Absorption of 17β-estradiol in a neovagina constructed from the peritoneum

Wim N.P. Willemsen, Jaap L. Mastboom, Chris M.G. Thomas, R. Rolland
In: European Journal of Obstetrics & Gynecology and Reproductive Biology · 1985 · vol. 19(4) , pp. 247–253 · doi:10.1016/0028-2243(85)90036-x · PMID:3924675 · W2062240576
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Abstract

Estrogen absorption from the neovagina was studied by administering 2.0 mg of micronized 17 beta-estradiol (E2) neovaginally to 6 patients. The neovagina in each patient was constructed by using the peritoneum from the pouch of Douglas. A mean peak of circulating E2 concentrations more than 15-times the basal level was achieved 90 min after the application. Until 12.5 h after the application, the E2 levels were significantly (P less than 10(-6)) elevated. FSH levels were significantly (P = 0.003) changed in comparison to the basal serum concentration. There was no significant (P = 0.08) change in LH levels. The resorption of estradiol from the neovagina is similar to that seen in women with normal vaginas.

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