Elevated serum alpha-hydroxybutyrate dehydrogenase in patients with ovarian carcinoma

Kikuchi Y, Y Kikuchi, Momose E, E Momose, Kizawa I, I Kizawa, Kuki E, E Kuki, K. Kato, Kato K
Acta obstetricia et gynecologica Scandinavica · 1985 · doi:10.3109/00016348509156361 · PMID:4082930
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Serum alpha-hydroxybutyrate dehydrogenase and lactate dehydrogenase activities, as well as LDH-4 and LDH-5 isoenzymes, were significantly elevated in ovarian carcinoma patients compared to those with benign ovarian tumors.

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Abstract

To differentiate between ovarian carcinoma and benign ovarian tumor, we compared alpha-hydroxybutyrate dehydrogenase (HBD), lactate dehydrogenase (LDH) and its isoenzyme activities in serum in 115 patients with ovarian carcinoma and benign ovarian tumor. Both serum HBD activity and total LDH activity in ovarian cancer patients were significantly (p less than 0.001) higher than that in patients with benign ovarian tumor. From analysis of serum LDH isoenzymes, a significant decrease in LDH-1, and significant increases in LDH-4 and LDH-5 in ovarian cancer patients were observed, when compared with those in patients with benign ovarian tumor. When the ovarian cancer mass could be removed surgically, a significant decrease in the HBD was observed, suggesting that the HBD might fairly reflect the tumor burden. Serum HBD activities in a half of ovarian cancer patients were higher than the mean +2 SD of those in benign control subjects.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma Hydroxybutyrate Dehydrogenase Ovarian Neoplasms Adenocarcinoma Adenocarcinoma Adolescent Adult Carcinoma Cystadenocarcinoma Cystadenocarcinoma Cystadenoma Cystadenoma Dermoid Cyst Dermoid Cyst Endometriosis Endometriosis Female Humans Hydroxybutyrate Dehydrogenase Isoenzymes

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europepmc
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pubmed
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