol/L), measured in the morning when levels peak [15]. Low free testosterone should also be considered if alterations in sex hormone-binding globulin (SHBG) are suspected to affect bioavailability [16]. Clinical symptoms commonly associated with hypogonadism include reduced libido, erectile dysfunction, decreased muscle mass, fatigue, and osteoporosis [16]. Additionally, altered levels of LH and FSH may help distinguish primary from secondary hypogonadism, although they are not diagnostic on their own [12].\u003c/p\u003e \u003cp\u003eIn females, gonadal dysfunction in WS can present as either primary (hypergonadotropic) or secondary (hypogonadotropic) hypogonadism [17]. However, its diagnosis is particularly challenging due to the limited number of studies evaluating ovarian function in WS. Unlike in males, where testosterone, LH, and FSH levels allow for a clear distinction between primary and secondary hypogonadism, hormonal monitoring in women with WS is rarely performed [10,18,19].\u003c/p\u003e \u003cp\u003eAlternative markers, such as anti-M\u0026uuml;llerian hormone (AMH) levels and ovarian imaging, have been suggested to assess ovarian insufficiency in WS [18]. However, despite its clinical significance, female hypogonadism in WS remains significantly underdiagnosed. Some researchers suggest that gonadal dysfunction, like urinary dysfunction, should be considered a relevant diagnostic feature of WS to ensure early recognition and appropriate management, including hormone therapy [9,17].\u003c/p\u003e \u003cp\u003eThe lack of systematic studies on female hypogonadism in WS highlights a critical gap in knowledge, as current research largely relies on male-centered diagnostic criteria. Given the increasing recognition of reproductive dysfunction in WS, further studies are needed to improve diagnosis and management in affected females [21].\u003c/p\u003e \u003cp\u003eGonadal dysfunction in WS has far-reaching consequences beyond fertility, impacting metabolic health, bone density, and psychological well-being. Hypogonadism can lead to symptoms such as fatigue, muscle weakness, and osteoporosis, as well as mood disturbances, cognitive impairments, and an increased risk of anxiety and depression [22,23]. Recognizing its impact across multiple health domains highlights the necessity of a proactive approach to screening and management. While previous studies have reported hypogonadism in WS, it remains an underdiagnosed and often overlooked feature, necessitating more structured diagnostic and therapeutic strategies [24].\u003c/p\u003e"},{"header":"MATERIALS AND METHODS","content":"\u003cp\u003e \u003cb\u003ePatients and Variables\u003c/b\u003e: This study included a cohort of 45 patients diagnosed with Wolfram syndrome (WS) between 1999 and 2024, consisting of 25 males and 20 females. Ten patients had passed away during this period, leaving 35 survivors with a mean age of 26.23 years (SD: 9.61). All patients were genetically confirmed with WFS1 mutations.\u003c/p\u003e \u003cp\u003eInclusion Criteria: Diagnosis of Wolfram syndrome based on clinical criteria and confirmed by genetic testing of the WFS1 gene.\u003c/p\u003e \u003cp\u003e Exclusion Criteria: Failure to meet the inclusion criteria.\u003c/p\u003e \u003cp\u003eThis research focuses on hypogonadism in WS, with gonadal function assessments conducted in all patients. Given that diabetes mellitus and optic atrophy are clinical diagnostic criteria for WS, the presence of these conditions was recorded in all individuals. For diabetes mellitus, particular attention was given to the absence of diabetes-associated autoantibodies, including islet cell antibodies (ICA), insulin autoantibodies (IAA), glutamic acid decarboxylase antibodies (GADA), and anti-tyrosine phosphatase 2 antibodies (IA-2A), as this is a defining characteristic of WS-related diabetes.\u003c/p\u003e \u003cp\u003eFor the assessment of hypogonadism, males underwent comprehensive hormonal assessments, including total testosterone, free testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), inhibin B, sex hormone-binding globulin (SHBG), and albumin levels. Semen analysis was performed to assess sperm concentration, motility, and morphology, categorizing findings into azoospermia, oligozoospermia, asthenozoospermia, and teratozoospermia. Testicular imaging was conducted to detect structural abnormalities, and testicular biopsies were analyzed to assess seminiferous tubule integrity, Sertoli cell predominance, and Leydig cell presence.\u003c/p\u003e \u003cp\u003eIn females, recorded variables included age at menarche, presence of menstrual irregularities or dysmenorrhea, and age at menopause, given the frequent association with ovarian dysfunction. Hormonal analysis included anti-M\u0026uuml;llerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol levels to assess ovarian reserve [17]. Pelvic imaging was performed to evaluate ovarian atrophy and uterine morphology.\u003c/p\u003e \u003cp\u003eAdditionally, hypogonadism was classified as primary (hypergonadotropic) or secondary (hypogonadotropic), based on gonadotropin levels. Hypergonadotropic hypogonadism suggested primary testicular or ovarian failure, whereas hypogonadotropic hypogonadism indicated hypothalamic or pituitary dysfunction. Testicular volume was measured using orchidometry or ultrasound to further assess testicular development and function.\u003c/p\u003e \u003cp\u003e \u003cstrong\u003eData Collection\u003c/strong\u003e \u003cp\u003ePatients were recruited from different regions of Spain and Portugal. Some attended multidisciplinary evaluations in person, while others were visited at home by the principal investigator.\u003c/p\u003e \u003c/p\u003e \u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eSTUDY DESIGN, COMPLIANCE WITH ETHICAL STANDARDS, AND DATA ANALYSIS\u003c/h2\u003e \u003cp\u003eThis study was a quantitative, observational, descriptive, and cross-sectional analysis conducted in genetically confirmed WS patients from Spain, with the inclusion of 2 additional patients from Portugal. The study received approval from the Research Ethics Committee of the Province of Almer\u0026iacute;a (Approval No. \u003cb\u003eAP-0009-2020-C1-F2\u003c/b\u003e, Internal Study Code: \u003cb\u003e2/2021\u003c/b\u003e) and was conducted in compliance with the Declaration of Helsinki and applicable national ethical guidelines.\u003c/p\u003e \u003cp\u003e Prior to study inclusion, written informed consent was obtained from all participants or their legal guardians. For participants under 18 years of age or those unable to provide informed consent, consent was obtained from a parent or legal guardian. Confidentiality and data protection were ensured in accordance with Spanish Organic Law, 3/2018, December 5th, on the Protection of Personal Data and Guarantee of Digital Rights.\u003c/p\u003e \u003cp\u003e \u003cstrong\u003eData anaysis\u003c/strong\u003e \u003cp\u003eStatistical analyses were performed using Python\u0026rsquo;s statistical libraries, including SciPy and Pandas, ensuring robust and reproducible computations. Descriptive statistics were applied to all variables, with continuous variables summarized as means\u0026thinsp;\u0026plusmn;\u0026thinsp;standard deviations (SD) for normally distributed data and medians with interquartile ranges for non-normally distributed data. Categorical variables were expressed as frequencies and percentages. Correlation analyses were conducted to assess relationships between hormonal and metabolic biomarkers, identifying statistically significant associations (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05)\u003c/p\u003e \u003c/p\u003e \u003c/div\u003e\u003cp\u003e\u003cstrong\u003eCONFLICT OF INTEREST STATEMENT\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no conflicts of interest related to this study.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eGeneral Findings: In all cases except for one patient with autosomal dominant Wolfram syndrome (WFS1-related disorder), diabetes mellitus was present. Among those with diabetes, the onset occurred before the age of 16 years. In 100% of cases, diabetes mellitus had an insidious onset, and none tested positive for islet cell antibodies (ICA), insulin autoantibodies (IAA), glutamic acid decarboxylase antibodies (GADA), or anti-tyrosine phosphatase 2 antibodies (IA-2A), confirming the absence of an autoimmune component. Additionally, all patients presented with optic atrophy before the age of 16 years, which was thoroughly evaluated and documented by an ophthalmologist. The patient with the autosomal dominant form of WFS1-related disorder, due to his young age (13 years), did not show any signs of hypogonadism at the time of evaluation.\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eMale Patients\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe hormonal values in the sample of 24 male patients were as follows: luteinizing hormone (LH) had an average of 12.40 IU/L with a standard deviation (SD) of 6.90 and a mean of 5.99 IU/L; follicle-stimulating hormone (FSH) had an average of 18.47 IU/L (SD, 13.21) with a mean of 19.72 IU/L; total testosterone levels averaged 9.88 nmol/L (SD, 7.056) with a mean of 5.99 nmol/L; and free testosterone showed an average of 0.13 IU/L (SD, 0.07) with a mean of 0.11 IU/L.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePopulation with hypogonadism:\u003c/strong\u003e17 male patients met the criteria for hypogonadism. The condition typically begins at an average age of 18.35 years, ranging from 15 to 29 years, with most cases starting during adolescence. The majority of cases are classified as severe. The average total testosterone level is 6.36 ng/dL, with significant variability ranging from 2.76 to 19.06 ng/dL, while the average free testosterone level is 0.091 ng/dL, indicating consistently low values. The mean luteinizing hormone (LH) value is 14.37 IU/mL, with a range from 1.2 to 25 IU/mL, demonstrating variability in hormonal regulation. Blood albumin levels average 4.05 g/dL, remaining within expected reference ranges. Sex hormone-binding globulin (SHBG) levels exhibit a wide range from 5.69 to 147, reflecting differences in testosterone bioavailability. Testicular volume is less than 12 mL in all 17 cases. Testicular biopsies were performed in 5 patients, revealing seminiferous tubule hyalinization, Sertoli cell predominance, and reduced Leydig cells. Semen analysis demonstrated azoospermia in 12 patients and oligozoospermia in 2, with associated teratozoospermia and asthenozoospermia. A correlation matrix between these biomarkers for the population with hypogonadism is presented in Table 1.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 1. Correlation matrix between biomarkers for the population with hypogonadism\u003c/p\u003e\n\u003cp\u003e\u003cimg 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\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePopulation without hypogonadism:\u0026nbsp;\u003c/strong\u003eThe population without hypogonadism showed higher hormonal values compared to the hypogonadism group. The mean total testosterone level was 18.08 ng/dL, significantly higher than the 6.36 ng/dL observed in the hypogonadism group. The mean free testosterone level was 0.234 ng/dL, also markedly higher compared to 0.091 ng/dL in the hypogonadism group. The mean luteinizing hormone (LH) level in this group was 7.35 IU/mL, with a range from 2.8 to 14.2 IU/mL, which is considerably lower than the hypogonadism group\u0026rsquo;s mean of 14.37 IU/mL, suggesting differences in hormonal regulation or feedback mechanisms. The mean albumin level was 4.63 g/dL, slightly higher than the 4.05 g/dL observed in the hypogonadism group. The mean sex hormone-binding globulin (SHBG) level was 61.93, slightly higher than the hypogonadism group\u0026rsquo;s mean of 57.80, though the difference was not substantial. A correlation matrix between these biomarkers for the population without hypogonadism is presented in Table 2.