Digestive Involvement in SARS-CoV-2 Infection: A Retrospective Multi-center Study

Digestive Involvement in SARS-CoV-2 Infection: A Retrospective Multi-center Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Digestive Involvement in SARS-CoV-2 Infection: A Retrospective Multi-center Study Haitao Shang, Chao Huang, Yuhua Chen, Shengyan Zhang, Pengcheng Yang, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-21375/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Coronavirus disease 2019 (COVID-19) is an emerged infection raised wide concerns for the pneumonia and respiratory manifestations. Also, digestive complications are frequently observed in COVID-19 patients but the significance remains undetermined. Methods A retrospective analysis of alimentary symptoms, liver dysfunctions and other clinical parameters of 514 hospitalized COVID-19 patients (282 mild, 162 severe and 70 critical cases) admitted to the 3 designated medical units of Wuhan Union Hospital from Jan 20 to Feb 29, 2020 was performed. Results 1) A series of alimentary symptoms, including poor appetite(50.2%), diarrhea(25.5%), nausea(16.3%), vomit(11.9%) and abdominal pain(3.3%), presented in COVID-19 patients. 2) Diarrhea was common gastrointestinal symptom with higher morbidity in the severe and critical patients (32.1% and 27.1% respectively), and 13.2% patients developed diarrhea in the first 3 days after onset of symptoms. Those with diarrhea were reported more apparent systemic inflammation and liver injury in severe and critical cases compared with patients without diarrhea. 3) Notably, 31 patients (6.03%) presented with diarrhea in the absence of respiratory symptoms. These patients were observed less systemic inflammatory activity relative to diarrhea patients combined with respiratory symptoms. 4) Also, liver injury was high incident in COVID-19 patients with increased alanine aminotransferase (43.3%), aspartate transaminase (36.7%) and decreased albumin (80.9%), but less increased total bilirubin (10.9%) and direct bilirubin(14.2%), which were more serious in the severe to critical patients. Conclusions Our data favored in the process of novel SARS-CoV-2 infection. There may be a “gut-type” in the clinical prevention and management that differ from the “lung-type” in COVID-19 sufferers. Infectious Diseases Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Digestive system Diarrhea Liver injury COVID-19 Figures Figure 1 Figure 2 Introduction Coronavirus disease 2019（COVID-19）is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV), which was firstly identified in Wuhan, China, last December 2019, and has rapidly outbreak worldwide[1-4]. It recently has been declared a public health emergency of international concern by World Health Organization (WHO). As of March 20, 2020, COVID-19 has affected more than 200,000 individuals and caused over 8,500 deaths globally[5]. It is well established that most patients with COVID-19 have fever along with respiratory symptoms, such as dry cough and dyspnea[1, 6]. However, there is increasing evidence that, in addition to typical respiratory symptom, COVID-19 can also present with gastrointestinal symptoms (especially for diarrhea) and liver injury[7, 8]. Moreover, it was also reported that some patients present initially with gastrointestinal symptoms[9]. This may lead to misdiagnosis in the clinic, and the digestive involvement of COVID-19 should be recognized and valued. SARS-CoV-2 is an accepted respiratory transmitting virus that spread via droplets [10], also through close contact with mucous membranes in the eyes, mouth or nose [11, 12]. Apart from the oropharyngeal swab, nasopharyngeal swab and sputum, the viral nucleic acid could also be detected in saliva and feces[13, 14]. Moreover, in clinical practice, we found stool samples test from COVID-19 were positive while respiratory samples are negative. Importantly, angiotensin converting enzyme 2 (ACE2), identified as the cell entry receptor of SARS-CoV-2[15, 16], were most remarkable expression on the surface of small intestinal epithelial cell[15, 17]. In summary, SARS-CoV-2 may be present in the gut, leading to the alimentary damage and symptoms, and possible fecal-oral transmission. In this retrospective study, we describe the clinical features of hospitalized COVID-19 patients with variable severity, that is the mild, severe and critical patients. We focused on the alimentary symptoms and liver injury in COVID-19 patients and attempted to find if there is any significant difference in the patients with or without digestive manifestations, to provide evidence for the digestive involvement in the clinical prevention and management of SARS-CoV-2 infection. Methods Study Design and Participants The protocol of this study was seen in Figure 1. The clinical records of 521 consecutive patients fulfilled with the diagnostic criteria of COVID-19 according to World Health Organization interim guidance [18], who admitted to the 3 designated COVID-19 care medical institutions affiliated to Wuhan Union Hospital of Tongji Medical College from Jan 20 to Feb 29, 2020 were enrolled. All patients were given verbal informed consent. Seven cases were excluded for incomplete data, and 514 laboratory-confirmed COVID-19 cases were used for analysis. Patients were divided into mild (282 cases), severe (162 cases) and critical (70 cases) subgroups based on the clinical classification of COVID-19[19]. The clinical outcomes were monitored up to March 8, 2020, the final date of follow-up. This study was approved by the Medical Ethical Review Committee, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, China ([2020] No.0033). Study Definitions The confirmed case of COVID-19 is defined as positive SARS-CoV-2 nucleic acid in oropharyngeal or nasopharyngeal swab specimens via real-time fluorescence reverse transcription-polymerase chain reaction (RT-PCR). Only laboratory-confirmed cases were included in the analysis[18, 19]. The mild cases refer to mild patient with fever, respiratory and/or other symptoms, and typical imaging findings of viral pneumonia. The severe cases had to meet one or more of the following conditions: 1) with shortness breath and respiratory frequency ≥30 per minute; 2) blood oxygen saturation ≤93% in resting condition; 3) arterial partial pressure of oxygen (PaO 2 )/ fraction of inspired oxygen (FiO 2 ) ≤300 mmHg. The critical patients should present with 1) respiratory failure that need mechanical ventilation, and/or 2) shock, and/or 3) combined with other organ failure and need intensive care unit (ICU) treatment. All definitions are consistent with the “Diagnosis and Treatment Scheme of New Coronavirus Infected Pneumonia” (trial version 6) released by Chinese National Health Commission and the World Health Organization interim guidance for COVID-19[19]. Data collection The demographic data, clinical charts including epidemiological history, past medical history, clinical symptoms and signs, medical and nursing records, laboratory findings, chest CT scans and viral nucleic acid test for all COVID-19 patients were extracted from electronic medical records. Particularly, symptoms of fever, cough, expectoration, fatigue, shortness of breath, chest tightness, muscle soreness, poor appetite, nausea, vomit, diarrhea and abdominal pain were recorded in detail. Main laboratory parameters were extracted, including routine blood tests (white blood cell [WBC], neutrophil and lymphocyte), inflammatory markers (procalcitonin, C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], ferritin and fibrinogen), liver injury marker (total and direct bilirubin, alanine aminotransferase [ALT], aspartate transaminase [AST], lactate dehydrogenase [LDH], alkaline phosphatase [ALP], γ-glutamyl transferase [GGT], Pre-albumin and Albumin), kidney injury marker (blood urea nitrogen [BUN], creatinine, urine protein and occult blood), and myocardial injury marker (high sensitive troponin I [hsTNI]). The treatment (ie, antiviral, antibiotic, corticosteroid, immunomodulation and respiratory support) and outcomes data were further obtained. The collected data were reviewed and checked by 4 trained researchers and attending clinicians independently. Statistical Analysis Categorical variables were described as number (%) and compared with χ² test, or Fisher’s exact test when the data were limited. Continuous data were expressed as median (IQR) and compared via the Kruskal-Wallis test followed by a Dunn’s post-test. A 2- sided α＜0.05 was considered statistically significant. All statistical analyses were performed using the R software, version 3.5.1 (R Foundation for Statistical Computing). The statistical graphs were created via the GraphPad Prism package, version 8 (GraphPad Software, LLC). Results Baseline Characteristics The demographic and clinical characteristics were shown in Table 1. A total of 514 hospitalized patients with confirmed SARS-CoV-2 infection including 282 mild, 162 severe and 70 critical cases were included in the present analysis. The media age was 54 years, ranged from 23 to 96 years, and older in the severe and critical suffers. Totally, 271 (53.1%) patients were male, and the proportion of male was much higher than female in the critical ones (70.0%). The common symptoms were fever (87.6%), cough (70.2%), fatigue (58.4%), chest tightness (52.0%), shortness of breath (44.2%), expectoration (29.8%), muscle soreness (19.8%) and pharyngodynia (2.9%). Compared with mild patients, more serious fever (92.6% and 90.0% respectively) with higher maximal temperature, chest tightness and shortness of breath were observed in the severe and critical patients. Hypertension (43.2%), diabetes (19.3%) and cardiovascular disease (12.7%) were the most common comorbidity. Especially, hypertension was associated with disease severity that higher in severe (60.5%) and critical (55.7%) patients. The severe to critical patients exhibited more serious infection and inflammation with higher white blood cell and neutrophil, declined lymphocyte, enhanced levels of CRP, ESR, procalcitonin and ferritin (all P<0.001). Table 1 Baseline Characteristics of COVID-19 patients. Total （ N=514 ） Mild （ N=282 ） Severe （ N=162 ） Critical （ N=70 ） P Age (years) 54 (48-68) 50 (45-64) 65 (56-72) 64 (57-72) <0.001 Gender (male/female) 271/243 135/147 87/75 49/21 0.004 Fever 450 (87.6%) 237 (84.0%) 150 (92.6%) 63 (90.0%) 0.025 Highest temperature, °C 38.5 (37.9-39.0) 38.5 (37.8-39.0) 38.5 (38.0-39.0) 38.8 (38.2-39.0) 0.020 Cough 361 (70.2%) 195 (69.2%) 122 (75.3%) 44 (62.9%) 0.137 Expectoration 153 (29.8%) 81 (28.7%) 52 (32.1%) 20 (28.6%) 0.735 Fatigue 300 (58.4%) 160 (56.7%) 93 (57.4%) 47 (67.1%) 0.274 Shortness of breath 227 (44.2%) 87 (30.9%) 92 (56.8%) 48 (68.6%) <0.001 Chest tightness 267 (52.0%) 130 (46.1%) 87 (53.7%) 50 (71.4%) <0.001 Pharyngodynia 15 (2.9%) 11 (3.9%) 2 (1.2%) 2 (2.9%) 0.275 Muscle soreness 102 (19.8%) 63 (22.3%) 29 (17.9%) 10 (14.3%) 0.241 Presenting Comorbidity Hypertension 222 (43.2%) 85 (30.1%) 98 (60.5%) 39 (55.7%) <0.001 Diabetes 99 (19.3%) 45 (16.0%) 40 (24.7%) 14 (20.0%) 0.079 Cardiovascular disease 65 (12.7%) 32 (11.4%) 21 (13.0%) 12 (17.1%) 0.422 Chronic obstructive pulmonary disease 21 (4.1%) 6 (2.1%) 11 (6.8%) 4 (5.7%) 0.044 Bronchial asthma 10 (2.0%) 7 (2.5%) 2 (1.2%) 1 (1.4%) 0.621 Cerebralvascular disease 9 (1.8%) 9 (3.2%) 7 (4.3%) 5 (7.1%) 0.322 Chronic liver disease 8 (1.6%) 2 (0.7%) 4 (2.5%) 2 (2.9%) 0.226 Chronic kidney disease 21 (4.1%) 2 (0.7%) 5 (3.1%) 2 (2.9%) 0.138 Malignancy 28 (5.5%) 13 (4.6%) 12 (7.4%) 3 (4.3%) 0.412 Infection and Inflammation White blood cell (x10 9 /L) 5.65 (4.38-7.60) 5.08 (4.04-6.64) 6.12 (4.66-8.34) 9.74 (7.19-12.27) <0.001 Neutrophil (x10 9 /L) 3.98 (2.97-6.32) 3.46 (2.62-4.38) 4.82 (3.48-6.73) 8.53 (6.30-11.41) <0.001 Lymphocyte (x10 9 /L) 0.93 (0.68-1.27) 1.08 (0.82-1.47) 0.77 (0.59-1.04) 0.54 (0.44-0.80) <0.001 Procalcitonin (ng/mL) 0.09 (0.05-0.16) 0.06 (0.04-0.09) 0.12 (0.07-0.20) 0.33 (0.17-0.89) <0.001 C-reactive protein (mg/L) 34.82 (11.10-71.97) 16.55 (4.00-38.99) 52.82 (29.27-77.53) 114.60 (74.27-138.80) <0.001 Erythrocyte sedimentation rate (mm/h) 46 (25-69) 34 (19-53) 61 (44-80) 71 (44-82) <0.001 Ferritin (ng/mL) 332.1 (127.1-768.9) 160.2 (101.7-300.2) 620.1 (391.0-862.8) 1768.2 (1215.3-2000.0) <0.001 Fibrinogen (g/L) 4.44 (3.58-5.07) 4.14 (3.35-4.95) 4.73 (4.04-5.19) 4.58 (2.48-5.52) <0.001 Note: Continuous variables are presented as median (25th-75th percentiles), and categorical variables are presented as count (percentage). Alimentary symptoms and liver function injury A series of alimentary symptoms including poor appetite (50.2%), diarrhea (25.5%), nausea (16.3%), vomit (11.9%) and abdominal pain (3.3%) presented in COVID-19 patients (Table 2). Diarrhea was quite common gastrointestinal symptom with higher morbidity in the severe and critical patients (32.1% and 27.1% respectively) than the mild patients (21.3%). The diarrhea was mainly watery in nature without mucus or blood, and abdominal pain was rarely observed. The severity of diarrhea varied among patients, most patients had a few loose or watery stools but some patients had up to 20 bowel movements per day. About 13.2% patients developed diarrhea in the first 3 days after the onset of symptoms, and 63.2% diarrhea was occurred in the previous 10 days (Figure S1). There were 31 patients (6.03%) presented with diarrhea in the absence of respiratory symptoms, including 23 mild cases and 8 severe cases (Figure 2). Moreover, 9 patients (1.75%) had only diarrhea without fever and respiratory symptoms. Table 2 Digestive system involvements in COVID-19 patients include the alimentary symptoms and liver function injury. Total （ N=514 ） Mild （ N=282 ） Severe （ N=162 ） Critical （ N=70 ） P Alimentary symptoms Poor appetite 258 (50.2%) 124 (44.0%) 92 (56.8%) 42 (60.0%) 0.007 Nausea 84 (16.3%) 50 (17.7%) 27 (16.7%) 7 (10.0%) 0.291 Vomit 61 (11.9%) 33 (11.7%) 23 (14.2%) 5 (7.1%) 0.310 Diarrhea 131 (25.5%) 60 (21.3%) 52 (32.1%) 19 (27.1%) 0.040 Abdominal pain 17 (3.3%) 11 (3.9%) 5 (3.1%) 1 (1.4%) 0.243 Liver function injury Total bilirubin (μmol/L) 10.8 (8.1-14.3) 10.2 (7.6-12.4) 11.5 (8.4-15.3) 14.9 (8.7-23.0) <0.001 ≤20.0μmol/L 458 (89.1%) 273 (96.8%) 140 (86.4%) 45 (64.3%) <0.001 20.0 ∽ 34.2 μmol/L 43 (8.4%) 9 (3.2%) 17 (10.5%) 17 (24.3%) ＞ 34.2μmol/L 13 (2.5%) 0 (0.0%) 5 (3.1%) 8 (11.4%) Direct bilirubin (μmol/L) 3.6 (2.6-4.9) 3.1 (2.4-4.0) 3.9 (3.0-5.2) 6.2 (4.0-10.8) <0.001 ≤6.8μmol/L 441 (85.8%) 269 (95.4%) 134 (82.7%) 38 (54.3%) <0.001 6.8 ∽ 13.6 μmol/L 61 (11.9%) 13 (4.6%) 23 (14.2%) 25 (35.7%) ＞ 13.6μmol/L 12 (2.3%) 0 (0.0%) 5 (3.1%) 7 (10.0%) Alanine aminotransferase (U/L) 34 (22-55) 28 (19-46) 41 (26-60) 87 (44-111) <0.001 ≤40U/L 290 (56.6%) 185 (65.8%) 81 (50.0%) 24 (34.8%) <0.001 40 ∽ 80 U/L 163 (31.8%) 82 (29.2%) 59 (36.4%) 22 (31.9%) ≥80 U/L 59 (11.5%) 14 (5.0%) 22 (13.6%) 23 (33.3%) Aspartate transaminase (U/L) 33 (23-47) 27 (20-39) 38 (26-55) 67 (44-82) <0.001 ≤40U/L 324 (63.3%) 222 (79.0%) 88 (54.3%) 14 (20.3%) <0.001 40 ∽ 80 U/L 150 (29.3%) 55 (19.6%) 59 (36.4%) 36 (52.2%) ≥80 U/L 38 (7.4%) 4 (1.4%) 15 (9.3%) 19 (27.5%) Lactate dehydrogenase (U/L) 277 (211-371) 229 (192-295) 314 (251-385) 561 (396-680) <0.001 ≤245U/L 204 (39.7%) 167 (59.4%) 37 (22.7%) 0 (0.0%) 245U/L 310 (60.3%) 115 (40.6%) 125 (77.3%) 70 (100.0%) Alkaline phosphatase (U/L) 54 (43-71) 52 (43-66) 53 (43-67) 78 (62-122) <0.001 ≤150U/L 496 (96.5%) 280 (99.3%) 156 (96.3%) 60 (85.7%) 150U/L 18 (3.5%) 2 (0.7%) 6 (3.7%) 10 (14.3%) γ -Glutamyl transferase (U/L) 31 (20-56) 27 (17-47) 33 (23-67) 60 (28-116) <0.001 ≤60U/L 396 (77.0%) 246 (87.2%) 115 (71.2%) 35 (50.0%) <0.001 60 ∽ 120 U/L 67 (13.0%) 22 (7.8%) 28 (17.2%) 17 (24.3%) ≥120 U/L 51 (9.9%) 14 (5.0%) 19 (11.7%) 18 (25.7%) Pre-albumin (g/L) 129.8 (90.4-186.5) 149.7 (117.5-207.3) 111.6 (80.5-156.2) 84.5 (56.2-109.9) <0.001 Albumin (g/L) 30.1 (26.8-33.9) 32.1 (28.5-35.3) 28.8 (25.9-31.6) 26.8 (24.1-29.0) <0.001 ≥35 g/L 98 (19.1%) 79 (28.1%) 15 (9.2%) 4 (5.7%) <0.001 30 ∽ 35 g/L 164 (31.9%) 111 (39.2%) 46 (27.6%) 9 (12.9%) ≤30 g/L 252 (49.0%) 92 (32.7%) 103 (63.2%) 57 (81.4%) Globulin (g/L) 31.6 (28.6-35.2) 30.9 (27.8-33.6) 32.0 (29.3-36.1) 35.7 (31.2-39.5) <0.001 ≤30 g/L 180 (35.0%) 116 (41.3%) 51 (30.7%) 14 (20.0%) <0.001 30 ∽ 35 g/L 203 (39.5%) 127 (44.8%) 59 (36.2%) 18 (25.7%) ≥35 g/L 131 (25.5%) 39 (13.9%) 54 (33.1%) 38 (54.3%) Albumin/Globulin 1.0 (0.8-1.1) 1.0 (0.9-1.2) 0.9 (0.7-1.1) 0.8 (0.6-0.9) <0.001 Note: Continuous variables are presented as median (25th-75th percentiles), and categorical variables are presented as count (percentage). Liver injury was also frequently observed in patients with COVID-19 (Table 2), with increased ALT (43.3%), AST (36.7%) and decreased albumin (80.9%), but less increased total bilirubin (10.9%) and direct bilirubin (14.2%), which were more common in the severe to critical patients. It indicated a major damage of the hepatocytes and synthetic function, but not the function of bile secretion, in COVID-19 associated liver injury. However, most of the cases were mild injury. Those with relatively severe liver damage (ALT≥80 U/L) only accounted for 7.4% of the total patients, and 27.5% of the critical suffers. The liver injury was associated with higher inflammatory activity, such as increased white blood cell and neutrophil counts but declined lymphocyte counts, and elevated levels of CRP, ESR, procalcitonin and ferritin (Table S2). Clinical characteristics of patients with and without diarrhea There were 131 patients (25.49%, including 60 mild and 71 severe/critical cases) presented with diarrhea, and 383 patients (74.51%, including 222 mild and 161 severe/critical cases) without diarrhea (Figure 2). In the mild cases, patients with diarrhea had only slightly increased neutrophil (P=0.021) and decreased lymphocyte (P=0.011), but had no significant difference in multiorgan functions, compared with those absent of diarrhea (Table 3). In the severe/critical cases, there was increased WBC (P=0.030) and neutrophil (P=0.010) and trend to decreased lymphocyte (P=0.082), as well as higher level of inflammatory ferritin in patients with diarrhea relative to those without diarrhea. Moreover, diarrhea evidently companied with the more serious liver injury with increased activities of serum ALT, AST and LDH, and raised levels of total and direct bilirubin (Table 3). Table 3 Comparisons of COVID-19 patients with and without diarrhea, including the systemic inflammation and multiorgan function. Mild patients Severe/ Critical patients With Diarrhea (N=60) Without Diarrhea (N=222) P With Diarrhea (N=71) Without Diarrhea (N=161) P Age (years) 52 (38-63) 54 (46-66) 0.068 65 (57-72) 64 (57-71) 0.798 Gender (m/f) 26/34 109/113 0.428 43/28 93/68 0.690 Fever 45 (75.0%) 192 (86.5%) 0.045 62 (87.3%) 151 (93.8%) 0.098 Highest temperature, °C 38.3 (37.7-38.9) 38.5 (37.8-39.0) 0.140 38.7 (38.0-39.0) 38.5 (38.0-39.0) 0.542 Infection and Inflammation White blood cell (x10 9 /L) 5.08 (4.03-6.27) 5.08 (4.07-6.70) 0.387 7.45 (5.07-10.14) 6.28 (4.50-8.49) 0.030 Neutrophil (x10 9 /L) 3.51 (2.66-4.76) 3.23 (2.40-3.96) 0.021 6.29 (3.91-8.48) 4.50 (3.04-7.32) 0.010 Lymphocyte (x10 9 /L) 1.05 (0.81-1.40) 1.17 (0.90-1.88) 0.011 0.61 (0.42-0.89) 0.79 (0.57-1.07) 0.082 Procalcitonin (ng/mL) 0.06 (0.04-0.09) 0.05 (0.04-0.09) 0.119 0.14 (0.09-0.28) 0.14 (0.07-0.40) 0.571 C-reactive protein (mg/L) 17.52 (3.90-36.85) 16.55 (4.25-39.00) 0.956 67.35 (38.70-109.60) 65.92 (26.82-98.94) 0.499 Erythrocyte sedimentation rate (mm/h) 31.0 (18.0-44.0) 34.5 (20.3-53.8) 0.327 62.5 (44.0-80.3) 60.5 (42.5-81.0) 0.689 Ferritin (ng/mL) 173.9 (98.8-300.0) 160.2 (105.4-300.2) 0.896 818.0 (547.8-1562.3) 663.1 (404.8-1298.0) 0.041 Fibrinogen (g/L) 4.03 (3.39-4.88) 4.18 (3.48-5.01) 0.460 4.65 (4.03-5.21) 4.68 (3.85-5.38) 0.786 Multiorgan function injury Total bilirubin (μmol/L) 10.5 (7.6-11.7) 10.2 (7.7-12.7) 0.632 12.5 (8.8-16.5) 10.5 (7.1-15.9) 0.024 Direct bilirubin (μmol/L) 3.1 (2.4-3.7) 3.0 (2.4-4.3) 0.339 4.6 (3.2-6.5) 3.8 (2.7-6.4) 0.046 Alanine aminotransferase (U/L) 24.0 (18.8-42.0) 30.0 (19.0-48.0) 0.230 53.0 (33.4-71.4) 43.0 (28.0-70.5) 0.036 Aspartate transaminase (U/L) 27.0 (21.8-34.3) 28.0 (20.0-39.0) 0.803 54.0 (33.8-74.5) 44.0 (31.0-68.3) 0.045 Lactate dehydrogenase (U/L) 225.5 (188.8-297.8) 229.0 (194.0-294.0) 0.634 381.5 (293.5-521.3) 320.0 (241.5-398.0) <0.001 Pre-albumin (g/L) 155.4 (122.8-241.1) 148.7 (115.8-205.2) 0.198 101.5 (72.4-133.6) 106.1 (73.9-139.9) 0.925 Albumin (g/L) 32.5 (28.4-35.2) 33.5 (30.8-35.4) 0.413 27.2 (25.8-30.2) 28.3 (25.5-30.9) 0.443 Globulin (g/L) 30.9 (27.5-33.6) 30.9 (28.1-33.6) 0.452 33.6 (29.5-36.3) 33.0 (30.0-38.0) 0.663 High sensitive troponin I (ng/L) 3.3 (2.2-8.0) 3.9 (2.2-7.5) 0.590 8.90 (4.90-32.60) 5.90 (3.95-23.20) 0.076 Blood urea nitrogen (mmol/L) 4.03 (3.15-4.91) 4.09 (3.18-5.12) 0.667 5.17 (3.81-7.33) 5.09 (3.73-7.50) 0.905 Creatinine (μmol/L) 65.2 (53.7-82.9) 63.8 (54.7-78.9) 0.714 72.0 (58.6-88.0) 70.0 (58.7-87.9) 0.771 D-dimer (μg/mL) 0.41 (0.16-0.77) 0.37 (0.22-0.69) 0.604 0.93 (0.43-6.77) 0.55 (0.34-2.46) 0.039 Urine Protein (+) 0 (0.0%) 4 (1.9%) 0.299 14 (20.9%) 36 (25.0%) 0.514 Urine occult blood (+) 0 (0.0%) 11 (5.3%) 0.081 11 (16.4%) 26 (18.1%) 0.771 Fecal occult blood (+) 1 (1.8%) 2 (1.0%) 0.603 6 (9.0%) 1 (0.7%) 0.002 Continuous variables are presented as median (25th-75th percentiles), and categorical variables are presented as count (percentage). Clinical characteristics of diarrhea patients with and without respiratory symptoms In the patients with diarrhea, 100 subjects (19.45%, including 37 mild and 63 severe/critical cases) presented with respiratory symptoms and 31 subjects (6.03%, including 23 mild and 8 severe cases) absent of respiratory symptoms (Table S1). As it shown, there were higher proportion of mild cases in patients with diarrhea only (74.2%) or with respiratory symptoms only (58.0%) than those with both diarrhea and respiratory symptoms (37.0%) (Figure 2). Notably, the patients with diarrhea in the absence of respiratory symptoms were observed less systemic inflammatory activity, including the lower levels of CRP, ESR and Ferritin, relative to diarrhea combined with respiratory symptoms (Table 4). Table 4 Comparisons of COVID-19 patients with diarrhea who are present and absent of respiratory symptoms. Mild patients with Diarrhea Severe/ Critical patients with Diarrhea With respiratory symptoms (N=37) Without respiratory symptoms (N=23) P With respiratory symptoms (N=63) Without respiratory symptoms (N=8) P Age (years) 44 (34-63) 60 (55-63) 0.040 66 (58-72) 58 (55-63) 0.057 Gender (m/f) 21/16 5/18 0.008 37/26 6/2 0.375 Fever 28 (75.7%) 17 (73.91%) 0.878 56 (88.89%) 6 (75.00%) 0.266 Highest temperature, °C 38.4 (37.7-38.9) 38.0 (37.5-38.8) 0.385 38.8 (38.0-39.0) 38.3 (38.0-38.7) 0.158 Infection and Inflammation White blood cell (x10 9 /L) 5.14 (4.26-6.08) 4.67 (3.90-6.38) 0.704 6.43 (4.50-8.49) 5.94 (4.88-8.27) 0.964 Neutrophil (x10 9 /L) 3.29 (2.41-3.82) 3.20 (2.46-4.00) 0.921 4.50 (2.98-7.32) 4.58 (3.76-7.14) 0.750 Lymphocyte (x10 9 /L) 1.17 (0.75-1.97) 1.08 (0.96-1.71) 0.755 0.77 (0.54-1.04) 0.72 (0.51-0.88) 0.363 Procalcitonin (ng/mL) 0.06 (0.04-0.09) 0.07 (0.06-0.18) 0.087 0.14 (0.07-0.45) 0.15 (0.10-0.22) 0.960 C-reactive protein (mg/L) 21.11 (5.11-52.09) 4.55 (2.13-56.19) 0.041 79.74 (36.82-118.94) 51.87 (34.79-101.75) 0.034 Erythrocyte sedimentation rate (mm/h) 34 (20-61) 18 (18-32) 0.033 61 (45-81) 46 (35-71) 0.046 Ferritin (ng/mL) 240.62 (143.99-344.87) 155.74 (98.80-234.85) 0.042 960.61 (663.69-1439.03) 660.02 (364.72-1258.32) 0.026 Fibrinogen (g/L) 3.92 (3.20-4.68) 3.72 (3.05-4.69) 0.738 4.68 (3.81-5.38) 4.73 (4.42-5.12) 0.709 Multiorgan function injury Total bilirubin (μmol/L) 9.60 (7.60-12.40) 10.60 (8.20-10.90) 0.933 10.90 (7.05-16.20) 9.60 (7.25-11.75) 0.757 Direct bilirubin (μmol/L) 3.00 (2.40-3.70) 3.20 (2.30-3.65) 0.709 3.80 (3.05-7.15) 3.15 (2.53-4.15) 0.358 Alanine aminotransferase (U/L) 26 (19-41) 22 (18-44) 0.386 52 (32-75) 38 (25-52) 0.034 Aspartate transaminase (U/L) 25 (21-35) 30 (23-34) 0.749 49 (31-77) 33 (27-54) 0.032 Lactate dehydrogenase (U/L) 218 (189-271) 227 (176-312) 0.808 314 (241-374) 406 (296-440) 0.220 Pre-albumin (g/L) 151.4 (128.5-212.0) 172.3 (114.4-266.7) 0.533 113.6 (73.9-147.7) 86.1 (75.0-106.4) 0.187 Albumin (g/L) 33.4 (30.7-36.9) 34.2 (32.6-35.1) 0.885 27.2 (25.7-30.5) 27.9 (26.4-28.8) 0.913 Globulin (g/L) 30.2 (27.5-34.3) 31.4 (27.8-32.9) 0.796 33.6 (29.5-36.2) 33.0 (28.9-36.5) 0.877 High sensitive troponin I (ng/L) 4.40 (2.60-11.10) 2.80 (1.37-3.32) 0.017 6.30 (4.20-28.20) 4.30 (3.65-14.05) 0.424 Blood urea nitrogen (mmol/L) 3.55 (3.06-4.37) 4.48 (3.51-5.46) 0.023 5.24 (4.04-8.30) 4.68 (3.26-4.91) 0.042 Creatinine (μmol/L) 66.0 (59.0-89.6) 60.8 (50.5-74.8) 0.188 71.2 (58.5-98.4) 63.5 (60.8-68.5) 0.141 D-dimer (μg/mL) 0.38 (0.16-0.71) 0.43 (0.26-0.85) 0.365 0.55 (0.34-2.90) 0.59 (0.48-1.69) 0.891 Urine Protein (+) 0 (0.0%) 0 (0.0%) - 13 (22.03%) 1 (12.5%) - Urine occult blood (+) 0 (0.0%) 0 (0.0%) - 11 (18.64%) 0 (0.0%) - Fecal occult blood (+) 1 (2.7%) 0 (0.0%) - 6 (10.17%) 0 (0.0%) - Note: Continuous variables are presented as median (25th-75th percentiles), and categorical variables are presented as count (percentage). Discussion COVID-19 is generally considered a lower respiratory disease via droplet transmission. However, the current study suggested that gut and liver involvement was common in SARS-CoV-2 infection, which may carry significant implications on the pathogenesis and clinical management of COVID-19. Alimentary symptoms were frequently observed in patients with COVID-19. Diarrhea was the typical gastrointestinal complain that troubled 25.5% of the total COVID-19 patients. This rate was a little higher than early reported 3.8% to 22.2% in 2019-nCoV infection[2-4, 20]. Similarly, SARS-CoV caused 20.3% diarrhea on presentation, and 38.4% patients developed symptoms of diarrhea during the course of illness[21], also middle east respiratory syndrome coronavirus (MERS-CoV) led to 26.0% diarrhea and 21.0% vomiting as for its enteric tropism[22]. About 13.2% patients developed diarrhea in the first 3 days after the onset of symptoms, and 63.2% diarrhea was occurred in the previous 10 days. Thus, diarrhea is more likely to develop in the early phase of infection, and the initial pathophysiology of COVID-19. All supported the gut involvement and diarrhea in the pathogenesis of novel SARS-CoV-2 infection. Moreover, diarrhea was more common in the severe and critical patients with higher morbidity (32.1% and 27.1% respectively). This was in line with the observation that higher incidence of diarrhea in the severe or ICU cases than non-severe COVID-19 patients[3, 4]. And in the severe/critical subgroup, COVID-19 patients with diarrhea were reported more apparent systemic inflammatory activity and liver injury compared with those without diarrhea. It further indicated that comorbidity of diarrhea may accompany with more serious illness in the severe/critical COVID-19 suffers. However, the severity of diarrhea, mainly frequency of defecation, was not apparently associated with hypoxemia (oxygen requirement) and the severity based on respiratory dysfunction of these patients. Therefore, the gastrointestinal tract and the lung may react independently and differently to SARS-CoV-2 infection. It may argue that diarrhea is related to the use of drugs in some cases, including mainly antibacterial drugs (moxifloxacin, cephalosporins and azithromycin) and antiviral drugs (abidol, oseltamivir, ribavirin and lopinavir/ritonavir). However, there no significant difference in the prehospital medications between the patients with and without diarrhea. Moreover, the use of antibiotics in the mild cases was rare, but the occurrence of diarrhea also very high (21.3%). In addition, lots of patients presented with diarrhea that had no prior medication history. So, the medication was inadequate to interpret the development of diarrhea, and other potential culprits for diarrhea such as viral load in the gut, intestinal dysbiosis and combined infections are necessary to future determine. Interestingly, there were 31 patients (6.03%) presented with diarrhea in the absence of respiratory symptoms, and 9 patients (1.75%) of which had only