Expression of platelet-derived endothelial cell growth factor (PD-ECGF) related to angiogenesis in ovarian endometriosis

Fujimoto J, J Fujimoto, Sakaguchi H, H Sakaguchi, R Hirose, Hirose R, Tamaya T, T Tamaya
The Journal of clinical endocrinology and metabolism · 1999 · doi:10.1210/jcem.84.1.5372 · PMID:9920107
other OA: bronze public-domain-us
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Abstract

Platelet-derived endothelial cell growth factor (PD-ECGF) is expressed in the lining epithelial cells of ovarian endometriomas, and in interstitial cells of the subepithelial area with angiogenesis. The expression of PD-ECGF persists in endometriotic endometrium during the menstrual cycle. This might suggest that PD-ECGF contributes to the growth of ovarian endometriomas via subepithelial angiogenesis independently of the sex steroidal milieu.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neovascularization, Pathologic Ovarian Diseases Thymidine Phosphorylase Adult Endometriosis Endometriosis Female Humans Immunohistochemistry Neovascularization, Pathologic Ovarian Diseases RNA, Messenger RNA, Messenger Thymidine Phosphorylase Thymidine Phosphorylase

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europepmc
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pubmed
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