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 2. Correlation matrix between biomarkers for the population without hypogonadism\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003cimg 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rmNSH5UMYx4P05nJQY7Uqekb93zyySfnKV/nUssyDMi263qpT+oCfU5OM/eHMoxkHPO4wEknnZT7ThtMJatXcUxyVrkvnVdfOi6mFU3v0X8yZQzprGOSI8/fmwJxvX333TfXiiXSlOUUnNtvnTeRuSYFZM3vfve7PGVvytj0jnGn98o49AewVXGfanCMgf/V+YDpGTZE7ak+VkumPic5+/y9qb8URObfqN3RVymYye9Db0B7E8loEpnM/yfHm20ceRwN7F20r5S7LtBn8uDYqCMmI66hzo2++I4NHAT6GPa5Pc3ufNEW01xt3HLLLVlvShhDxyeHnuvnSqhfItcB8uTYRPaznJqOM62q/03rGgNj7717SWQ8/46sGBO/jelXYF+Mu8/J1nhh7Ng49p6OO08im7nesQS5iOnXmKIl89Hf5Nk5TDN7z/YlQpePizKHRB5yvSQbzQ/5LKay2aMUrOXPnJM9Ov7443Ob9JWpcDpOHxzDPoRcpYAj65DPE3HLn/GLdNNnKWDKPi5stzFZkFBvH+0xjiloyzYgyj4CxjbaqC6cndY//jpHfPfRj360/4vZKMsV3KdxZ3vIH7mOaV82kk93HLvh3AsLo+fbFyE23njjvPIJRFRWsog87r///vxdCauDRMuiD2lQK7KgTIsnQcx/k4LkaFi0kgavlxQgs/tI62P7IKIRVUuPy6ZYkQdW54poAhi5jIDIW/QnkwEiHasQ23B+mSJRf+r/HNG7T9kRUY8sjshehJkcSY7QMX4ZpOmARMpzBlQEJyoUwXz961/P2R5ZIfev360YlrpOJDr3WTKeI9NyL3jBC3J2y+/1s0yGlUfOZRWy72W3ZDlEUCJJUacxTwqYIyOZK30e/WqMZf78XhsOOeSQnHFzvAhTtJcccJYzMhZtER1vvfXW+XqyJK4tOpYl0GaZI5GvLJjMHblyP3FdGSMZHxFsZGqMP8gqyJwlQ9tLBiO3TdQnKyQzNQxkDA8++OCciZAVDfkGK+YiQhTVyoTKoshouKbo3+/pm2NloNyv7DkkJ5kjdG2TrfSS6YjV3vMD0TZZobcy3zIGInwZV9ktGQ46kkhdjo6VT/irnyN7RS/1vQyXY5PTzvqvvcbQCmD9bUqfLiZSkfs1BQz5f5mNWK1uLPU90Fd9wm7I5rJPiYzl8VOOIFsnQwc+C7Bh55xzTrY7sinGIzmcfG1ypo9lQGTcYpqXXTIWIAsiO7fddtvl92TMtSCR3axDMp1k01iRNe1bENB2bdR3Xu6JrRoLpsZlnfVl6NCCgKy2rBf7GtC/kJx+b6eddsoZKFk88kTOZVLpoXax0XzNaJCJiqyTLNt4IWusH9idkFk+iz0cD2SanWP//ffP52MP6SnIOAO9J2f6gK2Lz+KvzB6wR2ZO9I3MljHVF+RV5tI9s9/h29g32SaITCu7TPfA1LfMXuiRbCifuaBAN9g7OmNc2SL2Xhtkr7tg7I877ricjfc3EeSh2qhci61nr90z3QsZS+R5RB+0pbQDYCza6PpsIpiypI7BNCUEBsOUh2kRRjOEMpCisewANtxww2xgGXxA8gKJtee/hN5xpl0Ir8EwgO0O5cgNsik5gxaOzLHlgPsdoWYogBEm0Mggx9QFDsPUH0ejvaa3/CZFBzmVyzkCUuLeKAIStLjDeCDFwHCZBuOUOGL3jYxzzJZ9m/5ALjhgRqcco3KsyAUwRvrPOAdRYSB9bqwpOGV3XtcJY9d1TmSKA+YYkEYv46MdlBXieGNliguhN1bG1LQ6uDZQanKHECKuJZyXrDt3GFnXBcfqH5+b0vj85z+f+4qsOdcwYKxNuSpX0I5Bxso9eDFMHATSq6QAvvnNb2ZCzJC7p5Bt7dMPiCCywqhr27CEczRwkuTFuCGKHJX2mz53fiQLTBsh/hwP8gddY0q+3AeEI+agtJmT8j2izbYguJzRqaeeOhJAOlfXeREpcA59xJkKBiLwK4813WU82B0OU3tM75ONqN3RJqDziBPEOegGkHPwOXkDDgYQOdNkCJ/+QhDLNkwEcY0SdIxMCX68THm73lgQXAm02MzxTle2be9oMOXoWjGNXUIft/tS0KY9xiI+k0QYC6HjbNZ4oE+NE0IGSAdZpPsCgvGMWZAqZNS4+G2QzPZ5vO86d9xz2TcxPuwTOCZsVIzDaO10bJCcOJdp8GHHcCLQRgGsIJs9Nj76FFFTv8aetKH0J+RYICdIj/4YDQIsNsILgcMVfMZuud+yr0od8r3paKUhynUEpIIy8joZmLKkDmS/wvkiWEgd59kGA0k5RL2ydrIlg0BoRRdjgYFCAGSNZMq0IwapjVKwOd1QskHOLRZdGGgKI/J3fwYaAVF/ptbPeZA/URKHsbhDPQanDAyQcVP7oLbLuKoHIeD6BJmhJPoFIgosQUHbfWwsQoGCgCH86l8AOVBfJRs3CBw0MOraJIqWHVPrFxnfAIIY4w0UOJxBtNlYh4yE4pb30zaQ8V04ddkkdZzaIduH3EVh7ljgpNwDY4NUaEsXIlIP6NeoEyHTyCsyovbPIiUZL+dioDgSNXPGTpYrCqbnBzE+alL0sSwlZyfzxFCrBXrnO9+ZdVIQp54nshNdCIIIMV762e/JpTGXTSAragKRZtl0pDGObYMhD/Lme/KslpMecxBQ2oZ2tt29AQcSbYrjEee2bHc5Utf1uXuI99rBdgl4yHp5/HghuAkyXEK/0VMEGYn1t6uP2tBn2uvYQfYUus7Fdgx7L+SQsw7/UcI54jzxt+t6g3SlRPyefI0H/Ap5FQB+8pOfzHY+gg06huwPi2gDOaLv0BVUDAPHx28G/R0P5ue34wXZEtwI7GXoJUsEm2ZwQPDZRb71mWCOPNN9vn+Y9tJZtlHySfBArs2uSdSwWeQP+AP6HPAbAai2Ipr8nM9itnB+MaVJHXIWK5dMoYmm2lk6kGYXUYsCOJbRSBsG3RVRhlLHX06F8+JIpOVNvxq0rsEuDUKQNQM+qB2UV0aD0+SgFOpyWsid9iE0skpSuxyyLIRsRcn2F0e418houhcE1vSHrIvokBNTPE4xQkn0v/6ITCtEf/ss0tqR3fIbJAhMrwLSgRSbGvcbBpXhHISITBlqSi5rq43GKTIpgZhmCDCssr8QsqI9MXZhuIc1GqAdrkMGQ06iH8dCXIdckedBv2s7WEYm7s24xFi5vrGSWdI+9+W32hR9NGzbRkNkC+i0aF8W0fkZSn0c03+mpxFc5CNWEXZBv0d/xrRI6LN7ZVfIGbJoGh2J9j0S7Vql/AX0T2QiHIO0GSPt7DLQbdkhZ86rD4NAhOwGURoG+j/6XMCoj7TBi3MZjTyVcthFbGQiZf+GQdfv22DDOVH3HDobMD5xHzFGJWSK9ctYQN7Ncsg6j3bvXRjmHkpEkBryOiwQbn5FMsLUO7snw+T6CLpMUxe62hef6c8IxKJcqLRPjovXwsLCvBaZEvAGwXbvgix2gtzon/G2p3181+/JWMwOAZnwmUUa/iJ0ZWDkHHQ7kk/0gZ5OFqY0qQPRODJAaQatCkJ+ZGUYKFNCoh5glMNYhlN1TPwfKI8Lo4pYYNI6HMGLKV3fI1kBA0RYwkCJ+Dkizi/qCEIQXMP1OT5PydAOdUscEmUkkK7luowSBxOZgsUBjGlkQ0pnEeA4GTDggEWq+l5qXP+qYTHlqtYJidVHFFQ/cX6REte/+stLit13jgvyxLFRJtk/x8j2OUa2LeqRwsHHX+11LDlC4pBp9yJLy9mLtkR+xgriPttw3Zgqj2iZkdY+MixbBuXvyUe8IGSJ/CAsCAPyom3OpR3aOhqi/+OcoCYrpkECcVx7vOhcTF1xMEiwY0xpk0/EQR0jyDTQO+1W42bKb36BxDHEMmZWF8pqGVdyYfzpJydv2k+kC5EhNabGwXuEVFYRgeLkIWprGFvyxwEiraasZALf9ra3jWRDnUcfchARDDqvMdEOtWsgsEQAyZ++kNUFvx8EmVcRu7GM6fTILrN1xgDiHDGW5Tnjs5gmZjeUC5AvNVvRjkEobVmbSBlHNYzD1L6VNnSQboAgjDOjD+F8A4IhRBTU3ZXZDf1CBpXflCjlNvpCu2W6lG4Mi9JPxDnb/d6F8BfkZ1i4NxkjY8wXhPwhAewO2P2gzAJHG6KdJWLcQtYRBDWeEGSDbmor2Vdq0EbYHBh0v12fj9Y3pUwsDNB7q26jHjVgFkLwxf61Z1q6UMpU2S9Q6kjIr3GKWQLnDztjtwS2BNjsyKYHSvkarR/Hi8EWZ4qAcWf8RDSDBiQ+Z8QY/dhyRG2UqT0wLQuETE1biai/ALVChJHhkY1Aso499thsYBl5Bj0KKb0YPELjupyCuXFKhaxxoBxRFJUiBzKOMgPqUQia2jL3ZroE3AumL4qTxmXYXBd5CVIzFaFfOJRwTgha1EWVUMyLrCHeoij1UOp/GDb9pR9jOgIRU9/AIVNYxxN+44zsUjBpdllNxkp63fQq46b/GDaKw4i6bjyCTsYpnLG/yBYyrvCfLHA8iAInjtBwJBYzIPgyMAprw/ka23Z9m7HUbjJnGkib/PYjH/lIHl8yqG4L3AM5lQ0JooYUcLbkyuIF2UI1dZyUbKMM5CBH63fGIfpdWxmcyCiUcK9kEjiZttFRYIzgRtaanDKaxooM26OLnuhf48iAcSrhmLpAZxDjWAwCdIJhLA2o6V46InNDp4yBKWSZHuMSY8zRu1c64nvgIAVVjLMgQX0a+VEvY2rYeLimqS+6atzJCdlC4gUBxpT8Kah3PWMQxAmhDAJHL923MVUyoTBf8EDGoMxyGYeS8OhDMqENghwZZFO3yLSCfaBHQVbJCTIZfRcEEsiFWmHfK2nQVoQu6gzb8FuySz4C+tlvkEIF42RYP+lbhIAtDRlBsrWXvOkrdixkDmkgJ0F4StDxWLzQriFiY8mUjCeZQnL0M13XT+6JPwCE2nWi/cZaDaj2sQMIYgQdQO6ixll/KqAnq7EYgj7TBRkV5wb6YbzYsRgD14v70gd0gx2PKb6xYAzZFuPmXMYBtI9Mx+yOdpFFn7GFcX1kNa6vLxEV+u5zC7ncN38VMxhsLXlyHwIg9V/kGuihe3XtmO51T8YcMY7gx19yZUyCpJEdfe53cQ9Rg+seQ5d9z65FokWfx3kXBNhZgRmdZn/pn8CELyfTfGhkzqLd2ube9AU5YC/iO+0nB+y0v+UiMH1JNtlJsiyJgIxHKQub49pKMYz3jBkzsn67VrRNu8hOZPwnA1Pq2a+DwIlLV6oV6QLFkiFgFKyKBNkEhlpHi7K9Z3QINMGXBaEUbp/ShsIbCA6EEUfeKJXo0bWlzCmb+iyOg/B7z3BaSOFY5+R8o34GWWD8KJVrMTSOp0imNgwuQ8QJiNxcH/nQHo6YMrs28uLcUxXGQLv1MefoXvWztsd0ZgCpltlglBklUw8iSkbG58aNkiAvxjOmoRgW3+svZCzIPCNnrDgX/cegGUOEgHHhvCml31FWMhHpbuPA2VJewQAyoJ8dx1ExVIyS8xkD8kMZEVH36RocTZvIaAtCxzgyNGQoDL92kGlGRD+5rnsOB+X6MpruQ/sc6wVkTzsGQR8ySmQnoj/nQc7KKQJwD8ila+s399GurSOHnIa/iJaxivHQNmOubQyle+Swo+i/C35j/J3P/+5fHxoPOhPTb2BcjR39pD9ICwflvuhNOBvEQuAXJB6cn94hJPoSgQL66JzGxHkiSwLOZ7zJCudGbt1vTGEZN5lK38smx5hzBIgEuUD6LTSh52SPDOkb13I+v4u2BBh5JMiY6VvyibwCJ8LOgDFiJ3ymfeB6ZIJcagc7RI6QA213/13gnPVru8bINYD863/jod+9N9b6270YN5l3ckWO6Y9xiO+035h0lbpovzYLlDjaNjhZAa3x0B73YgwR8hhf7XAcchEOmP03lvSOzLv/gLYJAIyd9jmnvjPe3nP2zm+sgnS4P36CvNJj90YWyKBxQgyMp+AD6RwGbA2d06+ur4+c0z04n+sEcXKvfAVbYkxdXztDB5Bs/7sHY2+82AbZvxKupz9N//NNzkcPXFf7+Tpy47r6Qh0ikqGtcU16wte5DgiEtd0xzud3zu/67ErMaOgnxJK+0nfn08+DfPn8QPvdJztlzLSLTNBD7aKv2ol0RoAU8mQsyI77810EKCF/2ouYRRAA7sXvvfQH++l6bbhvNjl8ibF3nN85r/4JmzoZWCxI3VSFrjOwAcJDAcrPJoI4r79eIXjTCV33FvcNnHhElMNirP7yHYxnfCbymxKMtfYs7mPIMI3Wr6P1+/winEE5Bq7nvb++H6+sjHY/EOcfD8Y652hwPbIylQO3yYQsh2l1BJtT6wIboE/Ha1MXls7Z4kPmyezCMLV+kwnyAtEv08XOTCb0iX6aSjqlTV7I4oIaq0rqKioqKioWKpA1i9rMRJhGb2eRpzpM4ZumNs03WrlBRcXCRiV1FRUVFRULHabLTO3LxClvWFxgyjqmXpWYVFRMJVRSV1FRUVGxyDCRUotFCWQUEa1TnRVTEXOROkWPHvAN460nqZjeUAegANcqSCJjpZxidMatYuHD9JVC7ne/+9256FYBvwLxxck5Viwc0F1b6djUXDG9VZIK2ausTBxRz1lCPyu2txUVWAmpuL7ayNHBllmsYdW2aXiLhix8q6R5dJA/cmjbN/uEBuYidQTQypWq7BVtiKZNNVg9RQkVOMd+cBULH9RWsS1HbdWZlYlWuVXdrWiD7lqNa8VprBS3YrUG7pMLdtEqSKuXwYpSq2mrjRwdbBnia9W41dJWg3tVWzY2yJwV0vH0CqjTrxUVFRUVFRUV0wCV1FWMG0TGHlH25atYdLDPlD2ZLNm3ea+9/ao6V3TBfnX2H5O1s59ebHRdMbmwKXhsfs9G2tuwYmzYu83WNv7a89R+fdWWjQ79I8Np9bVSnEAldRXjBsdgjyZTOdLlVYQWPuyJiMh50oQpH48RsxmpjTKl5CsqwNSf+jn1sJ5yYxNeNTj01gbMVXcnB6ayBbn61VMwwBMEbHCL6NV+Hgz+xIbP+k3gcdJJJ+WntnhaTbVlg0HmrMRWV/3mN7+5/2kldRUTAEXzyK599903P0UgdkCvWDhQa+KRRjvvvHMmdbIwhx56aI7aPA5NvVRFBSBuFjV5IoHHnyF1nrTgUXycpuL+ivmHDJOnh3jc25e+9KX82Vve8paso576IACumBeIiayxBXhnnnlmfkqQx6PJcLJpXY83rJgNur377rvnOvetttqq/2kldRUTAFLHMXiGocfHVCx8WKTiGbMePC9T57mmHj/lWbEVFSUQDY9NQuRs9iuq/8xnPpOzIhWTh2984xv5ub9f/OIX83vPBH7Pe96TH3FWMRhInSQBmUTqPvGJT2Q5ReoqRsduu+3WW3fddUeeHQ91WU5FRUVFRUVFxWKI9ir2SuoqKioqKioqKqYBKqmrqKioqKioqJgGePShHRPXf/jDH3J9gCXZP/vZz3oPPPBAXmVx//33j7wU3v72t7/NRdp1k8BHFpRhqhuxS/2zn/3s/qcTh4UWd999d5a15zznOf1PRwfZs7mnVVOWc9uAt4S6P09IsSJU/Zm6M5v1llAkfuutt/ZuueWWfE/PfOYz50llW15/7bXX5vZZxWZ1WxtWF2qL1ahPf/rT81YjJVzntttuy099UCviHtvXGS8UEHv6i9pGT5S44YYb8v2ttdZa/SOmBhQ8u++77ror94NxGOve9add5W2Ebhy7fqOvr7nmmt4999yTx79rXAJk5Nxzz+2tuOKKc+3u7xz6jQywcc94xjPmkiM2ThvYO/bP6yc/+UlebPCsZz0rH6MA3jGeYWrzdrLsu/kd38mEjVzpi01xtW/WrFl50+qJPkSfrtgWhV785S9/GcoH6N/zzjsv65o+W2qppebZlNd5jaf6P33+ox/9qPfEJz4xy3eAPLg2fVQTWJ7DinB65kk3MV7ht8iHsbUa1Xj/+Mc/nusY2wHR3baN0CZ6Rm+1eTSwX2zOW9/61vzegolXvvKVA2sXXffqq6/u3XvvvdmOKnwfDRZAXXLJJbnf//M//zPXn3U9rcK9OW/YPVselaCLZOC73/1uHjfj1wbff/PNN2fZ0W9s3yDoO/rqPvSh2l6gK/oAl9AG9rVrI2bjdv7554/IpPEhp6997Wv7R8wNq4wtSvH8XfdPb4cF+TnnnHOyfuqbLug3xxi3uBdwn2qYXZdds9NAW+79Vr+RczaaLWjfszaQbbLiGl26wwbaJNw19X3bvwUuv/zyvODJk0wCnZk6hs6jTggPAfFYGcW12267bXaSFNSy43e96129hx56qP+riYPi6IjJXulC+b0qpi441tNOO623+eab9y699NL+p6Pjpptu6r33ve/NhoJxs+KzvR+UcypaXmaZZbLyKL4tV6Apzv3ABz6QjQNDZGVg+/qM7n777ZcdwdOe9rTe4YcfnhW6BOPpPJSfETvggAOyoytx/PHHZ1Jh/yrHK1h/JKw6tJu+/uMg9J9VbcjvaECQjjzyyOzgOFiLcazeLOF8zqufOYGPfvSj2cl3wXYJBx98cO+QQw6Za1Uwo6qInUPheBljjylC4oHhdV4FyOzcHnvskV+2Aynb457Ijcf0MPLHHXfcSKH8dAS5tTWKxRfIgEfT0bPRgKRtvfXW+Td0QVG8LXjasDfZTjvtlP2M1ZD622eBv/3tb3m1t1Wl9NUYlbj99tvzePFdMV5WBzongg6K8QVCu+66a/7emO+4445ZzrrAsTof0jKZuOKKK7KtsGoWGfzgBz+YbeEg8I1sGGJsuw/bpbB7bTsyc+bMPD70DTk64ogjsg4EyKp7Z4/oBburT0sgsbYXQRbY1eACbbCnp59+eu/9739/tqeeWhIkCGE88MADe1/+8pfzMfpcu+cXbDJ9RHoQs49//OPZHwwLJEjfDbIXuIhzuieBUAAP0m/6hf22CObDH/7wXDbFPbMziCbbZfGaY0vgS/oe8XedcmwCfBJ5kBxAYMkmWzo00k3MgzPOOKNJRrNJF8zv/e/QxBabRPjyZykaalLk16QoOL+fH3zta19rXvGKVzTpBvqfzD+SwW+SwDZJQPufVEwWyMUb3vCGJpGl/icTRxLWJgUKTYrGm6RI/U8HIznfZuWVV26SM83vtSUFHE0ykPk9XHPNNc2SSy7ZJEOc3yfH0LzoRS9qEqHI7yEpVJOim+YPf/hDfu8771NklN8nZW0222yzZvvtt8/vQfuScWqSIc3vyX4yZE1yFPl9cjrNBhts0CSjmt8D+XvOc57TJIXP7/31m2SI8vuJQrvXX3/9JpHa/P7QQw8d6ZOpgmSYmte97nX9d02THFLW82hzG3/+859z/6WAsf9J06TIuEnRbnPHHXfk98l5NBtvvHGTHHV+D4ngN8lIjtirEmeeeWbz4he/uHn2s5+dZSeQCF2z1VZb9d/NHrv11luvSUY4v08EIY+18UtGNts9cvXyl7+8SaQuH5PIZZazRBDze9DeNddcs/mv//qv/ieLHvpgn332yf9HH6fAPL8fLy688MLmec97XpOcXH6fyFLu30Qg8vs26ArdTISuSeSlueeee5pNN920SQ4r93GJE044Ifd/IhBNcr7ZLyQy0/+2yf9/+9vfzjJErv7xj3/0v5mN5FCbgw46KP/emNGxRISalVZaKeuzVyJ9TQr48vdeN998c5OcdbPbbrv1zzIH7EYi8dn3Oc9YICPJ2fffNVkmv/GNb/TfzcHvf//7ZsUVVxyxG+SWr+JnB8G5zznnnCaRrPx78p8I1IhdAfdLzlPgmN87jq08//zz83v2at99981y7P8rr7yySUFvtkehkykwbVKAkm1yIBHfZoUVVmgSkep/MrvNxnWdddZpUqDb/3QO6LDx49O18SUveUnWry7w1WzZ/fffn98fe+yxTSJM+f82UnAwl94mct+sscYaQ+mbe/Zb43n22Wf3P50bZGK11VZrllhiiebee+/Nn6XgoUkELeu9c5BB/s95yGkck4KNufwQ28E+fPWrX+1/0jSJ1DXf+9738v26TinfwB8uv/zyWUZBP9OXQf1BdmN8A52ZOtND9j2JtGE5lRD/e9aYKKhM/6bzZWZveqINUZZpXX+lVlNj8+emLPbee+8cIYs6vJwnIALAmNtRGTjOOV3POb3ANTBmzyeN9pYRjf8x3zJz4/zeRxsCrl+2B7BnrxKOcf34vfvzmbS9bEAXHCM6K9vxSIPU+SqrrJJT4V1j3IYoksxssskm+T0ZTU4+PzxbxAsyKc636qqr5vemTaSnZVGAvJx66qk5QyOiBXtJiboiCyN9LqskqxDYaKONcqY6IkPHkoOkdPm9qNuUgSwh+TK+Mgp0JTm+fMyyyy6b9Ss5sPx+usKUl6i2nEJJRj1HvBdddFH/k7lhqkdGJJGi/ie9PGVIf2JDV9+bdk1GNb8H4yIDasxKmIoznWdapy1bxs2MQ+geXXVM2DyyIONhhsI9KDUw3eWYeLanqFum2D0FnIf+t23GdMHJJ5/cSw4+Z8BB9nk0eeYPPHNWtkcmU0ZTFoKNLrPexoK93nDDDbOc0ClbNZSlDP5PpDrvoB/+I8D22q9L9iQ5zDxma6+9ds7AejamzK9ryo7JuPjeS7kC/xI6HHA+WT0ZRtP7w9imYUH+ZZzYLSBz2iiDox+6wH7wyabizCxsueWW2feWU9NsmrayZeA4/cUGuR++SFZSPxkz19cfdDVkWCaL7WIbA8bOlLYyigAbZypSxjXsbID8y0QZP5l08qL0IUoWJgrPttY+2cWAMZaFJTujwdibXaTHg8bTmDj/29/+9swbQofN1JATfaff9KnZBFOiZhaA7fJbtihAphyjrwKJLOYnZ9CFLhshs2kPUjIM4d/4GtnJYdBJ6lIUlHcgHwsaHfPSDNxHPvKRLFj+GvBotGkpUx1SwQwlQWJUfS79zUkjT9LBOj6MIkO+11575ZS9VGVptBnjo446Kp+PoUEwpZspe4rWsiD739y4VGqk8U0FSFsjAfb0MjUHyKGBkppldAh2ihjyAHMiYLrnxBNPzGlVCu+vawIhkRrfZZdd8uBL27sXimiqkOKUIAR+f8YZZ+T2tL9/JEFNAQM1liP0PefNODBYAUYeOVYrYpqC4zd1UNaoMDycvBoFjp7x5GAC0uWcdhiHkKUgY0AntCGMm+uQ/7LewRSEczOClNOD9ilx1E24DoKp3KBM70830CuEhwEMMGj6yxh2gQ5wPqXB5bQYwJgu6RqXlVdeOX+GcAeQCXU6dI+s+L4EI+1cpkeMKX01RlEPhYjE454CjLb7iTpS9TBe7AWH4JocNpumFmy6gVOhO3SrhKDFmHJ+bXCgQYIDpm0FU6WTv/DCC/NULgfGhprKGgR63bYV9MqYlvVjiDldjTFFMEqdB0RBkFeSGDAliUAhfvzRZEJgSibLmkb7fbIX2tMF9Whl7RU7ts8++4zU67kHtoYt1BcBemJamm55pCBbVMLv2S9kBZA7ukIPA3SWPIcO8qWSJgJr55SQ4b8DbLn2BgRlyInp7vmB2jwyVtY2+l/72wFdG2wBeSOLXePps5gm1ielDVKPiaCWYANMNQvSwXhEwiogCOFTop64hP4sk2UBtbnupyTrxtD5je8w6CR1BqWreK8NxxgsN+JRFSINj49acsklM8kK54csKfDcbrvtcpTAGTKAOiWMM0X1HWNKMZEdG+vpPE8u8BtR89e//vV8vPOZa2ZQ7NpNgRVqalM8Qw5ECMinAUUi1WO4tt9g+KI2gkIIDSQyOnPmzExOsWO1D84LyKpaHsZDBkftjPNQBNc1wApDEUmEzmccm5oTtTcBxHKzzTbL7dBPBh0R9L5iMCgN8sYYlhG898absdGHjkEgSjDQIlXBRBDokhgaK+/JAgU0puSwdM5k1HXIEfL48/4ijZA1cA7KatwjG1wab/AbbZyMetSpCnVvEJlQ0MfeG6cuAi9rSwfpRwk2htPwnfMa+3JcGEGOrMyY0V22hIHuMuJsEfKlbo5N+NrXvpZ1PohGOQMBHJPgTqQf0F4BJ5mTDUQgZVDYwOkIpI7MRiAf4IDYXzLdhjE3fiXoH6IuOxVAtgTpbKsifv3IwXWhyxlC+zqcIB1G+qHrdwIBPqQkIeot2eQFMY4SA2wDO1HKmD5EpkoZ7gIbKJvDx5TZarbGq00WjBVdc01o95FMk2yX8QDHk2dBaRvsJ6ivkwQBOsMH6qvIWgVcV4AbazHbhHK80Ca6XtoU7/GIQRlOkBFms5FKfdNlexBtwQb5a8+s6TNyXEJb2PXIUkYCQeKghN+xP+1zdskiHWL7nNd9Bdg7x89Xpm68QHwQOtMmCJ1HRzHCmK+GGmxCgIjpBJk6N6sTKRRwjEidiIUAyswhi9KZjKfO9jmyB1g7JUCsfC7rFZH1aqutNhKx+V+0pWMQK07BOTl5BlrGLArkIwLVVkqmsFNGT+EuJZcR5JCd07Xcp8gqCqNlYIJsIG2EyFQCGOwQJsbLAFFK92bHcQasTG9XzAvKQa6MTRmNUjpCb6qFvEGbSEXfM6ox5VYackAakDrnIXvGsq3MZI7x9L3omHEuSV2Ag0P8oL0yMwxLGd1ON0TWpj0O9NIY6Ls2TMML8mTPGGF9TD9lwdgV46xPjUvbOcW4gMAPeQ+np7/bRpQjQMJkX2XXYuXqIHC2MhLIWwlTQQq3RdLOQ0a1ZToiAp52wMQBcVrDBCn6BuE2g1Fm6tj+mEHhS+ixmZSQo4lA+YRMElvfBW1B6qKUA+ikx1UhKX4XY9mWn4nCfZF9dr8kdWHPRgvs2QyLGPlARMUCkEg40Attb9u0sDWxAKiEa5kx4I8D/BWbZ8rQeCKRMtr+j/GSsUZiJEsERxZEIDnaUxIPv5HkQEL5SMd16f2wQCrZ2vCx4P7YAj67S++0wQwaeWv7jIAMpH4wSzcskED3HpxDplcWX0KIreBjJI3wA/Y/SN9o0H5jiJiXx7OZxiTs21iYFFIniwYicGlrRlValPHWeREpyXSZzpR9i5qMMs0ZkHpnyN1IOMRIR1rNStAQId+LsBlWhCgexxIOvARlMnBAIQy0GixOJwQxHLhrmYLmYAwcBXR+Ha6zQzjCmcd53WsoPycEcU736aXtEYHqN/0lcmVApvN03GRAX+r/9vjqU87G54PS2qHwxi7GL8gd+K1jGFrX4PTbcA0v3zkHOXGOUoadw7kcE7Lbbk+0JWRjOiIcf7uP2QR9E/pcQpZA5O+3ppaUVnC6DHNMf/hte/xjXIw9HZVtRxIEe5wZko50iObDqfjMakKZeqv7RchWXA6K+BEEmfh2loodcQ2ETlArkCtraBZHILeykoJ15QicuHuM7EE766DPyfgw8uxcxlc5ThfoFXuuVoutR+onAm1iX8vHJ7XB+ZKtsoZT5tX9GWf+wYt+Ryasy1+NB/qQnNKLUo5DT7rsTkAf80t0RGkQMhIrj9ksr1LfIALLrvNajex8ZfZZwsI5+WDBilpJ/s21Y4qajsiAGyf9JNOnLt7UfDlFyLf63NS6caBnpoInCjaDbLL3Affr5f7agR4g6PpbW8ysxHiyDaa7nUtfujcyIxj3uWMEapGdLMF/+9y9BVxDzbbpViVjZgDYBueLGsexEP6tDfLIZ3TZzC5MCqnTCaDDEThZKlk5N4lViwQID6hdMe0RU2BdiNQuhEMMYdXRvlcnoVbOYBIyU7SjLZkW8Rk0oFiyAtrBacjEQSiZc7brRiIDhDVHFjDA4On00nl3Kb/vtSEyArI8+st9aEdZlF8xL4wbY8Ixl8bL2HDqpnCMHTLVjngjykOeTTUYi/IY4+W8jJTfI/LlWAEZMs6cO+VD3B3j2oGQMQGBa3FSDEgJ1zWFUE4jTDdEVF8aRcaJY1S/M4gAMIAy57I2In99y4ZEcbTx0cclseCYjZ+CbItYBJUCSEXuInRORTsQOJkDUBsra2+LEs5LuYRsnb9doJ/tLB1bpASE3rJvnKTsvdrh0ezbVAd9klXhtLwQMASJTeQcEeISglF6p55rNHD4guPYrmE0qK3jIEsHPh6YQqWr7Rq6Ekir2RV2GMiVzyQKEHx+QQkQYiRQ0A/zk2kCjlnCg8xGcAfh86K2bRD4HkmReOZnLA5zD2yWoKkE24PsxIxYgH92v85Tgl6aTvW9AIV+kHNJmCB/dJv+laTUTBqUcs/Gsn+yWfRZ26O9E4H7Zo9LexsZSvdX+l/gI/ANL3bAeCqfIlOIsUx9TLWbVUQ83a/v/JZfbgdogj+BDr1H5EqwATJ4avqVU7H/7JKysWHAP/FNZKyUe2OqryMRNhaGInXtzmqDMAFB1ShTGkgTI8BAGNhZs2bl/bx0hOnYWHzQhZjfhxCcIEmMOgPCkOg8UYVpXJ0wc+bMfAyUAgeiw2C6BIEQaCdSFe2P+6QEbaNDoIBAhTIGsUACKEN5zUF9Vp6bcVRnoK+0hRBUjA5T6TLCEUiAqTpjwICTL9MCjEtpNKXBES0GVZocOSyLko2lyD2yvRQUcStrXGSPGZXIGlmhpC0lcUEUGFgOjqyKAGOPLCA/jhHdlgW/0w2yH8aiLHhnH0yLlpmBLiC7xsGYIErqdY0dyMAxfuW4GH/96rym25RuqFX1Oxk/fU0+fBbjq7AaCYwAjcFXWycz1A7IRPjsC9kr4d7YEiUjgOSL0MmD3yyuMG5sqSBZBpKDNy3HBqqDiym/gIwa+zVakGKMkCWONAJmY1YGTSXYUqSuqw6rbdu7YOEGojGoTUiJDFRZl8ZPKeORhEBokDiBgM/pvCCjK5MyXghckK2SILIJ+r3MGo4Gcqt/2BhAtsk2klIGPPodqQr/BYi1rJqxiPtpkzTkkj45nyCJr9U+YD/pcpl8AbMc5XVKOB8CXU65jxfuz1iUxFCAjPQIptrgk03h4x0SOMbTSl7nUILlf9PVav7ZirAXbIx7YROifArYegGi3wX55mNKkolnhL0J2xU2pwR+oL/LPtdeCTG+rZxq5T8kNNi2YTAUqQvyMgicGyGj7NK1mLM5dlOLSJ0aCh3P2LpJCGUOgsNoEhRRgcFXe6fD4ubCiVMu5Af7RgzVPsSihDiXQfMeGGjn8Jnl8iDqstJKG5yDsYFBBgYMNCesHdoJ0TbsHrQ3BinOVaaEfaft4RzUjkjl6l+Gs10g/khBKEaMWQnpa1mSiFzUvzBksWoZZAAQuahvECWZUo+Np5FnU+7S4uRAXaSojGOPcSKvri9KBQaNrJGzgDpOJC1ICRJAOcu2CFhE+Ry876zkQx4jgpXVRUhmjKN+Y3EEEia7Vm7orB5IABUZL+Pus5KgBZA/21MwkGXND4eo/03jBYwLB84hMrY2Bo2XLBryZmwV34eMMLrlVKuxEgkj++1pHFkqxrqdRWFo2bqy/QiLc5SB6eIGfcWBWGTmxYkHOeLQ6BU7DfTMWHGYEcjSgXKajW7JbLDrbCCiICvKL7ChiDH9LEkCQsnmdvUjW8BetMl3AEFx/XJ7iTaMmcRAZJiAD3PNkB2zQVZD+lzwz39Eyc38wHn5qvA7+gTRck2yA+we3Qj7pK1lIKvP+aFyMQcSwr6E3eNXECDBTCQ0kF3ZJ7ZN3yOTyO0555wzYmMD+ojPls1ThhTg75DIaD8YU3oW27SQj/J8ZECg20VwhoWxov9q9AL8N70M306W+FR9hZjxCzGe7DXS5HO2Am+REGIX4hj2QuBizPmaKB0j5+wQG0Hv3a+gToavrCMEXAeRtBMCG9a2J2BsBH9sYAmrc9maWBBKxt0jmRl2oUnnY8ICDJZ5e9t3aDhFMjBeWHsosYiBkFEkBtDqGIKlIb4z1aGjOWOpTjckvc9QUBKNJrSUkRLrDE5Bgabz+p35eDdlkQGBci0F1YRVOzl2y6wZbZ3iOtqggw0Qw8RQ+R0BUyNDKHUqIdV5hF2k7r7UFhjAuEfX5JB0ts8oIjLpHkUDlJRzoRz6ScQiAyfi1Q6/sRqPAJq+068Mm3v3cn4Cpa1THe5d4SvnOigyGxZIP9ImADCWlAjxDUVQ4yJlTuHIi34iG0iwazNSIhliHI6HfDIoHIVxQSyc03mifwUNvidfjlV8zIBH0TTHRmacX1sQAGPvHDGVQR4YBedH+P0VgVN+7QQyR7bJHBkw/ef3pvy6SOywYLyk+rVZv3EACGvppBYl3KvombPSv6au1ZjIDiBqoE85XseKiOkg8ks36BHbYRoVAQswyIiGcfG/7CnbQgdje4E26CVbgnhEZoKM6DPywAbRe+TcMZH9CIjkTaG4bgnyJ1Pgt8bf/8bXfYdzmwrQPjLIYSAJZk0Q65DR8YANRjhkevzeVFXIs/EARINO+2s8TX3xC/RNQG17CYTOjIsACBHxV7sQDc6SzAiIyHTAZwIkNpU/Yl/pX9tmsquuwx+Uvy8hi8ImxLT+IOgvZURsd8jtICBQZIhPALIgCAyiFhBUslVhN9gydkMNacg6nysI1T7ZJORKFlEfIHOIDYKEtAQEFHSJnSLDdIi8R0aOHhgTZI3s6yM6aXEKWyfZwAcjeo7VfiRX9qq0VdrDrvo9G8iGyujSHcQOORdYm8p2PjLA7xrPdl+AY8hEyCRd1e/tzDiwpxIyZI3d14eIU0yzCyj0ib4IQlZCW8ksXZBd7gL5EczLzLpXuuN+TLuSP/2qvWSIXSP7+l0mz/XJJ37EbhjrEriP/sc19AuewY6EnJJJ2Uz+Ff/QDv3JDnbpq+DWvQqYAo9KDnpgLluDkSVKrNEOpYg6lmMtGahjESXZOqRKxzIASJPPDRL27DdYcjTCOREwRsJ53WQIkM4lfH6jcylVpG9ltSi/8+t0A9hOlcrEYNUcXTh8DBuZ41AYI+l3HS+bwxBxlq5H2ZCWMFSArBFO1yaIDArm7xocEsMVGRmD6n7cl4F0n95HmlgkQyAZJ59TXv22OMC9IhOi75h6migomTooDtG4c8wIV/S7PiUfFCyiTbCa2NQCGKd2FkUURHaNs7EX4VGYEuRGlGoaBIFwnlKmgYwh5Qyp74PQBYyrc7iO9ouAyUUJ98ihOYYCk9PIKk8U5FW2kWFlwBl8uoncTCXQB+PHPnAcHDFbAj7jvDgnzk8f03djRyfodBzbBtuAKPsN4z+I0IFjjSFdLzMt4YTDoDLy7cwQ3TX7oK/bMgaCRjbBeOh/es9OzQ9hn2xwPmyWIFjfIqj6vcvBDgP3zOlzNpw63WIDgT6QSURLnyEISLf3ZVbC/+xy+AGEzjgh28izz9s6IgBEUEPv+QRZlbbdZHPJhkV5g2CWhMx0TduVYOcFT0gDwjIa9IlyoNgNQSCK6HRlp9hQNoxN0DdkpgyQjRe5cg73539Eji0zbtreVS/Iz2oHoozIIWXRP67HnpFN1wfj5fqOc33+iD0zPvw0u9gFvtC46mc6wy6GbfRbmVbj6fdkhF9vB0sBSRkJDTLpeAuYyOmgfJPxdy+uQ2fLfhAUkD/BOY7SBtlFlLRH8qgLbJbzC8wQKVwCZ9Bn0W/gfzaKD4wMIZ2QWPJZlw0gw8bWPWg/PuPY0jfpW3ZJwMoP0q+2TwnIoioVmkvW06BOKtKN9v+bg/gs3UTn96PB8Umx+u/moDxP6oT+f8NjvO0o4T4mcs0uzE87FhXcf3KQTRK8/ieLBtoxFsbqX99PxjGT0ZbxIBmPKf+YsMAw/Qd0Kjml/ruxMex5R4Pfj6bLvh9mbB0zv21ZUJjMx4SVGNQvkzEu84NhxmKYMR0vUkAy1GPCSiyIdsBEz8vXdvnbQRimr8dCIlpDPyYssKD6baLQnhQA9t9NDoa5x113HfIxYfODrsg6PpMFGRR5D4Ljy2xZoDzPRKLi8bajhPuYrEh8ftrxSEc7q9aFsfrX95NxzGS0ZbpimP4DOtWeShsNw553NPj9aLrs+2HGdiK2bXHHoH6ZjHGZHwwzFsOM6cLAgmrHRM/L13b520EYpq8XBKbK+AW0Z9BU/0Qx0XucWj1TUVFRUVFRUVExIVRSVzEh/L+itqBi4aNpZj+A3t9A+X9FRYBcVDlZ8Gj3c7WRw6Mtn1VGh0NXX426UKKioguMleXhiqNt3fE//zP3suyKBQvTHbEyXfG0QmQr56w6V/it0LaiAkylWThg8YGnNCgUtyhLkbji7Eo8Jgem8C16MGVmRSlY9cu9WthQbWQ32DKLkax4tQecRRcWJll5a/FItWWDQeYszrCxc7nBcSV1FeMGR2A1ULlvUsXCh9WWVq1Z5WZVoJVoVZ0rumB7BITf6kjkf36fjFAxL+ieFaSxFYetRWxVUjE2rHS2b5zV43bQsHK22rLRoX8QO6tn6XegkrqKioqKioqKimmASuoqxg0iYxNGe8tVLDqIbu39ZtWVx1J5VXWu6IIMkmjeNKB9skzDVkw+7CNnj0VgI+1fWDE22DIlAv7aw9VUdrVlo0P/KK+wZ6ESnEAldRXjBsfgsTHqHWxsWUVo4UIdimk0m+eq37ExpSetmBK3eWetk6oIqPGyeaoNWj2VwLSrWi/1dGpiq+5ODvSzjWeVRHiiAHikGvKM6FWdHAz+xEa7Z511VrZfnkDlKRvqPmu/DQaZ8zAFj16tNXUV8wWKZgdwj8zyJAAEo2LhQR2FekaPrvF4NaTO7uv2ePPMQbuWV1SAekuPwFNv+alPfSqTOk+D8b/HC9VC9MmBJ5UIqs4888xc5A8Wk3k0lho7iwEq5kUs+vKoTn2H1B1zzDF5FsijsTypoaIbdNsTJdRVC9QCldRVjBtI3WQ9JqxiYlhcHhNWsegx2Y8Jq+jGeB4TVjEH431MWMUcdD0mrO5TV1FRUVFRUVExDVBJXUVFRUVFRUXFNEAldRUVFRUVFRUV0wCdpO6+++7rXXfddb0rr7yy95WvfCW/rr766vyyg/2ll16a/3/44Yf7v6ioqKioqKioqFiU6CR19jz51a9+1ZsxY0Yu9jz44IPzsni7Y99xxx35kURW3t1///39X1RUVFRUVFRUVCxKdJK6Jz/5yb3XvOY1eQ8j++w84QlP6G2//fb5ZZmxVSq2sqhbJ1RUVFRUVFRUTA0MrKmzf0wX7PT8kpe8pLfzzjvnfbGgvSuKJcqWJJewH9JvfvObgUTQb37729/WPc8qKioqKioqKiaAoRZKIHh2L4bPfvazeefsddddt7fCCiv0brnllrwXj+lYdXimZ03Z7rXXXiPEzuNS9tlnn94555zTe//73583aSxx+eWX9w488MDe6aef3vvgBz+Yp34rKioqKioqKiqGx1CkTvYM0bJTNgLmeWN2M/aYmec+97m9q666Km9wiZSdcsopvbvuuisvskDq/A7J80ijXXfdNU/n7rTTTiP1eI7bZptt8rMJ3/Wud+Vz7bHHHr2//e1v+fuKioqKioqKioqxMRSpQ8w8umP//ffv/e53v8uPKQp4rt0zn/nM/D8yJ0Nndexpp52Widpxxx3Xu/fee3ubbrpprtVbddVV8xTuRRddlH9z7LHHZgJnV2QLNF760pfmFbY333xz/r6ioqKioqKiomJsDEXqllpqqfxMySOPPLL3nOc8Jz+AN2BqNkjei170ot7KK6/cW3311fNjP9Ta3Xnnnfm72267rXfuuefm7VI81kgWz0N8ET6QsTv77LMzwYvvKyoqKioqKioqhsNQpM6CCA8N99DYjTfeeOBihmWWWab/32w89NBDvT/96U/5fyto11hjjTwFe8011/T23HPP/FByCyT++c9/9pZccsn8/RFHHJG/9xDkioqKioqKioqK4TAUqZNxixWuHhy7xBJL5P/bML1a4olPfOLIscgd0rfiiivmKVbHmrZ90pOelB8QL0Mn0+d7f9XtVVRUVFRUVCwalL7/kYLx3u9k9M9k9vFAUjfoIssvv3zv8Y9/fP/dbMSxf//73/PfAGK2ySab5P8vu+yy3nnnnZe3NPE0iksuuaT3ghe8IK+ghZNOOinX0VlIoSbP1GzFIwPf/e53ezNnzsyroyOzOxpkiq+//vreF77whfybQaul77777nzMtddeO+p0Pvk1/e+cJXx+++2357KBCy64oPfNb35zLr2wTY9zX3zxxVme4+X9L3/5y/5RvbxVj99/8YtfzAuN/vjHP/a/mf7QXzYup9Nl2cZoIAOeYnPWWWf1br311hz0tWEFvrrcCy+8sPfDH/6w/+kcuO4999zT+/znP5+PUwvchvYYXzJy00039f7617/2v5kDswlXXHFFbst3vvOd/qdzI8bX2P7617/ufzp9IQD/xje+kfuEzgwzrnTFTgnGg850LYT78Y9/nMeCvunzBx98sP/NHPgd/0HHvMgJn9EF57OnavvJRz/4wQ+yvzn++OPzuI/WfrKnTdo+2SCfzk1uzGqNBce4509+8pNZpslmG/zmGWeckWvVLTo0C9ZG2E/+2G4VXce4b/3nem2/HrBFGb12jPbY1aLUVdfh08mJ78jAZIC9d03t18ZhwB5YnMleDJIXcsBnkKnRZMJ9OI7O33jjjXOd70c/+lH2Aa5DTkez9ewGOceNfvKTn/Q/nW1z6MknPvGJfI1hfGKJTlKn02L1Kug4F+86+X/8x3+MEDA36qkTJXbZZZc8Zetcu+22W+/1r3997+tf/3re3BgOOeSQ3korrZQNsyzglltumR1ikL2K6Q3GwIbWMroc70EHHTTq4+cYDUaNDD3vec/LcmPVNDkMOMbCHiuyn/WsZ2XF++hHP5qn+rvgXG9961uzzJdgjGbNmpVXeKslZYA5iSB2turZdttt85Y+tuyJ13bbbZcNHvz85z/vfehDH8qG8cUvfnG+RwuOBhHR6QTGjt2w3dF73/veoZw/srb33ntnZyPoO/PMMzMZLmFBljKOIGGHHnpo/qwEo0iunvrUp2Yjyc6UTpAjMy7G14IujpWTL52SMXr3u9+dgw6yZtGXRVwlkBvbNKkrFrCS3+9///v9b6cfODRPFDImz3/+8/M2VnRtLNgZwUsZz7e//e2RBXKBG264oXfYYYf1nv70p+fEAeeoL//85z/3j5gNumq3BDpPrpyna1bH+BpzMlA6XeTsne98Z9Zj4/2GN7whE7xBYBNmzJgx6aQO4VJqpCzJPZLhMhBsg17wn/rItmLk3wsxCPC/9o+1SNHrLW95S66FL/WOH2aj3I+xEBSzkyUcj5jwxUcdddRcgWyJT3/6070ddtghj4U+Qk5i6zN65LfaSnfYYPc7v7DIct9998084ylPeUoef4HZaNAWcsMu2zKta69c/aIftthii2z3y8WgJQQa5OqEE07Iu3+o//+3f/u3/B25dv7HPe5xeVaSDHvfxZsQR7t84FZ8lHsBJHC//fbLPk57PPBBH3cR+IFIAzYPEmtsEhNuEhNuzj///Pw3NaJJDql/xBwkQWqSs8vHfOlLX2pSp/e/mYPk2JqZM2c2H/7wh5uzzz67SQLa/2Y2ktFskoDk75OTb5KQ97+pmIpISt8kY9jceeed/U8mhuQ0m2TAmxSN5PfJEDfrr79+c/TRR+f3XSCHK664YvOLX/wiv0/K2Lzuda9rkgFrkvLmz7761a82SUmaZEjye9dJBKFJyprfl0jK0iSD1Dz5yU9uknPufzr7c79Jxq//SdOkyKtZeumlszwDeT388MOba6+9Nr9S9Jvfa18ytvmYZFSbFKzk/yERkdzeRDL7n0wMdEhfJeOW3yen0CTnmv+fKnjooYeaRHzz/Sfj16TIvf/NYCSD2bziFa/Iv4UU4ef+TFF2fp/Icb7vd7zjHfk9JCPYbL755vk7SIaySSS8Offcc/N7103GOo9NgK1KzqZJBCy/107vXS+QyHqz4YYbNol85PdsWApAR/qc7K211lpNIof5PSQj3CTSkHVkqiAR4yY58vw/27rBBht02ulhwD4nh9UkApLf/+AHP2hSsNLceuut+X0XkkPN4xHHkF2/ifEB42PsAykoytdJpKr/yWzdoU/sRSLX2UcNui4/s+yyyzYpIMv6Dymoa/bcc888ju6f71pnnXWaxz/+8c0999yTjynhmORQMZrmE5/4RP/TwUjEtHnb297Wf9c0KVBsEunvv5sD8kOmE8nN79kt9iuR2Py+C+4nEbrmO9/5TtYF9iMRjxGZTmS7ScFivjf26b777ms23XTT3PayDxORbVZYYYUmkYf83tgkcp59cIC8uw47Rd71exv0hqwn8pfH4sILL5xLptjDJZdcMp8HfvrTnzYveclL8vXaSKQ763ToeCJq2ba2Qafe9KY3NYnU9z+ZfT+vfvWrm0TU+p/MC36Fv9DHKYDr5DGJrGVZInOu0QU2yXdsT5f+pCCj2WWXXfrvZtsdMpgCx/4ns4EvvfSlL81ybNxKfOpTn8r+DwdzDWM6mvwlYp85WolOUregEE53EMb6vmJqYLJI3ZFHHtmkaLH52c9+1v9ktkK/8IUvnIf4Bygmp1SCcUwRb3bM8OY3v7lZeeWVs7EIbLvtts3qq68+12fwsY99rElRezZ0yEGA01piiSWaL37xi/1Pmuaaa67JJJTD4SC8ZzBKMMzvfve7+++aJkXOzdprrz1CDPxlLFMUm99PFIsDqQsw0M985jPHJHUczVJLLdW8733v638ymzghBCnize+vuuqq5jGPeUxz6aWX5vfAmSLxvgN9gUQGsYYjjjgikzafMaQcwUYbbTRiVI0LB7/lllvm94jAM57xjCZFzPk9+G35Gdl47GMfO5fjZrAFCKORnIWNySR16623Xia6JchzSbLb4AhXWWWV/rvZQPTXWGON3O/sPv3joAKICV276aab+p80mUDstttuA21D4I477mgOOOCALAfsS5A6f9ukAiHhNEuCCWSVzCGxT3va04bSrWFJ3WmnnZZlJIJD+PjHP57lPIhNGwLVCFqAXiAGyDAgHG2Z+9a3vpXlMwJIxGW55ZbLNikQBFsA0wYCjHx2kToBMEJZtqkEG0zHSmy22Wa5vW0/Pyypu/nmm/P9GLMAH/SkJz1pHuLUBaQY0ewidcAWvPa1r82+rQv77rtvHqMu3XFP9KAkhHyExIDgI6C9T33qU7Pva4MusGElQf3Tn/6Ux6dMDJToInVDLZSYLAx69FhgrO8rpg+S0cw1B6YA7HUYMOWmvsDUZhtJ6POUmL+mVwJJ0fIUi5onU6xS/c5T1n6azjdFW05xmEozLZoM0Dwruk3bmQYyVZqMZb6mKb2tt946t9nm20mJ55r6kcJXO7L55pv3P+nlfRnVlZg2cQ31RORcSv2RAouhhoEaI+Nj7AL/+q//mqf5THOC6b5kfHsvf/nL83swrW0cY4rMVJ7V9OX4m0K3AbrpDlPjjvW4w5hmcR3nNNamS0xlmfIwdRQw5qYHjTGQX9NNzhNwDnKg/nK6Qb/RMVNLJdy/HQvcdxumq/R1+zf6yXZW9Jk+mCo0FWja0Fiql6I7XpB8Va67NZ2XgqSBTx5Sd2Zq2NRkLMILWJgXZT8BcmJM2ZASNtpnlxKB7aw5mx+Y2lRuwsYEXvayl+X70b9dSAQpT+sFTNva1zXabVHiaqutlv8POL/pwaWXXjq/V6piStC1Au5x2WWXzTrTLk/R511I5CvXjJl2t0uFBw5EKQQkopinRNtjzgbTnYnWFCeSmsfCeAVst6Yv6O1YGItf0GU7fXTdtxpE0/RKbfQ7XSincZ1bmZlpdbVwbH0iW/mey508PDnLmCjbcQ7T53E945vIbbYzAfdGVkzRDouFSuoqKgKMAONgFXQpxIwMIe9aKEPoKTTSRyECYbg5Y/Up6tZi1XWAIrpm1Osp3k/Rbzb+XTU52qQmxDURuRTd9l75ylfmegegxO26C0aHQ3JcQP2OuiyKznGp0VGPERt2PxIQdTZjIRY8lM7O2Bhz5IBBV0ujhgUJC6ht8R4hZGh//vOfZ2NYjqvxB+NOPtQNkb0SHCMjy7lFW8rrMPhqX7SFzMV1fB5wTvLru+kGhADRFdSU0Ad0q4tk0VM6WQZuEL+JWiH1YpwfskbfjKMaxqhX4iTVF6lfRFLUHKmDfeCBB/L3oN/pFtIiEDDGJchD27ELJBAjAVwAIUdy1IOPRQTGC/dlMQ05Ku0HGSdTgwr/SxmDsHXIHtCxtj0ig+QXMYUYn3aQJfjxncB1GBgTNcq77757DqY9cOB973vfCLFzXXqEvJRwz+xjGViPB4IAdpmeBui+9pdysCDAbpMF/YnMeioW+eCLAt6/6U1v6h1wwAG57pNsnXjiiSN2hk1BPsma8yF4jheskN0unyJQEqhIPAyLSuoqFgkYXEaJgpZOP6IWzrsNxylkZRRF9AwkgY8NrkWcEW22HXZE2xFdybp5fJ0ISFsoVNuAM5iU1zlF/whhFwEMKBSWCSgJJQPK6FkMpDhWBigcVcXciILitjMAzsNYczz6tD0OHCICwfkbJySuJGQhY0hEyEib+Bt/8sc5aYvflOTb964r0+A8ZImclW3xG21BHKcbIpvd7jdO1XddGRh9KbPKoZcwNj4PPaeHFtMYe1kg5LuE4+m+DfBl0ThL2aBTTz21f8TsxQeu9453vCO/D0fZ1usAgkEnXTdIJznjZGfMmJHvM4jhoHOMF+GkEeOSqEUWTsAwDJACWUyLGQbBylTBaGS23BuUpAjcWwRNw0DbBasWzGgHG8kez5o1K3+vX52rLSf0xOdB5McL+obUIXIB+oYIOWebxE8WtJlsyequtdZaeWEIQivraNFJkGH3K+gXVJBhhK+09bFS1sMZ7ApiwYVMo3OZgegCWd9ss816r3rVq/qfjI1