diarrhea without fever and respiratory complaints. It further supported the view of “gut type” in the clinical management of COVID-19. Generally, these patients were mild illness and normal CT findings in the lung, and revealed less systemic inflammatory activity relative to the patients with both diarrhea and respiratory symptoms. It thereby may be easily misdiagnosed, especially for patients with diarrhea and gastrointestinal symptoms as the initial appearance. Identification of this part of patients with a gut-type may play a critical role in the prevention and management of the epidemic situation. The mechanism underline intestinal injury and diarrhea in SARS-CoV-2 infection was undiscovered. However, more and more evidences indicated the enteric tropism of SARS-CoV-2. It has been detected the viral nucleic acid in feces[14]. Swallowing sputum and saliva may be an important source of enteric virus[23, 24]. It makes the fecal-oral transmission possible that might be a major transmission route of SARS-CoV-2[14, 23]. Most important, ACE2 is widely expressed on the surface of intestinal epithelial cells[15, 16], which is the known entry target attacked by SARS-CoV-2[16]. All above favored the direct damage of SARS-CoV-2 on the gut mucosa, leading to diarrhea and gastrointestinal symptoms. The intestinal colonization of SARS-CoV-2 and the viral load may be associated with the severity of diarrhea. However, the mechanism of viral colonization and histological changes of the gut on SARS-CoV-2 infection are necessary to revealed. Apart from alimentary symptoms, the liver injury was also frequently observed in patients with COVID-19[8]. Generally, mild liver dysfunction was common on SARS-CoV-2 infection. Moreover, the major abnormalities were hepatocyte damage with increased activities of ALT and AST, and declined synthetic function with low levels of pre-albumin and albumin, while the function of bile secretion was less involved. However, ACE2 is negative in hepatocytes and sinusoidal endothelium, but high expressed on the bile ducts[15, 25]. Therefore, the liver injury was less likely to be caused by directly attack of SARS-CoV-2. The severity of liver injury and the proportion of serious liver injury were much higher in the severe to critical COVID-19 patients. As we shown, liver injury was associated with higher inflammatory activity, such as increased WBC and neutrophil counts but reduced lymphocyte counts, and elevated levels of CRP, ESR, procalcitonin and ferritin. SARS-CoV-2 activity induced systemic inflammation and immunoreaction may be one cause of the liver dysfunction. Other factors such as drugs and hypoxia injury are likely to participate in the process of hepatic damage under SARS-CoV-2 infection, but it lacks of sufficient evidences. The present study has several limitations. Firstly, this was a retrospective cohort study, and unrecognized biases cannot be excluded. Secondly, medications may cause diarrhea in some patients although we try to rule out potential drug-induced diarrhea. This should be avoided in the future prospective researches. Finally, only a small part of patients had tested the viral nucleic acid in the stool specimens, and preliminary evidence indicated its correlations with diarrhea. Further research is vital to determine how the dynamic changes and load of fecal virus on the severity and duration of diarrhea, and potential fecal-oral transmission. Conclusions In summary, our data favored the digestive involvement in the process of COVID-19. The enteric tropism of SARS-CoV-2 should be the major culprit for diarrhea and other alimentary symptoms, also makes the fecal-oral transmission possible. There may be a “gut type” of COVID-19 that is significant for the understanding and clinical management of this emerging infection. Abbreviations COVID-19, Coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; 2019-nCoV, 2019 novel coronavirus; ACE2, angiotensin converting enzyme 2; RT-PCR, reverse transcription-polymerase chain reaction; ICU , intensive care unit; WBC, white blood cell; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; BUN, blood urea nitrogen; hsTNI, high sensitive troponin I; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; ALP, alkaline phosphatase; GGT, γ-glutamyl transferase; ALB, albumin; MERS-CoV, middle east respiratory syndrome coronavirus. Declarations Acknowledgements The authors would like to thank the patients and their families for their contribution to this study. Competing interests The authors declare that they have no conflict of interest. Ethics approval and consent to participate The study was approved by the institutional review board prior to data collection. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was waived due to retrospective study. Author contributions Haitao Shang collected medical records data, analyzed the data and drafted the manuscript; Chao Huang and Yuhu Chen helped for data collection; Shengyan Zhang helped for data analysis; Pengcheng Yang and Gaichao Hong supported for data entry and sorting; Lei Zhang and Xiaohua Hou designed and supervised the study and revised the manuscript. Funding This study was supported by grants of an emergency science and technology projects of novel coronavirus pneumonia from the Science and Technology Department of Hubei Province, China (2020FCA014), and the projects of international cooperation and exchanges from the National Natural Science Foundation of China (NSFC), China (No. 81720108006). Availability of data and material The raw data generated and analyzed in the current study are not publicly available due to appropriate protection of patient personal information but are available from the corresponding author on reasonable request. Consent for publication Not applicable. References Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, et al: A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, et al: Clinical Characteristics of Coronavirus Disease 2019 in China. 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430022, China","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xiaohua","middleName":"","lastName":"Hou","suffix":""}],"badges":[],"createdAt":"2020-04-04 14:11:00","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-21375/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-21375/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":862091,"identity":"d534b829-d3aa-416c-9ce0-7b52beb06d5b","added_by":"auto","created_at":"2020-04-07 19:01:22","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":214466,"visible":true,"origin":"","legend":"The study protocol.","description":"","filename":"Fig1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-21375/v1/Fig 1.jpg"},{"id":862093,"identity":"6e922436-9b83-41b2-8b7c-26a8d7e29c69","added_by":"auto","created_at":"2020-04-07 19:01:23","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":367335,"visible":true,"origin":"","legend":"Diarrhea as the common gastrointestinal symptom in COVID-19 patients.","description":"","filename":"Fig2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-21375/v1/Fig 2.jpg"},{"id":13497319,"identity":"402f8172-5c5b-4c52-b3b7-3666d3c62ac6","added_by":"auto","created_at":"2021-09-16 22:53:16","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":765268,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-21375/v1/870a159f-a0fd-41ac-91b3-8b4b9ecfe1cd.pdf"},{"id":862096,"identity":"322c7111-5687-48cd-94e6-446908b3cd3b","added_by":"auto","created_at":"2020-04-07 19:01:23","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":21368,"visible":true,"origin":"","legend":"","description":"","filename":"TableS2.docx","url":"https://assets-eu.researchsquare.com/files/rs-21375/v1/Table S2.docx"},{"id":862095,"identity":"e4583a7a-0fc1-476a-ae98-4e219796bf51","added_by":"auto","created_at":"2020-04-07 19:01:23","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":25824,"visible":true,"origin":"","legend":"","description":"","filename":"TableS1.docx","url":"https://assets-eu.researchsquare.com/files/rs-21375/v1/Table S1.docx"},{"id":862094,"identity":"3991ec85-8d7a-449e-864e-2b6e6131aaff","added_by":"auto","created_at":"2020-04-07 19:01:23","extension":"jpg","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":739130,"visible":true,"origin":"","legend":"","description":"","filename":"FigS3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-21375/v1/Fig S3.jpg"},{"id":862090,"identity":"0c4b8c33-88d3-46c7-a2be-d810aa163158","added_by":"auto","created_at":"2020-04-07 19:01:22","extension":"jpg","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":2188168,"visible":true,"origin":"","legend":"","description":"","filename":"FigS1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-21375/v1/Fig S1.jpg"},{"id":862092,"identity":"e480c993-093a-4a70-9ef3-10c561603e1c","added_by":"auto","created_at":"2020-04-07 19:01:22","extension":"jpg","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":188065,"visible":true,"origin":"","legend":"","description":"","filename":"FigS2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-21375/v1/Fig S2.jpg"}],"financialInterests":"","formattedTitle":"Digestive Involvement in SARS-CoV-2 Infection: A Retrospective Multi-center Study","fulltext":[{"header":"Introduction","content":"\u003cp\u003eCoronavirus disease 2019（COVID-19）is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV), which was firstly identified in Wuhan, China, last December 2019, and has rapidly outbreak worldwide[1-4]. It recently has been declared a public health emergency of international concern by World Health Organization (WHO). As of March 20, 2020, COVID-19 has affected more than 200,000 individuals and caused over 8,500 deaths globally[5].\u003c/p\u003e\n\u003cp\u003eIt is well established that most patients with COVID-19 have fever along with respiratory symptoms, such as dry cough and dyspnea[1, 6]. However, there is increasing evidence that, in addition to typical respiratory symptom, COVID-19 can also present with gastrointestinal symptoms (especially for diarrhea) and liver injury[7, 8]. Moreover, it was also reported that some patients present initially with gastrointestinal symptoms[9]. This may lead to misdiagnosis in the clinic, and the digestive involvement of COVID-19 should be recognized and valued.\u003c/p\u003e\n\u003cp\u003eSARS-CoV-2 is an accepted respiratory transmitting virus that spread via droplets [10], also through close contact with mucous membranes in the eyes, mouth or nose [11, 12]. Apart from the oropharyngeal swab, nasopharyngeal swab and sputum, the viral nucleic acid could also be detected in saliva and feces[13, 14]. Moreover, in clinical practice, we found stool samples test from COVID-19 were positive while respiratory samples are negative. Importantly, angiotensin converting enzyme 2 (ACE2), identified as the cell entry receptor of SARS-CoV-2[15, 16], were most remarkable expression on the surface of small intestinal epithelial cell[15, 17]. In summary, SARS-CoV-2 may be present in the gut, leading to the alimentary damage and symptoms, and possible fecal-oral transmission.\u003c/p\u003e\n\u003cp\u003eIn this retrospective study, we describe the clinical features of hospitalized COVID-19 patients with variable severity, that is the mild, severe and critical patients. We focused on the alimentary symptoms and liver injury in COVID-19 patients and attempted to find if there is any significant difference in the patients with or without digestive manifestations, to provide evidence for the digestive involvement in the clinical prevention and management of SARS-CoV-2 infection.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eStudy Design and Participants\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe protocol of this study was seen in Figure 1. The clinical records of 521 consecutive patients fulfilled with the diagnostic criteria of COVID-19 according to World Health Organization interim guidance [18], who admitted to the 3 designated COVID-19 care medical institutions affiliated to Wuhan Union Hospital of Tongji Medical College from Jan 20 to Feb 29, 2020 were enrolled. All patients were given verbal informed consent. Seven cases were excluded for incomplete data, and 514 laboratory-confirmed COVID-19 cases were used for analysis. Patients were divided into mild (282 cases), severe (162 cases) and critical (70 cases) subgroups based on the clinical classification of COVID-19[19]. The clinical outcomes were monitored up to March 8, 2020, the final date of follow-up. This study was approved by the Medical Ethical Review Committee, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, China ([2020] No.0033).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStudy Definitions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe confirmed case of COVID-19 is defined as positive SARS-CoV-2 nucleic acid in oropharyngeal or nasopharyngeal swab specimens via real-time fluorescence reverse transcription-polymerase chain reaction (RT-PCR). Only laboratory-confirmed cases were included in the analysis[18, 19]. The mild cases refer to mild patient with fever, respiratory and/or other symptoms, and typical imaging findings of viral pneumonia. The severe cases had to meet one or more of the following conditions: 1) with shortness breath and respiratory frequency \u0026ge;30 per minute; 2) blood oxygen saturation \u0026le;93% in resting condition; 3) arterial partial pressure of oxygen (PaO\u003csub\u003e2\u003c/sub\u003e)/ fraction of inspired oxygen (FiO\u003csub\u003e2\u003c/sub\u003e) \u0026le;300 mmHg. The critical patients should present with 1) respiratory failure that need mechanical ventilation, and/or 2) shock, and/or 3) combined with other organ failure and need intensive care unit (ICU) treatment. All definitions are consistent with the \u0026ldquo;Diagnosis and Treatment Scheme of New Coronavirus Infected Pneumonia\u0026rdquo; (trial version 6) released by Chinese National Health Commission and the World Health Organization interim guidance for COVID-19[19].