Relationship Between Endometriotic Pain and Antagonist of Bradykinin B1 Receptor

Endometriosis is defined as ectopic endometrium locates outside the cavity of uterus,with pain as the most distinguish clinical manisfestation.So far,the pathogenesis of the pain in endometriosis is unclear yet.Bradykinin is the strongest algogen,and bradykinin B1 receptor is considered as one of the main factors that maintain inflammation and pain.Previous studies have revealed that bradykinin B1 receptor antagonist could effectively be used in treating inflammation and pain.Recent research progress on endometriotic pain and bradykinin B1 receptor antagonist has been reviewed in this article.