The effect of the anti-diabetic drug metformin on behavioral manifestations associated with ovariectomy in mice

Iman Fatemi, Fatemeh Delrobaee, Maryam Bahmani, Ali Shamsizadeh, Mohammad Allahtavakoli
Neuroscience letters · 2018 · vol. 690 , pp. 95–98 · doi:10.1016/j.neulet.2018.10.024 · PMID:30321576 · W2896464330
Lab / animal OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-10-11 ⓘ

Metformin administration improved anxiety, cognitive impairment, and brain-derived neurotrophic factor levels in ovariectomized mice, indicating its potential therapeutic value for conditions associated with surgical menopause.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The aim of this study was to evaluate the anti-diabetic drug metformin (Met) effects on the anxiety and cognitive impairment in ovariectomized mice. Thirty-two female adult mice were distributed into four groups: control, sham ovariectomy, ovariectomy + Met 7 mg/kg and ovariectomy + Met 15 mg/kg. The vaginal cytology was used to confirm the ovariectomy surgery. Anxiety was monitored using elevated plus maze test and cognitive function was assessed by novel object recognition task. Animal's brains were analyzed for the brain-derived neurotrophic factor (BDNF). Our results demonstrated that ovariectomy caused cognitive impairments and anxiety, as well as decreased BDNF levels. Moreover, administration of Met improves ovariectomy-related disorders such as cognitive impairments and anxiety, as well as increased BDNF levels. The results of the present study suggest that Met could be used as a novel therapeutic strategy for the treatment of ovariectomy-related conditions.

My notes (saved in your browser only)

MeSH descriptors

Hypoglycemic Agents Maze Learning Metformin Ovariectomy Recognition, Psychology Animals Brain Brain Brain-Derived Neurotrophic Factor Brain-Derived Neurotrophic Factor Dose-Response Relationship, Drug Female Hypoglycemic Agents Maze Learning Metformin Mice Ovariectomy Recognition, Psychology

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (41)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:23:08.188623+00:00
unpaywall
last seen: 2026-11-14T06:25:03.947826+00:00
License: CC0 · commercial use OK