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData collection\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe demographic data, clinical charts including epidemiological history, past medical history, clinical symptoms and signs, medical and nursing records, laboratory findings, chest CT scans and viral nucleic acid test for all COVID-19 patients were extracted from electronic medical records. Particularly, symptoms of fever, cough, expectoration, fatigue, shortness of breath, chest tightness, muscle soreness, poor appetite, nausea, vomit, diarrhea and abdominal pain were recorded in detail. Main laboratory parameters were extracted, including routine blood tests (white blood cell [WBC], neutrophil and lymphocyte), inflammatory markers (procalcitonin, C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], ferritin and fibrinogen), liver injury marker (total and direct bilirubin, alanine aminotransferase [ALT], aspartate transaminase [AST], lactate dehydrogenase [LDH], alkaline phosphatase [ALP], \u0026gamma;-glutamyl transferase [GGT], Pre-albumin and Albumin), kidney injury marker (blood urea nitrogen [BUN], creatinine, urine protein and occult blood), and myocardial injury marker (high sensitive troponin I [hsTNI]). The treatment (ie, antiviral, antibiotic, corticosteroid, immunomodulation and respiratory support) and outcomes data were further obtained. The collected data were reviewed and checked by 4 trained researchers and attending clinicians independently.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eCategorical variables were described as number (%) and compared with \u0026chi;\u0026sup2; test, or Fisher\u0026rsquo;s exact test when the data were limited. Continuous data were expressed as median (IQR) and compared via the Kruskal-Wallis test followed by a Dunn\u0026rsquo;s post-test. A 2- sided \u0026alpha;＜0.05 was considered statistically significant. All statistical analyses were performed using the R software, version 3.5.1 (R Foundation for Statistical Computing). The statistical graphs were created via the GraphPad Prism package, version 8 (GraphPad Software, LLC).\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eBaseline Characteristics\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe demographic and clinical characteristics were shown in Table 1. A total of 514 hospitalized patients with confirmed SARS-CoV-2 infection including 282 mild, 162 severe and 70 critical cases were included in the present analysis. The media age was 54 years, ranged from 23 to 96 years, and older in the severe and critical suffers. Totally, 271 (53.1%) patients were male, and the proportion of male was much higher than female in the critical ones (70.0%). The common symptoms were fever (87.6%), cough (70.2%), fatigue (58.4%), chest tightness (52.0%), shortness of breath (44.2%), expectoration (29.8%), muscle soreness (19.8%) and pharyngodynia (2.9%). Compared with mild patients, more serious fever (92.6% and 90.0% respectively) with higher maximal temperature, chest tightness and shortness of breath were observed in the severe and critical patients. Hypertension (43.2%), diabetes (19.3%) and cardiovascular disease (12.7%) were the most common comorbidity. Especially, hypertension was associated with disease severity that higher in severe (60.5%) and critical (55.7%) patients. The severe to critical patients exhibited more serious infection and inflammation with higher white blood cell and neutrophil, declined lymphocyte, enhanced levels of CRP, ESR, procalcitonin and ferritin (all P\u0026lt;0.001).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1 Baseline Characteristics of COVID-19 patients.\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse;\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eTotal\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eN=514\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eMild\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eN=282\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eSevere\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eN=162\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eCritical\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eN=70\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eP\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; border: none; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eAge (years)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e54 (48-68)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e50 (45-64)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e65 (56-72)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e64 (57-72)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eGender (male/female)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e271/243\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e135/147\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e87/75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e49/21\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.004\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eFever\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e450 (87.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e237 (84.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e150 (92.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e63 (90.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.025\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eHighest temperature, \u0026deg;C\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e38.5 (37.9-39.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e38.5 (37.8-39.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e38.5 (38.0-39.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e38.8 (38.2-39.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.020\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eCough\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e361 (70.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e195 (69.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e122 (75.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e44 (62.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.137\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eExpectoration\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e153 (29.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e81 (28.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e52 (32.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e20 (28.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.735\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eFatigue\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e300 (58.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e160 (56.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e93 (57.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e47 (67.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.274\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eShortness of breath\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e227 (44.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e87 (30.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e92 (56.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e48 (68.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eChest tightness\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e267 (52.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e130 (46.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e87 (53.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e50 (71.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003ePharyngodynia\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e15 (2.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e11 (3.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e2 (1.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e2 (2.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.275\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eMuscle soreness\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e102 (19.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e63 (22.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e29 (17.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e10 (14.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.241\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003ePresenting Comorbidity\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-indent: 4.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eHypertension\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e222 (43.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e85 (30.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e98 (60.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e39 (55.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;Diabetes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e99 (19.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e45 (16.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e40 (24.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e14 (20.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.079\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;Cardiovascular disease\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e65 (12.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e32 (11.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e21 (13.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e12 (17.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.422\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt 4.5pt; font-size: 14px; font-family: DengXian; text-indent: -4.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;Chronic obstructive pulmonary disease\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e21 (4.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e6 (2.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e11 (6.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e4 (5.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.044\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;Bronchial asthma\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e10 (2.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e7 (2.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e2 (1.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e1 (1.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.621\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;Cerebralvascular disease\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e9 (1.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e9 (3.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e7 (4.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e5 (7.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.322\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;Chronic liver disease\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e8 (1.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e2 (0.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e4 (2.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e2 (2.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.226\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;Chronic kidney disease\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e21 (4.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e2 (0.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e5 (3.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e2 (2.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.138\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;Malignancy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e28 (5.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e13 (4.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e12 (7.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e3 (4.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.412\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eInfection and Inflammation\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-indent: 4.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eWhite blood cell (x10\u003csup\u003e9\u003c/sup\u003e/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e5.65 (4.38-7.60)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e5.08 (4.04-6.64)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e6.12 (4.66-8.34)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e9.74 (7.19-12.27)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-indent: 4.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eNeutrophil (x10\u003csup\u003e9\u003c/sup\u003e/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e3.98 (2.97-6.32)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e3.46 (2.62-4.38)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e4.82 (3.48-6.73)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e8.53 (6.30-11.41)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-indent: 4.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eLymphocyte (x10\u003csup\u003e9\u003c/sup\u003e/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.93 (0.68-1.27)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e1.08 (0.82-1.47)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.77 (0.59-1.04)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.54 (0.44-0.80)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-indent: 4.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eProcalcitonin (ng/mL)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.09 (0.05-0.16)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.06 (0.04-0.09)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.12 (0.07-0.20)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.33 (0.17-0.89)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-indent: 4.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eC-reactive protein (mg/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e34.82 (11.10-71.97)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e16.55 (4.00-38.99)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e52.82 (29.27-77.53)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 11px; font-family: 'Times New Roman', serif;\"\u003e114.60 (74.27-138.80)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-indent: 4.