Immunohistochemical Analysis of CD44s and CD44v6 in Endometriosis and Adenomyosis: Comparison with normal, hyperplastic, and malignant endometrium

Lin Z, Z. Lin, Zhen Hua Lin, Cho S, S Cho, Seong Jin Cho, Hye Jin Jeong, Jeong H, H Jeong, Han Kyeom Kim, Kim H, H. Kim, I Kim, Kim I, In Sun Kim
Journal of Korean medical science · 2001 · vol. 16(3) , pp. 317 · doi:10.3346/jkms.2001.16.3.317 · PMID:11410693 · PMC3054744 · W2081208468
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CD44s and CD44v6 expression in endometriosis and adenomyosis mirrored normal cyclic endometrium, contrasting with aberrant patterns in endometrial hyperplasia and carcinoma.

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This study utilized immunohistochemistry to analyze the expression patterns of CD44s and CD44v6 across normal, hyperplastic, malignant, endometriotic, and adenomyotic endometrial tissues. The results demonstrated that both endometriosis and adenomyosis tissues exhibited staining profiles identical to those of normal cyclic endometrium, contrasting sharply with the abnormal expressions observed in all cases of endometrial adenocarcinoma. The authors concluded that ectopic endometrial tissue in these conditions does not display the aberrant molecular characteristics associated with malignancy regarding these specific markers. This paper is centrally about endometriosis and adenomyosis, using them as comparative models to distinguish benign ectopic tissue from malignant transformation via CD44 isoform expression.

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Abstract

The expression patterns of CD44s and CD44v6 were immunohistochemically compared with those of normal, hyperplastic and malignant endometrium. In normal endometria (n=37), endometrioses (n=46) and adenomyoses (n=20), the surface and glandular epithelial cells were negative for CD44s and CD44v6 in a proliferative pattern and positive in a secretory pattern, whereas the stroma was only positive for CD44s in both proliferative and secretory patterns. The endometrial hyperplasia (4 simple and 9 complex) had the identical patterns with normal proliferative phase of endometrium. Only one case showing complex hyperplasia with atypia was focally positive for CD44s and CD44v6 in glandular epithelia. CD44s and CD44v6 were positive in all endometrial adenocarcinomas (13), except one CD44s-negative case. In summary, the expressions of CD44s and CD44v6 in endometriosis and adenomyosis recapitulated those of normal cyclic endometrium. The expression patterns in endometrial hyperplasia were similar to those in normal proliferative endometrium, whereas the endometrial adenocarcinoma showed abnormal expressions for CD44s and CD44v6. Thus it was considered that the ectopic endometrium in endometriosis and adenomyosis was not aberrant as in endometrial carcinoma on the aspects of immunohistochemical expressions of CD44s and CD44v6.
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Published online Apr 24, 2009. https://doi.org/10.3346/jkms.2001.16.3.317 Immunohistochemical Analysis of CD44s and CD44v6 in Endometriosis and Adenomyosis: Comparison with normal, hyperplastic, and malignant endometrium Abstract The expression patterns of CD44s and CD44v6 were immunohistochemically compared with those of normal, hyperplastic and malignant endometrium. In normal endometria (n=37), endometrioses (n=46) and adenomyoses (n=20), the surface and glandular epithelial cells were negative for CD44s and CD44v6 in a proliferative pattern and positive in a secretory pattern, whereas the stroma was only positive for CD44s in both proliferative and secretory patterns. The endometrial hyperplasia (4 simple and 9 complex) had the identical patterns with normal proliferative phase of endometrium. Only one case showing complex hyperplasia with atypia was focally positive for CD44s and CD44v6 in glandular epithelia. CD44s and CD44v6 were positive in all endometrial adenocarcinomas (13), except one CD44s-negative case. In summary, the expressions of CD44s and CD44v6 in endometriosis and adenomyosis recapitulated those of normal cyclic endometrium. The expression patterns in endometrial hyperplasia were similar to those in normal proliferative endometrium, whereas the endometrial adenocarcinoma showed abnormal expressions for CD44s and CD44v6. Thus it was considered that the ectopic endometrium in endometriosis and adenomyosis was not aberrant as in endometrial carcinoma on the aspects of immunohistochemical expressions of CD44s and CD44v6.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenocarcinoma Endometrial Hyperplasia Endometrial Neoplasms Endometriosis Glycoproteins Hyaluronan Receptors Ovarian Diseases Adenocarcinoma Adenocarcinoma Endometrial Hyperplasia Endometrial Hyperplasia Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Glycoproteins

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