K6ioWCSiiaL0dHUa01zYIAWlrEY5VlVZ2SXGLiBhl+xuGEkX2LsDQgO+tKmIETPOJGk3LaQdjyzGFcaPIVlWaLjGl6rqyB11AJKzYXG+99fqfzAYj/vGPf3xkVZrpFVFc22lVzM7SQulcOGbOnwMMg+77IP/AmPvM2HIcjvO+lIEgJL4LJxdELxBOgYMlm9Bui3NqC8fomPY5Qn5dZ3GFvrIa2Mp0W0fYVoG8ItMIQNt5crb6vUtn9ZP+bOtjm2DYZsSUqwyckgernmU+4rgSSKQMu+8FW44R6Fmd7klGpv/oN33WVpkjAWQbricQRFACVsUiLWyDe/bSdqTHOcni/IDMuGd9XMpwzCC0CVcXtMl0IEIRZLAN3zu/WYLAILln+1y3nSUahJLgIiXGzJQ4OQGyT0fafUVOXHuiukG+2PGw5aAfvRdcDdv+8UIQSIb4l1e84hU58OAPZJSRMbILApSTTz45k102X0mC7DJ5hLD5G2ywQe43MobY6RN61gZfwadICowHldRVLBJwzpSEQS6VP7I1L3zhC/PfNkTslv+LQi0JV4Mgra2+jaI4ryxNOxpklH3nhRBSOFvoiOo5B05Bpo0SUk7OGWkUJa255prZ2KuZkCmwxUUblrMzWtpRApETsSGjtmD41Kc+lYmi7QAq5oZpNQ4jZADIhrGUyeEQET9EOUgacIgc73LLLZePsUWJc5SEzHQQqL/jwBjS+CyABDDYyIvpOwiSBpwHOVGfR45cR0auvI62OXe7nmhxAidGx8i/6VBTnuri3K/+bWeT9AGn2p6WBeOmv9uZS2OmD6NWSM2p96FjtiIRTCFeg+AJR36DuJnWUrtqGtC0rOkq+90hc0H+SqjRNGXnHoMMuG9kFjnxe7aBzpIB9X6miEvZnAgQUnWabYIY/VNOA3dB3yMOMollLWcJ9ol9lDUyXoEoawiSEXDf5F1fTgRIGjsZATodijKFEu6Z/S7rVMcDuouolrqv7V4TPecwcH/ktNRzUC7gntkEsL2K90ibbVeU7/AzMr8Q/V+SajV3EUCUMB1uaxWyy96MB5XUVSwSiOTWWWedLLylkZE1k+Yui3nb8FtKzKgx/MiUPa2A4tgL0VRcGQmLplZZZZVsGOyDJkISAZl6QQ5Ns3lMncgWKXS8tkTaG5mwrxXS4fnFbcjqmXptR6Gch+tGBlHGToTHSbYzHtMV5TiMBsXzxlXmNYBIqTOKIvCNNtooj39ZQxN1Lb6Lvz6L7AdYeCPS57yQE1Pr5Tgy2K5jaoRDUhdJDpD1AIcuYo+2mELhmH0WsEed7Em7IH9xAlIrAx4bo5Jtfar2TP+09+FDIlZcccWRTFAJ56JDbZ3Rr/qRDiPCathkewDJQs6cs5SFNjhHMmNcZVDUOtFpGSy/N8ZIlEdSltNXal9NndFF7YPI/sjGq4liI8I2GE/Bmmm3kiRNFJw+2+K+A2YMyB1bMQgIgylOY2EaEOhWSQ6dx7jpB3YUfO+lr9m/qBcFMk2X2GJ9NVGwi+uuu27+HwEiJ5HBClioxq53kf9h4J6RwrJ2k+8wdu0ZksmEayLbgsCyr8mf76JeV7+TWSDDxoAMeu49OId+MvYlfFYu1CEXss6SDlGfzVfwc8Ogk9SZgrKyy0t6UUF5vLy3gs93duMOZaioGC9EwxTDxpAg20KmCHPUMllMQeYiCiwRkbziaMY9oMaD4ofxEjEqfjbtyUBTNPV0EdHbgJRBkx1ECBEw7UIeSgWMaZl2VCjbKEvgt20gee0iXkZAVmpBTRdMNTBSjKGIugQixZbEohj9YoyMVRBehEGmhwMG0bHxk1EJkA81i0G2jKlxjoyq63Ao5IKjM7bqWHwfRdvGGfGzQSkYYzVcsaIWyKZxk80F4x21kgGyjACMFpRMdZBLuiDz6SWjHjWqVm1z1lELp88EUAhPwJRR1LmCDJdjgqDJiNLN6EcZona2gt4Yg3B2fu+8QYTIkn6fMWNGfu9Y406nvYwdm0AOTJVFVkuW3NQYEsh3aYe2qtEjo8hBnMPCJjVr7IBHW1pw0A7aJgJTxAILU6TA7vGnZD+ImL4gS5EpFqAcfvjhmYQ5RrvJtAykOl0QlAhWo8+MDfIss8enG0OZH7Vd0Y8IOrIQdYglkI0uuI6xDB2lQ3S4PAc5Ybsj4BFkeW/1qP6cCOia8ZGFDLgXWfGYIXEveEpkz0ogwKMFmMaBDHTdN1mV9S2DDAs32KIg4nxWmaCgR8aZ7IDAgv0SJAXokeuSXZCxlakWbERywTQsPxfB61h49KHy7C0ofqQsBFjDRG3S4baAkAmR/rS0XHrbQE5G9CJScxOUcLJAWXVSpPgrJgcUgzER3RHaiYISGBvkjKEy7cFomYoJmTr66KPzFIm6F5Gs8SToHDmjZ4ohMjQB2RgKSKb8RhqbkxK9dxEphFGKXCQVEZ8pBJ8zthwOZRXdS4UHGQ2Y+tEWU1Vt+dUW+qTP6BMiwdgiFa4xUTD2+svqKX3lXl07IvipAEaf0ZJdcM8rr7xy7stYWMA5MMb6JaJ8Y8BJceLu0SOPEK0YY78VDStEdt+xUtFu9c4N+pWd4vRlcfzlxDxBImqWXAeR83uE3nYF5Nm4MOpeiJkoWzvch+hZ9sZ0PIjSER4GVyaXk0YaTMPMz9hONjh2WQYklO02HkhPELXxQKbHNJpzCn7Uvuk3ZCF0gq7K8HHsPjMu+h8pNh6ur1RCJoODd4z3iLox1UaLIBAZGTOkz2+VMNBBNoLOIZzuYxD5cA7jq23GXbbQ/5wkQqQdapnYB9cX3LUhIFAq4R5j3AeBPPE5CCEocpdpaQeB+j3k0182RhBKhkM+lW2YNaDf7KTvbB2CrGizF7nTDwi1dsoqOpdVyq6tJpJdE3TqO7qD6OoTJAyZQPiQSdcJIDZ0k7yTGxlU8hy2UymKcWHLnJvc+31kqcDYGD/XQlDwBQs7ZE3bNljbcYyQSfdEBsqtQMA4az/dd47ISvIPQdplYWXQEdsI8tgh9sQ1jDtyZbzDDgGCTy5Ms7PVZm2MTcg0Ped7XI88C9QFfGx+8Au2HuF0Xi9tcRybYVzJOrujptv/7Ic2IYYSGfrSsT4jS8bQOFvUh0AKbNvZVDqjPUEc4VHpBuahri6KkSoKd1NqKhgqyoVlagQjTSkp9XjnfNuQ5XANzm8ihqYLBEqkJUr0t2LywBhQYk5SxDs/IH6ML6LGSaiRK6dxGEmGgYPg/P3P6VMgRoLidYGScvYiRQ6XQxsUZTMgah8Y39IwMTYMFofEMDAUiAllLCFaZDRk/7rAQGozXeK0GKaJTkEERN4CKgrP4CLCFB5xnSrQr5w/h2U83DvHGAsiRNWMPXsiCg8gDQwmYh7FyWFcA+SF0ZSxYfw5kRJklFxxXq7LkMd1AzJGyIKxY5hlYtqknBONDJH6l67pMe2Q8RAEkF+yOZXAnnNYCtrdh6CEY26TjWHB+SgrkAEne8YvyguA4zP25cpMfaOvyQKdFTy1a7j4HONF78gyMhH+gLwL/jhyxJLuy9AMInRARmS0IsPmPXvC4ZKPgP/dQ9e4ITiSGcaeLI4GfYIARv0eeyAz5dxtsCfkhrPWHlOypU0gc+wXEkT2ZbSNHYTL1m7BsMBIvzjeseW9uQ6bVdo1AQriRM/0oYCq1C9BTCRE/N540Vt6BIgKskGnkVakoqvv6DfbyBcjdl3lKUCHZS/JpPPY/sm9duSbMmSs9A/7QPfLcdFmZF0QaBEMkCd2CFHyP5kyPVzaA7ZAQBaZNnKN2JW2Xr8g4mQZSdOn7ftGdMkx+dWngux2WYLvtYf8x1Q1u0PGZRnJXEnLjKc+LksIAviN8UcKR4DUtZEGvEnK0H/X5B3eHZoaMdcO2anzRna0h3TxvEN1GsT+J3OQBCA/eikZhLxbt2MhCXV+LFC6ufx9uqH8eSAJRj5nGoz+J3Pg2BS15ev5Po5JAtGkqCW3ObH6/FkSzvwXXD9FIHPtlO233vvOC/xGe8s2abfrpQGY5/M02CO/9945k7Dkz7vgc/embxYn6JfJeKLERKDPQ3amCtoyOwiT2W5ykwjEYvFEiYpFi8l8okTFYCRSNdQTJYbFVLNzCwp8LFt2/xhPlJgqmErjMvQTJUSjg1YflpCujiJBDNmcv3oFKUlsOZGa/J10sHRtGqi83NeUGUYs2ydVL/uCzfud+qjkJDM7lRaXWvUgaJsdioR8DtiyqbmDDz44R6AyFKIPv3UeaWUQpVqJgqUDhq8YVlGtc4tIQNQpypLK1k7tc4x6DNcFTF3thWvKYiqoFQmCiFG2R2QmDY7RW+m46aab5uX37boq2Un3JFOhsDfqfypGh7T7aNH5okDXlG4Xplq7Kyoqpi6qvZiamOrj0knqpALb0x1diOMQKWTGHLw6AGl9aUHpdpBGNb+v2NCSdVNRSBRCGNMu0pmxqkc6GilzDilKKWgkyJRfFC47n6JQU1nOKyWLJPqt+eVI80rTI1bSqQiYZfDSnIif9wgYAqduQTrZdDIiqJbH/aiVkrYHhBQ5lYqeMWNGns9GShWAghSpOkO/VRPh/giAugbLmwNSr9rheggfQqf/pJMrKioqKioqKiaCsZnbEJCVkplTA4HQIT0ybwiS+XJkSyYPEVN8LNOFECI9sUoMCVP3ZI5ecabtI/7xj3/kTJn5eGQPGUOWwPw3MqmmCDmStYvaPteP2hj1OFG/Ya5ezQZiaT7dcbKE2g9R9K+t2qM2xPnVhiBeMm/mx51TLYL71Q6kDcyvR22JOgUF3rEkWRZRfQLI8lndhGya33cetVvqJioqKioqKioqJoJJIXWyaGB1kWJHiylkxhRkgmwZxPMvESxZLQiiU0JRr8ybaa3YR8gqRrAaDWFUxAiKQ5Ejv1FsCk1RZBj/K9pErMDKSdk07VXQGFOjkVb1maJOK2TiAe4Il0yaYlHth8hmKshuI5amB7kE59eOWMpuYYh2uFfXjO0VKioqKioqKirGi0khdVbRgKlPq1Esn7bqxTQmsqJGTbZMZk3dmWnVcsPONoIMIkFBiqI+z1QpUid7pqbN+ZEie1DJFg6C1TQIFcjIyaTJGJoKNQULQQCRtvbKMNlDkMFrr360Qs69lXPtUftXwvdWjsV+XYit/lJbZ0VM7JFVUVFRUVFRUTFeTAqpi2ya5eoyavaMsdDCnkQIDGJmGtMeLIif6Vj7GEGZVQvEMmHfmVqFyOghZLJlrmVLDcTRtVzn7LPPzsdA+7xlhs30qulTS6Fdq8ymgQxhHBuIhSPaEwQz/lqW7L7Ka5YEL+B7JDT2IrKVgvNGO7qIYEVFRUVFRUXFMBiK1EVmCbrIio0ZESGrXG2QKJumBs2+QmDFKAJkrzsZNYjas1jQ4HvXkXWz0EENHSIXU5KR2fOMOfvmWKSgFs5Gj2rUkKrYqdq0aEyNqstDnmTXYjNDe+zYe8jeNKZVYwWsDGCgTbBkGmXWZOxsfgnIIcT+ZDKBQT5l7iD6C6HzHVIXG62aqjZ9rB2mYmNn8IqKioqKioqK8WJUUicrZWWnXZgBMUGAkJoyK6WmzbYhMl4ecWFzS9uMqKVDYmywaNsO24n4nc0Qg9j4a+NQxMbqUgRMts+UpK1VLK4wlWvVq0UTsn2gbY5BhhBCG8NakQrIlzYherYMseAB6bTBsY36XCOewalNdp62XYkpUHDuIHoB5/RUDRk/hBCp1C+uGTuIq+sLMuie1eDZeBZM/8a2JVbQWvVrmtlu3jYOtFI46gQrKioqKioqKsaLzidKBGTcrO6MGjeHyqyZukRKyv25ZKkQLETHdKwVph6JgeR4dIksmHoy5AbhKneAR4ZcB3GSoYuMm8yfRQh+YyrX4z9iwYRauNiN27mtfLVzeGTobJliQYT3dmKO3bqtOpXhs2+dnck9msS51cUhj/a/AwsdZPacP+BeZNMQPkTSVDCSqE2ycPazk1HUT1a1xiOPnFPGznsrZ8E2KXaPNo2sfs8CkvaO91MV+mGynihRMTFYCT7VnyhRMTUw2U+UqOgG+z/sEyUq5sAM3XieKFExB11PlBiV1FVUdKGSukWPSuoqhkUldQsHldRNDJXUTRxdpG5SFkpUVFRUVFRUVFQsWlRSVzFudC2WqVi0qGNSUVFRUVGnXyvGDdOv0uWeoeuJGVYYVyw8qGW1N6T9IE2/qhe1F6Tp1/33339kG6CKCqv+bXCu1tkTcSzeMv3qMYxLL730yCr9ivmDflYj7YlHsV+qOmmPuLQYsOpkNwSjpl8tNjT9qq7eM9dNv1qYWPttMMicx4yq/fe40kAldRXjhkUh5vCRCI96Q/IqFh4YQqu1raa+4IIL8nOLjzjiiLyC2nZAsa1ORYUAwKIsi7Q8fxqpQzbULtkvs5r/yYEFeRa9+ev538DR0lX7mFYbORgCi29961v5WevqPE844YS8w4RdMqotGwy6bfcOgUNsqwaV1FWMG0TGqmSrouu036KBMeCUrewWsVkp/v3vf7//bUXFHJAVm5wj/Byoxzralqrq7uRCP9sRYfXVV8/vOVy7KtR+Hh36TYKALbO7hr1q7Wzh84rB0D+Ina3f4rGkUEldRUVFRUVFRcU0QCV1FeMGkfGoN/sYViw6iG5f/vKX530d7Y/4wAMP1Oi2ohM2Z1dDZzrL9ib29qwZpMmHUgiPyQQ2Mp6LXjEYbJbHcrJlZh1MY8vWVVs2OvQP2+8xo09/+tP7n1ZSVzEBcAyK9ImOR7bVepGFC87YhtZI3Pnnn58dydFHH50LtZdddtlah1IxAjVengpkiubwww/PBej2N+QEBAXV/E8O9LNHSCqJsC8g7LDDDnlT/lp3PDqUBNx33329mTNn5ocIWMRz4YUX5ocD1H4bDDJnmnqvvfbK+8YGKqmrGDcomtWvNrpVP1JXvy5cxOrXHXfcMRcXW/16yCGH5OcpW/3KkVRUgBolj0pUbxmrXzkAxegWS9TVr5MDGaavf/3rua+/9KUv5c+sMrY57Gte85q6inMABKhWv3pkp1XasfrVY0NtPmxBWEU36Pbuu++eV1frv0AldRXjBpHZcsst6xMlFiHaT5Sw/N8URn2iREUb9YkSCwf1iRITQzxRAqkjk/WJEsOjPlGiYlJQ44CphzomFRUVizOqDZscVFJXUVFRUVFRUTENMOVJ3YIulKxF5RUVFRWLFlMpSzOdM0ZqKGtGbNFAv//zn/9c4P3fWVP3s5/9LG9mqgBeIaNDnvSkJ/VWWGGFvNqxBCG5++6751m6HUvof/zjH+dNaqMgV5G3Al3LcEdbUu/4e+65J9cL+b2VRXG8gnCb7TmHwt+77rorz8FbDWL1n+8tiVYw7jeIoVVJdqh2H4HLL788F2J6RMlEYBsJj9/RP094whNy7cSdd96ZN/oslxhPN+hPxdYLoqaOLKn/edrTntZba6215pG3NsjG1VdfnbdXWWaZZfIjU5785Cf3v52DH/7wh7lYnPwh8uSEPAfck/H85je/2dtggw16SyyxRP+b2TCultr7fYBs2b7AdcmaJzpYlVrK9WMe85jcR1bAtXHJJZfkJembbrpp/5Ph0a6pO+yww/JqxqlcU2eMrrvuutzXq622Wh6DseA3xuSXv/xl3vJAX5b9y0jaTFf/02W793t0XTlOwB54AgcbYfzZoJVWWqn/7dy4+OKLc+H7Jpts0v+klwvdtZ1dZEsUJxv3QdBe4+upAmPJ8ILGZNXU+e21116bZT627RgN7CLb/NOf/jTXe6699trz6Cb7bXxt0rvUUkvlDWjpTAm+5dZbb83j67ove9nL+t/Mhut4aobx9b9z2AS4BJmzGbDjLCzSFuNYwobM9Nz1yMeaa66Z5WVYTLSmjjzyI2wUe2BhBfs3Fvhnm8DDaNdwfn3Mh7Jr7utxj3tc/k6fWUXvGDqj79pj9Je//CXfWxDC2CiYnwV20yIR57HB9YYbbjhP37LrxtA5+GH9H30bNXVkUr+Pp6buF7/4RX4aBdmgz8PIZYCtPvvss7MuL7fccv1PZ4Pd0V4gO3RYv4VskhFb1vAJ+nT99dfPNqML7sW5yDoZX2ONNXI/krXf/OY388iYxSL6sQ3X+9rXvpbr6MgJdNXUOfk8SBdqTj/99CYpYpMGv0lK1Hz1q19tHnroof4Rc5AGqUnkq9luu+2adMNNulizzTbbNMn4NcnQNqkhzRve8Ib8udd+++3X3H///U3qqP4Z5kVSruaAAw5ozjrrrCZ1SHPbbbc1acByW5IgNUlx8jkgCVyTnHqTDGyTHFqTBKtJjr455ZRTmtTZTeroJjmP5qqrrmqS8OTfBNIgNSeddFL/3fiRBrTZcsstkeImEYT8WTL8zT777NOkQczvpyOSAchjmoSy/8nkIDmfZqeddmqS42g+8pGPNO9+97vz+A9CchbNFlts0SRn37z4xS9ukiFpdtxxx+Z3v/td/4jZSArfJKPRJIffpGCjSUrTfPnLX+5/O/t+klFqkmI2yag0KajpfzMbyUE3Scny75/73OfmV1LOLF8XXHBBPuYrX/lK88xnPnPke6/kWJrkQJr77rsvH1MiGdP83S677NL/ZHxIRie3l6xDMoDNMccck/+fiqCX2267bXPyySc3l156af4/OYr+t92g44mANMnINykAa2bMmJF/W+Loo49u9t9//yY5jTyGieg2M2fO7H87B8m5joyPv8cff3z/m7mRyE/+fvfdd+9/MtvGHXTQQc3yyy/fJIeU7eLqq6/efPvb3+4fMS+SsW1SYNckR93/ZNHhzDPPzDYJkmNpUtCSx2M8YM/33XffbIMvu+yy/qejgw8h32wvfX7/+9/fPPzww/1vm+wf9txzz/z5DTfckMfo1FNP7X87G2Rg6623bs4444wmkeQsDzfeeGP/29m44oor8udkIwU52f8kotH/djYSoc3XSk6x+cAHPpD9SyJF/W+b3K6dd965OfLII5sUnDU77LBDtkfjgXtIRK7/rmne+ta3jinjoM3bb7999mP8kXaU/dQFNo5epGAx998gJCKX73XvvffO5y9tm/bSKT4rke/m4IMPbvbYY49sL0t84QtfGLF9bNZb3vKWbDMhkeRmnXXWyf6ZjeRvd91117l8rfFJQVzWHedJhDWPZ4APZ8vCpx977LHNhz/84fz/aEhBetZ3POHKK6/MMjAen0Qv/v3f/z3/to0DDzywScFyvmd/9V+AzTVG7Iw+1Aay1e43uOWWW5oU2GX7TBbCNyVSmHmV/gx/4ZUIc+YubdCVFPxn/6W/Avr6/PPP77+bjU5SBwbLACEsKWLtfzoYp512Wj7W64QTTuh/OhuEKr5jeEcDRePYOeEUHfc/bZrE/vPvEcMuQ8lJpKil/272gBMev0lMfJ4O//GPf5yNNGGeH1AE10AUQtAT+29S5NSk6Cu/n25YEKTu3nvvzX1488035/ecT4pYs4IPAkONJDBUnNS73vWuPBZth33RRRc1Rx11VJY9DoYRK40Omfv1r3+dFYRDb5M6QYSAAdn0e38ZfEQ+nONee+2VHVIcIwjiIMheKcdAKRliAQrnPxEsbqSO8/AKMFwMvfsYBM45RaEjunvhhRc2q6yyyshvEDmGUOAY4CxWXHHFufo8RfJZTzl0jg0BF7i2IYAQdLJ7nFvg+uuvz+PLVjDKn/3sZ/PYvfa1r+0fMTcEDO6N/UGGFjUmg9S5bzJPv4YhdWzf8573vBECJiGw9tprzyWjzifgpnuAUCMGHGVAsoADDdD3NdZYIztFePDBB5tXvOIVc/kcpIMtCLApbAufAIjOqquuOhf5//jHP57HjPMEQURbtsbCREgdP6sPrrnmmvyerAsYjjvuuPx+ENy/+2KvyGwXBKN8t+BYP5WQVNGPJ554Yv+T2YGXfiLvAQkWZBsx00YEKPqEH6BXAiskmk6xZ2QE0QLy5jOEO9qs7wXgAluYCKkTaCE5Ao2A4M7YDwP9vvHGGzf/8i//ku1BCckCQR1bHvYi2gZs91ZbbdV/12TeQde/+MUv9j+ZDfJgbPmpMoCA8847b4Ro8xf61u+XXHLJTt7At0hcGJ+xSN3A3LIpjpjmKKc7BqFMIbaPL79rpxrbSAYob6jqIbWRIoY4p8/aUytgCirSweD4uJb9XNq/SR2eU6FSwdKwXqZYkqDm1KiUqV3X/Q+meaTnk9Ll94HymgFTLlK27kHKtWJs2HDSeEXaWfo+KX8vGYc8Dm2YbpNuT8Y7b1hpKumggw7K0y7J6PSPmp36tpeblLeU/0YbbdRbb7318nRQQCrbtJ3pfOPfhk0wP/rRj+YUu9/7K9Xu+q5LLkxpSYXHMVLiyRH2Xv/6188lx5ACoF4iHvl65Gq6w9RLIta5bwL6x5RTMmb9T+aG6VLlESl4GNExumq6hX0AMmD6w5RogAwphSjtjK0STPWamjc1ZExMwbWRDGe+hmNNEwXIYorc83em0e0PmBxCnspLBrZ/1Gy4J1NV9o2aTmPrvk1r0xu2bSzYr43dtekxmKLye1NsdJK9tVceHad7YArM1J/fgnIJcrPOOuvk92D8fG5qG3xv2lLJRMC0ub3ijAWcdNJJeTrTuEIiQln32BzjzL5oVzx7FEy1mWY8/fTT8/sFBbaJnMT0KVn3Pxthim8QlPdEOVT4qBLGKJG9fI5EvHpPecpT+t/MhmsqXdGXJdi10qclMpenR+mOPib3McXJF+qzRHJyuRWdSmQsj3X0Pf/HRm+xxRa5zUpqUoCRZcD1J4rbbrst2w5bawW0z/SkafbRYLzZkEQA8/22+4/P4UdKe2FaGEzLkj22IKCURD+EPIEp6US4st9JpHpkujTg/HyK8/MX2q7f6EPIaeCWW27J59P3Xf6pjdEZ1gTRJnXDkEIggB/72MeykrdrBLoEtwQhHnRM1+eJIY8YArVQah8MAiVLEVwvMfHsUFJUmjuUYnhPQFNEk38HXec2726gGPcUtfc/rRgERsMYIGdhVCFFJbnmI0VJ/U/mgDJSpFK2GC6yEwoIyHuKtPJ4MvYp+hqoGMhX13iquWiT9xRd5TEG1y0dDzBaDCYCWYKRVGO0zTbbDOUcpwPU/eiP8qHTnDeH5CkYXVCLZQNSMhFALIzv9ddfn98zfhwMR8KQqzOkr4xo1L5wLrNmzcqbMjOK55xzTifZoqf0XEDWlg+BhqCxhOtqC8cf4MAQFbWOHNx0G1860K536wLCRu+MHT0NqEH05AA123QA2VcnGXCsPuXEnEOtFNtQygDH58WpA33SLvXbAeNFFtgOY612ybXLwN7xZIzPoaeCiLLGlmwK+tVCCfYXBBAA9ZuuVdoXfSJQaROuNtwPe9lls+iVcyN2xozPUoMXYOsQIjVl/J22IDPIbNRJk99zzz03EyA20AbnSE0AwReclXAvxjHGDIEuxxgQQLo8P3XnnjhBT8vaSUGB8VbfNxqQfLZDkNG2BWo73fPxxx+fg1A1koLHAJtknUAJPoh8qVsNonrsscfmYP8DH/hArmV03tKu8BftukP3xKeVOuO32oObOH4Ym7JASB2lFcVSWn/d0DBQiOy3Br28scmGjmfsg9SJ2ggC4babNQWz2IFh2nvvvfMAMQIGzzFHHHFE/t1oiGJeRbNdTqRiDhhWGRiKXkY0DAQQ7DYYtLaDITuMThkQIHgnnnhiJuSUEbnj2MeDdlDCQHrJ/A0CR8KIRqYCFM8jgyJb53ykkDqPsjFW5SIl+s05y2Z2gZMFxwToJTKoH2UJyIuiaoZ2u+226+277745Q2aMAxzHUUcdlckaO7TzzjvPU4BN9pD9QePSzrSCRVwi+FI22AaZCNH2dNT5QUFzG/RZX3P6Zf/QZ+dQHO4F7aJ878kEUofU0POy/8mNY/yek6SH5KrMzIazZOe92I92pkrmDpFxHvIEMrwlECaZ4JIMTSYEOtoWdi4g+NFPY2Wy9K3+6RoXZI2+uLcjjzyyt/322+eZo+h3EOggZR4zRWfoKH0K8uu8yIQstf7zKEIBiz4B12/bYGTdeATZY89LGQDE3kxFe3HCeKDfjFcpG+RN28uZmjYE+LLr7rdLR/2efdhjjz3yce9973tzHxgrIH+ug9uUIH/skABA284777xM9ASbFrHJCkpYkesuCEL4JxnNAPm0uAnRNiMUWcCxsEBInRvB+q3M81d6fBhEBqyMzBYEpGhFhCFUFDwMgcdeWUmy+eabZ4HRJmnYSKVCe0C7EFGIiKtOwY4ORlM01Da8YTBKQzQaTMXIxol2AqL2GTNm5NS46TzvPX1hrCh4NMgkCDzK7EAbV1555VxOP6Je5LJcddg2eNMR5J9xLwma+/YZEt4uaYD4TdvRMp5IQ2RPBGYcDaMoMyE6LkkZPd9pp51yYEY+TJMfd9xxOYsOiAE7JWthTAOjjQtCx8BykgGZI20oH9fzSIXsmvGT3SzJVoDzC5tYEn1wvO/YBLLBibYzOuFAw4myG+V1YuzICbuiPW3bQrbIiWNiCr1L1hDMBUXqtAuxaGdsov1BJMYL04uCFNkoNkiwIpgRzCpRCcgme8yUcZIlEkiVRAfBsSrVb5AUpI7eeNzcIDgOYYoymjaQGtlV2fRyVmY8oLMPPvhglp2ugItcdAHZkrwx2xZ97G8pO/rCLAofwV/QcXabjQCZQTZEZt99GCMzSWyC/mTj+BayK1lkZwMZTlk/5C4eIdeGrDH5K6de+RABTNgUbY12j4b5InU6t4s9brbZZvnh0aZF/B0to1EiamPaCjgMRBXD3DBITSNopVBFtFPW2viM8keKN5RvGMYcxkq01eW0Hqkw7S2db0qMAQhhNo1VprkhoppyamIQZMYYJQo0CKZXkDuGyzYYE4VsW1kf1oZ2a095DEKhfRRdoBAZAA5sQWYDFiZE6coXjK0MNUfBcUYmoiRbbId+olN0rA360zZiHDgHXP5GRiKcmAyZusZTTjklf1fCeWTfOSQRNIMM2ijDK8AzLjIb5MO4yDa1x8X1GXhZwZhO5kRMu4qokQTOw1/3KwsYBOaRAnaVPhvjEmE3jZ1AGtrZEmPse4SCH2CD23JjTCLzK2vSPkfYW21wLo6/bbPjnL4L+YwMVUBb2Kb25+NByC+CQCfoBvvH/rBrSGt5fxBkrouwDAPyhzCaXmTzEJVtt902Z4vCDoFZNDXsn/vc53of/OAH818kxm/bMBYyesqUEJquYxA+ck83BsH9m71AFoeBYImfiH7Tj8Zbe4xp+G2I/7v8BbmJGTf9yubSdb+h5wKyNnAB/EWSIOwFWbCVF2JnBkBWjz/QTnV2AhD9D0pvTD+bxtcnZo3U97blFQSk6uuCYLJJCCAfoq0SG+yMe/bdaDZlvkgdB91VxK5TQ+n87TLabejccOLlQAXGOofflvUtg2DwOFzEswttBYOu9gwLhqHrnI9UEGoFoqYEREMMBOXhIDnMsq+NFSHnhEcDZyyaYphKUt6F5ZdfPi9wkNGZCNRdUSp7SQ2Cmi+yX069MkruVeSstkuGybnokGiuXaexOEK0Kho1tl6MKPugzxmjyIgAvfAdQ9eewgEkiyEuo26/Ycz8hq4jkbIHHJYxRbZk1V17UH+aslXPEmSNo1X4rD7SuDCsjD0jzka4RoAxVjiv5shxATWDxlGpBiNs6sm9s0nahvA9koCwcWb0t9Rn2RWQjYjsW7s0x/jSYcSQ3hunUgYQNlkQzplPMJ7t7KzvgTNFaBzTdtqcJBkiZ5FEKG0C2SOfsuqI10SB1Gkb/WfvyCYdQQT0gfa1bVGQOt9NBO5H4NMmhUoD6CDiBaZVBZk+1yZ2GbnwGgTy3eVnEcRLL70075PZnlIPIGSyWqY0y2BtNJgVCX/hrwUtfILZPOPDJgSMsffsTRuSK+7L9DKyxf4iqOySuje62wX3Kotf2ijya1EVQuwcMvzkcpdddsnfkzsoM4D6hD/QjtIOAr1gr8r6a7OdbJBpc231HVtFts0iIrqDMGFSR/BEue2UNbQHbJgBdExMZ7UzNhBRMcPaJkk6yaudpu8CIRHdmdMfFtH+rvsYdG8xcNo0P0ZhukF0IwIhlBdccEFWBMLP0TIMZQSoNoIDl2EZBAohgtthhx2ygQLyUSp7CUrMGSABE4Fo1AIOr0FwDHJRwnSDoluGXfSnvoLjQxAYqwVdcrAwoJhaJsDYGhNGj4ORFRfoqa0LME6M8CByrF9MnUZJBhhrzjgyoLK8PouVaGyEfkUEZMgGgc4qswDZh3JcOA8kwPfGJaZkOXn3ZJxio09yxphbNMHZ+L0XGZcV4VRNfYnqH0ngE2Q3kPwyo2DhQwRwbD0djHo24FPCubHRxoDtVIAeQEhMiUYpjHIGvyvrz8z4aINMFacsg0r2Sr/hnJw/4iSbpT3lKmqyiXDS44lOEwJSy76Rr7B7/KZpTxBM6IMgcqDf9JFVlaNhkO8hv8gqe1rCfdBHpMS43HjjjblvgE1EbvxutNIUgYr+KokdXVOrpswhAnD2t5yhkkhhzxG64Az8PL0adB9g6pGf0G/6T+kEvWJr9G0ZvAnAjLHv2jAtqj7t4x//eNZrdsI0rLEReKmhGwTXKRfRgL7kl8iP7D+iJSgEPguJa/ejvif/MYsXQODYx3LjZPaPTQm7xKawe86LgJcEsI2BpK6MsNokCkSfOjQISzkw7fRiOYVhEAchOq6reJrTNwDOJSouYQm86LCs2RkEgmGapouMdsG9IwLQlUmMe/VZ2U+hpIjGMO16pIDxZEwJsPEOsk6x9JkiWhCdMwQK4COSZhREuDEeDDmhN5YiU7WbjDVlQAYcR2EYzRgb2TKy0kUmEMrRDAyQvTJL0wZDpWZTRq4E+eXc48UZUW7kkEEYVh6nMhgcY2ps4wXGmxEqp7z1I6MYBI0DkM2QBQXkSX0kZxHjbVd88oIwAVLMJpSro8kBwxlkzPhbBRkgUxxOGGByUI6LaSFjwTnJoHJeZMeUrikWC6DYPSRB5kH7tNUTVuIcMnwcsujeOUpjvTjDGLF3XVNv6owFM2EbkRb9FvXHSBJSx3mSE05MQGd1acz2GEcknc4DWSIDAvEAubHFUBSUy6Iojyl9gpX0dCqCPGTDlFjYFtNZCI+taYyR6Vf/q7cKX8Uh+3/GjBn5/UQR/cHRh93zN0p69IEpvXgyhGsqD2rbPeUFbb+qfx3fzvyAaVSLARHEgL4m3+wfv02XSuKH2NGd8MN0EfGLPmGT2TYBdIBttbhQAIboIMauKaCLgIzeqK23gE0w537oJb89Gh8ApKnstyCNyDabGtOiQBeVeiHz4Fp0lEzRaTIROsr+suP6ng2SrQTjzkZEuxBW09Xq7NpglxAsNgixCy5kbD1NhK9xbeDb9A2S2p7Odw9tf8EvRFu9tN29uwaZHy3R0UnqdAYhc3GsGANm1EQY9s+hsKYXKBdwrnG8GxRBG1DG099vf/vbWXl8z7APKnxnYN2Mjm0LMENpei2YqjZYmmzJtk4XEQcIOWF0fYJK8Bh2fzn9NpOPOWoO3bUZGYbbvfs95UA0I2I0QASTkQtDYYA5nYDvgVHvmuOvmBsiE5GiYl7OwZJy6WoZroAojbEjn/o+6kBmzpyZlYXica4yKlLgxlRkSIHJhywMGVATUU5NMLyMvnE2jpxPGTkHyPJYU6/azliGboyGKFOY7qD3ak+QATZENk8/GU/EDOiLFaqCroDfMMbq9Bg+vxNpx7QU483BWN1MNzkoRpxDC6PnOwbRtBBZsbeVqRZ2ZBA4p9Lwur7onkMzHULWLM5wnkEBm3GdTnovWOHsEAlOuwy8faaYnq4GwZCFs7qSPiNlbLWskOmqgOJ9jp5z5+SNj+/DPutD/U4XnYfsIGxsAxIB5EcWAyEjUzI62iO7EQGagMJCN47XjgZ+jywKJAMytmRGW5AQU10HHHDAuGZ0JgLX5MPcH79JXmXS2K0An0vOS7+JaBkHvpdN4odKgsTxyyi7V+dFFPlmQTAgB/QL0fMd24aE0KkoTeKrkRMyr19MOb7uda8bsX9Inhpm4+I6dEKfssGXXXZZvg96SU+QUvdpEUXYaeUn7HCZJBkW2m/c3bcFBdrAttuZIsgVmXAdXKALdJyu65eArKDfqM2NxZ76PgIzsqXddAGZxTGUZLQXWUUpELlnlwSs5L8kxKAP8aPRfEoAF4l7Gw2dz34VXWk4RdZAh1AwJ41ITYfYfwarN/icYkTUjqVsOkJEywA4hxdD5zs3WHZmgHHQEZSvPUVGkCkuI6EzRVgcqDnnKLwFGZsgXa7huqZBHYPNE7LIjBgkTpxwuFfHS/s7R9Q6xHUMTpBN9yaSYozct9+qvzAt4H+OxPHaKh0+naDPCP5kP/tV3zKoxsL4iF7KVLWxF2AwHIi3sdTX2hNg2EToMT1DjoyBsfe59rZrQowfw8c4+t+1EUpjXkK7KDNjWTr9Ehw//TD+Y0H7kYKIEscDmQ9GlNFBcgQ67msqP/uV46AvDJnxKZ/h6TOOzXSUKaCArAqZYF/8pqxTBNlzWyHRdXrOSXLEbBUI0tTMxTSc7yMDMgichGNiakoWiA0LWwJkztgJ2rqIedyr+1nUmXpkiXM1/YQgifxls8tV2GNBFs05yDbHEtOn9A/0mTFEAqI/2GuBbkyH0uewuwEkEFETqCEBZlHa/akvyYC2k4EuosXPcI4ytew3h1qCnPBT7AdfoC0cegk2BQHwV1Dm/gbpeRfYJ1P5CCHoCyS1vedqG2yOtskK8TXuMRZvgD7U9whRtNk0tM/5qPC37tu0dUDfkl3BrSA3CvlL8PV0xLh46f+QV2OCLNE9Nor9dJ4Yc9+zd+x26AWwwbJqstWSKfwrfSzttP/5beScTMkgkkkZTXVvxhrpHAt8rHugm64XJVyAw6jzI++RGS3hGmywUoH4nqyxF+yJz9miCCLBWCHBMnAyZzjQIKKFcCOzwQ30bTk+YIpfDfZoPiUg6cAH8S1h35BPRDtKQjLSYEwppJvMz5LzfL7FFclI5cd5XHzxxf1PpheS0i6QZ79WDI9kUBerx4RVLDqcOQmPCasYGymAnNCzXx/pSORzQs9+rRjnY8IWFTB3jB0TxrJTG/vfLB6QWZBxkDEZdtl2RUVFRUVFRcX8YsqROpDyVEshbSkNurgAAZUOnjFjRl5ZM10R6feKqYM6JhUVFRUVnTV1UwXm5s2VLy4OS1eac4/57ukK9RCykIpBFdbG6qhHKha2fKq9UFOjttD+fOqHbPStXsNik1ilXTFn9eEjFWqwzHyobbJQQH2VelibcFuUxl5VzD/UVam1UjQfi33Uclnta+GHGvDpiPm1fX6vpk79ITklkxYgkFOJnWrLBsP6BAuArAS2yCwwpUldxdQEsq1olyGzCKQsgK1Y8GAIZbAVOHMgiqTtu2RRiIVLxqeiAgQAFn15bJOVw5zlW9/61rxaz6KCav4nB5IPit4F9MpvwCpPtlHQVW3kYAgsLHIRoFpQYAWwxQoWqlRbNhhkziIUq87pdKCSuopxg8hYeWVV1OKSRZ1uMAZWq1mVZlsAW/BYZVjVuaILVgVasc+B2n7Kqsmqu5MLuqcm3CpH4HBtQ1L7eXToN6vTrfqVWbbSWsBabdno0D9WPluBG1v8QCV1FRUVFRUVFRXTAJXUVYwbRMaeOeq6ahS66CC6tW+bKR977NmDq6pzRRc89cIefaazTHXZU67q7uSC7tnTzFQ3qGPsejpSxbyQobOPnjoxmwjbj63astGhf2Tq7AlY7oVbSV3FuMExqBfhFGzqW+tFFi70uwJiJM7TM8pd9a0cr3UoFQE1dZ64Y4rGE1XU1Nm0msyYvq/mf3KgvslmswItTyIAT2Kgp/q62sjBUBJgulUtopo6Gzh7ekytDx4dZM6m1Da4jkcnQiV1FeMGA2X1q0dv2cX8kb76dWEjVr96XmW5+lWU69FMngRTUQEyIGeccUZ2muXqV8/urqtfJw8WjQmq9HWsfuVo7fjvEVDTdfXr/EKAavWr1Zv6Lla/yiR7Ss7itKXZwgbdtnWaJ0rU1a8V8wUi49mCk/2YsIrh0X5MmGc62tJkKj8mrGLRYDIeE1YxNib6mLBHOubnMWGPdHQ9JmxKbj5cMbVR44CphzomFRUVFRWV1FVUVFRUVFRUTANUUlcxJbCgMk2LIoOluLdmzh5ZMN51zCcX+rOr5k9N7yO5rydL1qbKOSaKiVx7rN8szPtZUNd69KFDTlz/5S9/yXUZNrlrL4VXmH3jjTfmzRYtRX7qU5+aV2b47K677sobo6r7Uci9KGDOXkG5ndUt/61L+ecPhFHdyDrrrNN79rOf3f90YkCA7rzzzt61116bt+V4+tOfnmvDRoNFAuedd17v0ksvzbVlaoNswFtCge0tt9ySn7LgvEsuuWQuZg64h5tuuinfh81YrVojoyUco222b7nuuutyYaqVbINAP9TV2DxzqaWWGmmTLSQuvvji/BghBdO2l6Af8wP3d8EFF+Sid6sY3afr2Yx4KuFXv/pVHlt9rH2j9R9w2Ppw1qxZvTvuuCM/9aD9m4cffrh39dVX5z61bQR749UG23P99dfn8VhiiSVyP7WhIPsrX/lK3ham6xzgWs5lscH3vve93pOf/OTcroDnPRvbe+65J8vuoPMsKpA/G4W//vWvz4ua9O0WW2yR72MicA796qX/+ARbK4yFBx98MOuR37d1rYSNkcmLVbt/+MMfsi6B3/Ep5OLuu+/Oiz7odVuXbIlhzIwX+XDvCvADNk63apzO8F3quMpzIJLujY259dZbs98axs6xM+xF7O5vwYTHKA6qXXQ/ZN2TKNiEscAekT99yCY96UlPmmcM2dPbbrst99MvfvGLbE/ZrRLGwaIO9jHsZ7sPQ29dh062x8tn5N15Qge1p8Q///nP3s0335xfxsCCrq5HaDrOeIRM6nN94/FXXdBf2mb8yF258e4g2ASajpIdttMTVUq4nnvhE9zXU57ylE79IFOO81ffkP9y7MiT8XEe/2ubhW0lfv7zn+e2kBWy1iVbzn/FFVfkHQ7YrtLelLj88suzbMc2OjC0ZzEwe+21VxaINjjLBx54ID+Lcuutt87kjiD5awWQB9y7kUUFSqygcL/99luk7aiYFwynVXkUg4IYI4ZmEBA6jzvimBiunXfeOa/8ZGQCjJ9jvvCFL+Sd9Cmf7RzKlVSWz++999556fxxxx3Xe8Mb3jCyai1w9tln5+MYRsbISqMvf/nL/W/nQMBz+OGH58fbMDLLLrvsCIHkHI444ohsgBSs0w8G6ZEATsWzaBnhZZZZJq+41N+jQZ/vs88++bhjjz02G/ryN8bQohB96nPn98g6tqaEBSTkypY7nO2BBx6YCUIJDtLzi2094ZgucJCe32kByr777psfx1auZGTgtYHjZ3itPubkpiuQBn2PCBtTsnz00UePuYrW0078zuIejnUQjInHHhlPZL4kRJ5X6/FRrvviF78466Jrt0EP+SpjRsfZiQBHaTwFc6eeemomYCeddNJc9oM90IbLLrssF+2Twauuuqr/7eTA9ifkk38UnA4DfX7QQQfl4Ii8kTtJlBLunc1CJgQicjblanhEWL8gTvoQmTrllFP6386GIIWsW6wgEPIM1rIPQUBpGyX7oyFl7DZ9D7DBxubCCy/MxNvvjT/yND8gR9rmPpB9Y0UHRwOCSg4QS7b5+OOPz+0vcdppp+VAwF6O7JXxR7pKuE/9yT7pQ38R44Dk0QEHHJBtBr/D/5CtEgIVu0ZoPzLGniB4JcgoG4coGwOyLDAdGqnzh8I73/lOucImKVL/k7mRlLBJAtA86lGPapLi5c9SY/NvUvTapGgxf7Yo4Nqrr756s+mmmzaJMPQ/rZgokmFvEglqktD3P5kYUhTSJAPdJDKV3yeFb1J01iQClt93gWxdfPHFTXLuTVKMZptttmkSgWqSIeof0TSJSDVJ4Ztk1PJ7Y77GGms0n/nMZ/L7pFjNrrvu2iRj0PzpT39qUrTcvOhFL8ptSRFdPuaHP/xhs9xyyzVJQfN72GWXXZqVVlqpefjhh/ufNLkdKWBo1llnnSYFDP1PZyMpefPpT3+6SaQy9xk5TBFikwx5/4iJIxGUZv3112+Sc8jvk7FpjjnmmPz/VMHuu+/ebLTRRk0yhvl9ImzNyiuvPFAHk8HO45IIcJMIfh7HZITzOCSDnI9JkWmTHFseQ+f57Gc/2yTC3SSykL+H5OiaZDCz/YG//e1vzSabbNIkYpffg/H45S9/2SSjm21WHFvCMe95z3uaRMabFHk3X/va17LMJwKTvyd/5Oqwww7L74E8brnlllmWpwrOPPPMJjmg/L82b7DBBk0KwvP78YL9T45vRE/I/Mte9rImEaD8fhAc7xh9bcy6cPPNNzerrLJKk8h8k4hz/9PZ0F5ykMhI/5PZ/oXeJifc/2T22JMPOk2/HRM6Qh8ToWuS02wefPDBbB9e/epXN//yL//S3H777fkYfiwRgCaRkCyDxvzZz352s+qqq2ZbMRrI7dve9rb+u6ZJhDG3owuJAGV7kALGJhGE/qeDoS18WCIx/U+aJgUjzbbbbpvlFPRNCo6be++9N793j+QzkeH8Hsg7HfQdaB9d+eY3v5nfJ3LbvOlNb2oSkcjvIRHFZs011xy5/0SSmkQImxQ45fd+s9566zWJCOX3kMh+Pm/ImTFw3fhNiRQUZ1uWiEt+b/xToJ7/L+E6G2+8cfP2t7+9/0nTJELarLvuutkOD8Kee+6ZfX+A/LErxgDotrZFW+n3m9/85nzeUo+vvPLKbA/IachWactSkNCsuOKKTSJi+T3fQVfuvvvu/B7IBBsXSEFD7tvwKc6nb9lKCF/rHrrgXImY99/NxlCZOilAGQcQAZdRTcCUZkxrxt+A99K7mKxMX2po/5vZqW6ZDhF4sHiRhfdecaz//T6OS23PmZ3yfM4ldY/dBnwnvS4Lc/rpp2f2q/1xLptDOpfoWyQ/VsRZMXkgSyKW1VZbLb+XDdtss83yOImqumDPp6SgI5kRKXqpdClqMJaiI9MFIlEw5snx5CXzxtkYi7L8VordlgNJaXIUJUoD0S45E7kFbONiirXMtIlGk7LnqLud0nc/stdS4+TfBrAeUl1OA09XyIjLwpqij6m5DTfcME+NyQ50QST83ve+N//GeBrrRAxzdG76BIylSFck7P8ddtihl0hKzlhERmLmzJl57JKBze/1t7H2eYyv8ZBBcIxZBXLThqmx5CCzfKy99tq9ZOTzFj4xnXLNNdfkbEgirvk9yPiSDzMb0w36SJaDXplKAzIvky3T0dWHAcfra7LQdZzxlUHz/E9Zn3Y5BTtt2r3MTLHhdLks65HplT2ia8bcdg8xdej3srKJ4OfpNU8wkPXhD8glkEHy9apXvSrLoDFPwVzOXk3m0yFkmbRxkOy1IZvH9tCNgOl02crIUss8uq+wWf5ne4wNX8cvso1KNHwH+oANdAyY1paVLLdh0QdmOxLBze9luYyX8wD/Trfpu2lDICf0KzKtxoDOmq2YqI+VAUtEKmfmA6a3TZeywV0wgyhjxmcEjC3eEHbI9+4h2kq/7ftGh+k3kAt9lIKI/BSfkC02CPSt7Wy0J8o8/E82IxOqD2V/ZX4DxpNsRfuViZEzegDsFJvCV7KDw2AoUsdIxXy5Runc8UCHOcdOO+2UG2hTQeln4LylGhln02gMsxucMWNG3lzVIAKHK7W53Xbb5ak1KUpTWZtvvnlOOSNzBMneQF5BQjlxxtxvTcERRkSPcFNwSu1cFJlxPuSQQzLJrFiw4HSlzSk+pxCgNBSRM+0CA1TWZSAP0tPhZFKkk2VGmr2sJXFeRtG5PXUhCF9AGxjaeNyKlD1DWBpcv+NswmFTUhtl2veLwWLQOI6Adpa1EIIGxhShnO6gf4IuD5EPMIBe6kC6YMyMUwnjgjjEuNjsOgg8MHqmmkzVqWfjoI2Pz9RJBkx1xOOHSrBNXl1gN0xTsQscu/EuYTrMb0viz+AjIJzjdANdU58nSC6hTtk0FEc5GujOoL4WyDm/aS9/TYdzpAFywdGZ9iJb9AzR4TeCoPidaVX+heM2XVvqI1lq76up7MPnQfx8365xIm/sTleN1cICHyU4YYMCCJv7Q+rIvWltxKS0j1F+ws+SfQSitH0ICP3yW36R7rDNUccI7hs5UUIC2qKsoZwaX3XVVbPtdX6+WJtMk5fQFrWSEyXHZEzbykdisfv6RQ1bF1xPe0q7whYY8yDDfIJ7L+WNDLhWlFLoH6T24IMPzmRW0F8er2yA/W/rBpsWXEQQyDaU9Yn6hF5oJyDU+lb7AsbCOA9b1jEmqSMICBWyI8ri6DDPYaKLgBth4NUkxRw9xXMOTh2JUiOl8BkJ0xHmtzFpjhgIszl7UYLaHG0SHSCY5rnVxrh5xlzHIHHYM0PvhY07nwEm9BRV9u7MM8/Mx1MQRsEct3ZULFiQiSgCLclXRDkROQ+C76PGRrQZIEvGuG2AvXdNhgfazkX9hIg0sm2UiiFkpALkxu/IMpAT1yNfajs4HDVD7foTUBMhcBClliRguiJqQBiogAiYAxbQdWX7o39LGJf1119/xNG2i471vwBAcAfGnh6TKYQvYPyd23fDgMEWrcvAIghsB/Iexhc4A8QxMpEQxLKsL5ouQLQQt3JMAVHnF0K3xgvBjgwOW6B/Ben6Wg2W8wbUrbLvMjWCfpkudj6AeAj4ZfqMv7++51OAfJUyARwlR+yRVEC+2jJogd3GG2885iKfBQmyJkAsCVsELfQJUWKvyF/ZfmNDHgWpkaVuF93rK9+FTUaSSvvpvaSOeuaQbXa67MvIWGmDczm23V/kJmbEJgI+X1vLBRn6QFtksbo4SdTKuoeAPtRP+hTYFv9b0NlGzPo5hi0QRLDhuIxkVGQd9Yn/ox8C2mo2il0yBlD6O8e7BzLG5kg66fsyIHUOcjmo7reNMUmd9C6Bl/2KaTIRqohtWGCipq6kLKXYAdPFbiEMNmGMyDuirxAc5wghESHoVFk7goLFYr8cKgcABCCmbIIoQAh8sH0DbIps1113zawZgkhWLDhQAONGYNuGFmLsBoHxl/GhDKZOI7MXWdZScSCiKoarDUbI7zmBgFWlZIuDQSA5M5EWJxNygnCIFMmcbCElZ1z9XxouCi1wME0guLDLfFm8PB0R91cSALrH8erDYe5fvxtf2fRBkFkwBp5FDBFA0u9yWo7B9+JshgG7YFxl6D772c/mrJ2xFdyK4J3LfTDAJakDjo9zm24I3QnbHHD/+mTYvm2D7nGK/APyZMbGFBUSZzoqIPA2HmyHbBEbUWZL+Ad6azEBvyXrJ2gX+HVBmyUPyFdJYkpIanD2o8nggoZ2IkP6vR3UAHkniwhIzFgE4nj2yHQ1lP4Q2F9j5xqIOQJUEj/fG2My7Vr6vH2O0AHX0V6Zry458duJZurYdnYdIQtom3vUrq5Ake2FktQBWxSzhTLxfBFbz85rnxWsIOkEsnsCCcG7BVrKhJTexJR0kL82kXVdtk6/+CtwKQlb9JXr+18f6/s2CdV3Y2XCA6OSOgPMcalt0Xnm8OPzsVaxtRHCFSlbAjZoig26WHd8Vt40sgfRmfFeR3mNBedpC5/OrViwIA+EO6LoQETmbeVoQ2ZGDYdHHzG8snbA2FCCtvyU0XoJDsLUj8esiPwD6iEoMGKB7KlpkIGjB9LvEVWRZ8eKuExBIGwCnnJVFOLKINCZqI8YbwnD4oYwvDGewOgyzMhWSbi6oH+Ni2wZZ94FRnnWrFmZTIcTcl79bVxLIx86PdZ1u0BWBaWy+Iy4bAanQNbCrgXiftvZkMUJdEW/klOkCqF1z+wk+W/bVffM6Uz0nvkTYxX1b/pVVps+0m9jCWZWTIMhaZIMsnIycfF9CedBDumqFZhdMFWrPKB8xFIJ/YAUKgMqywgWNvg0tpJOlHYt5DtsHl/W7os43neRRWrLrPs0dsbQuZyjDH6dw7X8jm7RoSBxgQjStNNLe9py4pg4x0TAJ9Dj0j/H+5DNNoKsl99pl3tGEN2bR5RZ5axkgjwJwE01+749hQxmWsilZJSgAEqiWQLPMX7u2TGuXY5h2Cl9qs+Mkfsp+845tHfYfhuV1KlZwEA5Iw7OxSLypijjSaPGjZQ3FIJTfjYMyuPj/xDw8Z4L2r+JbF7FggMBV9shQmGsAt7DWPs2URRRj8id4ZbRAUrMoEeqOyBi85uyVgE4LG1RX1mCDMgE0wEZA1lgzkddj+k4RiLIQyk/jD+DV2YaGTJKa5pHpofRG3YacHFF1O1EpAwMFZthfNpOoQ0F7/pXFr0LHATSh9zHggjwG9G165ZyFdmB+XHOskCytOFUzCjIcJSOVDRNdiKbuzgCSVPiIhOhZhSZRaaUt+jfKD8I6FtONWZcxovQyVImOFTjGv2rTZHBs2hFUToyRgYGzRohKArkg3CU4IzZDPWtXWSAP1EYrxSoLMxfVBA8kunwcxCZG7ZSZlqWjo0qYRaC7VFTFsmL8hi2y3g6f9hk/Y1EBJAKv1E7aYzob2S5ApGlVb6iHca01H1wDPIY2a/xgk6Rg8iKgbYJFPVBl9+O2sDyN3iHl7H1G/cU21vZkkjyyv3RdzWyXSDrFjmEbLk+O9+eYeLP9JeX+9beUh61g53iG/gn96ivY8YJou1lPeVoGEjqXFiBpboG2QXKZK83056gKLC918sg6Ljo8IhkKS0hATczCF0DFSjPOwzGOnY856qYP4hKREiUoEzHy7pxllHjMhYopMgpBB6pM42D1JVOnQGnoBQ5YNEPOafQEb1SpjJKYpz8RmZN1vpDH/pQllfHyyQwVCHTQK4Z0ajNa4Px9GovCJhuQLT1gSnnAELnZfXhaECkORXT2OFwGbYYF4bQNLbxJEMB40Cu1EbKLJXTFWYFBKTDGsYukBWGOZySa3OAZf2c2h5ZEbMbiys4XqSak2PjjYcpKnopK00PSqhL83k7YBoWxoSTbJe9sMe+o0+yKMY9SDlyqWidLhrrQeBEta0EmdRmNbCIH9D7sBeIk+ld15gxY8aIX0BSJpI0GAvDnJP/Jd9lsMo/CxDpGpmzYpWcR9AB+hRRMHYIG7saATDQEQEmeWVLEWZ/y1piNtq9C2ZB1tr7ktjhA/TL7/XbmmuumfeHLaFtdiFAcCYC92e8oxYO/I84xSxiGxZWyX7xKwFE132Xdog910cyc+pn2XXZ4tHA1scqVbsaeJX9xl4pMYvrrLfeelm3YoUwKBPT/lgR6z60rbRdaulkKQcRzDYGkjqKjLlrqBvl2Bhp0VGkNEUybTZOQEtnCm4u2GkUwLtBAwxR36ag0M1YRhznLQW0jIiB8pXfl3DNcAKhNN7HOboUadC5KhYMCDujFCuXOHI1UoKHqA1hgMhijA35KQ0bksDYq4kMWGXNEIXxQhrJlMwbgwVnnXVWdlqUUlE/p2GF9jnnnDNC8ALaZzGOBT5qfgJWXyMdyGGAw6AzjBpQ8jJK1I4wANMZImTjayojdM4qMI5F1hM4KYtNygJl013G27hw1sZFLaNpQONirI0Fw8wucRT63LjFqmSZFQY3nArHbgwVObezBOxAvEqwP9obWQ02zXSkMY/ZClupWKTjHgNqcdi2cvHO4gb9rG8FSxEwRZZHZtx4Rc0gHTMWdCtgK5hYKVmCHHTZXbquX02rht03zhxi6DWi4PdlAIgcIHmRFZWxIy9h97UNeXPugNXMpm2RG+ciO+SGLws5tWhDW/gnDhgxIpNkcEEE/qV9CCAr7BPZBc7eOJQrx/Wx2q5IjpBv/Re16kiX+zdmiDECqz+VkcR52SeENjLiAlVBcbmaVA09eSbvYBELAhSrOkFZglIJnwMbzFZHwMPG0mdtCRs8Xsjc6odys2EZZG22aBLcl7ELoo+3mIUptzwx3jhHEKkSajHZIIsiynIctqQkY94j0rFVCnvjngU80bfaxsZF4Mnm22y69Bd2aqBjsYWMBBoCF+U5ZJJ90eeDEgVtdD4mzGCJgigSwTbNRZgppEiUYHGy0raERWcTFCltREsqUpGxjtVJGCYjIIq2cpYySu+H40YS/d7xDAYhIwQ6h5DoOMJB2fx1PIeBwTK0DK7Mh3SotlFcgmN5OoF3jEGIz9zTrFmz8uBqv0jOoNjHDGvmkAg2wlExL8jBZDwmLKZsGA0Gh7Abc3UNEUGb+jHtwlE73pSQ7DHSxhhScJGq8QpIZZNDdW3Oo/aO4VcbRwZcTxQmGuOEGU/lBIgeWRWRMo6iKMbN9wxmeypQ28mPyI7M0AcRvikdBtj5OTvXQFgt7hAxWtgx0Wg1wFjIopgicI8MvChWX0wFsBd0jaPlPOk/x4iwqz0EDgVJ1n7ZNbpr+kO/IdiRKZI1oqPuzXQgg8thsS3OqdaK7eGwGEQZIy/nYyucA/m24r7UaePlHAwrp6UYOr5nh9RtOa/2cP7sFRmI7KH+9hvndz2ZE6Qd+Q/nNhVgDPQ/h8hus30cWgTn40FMDyFPHI6xkZ3hrCMYsmjF+HGm0Vf0Wl9zUJwTUsWvBDg8uobM6Dtjz494Ygy/EfVUCD7dIf+OQeo4PGAr+C22wVgg/MYrajL5LrpnjLSfzjuHe3AtBIkNYn8QVXor6HCcMZbQGG36nj/i1Id5TJh74fTZDsmTyCgFafQ0Fe2g3+6XnUFQtC9WCdMfpSERZMRUI3mmU/weW0inyCrod75Qdo4dZxtdwwuMF5+JAyDHSKGxVLfKpoFzk3d9wwayPfoclcAZwD2zeciJ6+hjY6z/26SO/9YPIZP8t/4pbXqATQmegbQbIyUt9BDcm3Ekp/oU+HtyI7HkJctvEU1kcPl8fem8+k4G1zlKsB36mi1D8hE88k1uAjgI+46j8B/uWVaTPMS4aksQc2OAgHraTZSQyOSRf+3Vl+ST/XHt6NsSzuXey7rjR6UOnyd0MkiMJqJDYHQOxTJIyJeMGuhYwkIIsPKIaiMVLOum40XdlFnjCIPBahs9hoeQu6aCWZ3G6Lquc8nIEDDN1UEETDQXy3z9TjsMDgPiOGxcZoCiabvP3I8OMPiRPaQ0Po8Ih2Bj6REBVswN484ImIqkZPMLY89pEmjRoL8BewkZP8aZw2WQRYVh5Ly6xonDIU/hJCgw4wnOyWlzQu4lQK5kWRhXAQaD5H+yMMhJM3zhjMgQoxkGhsxROtfiyJACyhuZ6fkBXZPxYrjJbxAWBmkqITJenDDiVDpF+sfwsS+IHp1EpLvGhVxwJox4ZDbCdPnL0SGGbA/4PcfNuZMV5LEkEcDGGBvjxH5wRMbP9XzG4PqeDeGQfN+VZXANtkP73EcEq1MFgmGOSHG3vkOCBLBdZGMYGEsBE6fEqbPX7HRAYKMPy+kt+oFksdn6EAEJch/gc+g2OTZW5CJ0FowpXeM0+R06KSMeZNJYubb3HCwHWgZPHC7dd/1Svvxv+tH5wmZofylf5IPf6nKsARlKtX4CXhAUWDgVWZgS9EJbEArt5RcFLUGC2R4kFCFw7YB7YAPJmt0okN0SyBB7yQ+yXYh8+XvgSxEnfpJss0nRhwF9QB/5cH3TLhfRZ75nJwXb/ECQy4Cxdh8SNMaBbQ39LKEdsllkEgm1aIGcduSbMrTNPUr+CCiCbAJyifjK3DlXAD8xtsaSjrvvAA6hnfwOmTMWbdBvyQD36rzut0sWtFvfuh6/ZOy7+lZb+A7X61qMgevQWXJoDCNT3oYgmf6Vi306SV1FxWig0JNJ6irGj8WF1FUsekw2qavoxnhIXcUcjJfUVcxBF6kbWFNXUVFRUVFRUVGx+KCSuopxQ0q4YmqhjklFRcXijGrDJgd1+rVi3DD9Kl3+gQ98INeqqeOoWHhQo6E+VaGuFXlquCwmUTvjcXlRK1pRQSZMa6lns8BEPbTSCdOEaj9jxWfF/EGtmHpA++ZZIAFWOu6+++65Fk+NZsW8QORMv5o+POOMM7JMWgxFTi04qrZsMOi2xWFqia08DlRSVzFuKPAkRAqOFZWWRccVCx4MoSJkhdRWMiqWtk2DlcAWIsSWDhUVAgDF9RYNWB3KWar1ssBBsX01/5MDCxwU6VuUM3PmzPyZxV1Wdqp5rTZyMAQWFhsJUNV5nnTSSXnVJ5mttmwwyJxFhuo2BRCBSuoqxg0iY2Wh5d01Zb5oYAw4ZaunrAS0atSrqnNFFxSgW8HIgVq1aGeBqruTC7onax57UHK4VvTWfh4d+s0qZ6t5ZZ+sRrVrRrVlo0P/SKzYzaNccV9JXUVFRUVFRUXFNEAldRXjBpGJDU1rFLroEHtVydTFxt1VnSu6oFbJfl4ydfZHs09a1d3JBd2z1108icDem6Zkaz+PDv1mOya2zPS1/Q9l6uqU9ejQbzJ19hks92OspK5i3Iiautg0syrfwgUnoaZOrVS7ps6mmrUOpSJAR5H9dk0d8lFr6iYP6ptMtbZr6iwiqzV1o0OgYSGPPTfLmjpkpdqywSBzAgdPx4inmEAldRXjBgNVV78uOsTqV48uYwjr6teKQairXxcOYvWrvhZoQV39OjYEqHX168RQV79WTBqIjGfa1SdKLDq0nyjh2YyKjesTJSraqE+UWDioT5SYGOoTJSaO+kSJiklBjQOmHuqYVFRUVFRUUldRUVFRUVFRMQ0wFKlTrFhmAqZCVkAb2sWnPqsZi4rJxrByNdYxtVh6/BirT8ej7/q/6/jxjkst3l60GO94qRucqrpHHscjwzDMbxbW/U6k/YsSk9HWyejbBdlvjz50lInrH/zgB71LL720d9ttt+XNZm2dYBsLSmKVj89uv/32vL2FQly7Qj/88MO5aNT/t956a67l+O53v9v7/ve/n3fXtgT3+uuvzxtg+o2X7xxvNZ/59ac97Wn5uDYY0+9973u9q6++unfttdf27rjjjpGNNK3CvO666/JftUUVCw6EUd3IOuusk3emn1/YYuGrX/1qXqVnVZ4C0GHxwAMP9E499dTeCiusMPB35Peaa67JmzRaZAAU0zXtYn7LLbdkmXHtcvsBx/juzjvvzLJFrstNHgNk/qqrrsq6oSakDfUhiqhvvPHGvFz/Oc95Ttal+cFf//rX3gUXXJCL3q1ivOGGG/I511prrf4RUwNWBH7lK1/Jegpd/dcG+0IWrOZ1fJc+O8bKL3VMxn60bSOMn+NsL0FeH/vYx+bPbdZsXNkdduqJT3xi78lPfnL+ro0//OEPeYzZn1j1DRasXHLJJb0LL7wwbyvj8yWWWCJ/N1UQ2w+9/vWvz4uaFPJvscUWA+91LFh5TZ5vvvnmPL5lnw4DesB+r7LKKv1P5oAcGys+Q7uNyVOe8pT8nTHnU8hFKU9dYx/y4Tiy9IxnPCPLkX647LLL8rn5HOPuRRaWWmqprOMl+ByrWf/yl7/0nvvc5/Y/7YZNc8larET0uDALybpqF9lQ16cbfmMF+1hy4zfuif+86667st4/9alP7X87G+6PrdPHnjhjbNr6E7bP+EU/s538boCdcozrWGWpfSX0i76lP85BltryZHGI8bzpppt6v/71r7N97bJ7eMH5558/IpPGmJxaYNIFY+ua5GSZZZbp5Apt/OIXv8j6izOwx8ayLTd4iL7zV3+0+1ab3Iv+x43Inq1YSpAT5+BzHnzwwd6SSy454nMC999/fz5G+52zS67IBjklu3RgkGxcfvnleXEJ3xYYmKmjtNttt10eDPvHUIoTTjiht/XWW2dhMTg+M/BWXmy11Va9c845Jw++7xg3xsN3fkOAfIYMGgSF3X7z/ve/PwuiQdpvv/1yAf7hhx8+z6oXjvPII4/sveENb8g3svTSS+d2KRJnUDfeeOPeQQcdtNAilIrJAWU+8cQTs+HjLPbZZ5/8pIphQLkPOeSQLEtWS3WBI3/Xu97VO+uss+aSDcXj+++/f1auU045JcvVF77whf63s2E1FvKqbeTWSjayVuKXv/xlLkC3aIEBa4PSWlAiELGtBGXX3kfCajiEm04jRJ5mcPLJJ48UkY8G/WhVF1noWv1GTi6++OJcHHzaaacNJHRsBpugAPtJT3pSdgDhtDlytodzMi5kwwpipK0Njte2Ab/61a+yLAQxZbQtTFEcf8UVV/T23XffbOsEqtMVdO6www7Ldn/ZZZfN5IFd5piHARKsL41JG+Rlzz33zDJj7G3TI3gJGGtEKba6oNfa0YbfHHXUUXm1L7Jpmx/jDxYW7bzzztluHHzwwfnve9/73jz2yEsbCPsuu+yS9XYywY6wA/wX+bWTACI1Gr785S/ndnLwXmQPAQmQxwMOOCCTFoEOn6uvEe8Sgg/6pZ/du1WmfhtAKHxnrPn4I444IvOBEuy28dF+fUz2kZUAfSIX9OKFL3xhJq6TYfeQJjbEdjGuz76OBWR77733zrKH/NDXth13f2SBnLifAw88MPdDieOPPz7Lj751LmOmrwNslc8QYbrhGnxDmZGz/17YHWSOnCKbJdg2fS7IMAYW2yB3QyNdcB4kBW1e85rXNKkDmqQg/U+bJpG5ZvXVV2+ScPU/aZoUxWhxfiWB6386Gx/72MdGvktOtf9pk8/5ute9Ln+eDG2TSF3+/Ljjjhs5/qSTTsqfwX//9383aRDz55tssknz0EMP9b+ZjWS8mx133LFJAtYkB9L/tGJBIQlkk0hQkxS1/8nEcN999zUpymguuuii/D4JcJaL5DTy+7Fw7rnnNikSblIk3ySH0P90DshZUqAmRatZnhMZyJ+7bnIIzS233NIkI9HcfvvtTVLU5vnPf36THHc+Jjn3Jilmk6LR/B4SqWuSQ2mSAex/0uT/U/TWJCM7j/xDUuwmGbUmGbz8Pilnlnmfzw/I+frrr98kg53fH3rooc0xxxyT/58qSA66ScFWHlcwXolANYm05/ddSM4g31Mi3HlcU4Td/2YO2APjvcoqq+Rx7YJx3WabbbI8RR+VSM6uSQFn/12TZWPdddedR/ZSAJnlIAWs/U/mIBn4JjmuLDPuKZGOJhGDLCdTCWeeeWaTSFL+PwU/zQYbbNCpL8OArpY2273TiUR88/vRkBxw7t/kzJo111yz/+kcJAfYnH766c3111/fpCCoufXWW7OtAXqYAoPm7rvvzu9hp512atZaa60mOdb+J02THGv2BfzET37yk/6ns2GMfDdr1qx87kR6sg3bbbfdmkTc+kfNgd9vv/32eUyPPfbY/qeDkYKR5m1ve1v/XdO89a1vbb7xjW/0380BG7D00kvncQEy/+Y3v7lJwV9+34U//vGPWd5POOGE/idN9olbbbXViH4lQtdsuummI32WAs5s0w4//PD8PsBWkFtti37WBnCuLbbYoklkL7+HFPQ2q622Wm4DJPLZLLfcctn3B9gi/RggD64d+qvvV1111RFbX4Ku+n3YSH3dZUuB/BqXzTffPMsd3z8WEoHN9xRIAX3mNiHDzqltiezl95AIc5MC9f67JvsKchs+j8yxZeVv9NNKK62U7ROQWbpS+sk3vvGNc9mHRBRz3/7pT3/K7xNZzP6CbQmQjbJvS7i3RLD772ajM1MnYpBeFGFLEQawT4y3TOeKfCNSbqcIywh6UDQNWD1It8Y5yutix7KAriXybl8Huz766KN7a6+9dmbAFYsHjKvp9qRQ+b009Wabbdb77Gc/mzNso0GEKrtre4aQnzZMT4p27ONTRnRkRISaHEtOn3t+6h577JEzBRHVapvsQzmdanpAFsbUUcDUkMyBv+12+L2NNO3kH1MwkSoXLU7nbJ2+NLVtO4eYflhvvfVy/5533nn5fRfYCdE/W5PsU//TucH+6E+vQWOfAsQ8TSdb43xtyOaYhSB/ICL2v6mOgGkpcmG2IRHE/qdzYGpFRskUl4yGmQ2zB6LxYTIIixv0tf4kvzEd5979T84HjVeAPMiGKRHQ3yVMgdMrurjGGmv0Ntxww/w3smeypW191N+m03wXiKySDInZnBL0zXiZHnVu7bAlk6k5W2qUIAsy+I6l22Pd23hg1kBmLBHP/J7Mk5uzzz47600XlEHJIvNxgURs8qyVzJD2yp6Z0o4+I5+ON30cMxlkU/aMTXTN6Ofwz2TeOJTXUWbD3ka2jl01u1Zu1bLRRhvlmTk2GciDMhP2F+gH2+fz9tiPB/TTuDr3ML5eVlJmL/oa3JvZIO0FfSsT1r5nmVFTzGDMyEFs4WXqm/9Q+iNbJ0vn3shv8CN+zf+OAX1LVvm4gD4k+8YE8BxPezFtHzDObCZONgw6SR3SZD6ZAZZ6Nh2qc0CDwglDKeztuePRiFzAMSGEhFZ6FaLz7Mcl7Qmmb5dffvn8fxvqAaQ+24SvYmqC01ObwCmUtRycuaCiaxosYFrNVAyjzlh0OXbGhcEnvyFfAdNwrlNCLYd0eDgrpJKiludGzpQWqLMbBqbr1GC4XuiCtri21D7Znq4wtmpdX/KSl/Q/mU2A2ZXSCQ/CMAZ7kH1hPDl1U6HGlEMqp5fgNa95Ta7dMRWC4F155ZWZ/JEpYNc8gUE7kDolJ2xg6ZAY/rKO0xS9c5DprtqhxR300rQ1h1rCGNOJ0eTZmHCQkgJ0oE2SkBNTqeuvv37e383UYXkM4mUsSrngD/RzTHdrm3E3Xuq3EJhyegzBEICVMK7IHoJTwvSwsbQH2LBTy8PCVC5dQAwC2sVeuIcukE9JDTYowBe6P6SOTezqf1OfSIMABkwJOp4fRxb0cwk20/0GGQM+lWxHooX+Ild0K4BMIiP6k96rk2b3SnivBh8hXFhwPX1T9pvAQP8rHQB9QI58FqDD5MK0sf5AuviaEsYM0TK9yzbo57JPgK2P6yDLzlkGmdqib10HHMMflvV8yDlSPmxZRyepc1K7YQNFVntAAGJ+eFCBLaHkTAmNv347FtTHuOkzzzwz74ZPCNUNqK0A8/TqlmAsY4kltwtdK6YmOFJjS5ZKxxiZkhjzLqjtpCxqZbqiPlHr6aefnh20c7cJgprONiGg/BxKGDOKJ5oryaWgxe8i6h0Lfs8gtAMN2UE1GcOeZ3FEZBxKwq7/GE5GfRjSNlGIwDkY/Sx6RtwQBUQzIMNr4051k2wbUsKRR3tF7iJ1WQEZimOPPTbX8Kk/iuxeO1gws8HAO990BHuuX5GpEvqMHXf/XRCoyyLtuOOOWb+7gjCZI2MlY8bB6Wt1qAF6iZhY0BBQ++QV11WLJBCjczIe/InsOt0eBARFBql02Mi+oE4t06BM8EShfXSffdH2QASn5K4L+t6MVLkoIDJC/C69Mg7aXs4AxDWMD2ywwQY5A6meHSGhF2XmnL1DMkofz6e6tnbTW7aZTSvlPwiRRJDv2b6SvIBjBPPOs7AQHKTkDfpE39FV/kPQRy7LRQ/6wG/YKmSZ3LcXTggcyJrv+TL3Vto7cF6kUlAZs09tf6d/BSDO5Rh9X7bFMWznoCxuG52kDhRcynyFAhtsxZN77bVXjpq6IMqQyrRqw99SAQeBsIkORGo6zg2EkQACEtGWAuU2qWtHfN63P6uYemAckBrjXRqHGLuYBm3DlJrfysANAqfuodqR7W073zbIM6VS7Bvg9GXtTDf5npHiAJDR9rTOIETWOYq0A0EonWu6Iu6tNHLum/76bkHdO8coqOQkEQWF4qbkZA/YrnAojLpCezIiqIxVcQH2jg0yNUUWZO38dS4EpQtsmOjdYq/piCAL7aCew+HQBmXqTCtaKBOrXbv0caWVVsoLGARjFicgBEptIquDnHG0yhZCH5FtDjOmZBEa/mrTTTfNCwFs7OD3EgR8SxvsiHMgOAHOl+/SFs42SN2grPB4QaYEBZx22Q/h19oZZdC3+l6/t2fDAKlFFBA09tE0t/uVNRPIIILhx2Uk2U6L05A5+imJEnrh+tpSZhG10zmC4LiHMqsFQTb9HjnRb+1g1jG+G0T+FwToPZCdNoKkItr6ryRb+sDLMey4+yn7BMJXsWUR6MVMT4AM+V6/OcYYBhmHOAdfiGD6SzbK5BQSatzjXsZCp7dzcicy7Wq1kW0TOCYNmDlzZhaILjCiyKBVhf6Wc9SD4LwiIisPOVAZPsbXSkMooxmdE0oGFJvBcCwl9JLFEblUTG0QUkpSRpUQzr4d5QGjYtUquRK1M+7IH8UUKVEaht2Up5oEn4nGKIrriIJD+QIMJkdiqs6qpoASA7LkmuRZXYZpE+1WizMMwpAyZCXiHsOQT0eEAWQwA3SXgWRgSwM6mTC+xkwmF2FjXxB8tXGmvCNrw+l5HBGHpl7G9KD6qSgziQj/Va96VSaInB87g9CzVaUdAr+zalcmr7RZiyPoCmJA1/SNGle6w5Fz8PSthDHmsLtKXxBsOonQ0Uf9RAYQA/obgU8AeTLjYlWg46OOyBjSR4kCY8YvOa++Ng0ObIKMHvugPX5Dd00FljXaAZkPBMPq54AV2uTTS1u9jDWZkkXpmhkYD5yXU2d3yuQDcgqC3DaCZLV/EzIYv5GRFsTwiWbVBKH6X3+2s6tAtq0gZUNj+s912KuwUeCarqUd9En72yQ37CpC4uXYdl+FnLSDggWJIJ9le8mvvmSD2HPH+KzUad/rB211z+6nLfel7EZmrW0XHIOgOY++1SflMfFeW/RNjHN5LX3rsy796kInqSPIolcXsXiBghMU0RREhNSGxlN6DfR3GOOmsx1H2C1TDsdqDts+eCJfaU7AdktBMRhqY9QbMDzqBRiP2HKgYuqCEqjFIUcl6YlopF2bAAyUyFPAIGsi2EDIOAhTaRyQLUpM28yYMSOXEDgOyRO1imTbWxNEASxSV4JcmgKSdZadUacjiEDohglWgBIyBu0sAZKJKCxM47awYWocyuiSoaLD9LMr4zAZYEcYYXaidIBkzTU5ZzAFxZlZvCFTg8DIznGGoI6FDQtjDZynjBMjW8qsc5JD9qss5F9cwaEr7lbLLNBGftXDqaXTt215phemprrsLqLrJeCmj3QQGUPO6O+gqVGEQw1W2c/KKUyx2nrCuQRsgjekxVjHFKpxC4QcxriXuOiii3LmKggPB8zvzJo1K2dbkfwddtgh9wf5kOHq8nvjAUKkH52n9GWRKRtUM84H0qXS2UdmNGYOBB4WDFrkpXaRLyWrbCO96AJCjPwGQXF97SqDbedwLedzHgF3eyYl2m/xkv5k27rkBGkJf74wEOU0bG7AePIZAj8ch866x5LIytrrA1Pzsm/uqX0/xpBNIffshXO1+8UxviebjmlfRzvIuOvgQf7q65IwRtvZnmHQSeqcMFb/gYFU64DVQ2kw24x9GPhN1+84wFBIwutmOPdIj5siK/eO0QmEKKZ4GGAkUOdWTG0YIzIlui4NLvJFEa2wa2PllVfO5B3JsgcSA2Z/OIbSvkL2KvRenZQssykzEb9InGL5LAITEAyQM5nikDtKVhpbzorRRCaRSvWlZWp8NLgPpKEsQ6BT5JgjouTTFcgvY1nWJDLqMiPjqTkby760v2cTjDGZMpYBYybYDNKlKJ+RDFuBbJAdGTvg6MiVbFEJ1zNuIQMcLZm0sa+ieiBTbQewOAF5Zf9NQyJRppXpFmduXNtEzOyKlYBd2SDkSK0i3aOzdBI5oBvHHHPMXFmyEpwh3eN4A3SUczSGNr2VxbP3GRgXmVnyVdqTyMS0SyaMEaJq3ALGlE1B7NkY/k5W0Of2saT7kxGIqWuTOCmnIRFUbTTd3wUEmDyXtcZ8IZKEAAf4UKRRQOk+yGT5sPc2nFM/x0IRqzHpUKm3bDR5ZrOA/pL7qBEDxxsb8uF8zhPZvwA5oZtd5H+8GJZ/IP3kkl8JuB/TxKbpgQzgPGXfGh99GatQLSzxWUnILFwQLPJVZFpCqew3fsT7uI4EFI5SLniQASfr5Aus0tW2UjbYILoX5QtjoZPUuRkb4llhWDq4WPWkASHcUofRwaURhZLtlylH/0snAuUK8qgegMMDgh+rbKWV1VRI31K0svYF4tzaUV6nYmoD4WFAYmqEwsiqmeaK2gSG21QL2WIMyIXl816m+8Poyygzihw1JfW95fquwYEwOBRGAEBOZJ45LEaG4iFsMnwi8nZQoH0cENlz/UEoswrAoZj2cw9R5GrKyf9qfqYzEB/GHzGIfkGkGEAECkStsutWjXWBLrf7tIRxLG1MYPvtt899b3wDMQ0VjsmiK2NRgvGPaBhxEEyec845I9lGhhYxjUVkPje9p43kysyC2jxZuyCHiyP0nWBZH3jRq5j6kfXhZMKhc1CcpD4PsOOxKMXvQx+96I9MjfPRWXrJniNpUTbD59BP32tHG/QRYUES2YCATB4nX27mauqVY+ZQS5A591Fm3dkiZKRsK/vBHsj4OY++mV8IZiUrZCyBD3T/ZhX0B3D2pvnD17FdCITFOwF97Fzt7B5bqW/ohsUn/Dnwn2bZop/JbWxvIkMEghn3Xa7wN1uBMOsTMGvBppYbP/tfpjoIG/vmOsgquB/9rY51MvoweIO/JfSXmtcgcbK9M2bMGNkyBPS7dkZw6X7pPd8TcDy5lSQCcu96QVQRL3LofsgH4i+TS95izPShMYgaW3zGGJdjaGaJbAUxx63YppANNpBf8vmwSYDOx4SJdMzHGwjZMgSM4qo3kC2R/hb1GjDKpwMNlNS8wSdEmL06JN9F9KDxjmNgRYLOS5F0is+k/Blqe0KJwMKxi0YIHkPAYLhhN+saOjGWWBM6Ec1kCE3FYBgjYyt1TwAnCk6U0jHCZERGwLhylLIkgEzZwV4WRQTYBqeiVIBCheNpg1IgEIwRWZOhcw2pcsZUYTbDpcxANMTQS4ELMCiudpk+CjJSggElj/ZuYpAZWO2MCBLppDuyAtrnGqJxKwHHijJHAwI81R8TJvo3PmHcjQMjGNlS/ctZ0d3SOSNOyCCy7VgkgL0JMJRq3jg9xtU9R90LxPFkVIRrLI2z4BDJAM6LU0TU/M61PILJ/oXkUlYIASUXMb1IThEcBp6cyuIYT/ZSex0rADHFL/s7VabXEUxt5KTY3FmzJv6YMP3HJ1gUZxxmzpyZs0HkObLdyJX+RvTisxL6UWbE1CYg13STXhorjtO4OU9kRF2TvNh+gr7utNNO2SaU4C9kQjh1Y0i/+QsL/tp2SvBGX8s9w7rAkcv8c7qDsmgBMq7tpm2BLCCCbWKq3/lCMsMmkBvjYrVu1MfZZ9HsgwBCX5gt8xtTxmSRzeGf1XBG3RidQJzIJL2QHS0zlIIQ/UYvyDQS43r6OXTHeMk6sSdIINlxnHPZmQL0MVIkaNIWfezceAFbBEgr+UBs6IrgSP/RnbZ/1sfGLGTSvekPpL4NvkdQ7B7ZVf2LW8Q52VkkSlsjgJMNRmbxBVkx/U4/I2nk3vkhBEs/+ysrJ6scs4Bkhe8guz5je8kYmxJ9Z9sU/a99gh72iYyWC6f4F3yF3yCfyKMFQUHM9Z++Yyud13jrWyQ9ZKME34SQlzNbj0qdNKfwpA9G2Bw5YTGoOs8FKAbj68YNRBgLp+CgvPzGzZVF7L7XIYRTRxBGTjacmr/BdimAm+oiZs7FScSg+w3jTRAwaoMbHVyx4EBJkQmPv0Li5xccqiwHx8xBlHVMHK3vEKogeiXIGQfDAJS/K+F7ToHzZ7Sck9KSsbb4Ow9Da5m731FgBCAi6DYYR9MgDCDZ0wbGpJRD35FZRoUCMjKCmfkB58dgCI7oFeLr2h4dNJWg3xFj984Al/tFIaaMOUOnj8F4GB9Gkb6zCRwToxsQCRsb5wTGjv6XpJ+M6nMG1hhyVDHTEDDd4hhgtxzTrveJY9gotkk7jS37xfGVpSjgutoRxfpTAQiM/pLd0neyBaZEu7Jgw4Cz5jwF7PqUzpT3GptzD8pqawvnGpvX6jPO0vnIsj4mJ+U56TlCx9aPNYVnXBxvHBChktgErPz0OZkcDcYXQXVsKbtdIOdW5yJNwGYhD3GfJcgMu2FKkvw6piTZkhXsorEq7Z7f6Cef0Rv9Bc6HfPHbsmj6MAhxCQEw4inro2/oTRfxxgEcR8cE76X+gevx/2Yh+HQ2rx1U89EhJ/QKd+jyz3RJxpFMChrUcJLTjnxTHo+Sd/D/fFBc2+cIkWuV+s6eyKJrk35r3w8ok+Fr2CXbW7VtgWvrE8TNuZHCtk9yL47BcWT/2IF2/5JN/aL9ztGlhwIY9+maZpwG+R8kuT3F3knqKipGw2STuqkIahFBx1TE4kLqKhY9JpvUVXRjPKRuQWCq26xBGA+pq5gbXaSus6auouKRjsXROFZUVDxyUW1WBVRSVzFuVOMx9VDHpKKiYnFGtWGTgzr9WjFumH61GkcBsloKdQoVCw9qAdXOzJgxIxcMqy+KxUvGRA1fRQWQCdNa6rNs3qvGUemEDeTVd6rZqZh/qF9TjG9RhQUSYJrbwiA1h+oQK+YFImf61UpzfUcmbStDTpWUlFuIVMwNuh3TrxYaBSqpqxg3FLBboawAVBE6klex8MAQWj2lGFf9jlV/9uPjVBQ/t5f5VzxyIQAgJwrnraDjLNViqsO00q6a/8kBW2hhIEdrRwiw+heZo5/VRg6GwELQYYWsOk91iVZ9WtFZbdlgkDm1suo2BRCBSuoqxg0iY4ViuUFixcKHhRFWT1lRZkWWFb1VnSu6wFnaXocDtcLP6tOKyQeyHHubcbhWx1eMjVjNa2cNW7PYR7DastGhf6wQtx1KrIKGSuoqKioqKioqKqYB6kKJioqKioqKioppgErqKioqKioqKiqmASqpq6ioqKioqKiYBqikrqKioqKioqJisUev9/8DreBoj+ABTKEAAAAASUVORK5CYII=\"\u003e\u003c/p\u003e\n\u003cp\u003eThe