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eErythrocyte sedimentation rate (mm/h)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e46 (25-69)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e34 (19-53)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e61 (44-80)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e71 (44-82)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-indent: 4.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eFerritin (ng/mL)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e332.1 (127.1-768.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e160.2 (101.7-300.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e620.1 (391.0-862.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e1768.2 (1215.3-2000.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-indent: 4.5pt; text-align: left;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eFibrinogen (g/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e4.44 (3.58-5.07)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e4.14 (3.35-4.95)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e4.73 (4.04-5.19)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e4.58 (2.48-5.52)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eNote: Continuous variables are presented as median (25th-75th percentiles), and categorical variables are presented as count (percentage).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlimentary symptoms and liver function injury\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA series of alimentary symptoms including poor appetite (50.2%), diarrhea (25.5%), nausea (16.3%), vomit (11.9%) and abdominal pain (3.3%) presented in COVID-19 patients (Table 2). Diarrhea was quite common gastrointestinal symptom with higher morbidity in the severe and critical patients (32.1% and 27.1% respectively) than the mild patients (21.3%). The diarrhea was mainly watery in nature without mucus or blood, and abdominal pain was rarely observed. The severity of diarrhea varied among patients, most patients had a few loose or watery stools but some patients had up to 20 bowel movements per day. About 13.2% patients developed diarrhea in the first 3 days after the onset of symptoms, and 63.2% diarrhea was occurred in the previous 10 days (Figure S1). There were 31 patients (6.03%) presented with diarrhea in the absence of respiratory symptoms, including 23 mild cases and 8 severe cases (Figure 2). Moreover, 9 patients (1.75%) had only diarrhea without fever and respiratory symptoms.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2 Digestive system involvements in COVID-19 patients include the alimentary symptoms and liver function injury.\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse;\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eTotal\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eN=514\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eMild\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eN=282\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eSevere\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eN=162\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eCritical\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e（\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eN=70\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e）\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border-top: 2.25pt solid windowtext; border-left: none; border-bottom: 1.5pt solid windowtext; border-right: none; padding: 0in 5.4pt;\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman', serif;\"\u003eP\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eAlimentary symptoms\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 9pt;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003ePoor appetite\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e258 (50.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e124 (44.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e92 (56.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e42 (60.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.007\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; Nausea\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e84 (16.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e50 (17.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e27 (16.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e7 (10.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.291\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; Vomit\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e61 (11.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e33 (11.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e23 (14.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e5 (7.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.310\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; Diarrhea\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e131 (25.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e60 (21.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e52 (32.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e19 (27.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.040\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 4.5pt;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;Abdominal pain\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e17 (3.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e11 (3.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e5 (3.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e1 (1.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.243\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eLiver function injury\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eTotal bilirubin (\u0026mu;mol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e10.8 (8.1-14.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e10.2 (7.6-12.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e11.5 (8.4-15.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e14.9 (8.7-23.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026le;20.0\u0026mu;mol/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e458 (89.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e273 (96.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e140 (86.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e45 (64.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;20.0\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Microsoft YaHei Light', sans-serif;\"\u003e∽\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: SimSun;\"\u003e34.2\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026mu;mol/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e43 (8.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e9 (3.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e17 (10.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e17 (24.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 9pt;\"\u003e\u003cspan style=\"font-size: 12px;\"\u003e＞\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e34.2\u0026mu;mol/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e13 (2.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0 (0.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e5 (3.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e8 (11.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eDirect bilirubin (\u0026mu;mol/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e3.6 (2.6-4.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e3.1 (2.4-4.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e3.9 (3.0-5.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e6.2 (4.0-10.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026le;6.8\u0026mu;mol/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e441 (85.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e269 (95.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e134 (82.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e38 (54.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;6.8\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Microsoft YaHei Light', sans-serif;\"\u003e∽\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: SimSun;\"\u003e13.6\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026mu;mol/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e61 (11.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e13 (4.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e23 (14.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e25 (35.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 13.5pt;\"\u003e\u003cspan style=\"font-size: 12px;\"\u003e＞\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e13.6\u0026mu;mol/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e12 (2.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0 (0.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e5 (3.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e7 (10.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eAlanine aminotransferase (U/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e34 (22-55)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e28 (19-46)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e41 (26-60)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e87 (44-111)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026le;40U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e290 (56.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e185 (65.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e81 (50.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e24 (34.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;40\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: '微软雅黑 Light', sans-serif;\"\u003e∽\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e80 U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e163 (31.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e82 (29.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e59 (36.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e22 (31.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 13.5pt;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026ge;80 U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e59 (11.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e14 (5.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e22 (13.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e23 (33.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eAspartate transaminase (U/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e33 (23-47)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e27 (20-39)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e38 (26-55)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e67 (44-82)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026le;40U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e324 (63.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e222 (79.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e88 (54.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e14 (20.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;40\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: '微软雅黑 Light', sans-serif;\"\u003e∽\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e80 U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e150 (29.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e55 (19.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e59 (36.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e36 (52.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026ge;80 U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e38 (7.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e4 (1.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e15 (9.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e19 (27.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eLactate dehydrogenase (U/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e277 (211-371)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e229 (192-295)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e314 (251-385)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e561 (396-680)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026le;245U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e204 (39.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e167 (59.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e37 (22.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0 (0.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 4.5pt;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u0026gt;245U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e310 (60.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e115 (40.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e125 (77.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e70 (100.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eAlkaline phosphatase (U/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e54 (43-71)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e52 (43-66)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e53 (43-67)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e78 (62-122)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026le;150U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e496 (96.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e280 (99.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e156 (96.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e60 (85.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026gt;150U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e18 (3.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e2 (0.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e6 (3.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e10 (14.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px;\"\u003e\u0026gamma;\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e-Glutamyl transferase (U/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e31 (20-56)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e27 (17-47)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e33 (23-67)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e60 (28-116)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026le;60U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e396 (77.