Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model

Salah, Mohamed, Tahoun, Mariam, Rudzitis-Auth, Jeannette, Stotz, Lisa, Van Koppen, Chris J., Laschke, Matthias W., Abdelsamie, Ahmed S., Frotscher, Martin
2023 · doi:10.22028/d291-43361 · W6963702521
other OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-08-02 ⓘ

Researchers developed potent dual inhibitors of steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 with favorable pharmacokinetics for in vivo endometriosis studies.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Full text 1,893 characters · extracted from oa-html · click to expand
Please use this identifier to cite or link to this item: Volltext verfügbar? / Dokumentlieferung doi:10.22028/D291-43361 | Title: | Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model | | Author(s): | Salah, Mohamed Tahoun, Mariam Rudzitis-Auth, Jeannette Stotz, Lisa van Koppen, Chris J. Laschke, Matthias W. Abdelsamie, Ahmed S. Frotscher, Martin | | Language: | English | | Title: | Journal of Medicinal Chemistry | | Volume: | 66 | | Issue: | 13 | | Pages: | 8975-8992 | | Publisher/Platform: | ACS | | Year of Publication: | 2023 | | Free key words: | Inhibition Peptides And Proteins Plasma Rodent Models Scanning Tunneling Spectroscopy | | DDC notations: | 610 Medicine and health | | Publikation type: | Journal Article | | DOI of the first publication: | 10.1021/acs.jmedchem.3c00571 | | URL of the first publication: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00571 | | Link to this record: | urn:nbn:de:bsz:291--ds-433618 hdl:20.500.11880/38889 http://dx.doi.org/10.22028/D291-43361 | | ISSN: | 1520-4804 0022-2623 | | Date of registration: | 6-Nov-2024 | | Description of the related object: | Supporting Information | | Related object: | https://ndownloader.figstatic.com/collections/6716299/versions/1 | | Faculty: | M - Medizinische Fakultät NT - Naturwissenschaftlich- Technische Fakultät | | Department: | M - Chirurgie M - Frauenheilkunde NT - Pharmazie | | Professorship: | M - Prof. Dr. Michael D. Menger M - Prof. Dr. E.-F. Solomayer NT - Keiner Professur zugeordnet | | Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes | Files for this record: There are no files associated with this item. Items in SciDok are protected by copyright, with all rights reserved, unless otherwise indicated.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-05-10T11:01:59.892497+00:00
License: CC0 · commercial use OK