Clinicopathological features of ovarian clear cell carcinoma associated with ovarian endometriosis

Lisha Zhu; Ling Liu

doi:10.3877/cma.j.issn.1673-5250.2015.01.015

Clinicopathological features of ovarian clear cell carcinoma associated with ovarian endometriosis

Lisha Zhu, Ling Liu

In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2015 · vol. 11(1) , pp. 68–72 · doi:10.3877/cma.j.issn.1673-5250.2015.01.015 · W3029490003

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This study analyzed 60 ovarian clear cell carcinoma cases, finding those associated with endometriosis were more common in younger, nulliparous women, diagnosed at earlier stages, with no significant difference in survival.

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This retrospective study evaluated clinicopathological features and prognosis in 60 women with ovarian clear cell carcinoma (OCCC) undergoing surgery (2002–2011), stratified by whether they had co-existing ovarian endometriosis (EM) and whether EM showed malignant transformation. Patients were categorized into those with OCCC associated with malignant transformation ovarian EM (n=7), OCCC with ovarian EM without malignant transformation (n=15), and OCCC without ovarian EM (n=38), with outcomes compared using chart review of clinical symptoms, investigations, pathology, and follow-up survival; the authors explicitly note their analysis is based on retrospective data from a single center. The incidence of OCCC associated with ovarian EM was 36.4%, with malignant transformation occurring in 11.7% of OCCC cases; those with malignant transformation were younger and more often nulliparous, and the groups with ovarian EM had a higher proportion diagnosed at FIGO stage I, while CA125 levels and 5-year survival did not differ significantly across groups. This paper is centrally about endometriosis — it analyzes how ovarian endometriosis (including malignant transformation) is associated with the clinicopathological characteristics and prognosis of ovarian clear cell carcinoma.

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Abstract

Objective To explore the clinicopathological features and prognosis of patients with ovarian clear cell carcinoma(OCCC) associated with endometriosis(EM). Methods From January 2002 to November 2011, a total of 60 women with OCCC were included in the study and analyzed retrospectively.They were divided into group A (n=7, OCCC associated with malignant transformation ovarian EM), group B (n=15, OCCC associated ovarian EM)and group C (n=38, OCCC only). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Dalian Maternity Hospital.Informed consent was obtained from each participants.The clinical data were compared among these groups. Results The incidence rate of OCCC associated with ovarian EM was 36.4%(22/60), and 11.7%(7/60) women were diagnosed as OCCC associated with malignant transformation ovarian EM.There were more nulliparity in group A than that of group C, and significant difference was found between them(χ2=23.72, P=0.021). The mean age in group A was significantly younger than that of group C, and there was statistically significant difference (F=24.48, P=0.005). Through ultrasound examination, Group C showed more cystic and solid mixed mass than that of other groups (81.6% vs 42.9% and 53.3%), and there were significant differences among them (χ2=6.88, P=0.032). There was no significant difference among three groups in the incidence rate of serum CA125 0.05). Most of the patients in groups A and B were diagnosed at stage Ⅰ, which was obviously higher than that of group C (100.0% and 80.0% vs 57.9%), and there was statistically significant difference (χ2=6.10, P=0.047). The five-year survival rate among three groups were 50.0%, 71.4%, 36.8%, respectively, no significant difference was observed among them(P>0.05). Conclusions Most of OCCC associated ovarian EM patients were found to be younger, nonporous, and at an early stage, lower serum CA125 level with better prognosis.Young patients with ovarian EM still need to wary of the malignant transformation. Key words: Endometriosis; Ovarian clear cell carcinoma; Malignant transformation

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Objective

To explore the clinicopathological features and prognosis of patients with ovarian clear cell carcinoma(OCCC) associated with endometriosis(EM).

Methods

From January 2002 to November 2011, a total of 60 women with OCCC were included in the study and analyzed retrospectively.They were divided into group A (n=7, OCCC associated with malignant transformation ovarian EM), group B (n=15, OCCC associated ovarian EM)and group C (n=38, OCCC only). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Dalian Maternity Hospital.Informed consent was obtained from each participants.The clinical data were compared among these groups.

Results

The incidence rate of OCCC associated with ovarian EM was 36.4%(22/60), and 11.7%(7/60) women were diagnosed as OCCC associated with malignant transformation ovarian EM.There were more nulliparity in group A than that of group C, and significant difference was found between them(χ2=23.72, P=0.021). The mean age in group A was significantly younger than that of group C, and there was statistically significant difference (F=24.48, P=0.005). Through ultrasound examination, Group C showed more cystic and solid mixed mass than that of other groups (81.6% vs 42.9% and 53.3%), and there were significant differences among them (χ2=6.88, P=0.032). There was no significant difference among three groups in the incidence rate of serum CA1250.05). Most of the patients in groups A and B were diagnosed at stage Ⅰ, which was obviously higher than that of group C (100.0% and 80.0% vs 57.9%), and there was statistically significant difference (χ2=6.10, P=0.047). The five-year survival rate among three groups were 50.0%, 71.4%, 36.8%, respectively, no significant difference was observed among them(P>0.05).

Conclusions

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