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e246 (87.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e115 (71.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e35 (50.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;60\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: '微软雅黑 Light', sans-serif;\"\u003e∽\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e120 U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e67 (13.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e22 (7.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e28 (17.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e17 (24.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026ge;120 U/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e51 (9.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e14 (5.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e19 (11.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e18 (25.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003ePre-albumin (g/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e129.8 (90.4-186.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e149.7 (117.5-207.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e111.6 (80.5-156.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e84.5 (56.2-109.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eAlbumin (g/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e30.1 (26.8-33.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e32.1 (28.5-35.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e28.8 (25.9-31.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e26.8 (24.1-29.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026ge;35 g/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e98 (19.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e79 (28.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e15 (9.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e4 (5.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;30\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: '微软雅黑 Light', sans-serif;\"\u003e∽\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e35 g/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e164 (31.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e111 (39.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e46 (27.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e9 (12.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026le;30 g/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e252 (49.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e92 (32.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e103 (63.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e57 (81.4%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eGlobulin (g/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e31.6 (28.6-35.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e30.9 (27.8-33.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e32.0 (29.3-36.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e35.7 (31.2-39.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026le;30 g/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e180 (35.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e116 (41.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e51 (30.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e14 (20.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;30\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: '微软雅黑 Light', sans-serif;\"\u003e∽\u003c/span\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e35 g/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e203 (39.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e127 (44.8%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e59 (36.2%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e18 (25.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp;\u0026ge;35 g/L\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e131 (25.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e39 (13.9%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e54 (33.1%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e38 (54.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 126.45pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"24.926253687315633%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003eAlbumin/Globulin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e1.0 (0.8-1.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e1.0 (0.9-1.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.9 (0.7-1.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"16.666666666666668%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e0.8 (0.6-0.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 2.25pt solid windowtext; background: #ededed; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"8.4070796460177%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian;\"\u003e\u003cspan style=\"font-size: 12px; font-family: 'Times New Roman', serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eNote: Continuous variables are presented as median (25th-75th percentiles), and categorical variables are presented as count (percentage).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eLiver injury was also frequently observed in patients with COVID-19 (Table 2), with increased ALT (43.3%), AST (36.7%) and decreased albumin (80.9%), but less increased total bilirubin (10.9%) and direct bilirubin (14.2%), which were more common in the severe to critical patients. It indicated a major damage of the hepatocytes and synthetic function, but not the function of bile secretion, in COVID-19 associated liver injury. However, most of the cases were mild injury. Those with relatively severe liver damage (ALT\u0026ge;80 U/L) only accounted for 7.4% of the total patients, and 27.5% of the critical suffers. The liver injury was associated with higher inflammatory activity, such as increased white blood cell and neutrophil counts but declined lymphocyte counts, and elevated levels of CRP, ESR, procalcitonin and ferritin (Table S2).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical characteristics of patients with and without diarrhea\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThere were 131 patients (25.49%, including 60 mild and 71 severe/critical cases) presented with diarrhea, and 383 patients (74.51%, including 222 mild and 161 severe/critical cases) without diarrhea (Figure 2). In the mild cases, patients with diarrhea had only slightly increased neutrophil (P=0.021) and decreased lymphocyte (P=0.011), but had no significant difference in multiorgan functions, compared with those absent of diarrhea (Table 3). In the severe/critical cases, there was increased WBC (P=0.030) and neutrophil (P=0.010) and trend to decreased lymphocyte (P=0.082), as well as higher level of inflammatory ferritin in patients with diarrhea relative to those without diarrhea. Moreover, diarrhea evidently companied with the more serious liver injury with increased activities of serum ALT, AST and LDH, and raised levels of total and direct bilirubin (Table 3).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3 Comparisons of COVID-19 patients with and without diarrhea, including the systemic inflammation and multiorgan function.\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:133.45pt;border-top:solid windowtext 2.25pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:26.1pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:206.4pt;border-top:solid windowtext 2.25pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:26.1pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eMild patients\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:227.2pt;border-top:solid windowtext 2.25pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:26.1pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eSevere/ Critical patients\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eWith Diarrhea\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003e(N=60)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eWithout Diarrhea (N=222)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:36.3pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.55pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eWith Diarrhea\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003e(N=71)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eWithout Diarrhea (N=161)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAge (years)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e52 (38-63)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e54 (46-66)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.068\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e65 (57-72)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e64 (57-71)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.798\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eGender (m/f)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e26/34\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e109/113\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.428\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e43/28\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e93/68\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.690\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eFever\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e45 (75.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e192 (86.5%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.045\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e62 (87.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e151 (93.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.098\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eHighest temperature, \u0026deg;C\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e38.3 (37.7-38.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e38.5 (37.8-39.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.140\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e34.5 (20.3-53.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.327\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e62.5 (44.0-80.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.896\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e818.0 (547.8-1562.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e663.1 (404.8-1298.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.041\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eFibrinogen (g/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4.03 (3.39-4.88)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4.18 (3.48-5.01)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.460\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4.65 (4.03-5.21)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4.68 (3.85-5.38)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.786\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eMultiorgan function\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;injury\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eTotal bilirubin (\u0026mu;mol/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e10.5 (7.6-11.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e10.2 (7.7-12.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.632\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e12.5 (8.8-16.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e10.5 (7.1-15.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.024\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eDirect bilirubin (\u0026mu;mol/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e63.8 (54.7-78.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.714\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e72.0 (58.6-88.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.604\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.93 (0.43-6.77)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.55 (0.34-2.46)\u003c/span\u003e\u003c/p\u003e\n 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style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0 (0.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4 (1.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.299\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e14 (20.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e36 (25.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.514\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eUrine occult blood (+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0 (0.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e11 (5.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.081\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e11 (16.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e26 (18.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.771\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 2.25pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eFecal occult blood (+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 2.25pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1 (1.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 2.25pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e2 (1.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 2.25pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.603\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 2.25pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e6 (9.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 2.25pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1 (0.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 2.25pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.002\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eContinuous variables are presented as median (25th-75th percentiles), and categorical variables are presented as count (percentage).