Study on the Relationship Between Myocardial Microcirculation Perfusion and Electrocardiogram ST Segment Depression in Patients With Hypertrophic Cardiomyopathy

Objective: To investigate the correlation between myocardial microcirculation perfusion status and the ST-segment depression(STD) in patients with hypertrophic cardiomyopathy (HCM) Method: Myocardial microcirculation perfusion of 32 patients with HCM (HCM group) and 28 healthy volunteers (control group) were examined using MCE, and the parameters including peak intensity (PI), area under the curve (AUC), rising slope (RS), and the time to peak (TTP) were analyzed. All subjects were examined by electrocardiogram, and the amplitude of downward movement of ST segment was measured. Then patients were divided into 3 groups according to the degree of downward movement of ST segment: ST1 group (0<ST≤0.1 MV); ST2 group (0.1 MV<ST≤0.2MV); ST3 group (0.2< MV<ST≤0.3 MV). At last, the relationship between myocardial microcirculation disorder and the degree of ST segment depression was explored. Results: : Patents with HCM exhibit lower PI and AUC than their healthy counterparts ( P 0.05). ST depression was found in all the patients in the HCM group (P < 0.001). There was no significant linear correlation between PI and the degree of ST segment depression (r = -0.348). Then PI value was compared among ST1, ST2, ST3 and control group. The results showed that the PI value in both ST1 group and ST2 group differs from ST3 group (P < 0.01), while there was no significant difference between ST1 and ST2 group (P < 0.05). Conclusion: When ST depressed more than 0.20 mV, the STD is related to the decrease of microcirculation perfusion in hypertrophic myocardium.