group without hypogonadism exhibits higher total and free testosterone levels compared to the hypogonadism group. In accordance with a functional hypothalamic-pituitary-gonadal axis, LH levels are significantly lower in this group, reflecting appropriate negative feedback regulation. While albumin and SHBG levels are slightly higher, these differences are minor compared to the variations observed in testosterone and LH and are unlikely to have a clinically significant impact on testosterone bioavailability.\u003c/p\u003e\n\u003cp\u003eTestosterone and SHBG have a strong positive relationship, while Free Testosterone and SHBG show a moderate negative relationship, which could suggest different regulatory mechanisms for the bound vs. free forms of testosterone. LH and Albumin have a strong positive correlation, which may suggest they are regulated similarly. SHBG and Free Testosterone show a moderate negative correlation, suggesting a potential relationship between SHBG levels and the bioavailability of testosterone.\u003c/p\u003e\n\u003cp\u003eConversely, in the group with hypogonadism the strongest relationships are between Testosterone and Free Testosterone and Testosterone and SHBG, both showing strong positive correlations. LH shows weak correlations with most variables, suggesting less direct interaction with testosterone and SHBG, but a moderate negative correlation with SHBG. Albumin has weak positive correlations with both testosterone and free testosterone, but it does not show a strong connection to the other variables.\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eFemale Patients\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll 20 female patients experienced menstrual irregularities, requiring hormonal therapy. The mean age of menarche was 14 years (SD: 1.57). 4 patients entered menopause at a mean age of 35 years (SD: 5.56), with the earliest case at 27 years. Only one woman had given birth at the age of 25. Menstrual irregularities were common, and 20% experienced premature menopause. 4 women exhibited low AMH levels (\u0026le;0.53 ng/mL). The mean AMH level was 0.30 ng/mL (SD 0.21), with a median of 0.35 ng/mL. The average age of the women was 23 years (SD 4.32), with a median age of 24 years. Notably, the woman with the highest AMH level was 17 years old, with a value of 0.5 ng/mL, while the woman with the lowest AMH level was 29 years old, with a value of 0.01 ng/mL., with ultrasound evidence of ovarian atrophy in 3 cases and a uterus compatible with a menopausal state in 2 of them. Notably, the woman with an AMH level of 0.01 ng/mL, after 1 year and 2 months of hormonal treatment to achieve an adequate endometrial thickness, successfully achieved embryo implantation using a donor oocyte. These findings suggest an increased predisposition to hypogonadism, or an earlier onset compared to the general population.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eOur study demonstrates a high prevalence of hypogonadism among patients with Wolfram Syndrome (WS), particularly in males. Hypogonadism was present in 79.1% of male patients, with 89.47% of them exhibiting hypergonadotropic hypogonadism, characterized by elevated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels accompanied by low total and free testosterone levels. These findings suggest that primary testicular failure is the predominant mechanism of gonadal dysfunction in most cases [9,10,25]. Semen analyses conducted in hypogonadal patients revealed azoospermia in 12 cases and oligozoospermia in 2 cases, frequently associated with teratozoospermia and asthenozoospermia [5,13]. Additionally, testicular biopsies demonstrated seminiferous tubule hyalinization, Sertoli cell predominance, and reduced Leydig cell populations, findings consistent with primary testicular failure. These histological features align with previous reports describing testicular dysfunction in patients with WS [5].\u003c/p\u003e\n\u003cp\u003eIn female patients, the prevalence of hypogonadism is less clearly defined due to the widespread use of hormonal contraceptives, which may obscure underlying ovarian insufficiency [11]. However, low anti-M\u0026uuml;llerian hormone (AMH) levels were identified in 20% of female patients, with ultrasonographic evidence of ovarian atrophy in 3 cases [17,18]. These findings suggest a significant reduction in ovarian reserve, which may remain undetected due to hormonal therapy masking the condition [16,18].\u003c/p\u003e\n\u003cp\u003eThe comparative analysis between patients with and without hypogonadism reveals essential differences. Patients without hypogonadism exhibited significantly higher total and free testosterone levels, along with lower LH levels, reflecting appropriate negative feedback mechanisms. In contrast, patients with hypogonadism displayed elevated LH levels concomitant with low testosterone levels, supporting the diagnosis of primary testicular failure in the majority of cases [5,10,13].\u003c/p\u003e\n\u003cp\u003eOur study highlights the substantial impact of gonadal dysfunction on patient quality of life, further emphasizing the necessity of comprehensive management protocols. Male patients with hypogonadism reported erectile dysfunction and difficulties in romantic relationships, illustrating the emotional burden of the condition. Considering that hypogonadism can adversely affect both physical and psychological health, implementing multidisciplinary strategies involving endocrinologists, reproductive specialists, and mental health professionals is critical [1, 5, 10].\u003c/p\u003e\n\u003cp\u003eFindings in female patients warrant special attention due to the paucity of literature addressing ovarian insufficiency in WS. Although 20% of female patients exhibited premature menopause, the actual prevalence of ovarian insufficiency may be higher [17]. This discrepancy may be attributed to the use of hormonal contraceptives, which can suppress ovarian function and mask underlying insufficiency. Furthermore, the low fertility rate observed in our cohort, with only one woman achieving pregnancy using donor oocytes after prolonged hormonal therapy, highlights the need for tailored reproductive counseling and management.\u003c/p\u003e\n\u003cp\u003eAlthough clinical guidelines such as the French National Diagnostic and Care Protocol for Wolfram Syndrome (PNDS) [22] and the Clinical Practice Guideline for Wolfram Syndrome (DIDMOAD) [23] are available, no standardized protocol currently exists that addresses systematic gonadal function evaluation in both sexes and its impact on quality of life.\u003c/p\u003e\n\u003cp\u003eBased on our study, it is essential to produce scientific articles that thoroughly address genetic counseling for individuals affected by WS and their families. Given the genetic nature of this disease, providing clear, evidence-based guidance is crucial to improve patient care and support informed decision-making. Notably, we have only identified one recent scientific work specifically focusing on genetic counseling for WS, authored by the principal investigator of this study. This publication provides a robust foundation for our recommendations and underscores the critical importance of interdisciplinary collaboration in the management of WS [23].\u003c/p\u003e\n\u003cp\u003eAs noted by other authors and supported by our results, the need to implement early screening protocols in WS patients becomes evident. These protocols should include periodic hormonal assessments (total testosterone, free testosterone, LH, FSH, and inhibin B) and semen analysis in males starting at the age of 14, particularly in those presenting with delayed puberty or clinical signs of hypogonadism. In females, AMH measurement should be initiated during early adolescence, even if menstrual cycles appear normal, to detect early ovarian insufficiency [17,18]. Such an approach would not only facilitate early diagnosis of gonadal dysfunction but also enable timely therapeutic interventions aimed at improving quality of life and potentially preserving fertility.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThis study confirms that gonadal dysfunction is a prevalent and significant feature of Wolfram syndrome (WS), predominantly manifesting as hypergonadotropic hypogonadism. Among males, 17 of 25 patients (68%) exhibited hypogonadism, including 12 cases of azoospermia and 2 cases of oligozoospermia. The mean total testosterone level in affected males was 6.36 ng/dL, significantly lower than that of the non-hypogonadal group (18.08 ng/dL). In females, 20% experienced premature menopause, and 4 patients exhibited AMH levels \u0026le;0.5 ng/mL; ovarian atrophy was detected in 3 of these cases. These findings indicate that primary gonadal dysfunction predominates, although 2 cases of hypogonadotropic hypogonadism suggest hypothalamic-pituitary axis involvement.\u003c/p\u003e\n\u003cp\u003eThe high prevalence of primary gonadal failure, particularly in males, and the reduced ovarian reserve detected in female patients underscore the need for standardized protocols for gonadal function assessment. Early detection through hormonal evaluations \u0026mdash; specifically testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and inhibin B \u0026mdash; and semen analysis in boys from age 14, as well as anti-M\u0026uuml;llerian hormone (AMH) measurement and ovarian imaging in girls during preadolescence, is critical for timely diagnosis and intervention. Additionally, considering the emotional and psychological burden associated with hypogonadism, particularly its impact on fertility and interpersonal relationships, implementing psychological support as part of comprehensive care is essential.\u003c/p\u003e\n\u003cp\u003eFurthermore, the lack of standardized reproductive health guidelines for WS management necessitates the incorporation of routine gonadal function evaluations into clinical practice. Genetic counseling should be systematically provided to patients and their families, given the hereditary nature of WS, to support informed decision-making and enhance overall well-being. Future studies should also explore fertility preservation strategies to improve long-term reproductive outcomes and quality of life for individuals affected by WS.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eCOMPLIANCE WITH ETHICAL STANDARDS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eEthical Approval: This study was approved by the Research Ethics Committee of the Province of Almer\u0026iacute;a (Approval No. AP-0009-2020-C1-F2, Internal Study Code: 2/2021) and was conducted in accordance with the principles outlined in the Declaration of Helsinki and national ethical guidelines.