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical characteristics of diarrhea patients with and without respiratory symptoms\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn the patients with diarrhea, 100 subjects (19.45%, including 37 mild and 63 severe/critical cases) presented with respiratory symptoms and 31 subjects (6.03%, including 23 mild and 8 severe cases) absent of respiratory symptoms (Table S1). As it shown, there were higher proportion of mild cases in patients with diarrhea only (74.2%) or with respiratory symptoms only (58.0%) than those with both diarrhea and respiratory symptoms (37.0%) (Figure 2). Notably, the patients with diarrhea in the absence of respiratory symptoms were observed less systemic inflammatory activity, including the lower levels of CRP, ESR and Ferritin, relative to diarrhea combined with respiratory symptoms (Table 4).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 4 Comparisons of COVID-19 patients with diarrhea who are present and absent of respiratory symptoms.\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:133.45pt;border-top:solid windowtext 2.25pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:26.1pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:206.4pt;border-top:solid windowtext 2.25pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:26.1pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eMild patients with Diarrhea\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:227.2pt;border-top:solid windowtext 2.25pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:26.1pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eSevere/ Critical patients with Diarrhea\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:85.05pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eWith respiratory symptoms\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;(N=37)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.05pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eWithout respiratory symptoms\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e(N=23)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:36.3pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.55pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eWith respiratory symptoms \u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e(N=63)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eWithout respiratory symptoms\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;(N=8)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border:none;border-bottom:solid windowtext 1.5pt;background:#EDEDED;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAge (years)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e44 (34-63)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e60 (55-63)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.040\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e66 (58-72)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e58 (55-63)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.057\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eGender (m/f)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e21/16\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5/18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.008\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e37/26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e6/2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.375\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eFever\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e28 (75.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e17 (73.91%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.878\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e56 (88.89%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e6 (75.00%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.266\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eHighest temperature, \u0026deg;C\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e38.8 (38.0-39.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e38.3 (38.0-38.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.158\u003c/span\u003e\u003c/p\u003e\n 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.964\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eNeutrophil (x10\u003csup\u003e9\u003c/sup\u003e/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e3.29 (2.41-3.82)\u003c/span\u003e\u003c/p\u003e\n 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eLymphocyte (x10\u003csup\u003e9\u003c/sup\u003e/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.17 (0.75-1.97)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.72 (0.51-0.88)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.363\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:DengXian;margin-left:14.25pt;text-indent:-9.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eProcalcitonin 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5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e4.55 (2.13-56.19)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.041\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e79.74 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eErythrocyte sedimentation rate (mm/h)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e34 (20-61)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e18 (18-32)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 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5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.046\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eFerritin (ng/mL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e960.61 (663.69-1439.03)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e660.02 (364.72-1258.32)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e3.72 (3.05-4.69)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.738\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4.68 (3.81-5.38)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4.73 (4.42-5.12)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.709\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eMultiorgan function 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eTotal bilirubin (\u0026mu;mol/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New 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style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e10.90 (7.05-16.20)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e9.60 (7.25-11.75)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.757\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eDirect bilirubin (\u0026mu;mol/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.00 (2.40-3.70)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.20 (2.30-3.65)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.709\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.80 (3.05-7.15)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.15 (2.53-4.15)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.358\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAlanine aminotransferase (U/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e26 (19-41)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e22 (18-44)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New 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top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e30 (23-34)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.749\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e49 (31-77)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e33 (27-54)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.032\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eLactate dehydrogenase (U/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e218 (189-271)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e227 (176-312)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.808\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e314 (241-374)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e406 (296-440)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.220\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ePre-albumin (g/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e113.6 (73.9-147.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e86.1 (75.0-106.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.187\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eAlbumin (g/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e33.4 (30.7-36.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e30.2 (27.5-34.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e31.4 (27.8-32.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.796\u003c/span\u003e\u003c/p\u003e\n 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.877\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHigh sensitive troponin I (ng/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4.40 (2.60-11.10)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eBlood urea nitrogen (mmol/L)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.55 (3.06-4.37)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e4.48 (3.51-5.46)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.023\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e5.24 (4.04-8.30)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e4.68 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e66.0 (59.0-89.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e60.8 (50.5-74.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.188\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n 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133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eD-dimer (\u0026mu;g/mL)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.38 (0.16-0.71)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.43 (0.26-0.85)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.365\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.55 (0.34-2.90)\u003c/span\u003e\u003c/p\u003e\n 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eUrine Protein (+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0 (0.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0 (0.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.3pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e13 (22.03%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1 (12.5%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 133.45pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:DengXian;text-indent:4.5pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eUrine occult blood (+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.05pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New 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style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e11 (18.64%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0 (0.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;background: rgb(237, 237, 237);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e6 (10.17%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 2.25pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0 (0.0%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 2.25pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eNote: Continuous variables are presented as median (25th-75th percentiles), and categorical variables are presented as count (percentage).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eCOVID-19 is generally considered a lower respiratory disease via droplet transmission. However, the current study suggested that gut and liver involvement was common in SARS-CoV-2 infection, which may carry significant implications on the pathogenesis and clinical management of COVID-19.\u003c/p\u003e\n\u003cp\u003eAlimentary symptoms were frequently observed in patients with COVID-19. Diarrhea was the typical gastrointestinal complain that troubled 25.5% of the total COVID-19 patients. This rate was a little higher than early reported 3.8% to 22.2% in 2019-nCoV infection[2-4, 20]. Similarly, SARS-CoV caused 20.3% diarrhea on presentation, and 38.4% patients developed symptoms of diarrhea during the course of illness[21], also middle east respiratory syndrome coronavirus (MERS-CoV) led to 26.0% diarrhea and 21.0% vomiting as for its enteric tropism[22]. About 13.2% patients developed diarrhea in the first 3 days after the onset of symptoms, and 63.2% diarrhea was occurred in the previous 10 days. Thus, diarrhea is more likely to develop in the early phase of infection, and the initial pathophysiology of COVID-19. All supported the gut involvement and diarrhea in the pathogenesis of novel SARS-CoV-2 infection.\u003c/p\u003e\n\u003cp\u003eMoreover, diarrhea was more common in the severe and critical patients with higher morbidity (32.1% and 27.1% respectively). This was in line with the observation that higher incidence of diarrhea in the severe or ICU cases than non-severe COVID-19 patients[3, 4]. And in the severe/critical subgroup, COVID-19 patients with diarrhea were reported more apparent systemic inflammatory activity and liver injury compared with those without diarrhea. It further indicated that comorbidity of diarrhea may accompany with more serious illness in the severe/critical COVID-19 suffers.\u003c/p\u003e\n\u003cp\u003eHowever, the severity of diarrhea, mainly frequency of defecation, was not apparently associated with hypoxemia (oxygen requirement) and the severity based on respiratory dysfunction of these patients. Therefore, the gastrointestinal tract and the lung may react independently and differently to SARS-CoV-2 infection. It may argue that diarrhea is related to the use of drugs in some cases, including mainly antibacterial drugs (moxifloxacin, cephalosporins and azithromycin) and antiviral drugs (abidol, oseltamivir, ribavirin and lopinavir/ritonavir). However, there no significant difference in the prehospital medications between the patients with and without diarrhea. Moreover, the use of antibiotics in the mild cases was rare, but the occurrence of diarrhea also very high (21.3%). In addition, lots of patients presented with diarrhea that had no prior medication history. So, the medication was inadequate to interpret the development of diarrhea, and other potential culprits for diarrhea such as viral load in the gut, intestinal dysbiosis and combined infections are necessary to future determine.