High-sulfated derivative of polysaccharide fromUlva pertusaimproves Adriamycin-induced nephrotic syndrome by suppressing oxidative stress

Yuzhou Wan, Shaopeng Wang, Kexu Chen, Lin Liu, Xiaoqian Wang, Bo Zhang, Lin Hu, Shunmei Liu, Tingting Zhao, Huimin Qi
In: Food & Function · 2023 · vol. 14(20) , pp. 9167–9180 · doi:10.1039/d3fo01290e · PMID:37721012 · W4386645137
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Abstract

). After treatment for 6 weeks, we assessed urine protein, renal function, and blood lipids, and observed morphology and histologic injury of the kidney and glomerular microstructure. Furthermore, we detected antioxidant enzyme activity and expression level of the Keap1/Nrf2 signaling pathway to explore the potential mechanism of HU. Results showed that HU not only alleviated hyperlipidemia and hypoalbuminemia, but also reduced urine protein by inhibiting podocyte detachment, thickening of the glomerular basement membrane, and expression of kidney fibrosis markers (collagens I and IV). In addition, HU enhanced antioxidant enzyme activity (GSH-Px, CAT, SOD) in both serum and the kidney, which may be due to upregulating the expression of Nrf2 and downregulating the expression of Keap1. In conclusion, HU appears to be effective in attenuating NS in rats through suppressing oxidative stress by regulating the Keap1/Nrf2 signaling pathway.

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