\u003c/p\u003e\n\u003cp\u003eInformed Consent: Written informed consent was obtained from all participants or their legal guardians before inclusion in the study. For participants under 18 years of age or those unable to provide informed consent, consent was obtained from a parent or legal guardian.\u003c/p\u003e\n\u003cp\u003eData Protection and Confidentiality: Patient confidentiality was ensured, and the study complied with the\u0026nbsp;Spanish Organic Law, 3/2018, December 5th, on the Protection of Personal Data and Guarantee of Digital Rights.\u003c/p\u003e\n\u003cp\u003eConflict of Interest Statement: The authors declare that they have no conflicts of interest related to this study.\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eACKNOWLEDGMENTS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe sincerely thank the families affected by Wolfram syndrome for their invaluable participation in this study, as well as the Spanish Association for Research and Support for Wolfram Syndrome for their continuous support and collaboration. We would like to acknowledge the work of the Spanish Wolfram Syndrome Clinical Team, which has been evaluating patients since 2011. In particular, we highlight the contributions of the specialties involved in this article, urology and endocrinology, with the participation of Dr. Jos\u0026eacute; Ignacio Abad Vivas-P\u0026eacute;rez (urologist) and Dr. Manuel Romero Mu\u0026ntilde;oz (endocrinologist), who have played a key role in patient assessment.\u003c/p\u003e\n\u003cp\u003eAdditionally, we recognize the incorporation of Dr. Pedro Mezquita Raya (endocrinologist) in recent years, further strengthening the team and contributing to the specialized evaluation of these clinical aspects.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003cstrong\u003eFUNDING:\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eWe acknowledge the Andalusian Regional Ministry of Health (Consejer\u0026iacute;a de Salud de Andaluc\u0026iacute;a) for supporting this project through the AP-0009-2020-C1-F2 FPS 2020 - Research Call for Primary Care, Regional Hospitals, and CHARES. Additionally, we thank the Consejer\u0026iacute;a de Salud de Andaluc\u0026iacute;a for its support through the \u0026ldquo;SAS 2024 - Refuerzo con Recursos Humanos de la Actividad Investigadora en las Unidades Cl\u0026iacute;nicas del Servicio Andaluz de Salud\u0026rdquo;; which has provided dedicated time for scientific investigation and contributed to the development of this study.\u0026nbsp;\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eEsteban Bueno G, Romero Mu\u0026ntilde;oz M, Navarro Cabrero M, Fern\u0026aacute;ndez P, L\u0026oacute;pez J, Garc\u0026iacute;a A, et al. Clinical Practice Guideline for Wolfram Syndrome (DIDMOAD). Soria, Spain: CEASGA-Publishing; 2020. Available from: https://reunir.unir.net/handle/123456789/15796.\u003c/li\u003e\n\u003cli\u003eNational Organization for Rare Disorders. Wolfram syndrome: symptoms, causes, treatment [Internet]. Danbury, CT: NORD; 2024 [updated 2025 Mar; cited 2025 Apr 8]. Available from: https://rarediseases.org/rare-diseases/wolfram-syndrome/.\u003c/li\u003e\n\u003cli\u003eCentre de Reference for Rare Eye Diseases (OPHTARA). National Protocol for Diagnosis and Care (PNDS): Wolfram syndrome [Internet]. Paris: Haute Autorit\u0026eacute; de Sant\u0026eacute;; 2019 [cited 2025 Apr 8]. Available from: https://www.has-sante.fr/jcms/p_3113807/fr/syndrome-de-wolfram-pnds\u003c/li\u003e\n\u003cli\u003eEsteban-Bueno G, Ruiz-Casta\u0026ntilde;eda D, Ruiz-Mart\u0026iacute;nez J, Romero-Mu\u0026ntilde;oz M, Carrillo-Alascio P. Natural history and clinical characteristics of 50 patients with Wolfram syndrome. Endocrine. 2018 Sep;61(3):440\u0026ndash;6. doi: 10.1007/s12020-018-1608-\u003c/li\u003e\n\u003cli\u003eDas L, Rai A, Mavuduru R, Vaiphei K, Sharma A, Gupta V, et al. Wolfram syndrome: clinical and genetic profiling of a cohort from a tertiary care centre with characterization of the primary gonadal failure. Endocrine. 2020 Aug;69(2):420\u0026ndash;9. doi: 10.1007/s12020-020-02320-6.\u003c/li\u003e\n\u003cli\u003eBarrett TG, Bundey SE. Wolfram (DIDMOAD) syndrome. J Med Genet. 1997 Oct;34(10):838\u0026ndash;41. doi: 10.1136/jmg.34.10.838.\u003c/li\u003e\n\u003cli\u003eEsteban-Bueno G, Berenguel Hern\u0026aacute;ndez AM, Fern\u0026aacute;ndez Fern\u0026aacute;ndez N, Navarro Cabrero M, Coca JR. Neurosensory Affectation in Patients Affected by Wolfram Syndrome: Descriptive and Longitudinal Analysis. Healthcare (Basel). 2023 Jun 29;11(13):1888. doi: 10.3390/healthcare11131888. PMID: 37444722; PMCID: PMC10340328. \u003c/li\u003e\n\u003cli\u003eEsteban G, Ruano M, Motero I. The quality of life in the relatives of Wolfram\u0026apos;s syndrome patients. Eur J Investig Health Psychol Educ. 2015;5(1):89\u0026ndash;97. doi: 10.3390/ejihpe5010009.\u003c/li\u003e\n\u003cli\u003eToppings NB, McMillan JM, Au PYB, Suchowersky O, Donovan LE. Wolfram syndrome: a case report and review of clinical manifestations, genetics, pathophysiology, and potential therapies. Case Rep Endocrinol. 2018;2018:9412676. doi: 10.1155/2018/9412676.\u003c/li\u003e\n\u003cli\u003eFrontino G, Di Tonno R, Stancampiano MR, Arrigoni F, Rigamonti A, Morotti E, et al. Paediatric Wolfram syndrome type 1: should gonadal dysfunction be considered a major criterion? Front Endocrinol (Lausanne). 2023;14:1155644. doi: 10.3389/fendo.2023.1155644. \u003c/li\u003e\n\u003cli\u003eJodoin A, Marchand M, Beltrand J. Wolfram syndrome in a young woman with associated hypergonadotropic hypogonadism: a case report. J Pediatr Endocrinol Metab. 2022;35(12):1552\u0026ndash;5. doi: 10.1515/jpem-2022-0268.\u003c/li\u003e\n\u003cli\u003eSimsek E, Simsek T, Tekg\u0026uuml;l S, Hosal S, Seyrantepe V, Aktan G. Wolfram (DIDMOAD) syndrome: a multidisciplinary clinical study in nine Turkish patients and review of the literature. Acta Paediatr. 2003;92(1):55\u0026ndash;61. doi: 10.1111/j.1651-2227.2003.tb00469.x.\u003c/li\u003e\n\u003cli\u003eCalapkulu M, Sencar ME, Unsal IO, Duger H, Kizilgul M, Bostan H, et al. A case of Wolfram syndrome with primary hypogonadism. Endocr Abstr. 2020;70:AEP601. doi: 10.1530/endoabs.70.AEP601. \u003c/li\u003e\n\u003cli\u003eSalzano G, Rigoli L, Valenzise M, Chimenz R, Passanisi S, Lombardo F. Clinical peculiarities in a cohort of patients with Wolfram syndrome 1. Int J Environ Res Public Health. 2022;19(1):520. doi: 10.3390/ijerph19010520.\u003c/li\u003e\n\u003cli\u003eBhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, Snyder PJ, Swerdloff RS, Wu FC, Yialamas MA. Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. \u003cem\u003eJ Clin Endocrinol Metab\u003c/em\u003e. 2018;103(5):1715-1744. https://doi.org/10.1210/jc.2018-00229.\u003c/li\u003e\n\u003cli\u003eBasaria S. Male hypogonadism. Lancet. 2014 Apr 5;383(9924):1250-1263. doi: 10.1016/S0140-6736(13)61126-5. \u003c/li\u003e\n\u003cli\u003eDewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, et al. The physiology and clinical utility of anti-Mullerian hormone in women. \u003cem\u003eHum Reprod Update\u003c/em\u003e. 2014 May-Jun;20(3):370-385. doi: 10.1093/humupd/dmt062.\u003c/li\u003e\n\u003cli\u003eRigoli L, Bramanti P, Di Bella C, De Luca F. Genetic and clinical aspects of Wolfram syndrome 1, a severe neurodegenerative disease. \u003cem\u003ePediatr Res\u003c/em\u003e. 2018;83(5):921\u0026ndash;929. doi: 10.1038/pr.2018.17.\u003c/li\u003e\n\u003cli\u003eNewell L, Cunningham O, Williams D, Barrett T, Dias R. Hypogonadism and pubertal disorders in Wolfram syndrome. \u003cem\u003eEndocr Abstr\u003c/em\u003e. 2022;85:OC7.3. doi: 10.1530/endoabs.85.OC7.3.\u003c/li\u003e\n\u003cli\u003eCorona G, Goulis DG, Huhtaniemi I, Zitzmann M, Toppari J, Forti G, et al. European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males. \u003cem\u003eAndrology\u003c/em\u003e. 2020;8(5):970\u0026ndash;987. doi: 10.1111/andr.12770.\u003c/li\u003e\n\u003cli\u003eEsteban-Bueno G, D\u0026iacute;az-Anad\u0026oacute;n LR, Fern\u0026aacute;ndez-Burriel M, Fern\u0026aacute;ndez-Burriel T, G\u0026oacute;mez-Trujillo F, Gonz\u0026aacute;lez-Casado I, et al. Genetic protocol in Primary Care for rare diseases: Wolfram syndrome as a prototype. \u003cem\u003eAten Primaria\u003c/em\u003e. 2022;54(5):102280. doi: 10.1016/j.aprim.2022.102280.\u003c/li\u003e\n\u003cli\u003eBoehm U, Bouloux PM, Dattani MT, de Roux N, Dod\u0026eacute; C, Dunkel L, et al. Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism\u0026mdash;pathogenesis, diagnosis and treatment. \u003cem\u003eNat Rev Endocrinol\u003c/em\u003e. 2015;11(9):547\u0026ndash;564. doi: 10.1038/nrendo.2015.112.\u003c/li\u003e\n\u003cli\u003eRamasamy R, Armstrong JM, Lipshultz LI. Preserving fertility in the hypogonadal patient: an update. \u003cem\u003eAsian J Androl\u003c/em\u003e. 2015;17(2):197\u0026ndash;200. doi: 10.4103/1008-682X.142772. \u003c/li\u003e\n\u003cli\u003eDewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, et al. The physiology and clinical utility of anti-Mullerian hormone in women. \u003cem\u003eHum Reprod Update\u003c/em\u003e. 2014 May-Jun;20(3):370\u0026ndash;385. doi: 10.1093/humupd/dmt062.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Wolfram syndrome, Gonadal failure, Hypogonadism, DIDMOAD, Quality of life, DIDMOAD","lastPublishedDoi":"10.21203/rs.3.rs-6403130/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6403130/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Wolfram syndrome (WFS), also known as DIDMOAD, is a rare monogenic neurodegenerative disorder characterized by 4 key components: non-autoimmune insulin-dependent diabetes mellitus (DM), optic atrophy, sensorineural hearing loss, and diabetes insipidus. Although it significantly affects quality of life, gonadal dysfunction, particularly hypogonadism, remains underrecognized.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003e45 patients (25 men, 20 women) with genetically confirmed WFS from a single tertiary care center were prospectively followed to assess gonadal function. Men underwent hormonal evaluations, semen analysis, imaging tests, and testicular biopsies. In women, data on age at menarche, menstrual irregularities, and age at menopause were recorded. Hormonal analyses, including anti-Müllerian hormone (AMH) levels, and imaging tests were also conducted.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e Hypogonadism was identified in 17 men, predominantly hypergonadotropic. Testicular biopsies showed seminiferous tubule damage, Sertoli cell predominance, and reduced Leydig cells. Azoospermia was observed in 12 patients, whereas others presented with oligozoospermia, teratozoospermia, or asthenozoospermia. Most patients exhibited low testosterone levels along with elevated LH and FSH, suggesting primary testicular failure, except for 2 cases of hypogonadotropic hypogonadism.\u003c/p\u003e\n\u003cp\u003eIn women, menstrual irregularities were universal, with 20% experiencing premature menopause. 4 patients had low AMH levels, with ovarian atrophy in 3 and a postmenopausal uterus in 2, indicating early hypogonadism risk.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions: \u003c/strong\u003eGonadal dysfunction is a significant yet overlooked feature of WFS, requiring systematic evaluation during puberty and beyond. Proper management is essential to mitigate metabolic disturbances and psychological impacts, including infertility distress, relationship challenges, and quality of life concerns. Addressing sexual health is crucial as WFS patients live longer and aspire to establish relationships or start families.\u003c/p\u003e","manuscriptTitle":"Gonadal Dysfunction in Wolfram Syndrome: A Prospective Study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-04-16 06:09:43","doi":"10.21203/rs.3.rs-6403130/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"91510336-7c8d-4c73-ada9-429f42e1b391","owner":[],"postedDate":"April 16th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-05-04T10:23:12+00:00","versionOfRecord":[],"versionCreatedAt":"2025-04-16 06:09:43","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6403130","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6403130","identity":"rs-6403130","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}