\u003c/p\u003e\n\u003cp\u003eInterestingly, there were 31 patients (6.03%) presented with diarrhea in the absence of respiratory symptoms, and 9 patients (1.75%) of which had only diarrhea without fever and respiratory complaints. It further supported the view of \u0026ldquo;gut type\u0026rdquo; in the clinical management of COVID-19. Generally, these patients were mild illness and normal CT findings in the lung, and revealed less systemic inflammatory activity relative to the patients with both diarrhea and respiratory symptoms. It thereby may be easily misdiagnosed, especially for patients with diarrhea and gastrointestinal symptoms as the initial appearance. Identification of this part of patients with a gut-type may play a critical role in the prevention and management of the epidemic situation.\u003c/p\u003e\n\u003cp\u003eThe mechanism underline intestinal injury and diarrhea in SARS-CoV-2 infection was undiscovered. However, more and more evidences indicated the enteric tropism of SARS-CoV-2. It has been detected the viral nucleic acid in feces[14]. Swallowing sputum and saliva may be an important source of enteric virus[23, 24]. It makes the fecal-oral transmission possible that might be a major transmission route of SARS-CoV-2[14, 23]. Most important, ACE2 is widely expressed on the surface of intestinal epithelial cells[15, 16], which is the known entry target attacked by SARS-CoV-2[16]. All above favored the direct damage of SARS-CoV-2 on the gut mucosa, leading to diarrhea and gastrointestinal symptoms. The intestinal colonization of SARS-CoV-2 and the viral load may be associated with the severity of diarrhea. However, the mechanism of viral colonization and histological changes of the gut on SARS-CoV-2 infection are necessary to revealed.\u003c/p\u003e\n\u003cp\u003eApart from alimentary symptoms, the liver injury was also frequently observed in patients with COVID-19[8]. Generally, mild liver dysfunction was common on SARS-CoV-2 infection. Moreover, the major abnormalities were hepatocyte damage with increased activities of ALT and AST, and declined synthetic function with low levels of pre-albumin and albumin, while the function of bile secretion was less involved. However, ACE2 is negative in hepatocytes and sinusoidal endothelium, but high expressed on the bile ducts[15, 25]. Therefore, the liver injury was less likely to be caused by directly attack of SARS-CoV-2. The severity of liver injury and the proportion of serious liver injury were much higher in the severe to critical COVID-19 patients. As we shown, liver injury was associated with higher inflammatory activity, such as increased WBC and neutrophil counts but reduced lymphocyte counts, and elevated levels of CRP, ESR, procalcitonin and ferritin. SARS-CoV-2 activity induced systemic inflammation and immunoreaction may be one cause of the liver dysfunction. Other factors such as drugs and hypoxia injury are likely to participate in the process of hepatic damage under SARS-CoV-2 infection, but it lacks of sufficient evidences.\u003c/p\u003e\n\u003cp\u003eThe present study has several limitations. Firstly, this was a retrospective cohort study, and unrecognized biases cannot be excluded. Secondly, medications may cause diarrhea in some patients although we try to rule out potential drug-induced diarrhea. This should be avoided in the future prospective researches. Finally, only a small part of patients had tested the viral nucleic acid in the stool specimens, and preliminary evidence indicated its correlations with diarrhea. Further research is vital to determine how the dynamic changes and load of fecal virus on the severity and duration of diarrhea, and potential fecal-oral transmission.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eIn summary, our data favored the digestive involvement in the process of COVID-19. The enteric tropism of SARS-CoV-2 should be the major culprit for diarrhea and other alimentary symptoms, also makes the fecal-oral transmission possible. There may be a \u0026ldquo;gut type\u0026rdquo; of COVID-19 that is significant for the understanding and clinical management of this emerging infection.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eCOVID-19, Coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; 2019-nCoV, 2019 novel coronavirus; ACE2, angiotensin converting enzyme 2; RT-PCR, reverse transcription-polymerase chain reaction; ICU , intensive care unit; WBC, white blood cell; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; BUN, blood urea nitrogen; hsTNI, high sensitive troponin I; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; ALP, alkaline phosphatase; GGT, \u0026gamma;-glutamyl transferase; ALB, albumin; MERS-CoV, middle east respiratory syndrome coronavirus.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors would like to thank the patients and their families for their contribution to this study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was approved by the institutional review board prior to data collection. All\u003c/p\u003e\n\u003cp\u003eprocedures followed were in accordance with the ethical standards of the responsible\u003c/p\u003e\n\u003cp\u003ecommittee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was waived due to retrospective study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eHaitao Shang collected medical records data, analyzed the data and drafted the manuscript; Chao Huang and Yuhu Chen helped for data collection; Shengyan Zhang helped for data analysis; Pengcheng Yang and Gaichao Hong supported for data entry and sorting; Lei Zhang and Xiaohua Hou designed and supervised the study and revised the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was supported by grants of an emergency science and technology projects of novel coronavirus pneumonia from the Science and Technology Department of Hubei Province, China (2020FCA014), and the projects\u0026ensp;of\u0026ensp;international\u0026ensp;cooperation\u0026ensp;and\u0026ensp;exchanges from the National Natural Science Foundation of China (NSFC), China (No. 81720108006).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe raw data generated and analyzed in the current study are not publicly available due to appropriate protection of patient personal information but are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eZhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, et al: A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733.\u003c/li\u003e\n\u003cli\u003eGuan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, et al: Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;0.\u003c/li\u003e\n\u003cli\u003eWang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, et al: Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. Jama. 2020.\u003c/li\u003e\n\u003cli\u003eHuang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.\u003c/li\u003e\n\u003cli\u003eWorld Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report-60. Mar 20, 2020. (https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200320-sitrep-60-covid-19.pdf)\u003c/li\u003e\n\u003cli\u003eKanne JP: Chest CT Findings in 2019 Novel Coronavirus (2019-nCoV) Infections from Wuhan, China: Key Points for the Radiologist. Radiology. 2020;295(1):16-17.\u003c/li\u003e\n\u003cli\u003eLovato A, Rossettini G, de Filippis C: Sore throat in COVID-19: comment on \"Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis\". J Med Virol. 2020.\u003c/li\u003e\n\u003cli\u003eZhang C, Shi L, Wang FS: Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020.\u003c/li\u003e\n\u003cli\u003eXu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL, Li SB, Wang HY, Zhang S, Gao HN, et al: Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. Bmj. 2020;368:m606.\u003c/li\u003e\n\u003cli\u003eLai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2020;55(3):105924.\u003c/li\u003e\n\u003cli\u003eChen J: Pathogenicity and transmissibility of 2019-nCoV-A quick overview and comparison with other emerging viruses. Microbes Infect. 2020;22(2):69-71.\u003c/li\u003e\n\u003cli\u003eLi JO, Lam DSC, Chen Y, Ting DSW: Novel Coronavirus disease 2019 (COVID-19): The importance of recognising possible early ocular manifestation and using protective eyewear. Br J Ophthalmol. 2020;104(3):297-298.\u003c/li\u003e\n\u003cli\u003eTo KK, Tsang OT, Chik-Yan Yip C, Chan KH, Wu TC, Chan JMC, Leung WS, Chik TS, Choi CY, Kandamby DH, et al: Consistent detection of 2019 novel coronavirus in saliva. Clin Infect Dis. 2020.\u003c/li\u003e\n\u003cli\u003eLing Y, Xu SB, Lin YX, Tian D, Zhu ZQ, Dai FH, Wu F, Song ZG, Huang W, Chen J, et al: Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients. Chin Med J (Engl). 2020.\u003c/li\u003e\n\u003cli\u003eHamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H: Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203(2):631-637.\u003c/li\u003e\n\u003cli\u003eWu Y: Compensation of ACE2 Function for Possible Clinical Management of 2019-nCoV-Induced Acute Lung Injury. Virol Sin. 2020.\u003c/li\u003e\n\u003cli\u003eChen Y, Guo Y, Pan Y, Zhao ZJ: Structure analysis of the receptor binding of 2019-nCoV. Biochem Biophys Res Commun. 2020.\u003c/li\u003e\n\u003cli\u003eWorld Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance. Jan 28, 2020 (https://www.who .int/ docs/ default -source/coronaviruse/ clinical -management-of-novel-cov.pdf)\u003c/li\u003e\n\u003cli\u003eNational Health Commission of China. Diagnosis and Treatment Scheme of New Coronavirus Infected Pneumonia (Trial version 6). Feb 18, 2020. (http://www.gov.cn/zhengce/zhengceku/2020-02/19/content_5480948.htm.)\u003c/li\u003e\n\u003cli\u003eSong Y, Liu P, Shi XL, Chu YL, Zhang J, Xia J, Gao XZ, Qu T, Wang MY: SARS-CoV-2 induced diarrhoea as onset symptom in patient with COVID-19. Gut. 2020.\u003c/li\u003e\n\u003cli\u003eLeung WK, To KF, Chan PK, Chan HL, Wu AK, Lee N, Yuen KY, Sung JJ: Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology. 2003;125(4):1011-1017.\u003c/li\u003e\n\u003cli\u003eAssiri A, Al-Tawfiq JA, Al-Rabeeah AA, Al-Rabiah FA, Al-Hajjar S, Al-Barrak A, Flemban H, Al-Nassir WN, Balkhy HH, Al-Hakeem RF, et al: Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis. 2013;13(9):752-761.\u003c/li\u003e\n\u003cli\u003eZhang J, Wang S, Xue Y: Fecal specimen diagnosis 2019 novel coronavirus-infected pneumonia. J Med Virol. 2020.\u003c/li\u003e\n\u003cli\u003eXie C, Jiang L, Huang G, Pu H, Gong B, Lin H, Ma S, Chen X, Long B, Si G, et al: Comparison of different samples for 2019 novel coronavirus detection by nucleic acid amplification tests. Int J Infect Dis. 2020;93:264-267.\u003c/li\u003e\n\u003cli\u003eAbdul-Hafez A, Mohamed T, Omar H, Shemis M, Uhal BD: The renin angiotensin system in liver and lung: impact and therapeutic potential in organ fibrosis. J Lung Pulm Respir Res. 2018;5(1).\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Coronavirus disease 2019, Severe acute respiratory syndrome coronavirus 2, Digestive system, Diarrhea, Liver injury, COVID-19","lastPublishedDoi":"10.21203/rs.3.rs-21375/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-21375/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eCoronavirus disease 2019 (COVID-19) is an emerged infection raised wide concerns for the pneumonia and respiratory manifestations. Also, digestive complications are frequently observed in COVID-19 patients but the significance remains undetermined.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eA retrospective analysis of alimentary symptoms, liver dysfunctions and other clinical parameters of 514 hospitalized COVID-19 patients (282 mild, 162 severe and 70 critical cases) admitted to the 3 designated medical units of Wuhan Union Hospital from Jan 20 to Feb 29, 2020 was performed.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e\u003c/p\u003e\u003cp\u003e1) A series of alimentary symptoms, including poor appetite(50.2%), diarrhea(25.5%), nausea(16.3%), vomit(11.9%) and abdominal pain(3.3%), presented in COVID-19 patients.\u003c/p\u003e\u003cp\u003e2) Diarrhea was common gastrointestinal symptom with higher morbidity in the severe and critical patients (32.1% and 27.1% respectively), and 13.2% patients developed diarrhea in the first 3 days after onset of symptoms. Those with diarrhea were reported more apparent systemic inflammation and liver injury in severe and critical cases compared with patients without diarrhea.\u003c/p\u003e\u003cp\u003e3) Notably, 31 patients (6.03%) presented with diarrhea in the absence of respiratory symptoms. These patients were observed less systemic inflammatory activity relative to diarrhea patients combined with respiratory symptoms.\u003c/p\u003e\u003cp\u003e4) Also, liver injury was high incident in COVID-19 patients with increased alanine aminotransferase (43.3%), aspartate transaminase (36.7%) and decreased albumin (80.9%), but less increased total bilirubin (10.9%) and direct bilirubin(14.2%), which were more serious in the severe to critical patients.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eOur data favored in the process of novel SARS-CoV-2 infection. There may be a “gut-type” in the clinical prevention and management that differ from the “lung-type” in COVID-19 sufferers.\u003c/p\u003e","manuscriptTitle":"Digestive Involvement in SARS-CoV-2 Infection: A Retrospective Multi-center Study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-04-07 19:01:20","doi":"10.21203/rs.3.rs-21375/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"6eee9599-afed-42f2-a447-768a9b93ba70","owner":[],"postedDate":"April 7th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":80348,"name":"Infectious Diseases"}],"tags":[],"updatedAt":"2020-04-10T18:24:55+00:00","versionOfRecord":[],"versionCreatedAt":"2020-04-07 19:01:20","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-21375","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-21375","identity":"rs-21375","version":["v1"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}