Clinical features and differences of Miller Fisher syndrome in southern China: Retrospective analysis of 72 patients from 13 provinces in southern China

Clinical features and differences of Miller Fisher syndrome in southern China: Retrospective analysis of 72 patients from 13 provinces in southern China | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Clinical features and differences of Miller Fisher syndrome in southern China: Retrospective analysis of 72 patients from 13 provinces in southern China Hang Yu, Man Ding, Hong Chu, Rumeng Zhou, Jiajia Yao, Rong Fu, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1739866/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objectives: We aimed to analyze the clinical features of Miller Fisher syndrome (MFS) in southern China and compare it features presenting in other countries. Methods: Medical records of patients with a diagnosis of Guillain-Barré syndrome (GBS) admitted to 31 tertiary hospitals, located in 13 provinces in southern China, from 1 January 2013 to 30 September 2016, were collected and retrospectively reviewed. Results: A total of 72 patients (36 from rural area and 36 from urban area) were enrolled. Their age at onset was 47.42±15.65 years old. Winter (29.2%) and spring (41.7%) were the seasons with the peak incidence of MFS. Thirty-eight (52.8%) patients had a history of upper respiratory tract infection one week before onset, while 4 (5.6%) patients experienced gastrointestinal infections. Among the 65 patients who underwent lumbar puncture, 48 (73.8%) patients exhibited albumincytologic dissociation in the cerebrospinal fluid study. Overall, 83.5% patients presented with limited outward movement of the eye, 64.2% had bilateral symmetrical ophthalmoplegia, and only 25.4% had unilateral ophthalmoplegia. No significant differences were observed between the rural and urban areas, such as age of onset (p=0.777) or sex distribution ( p =0.609). Patients with complete ophthalmoplegia were older than those with incomplete ophthalmoplegia ( 64.53±7.69 years vs 43.19±14.40 years, p <0.001). Conclusion: Winter and spring are the peaks of MFS incidence. The incidence is higher in men than in women. The most common pattern of ophthalmoplegia in MFS is bilateral symmetrical ophthalmoplegia, There is no urban-rural difference in MFS in southern China. Patients with complete ophthalmoplegia were older than incomplete ophthalmoplegia. There is no significant difference of MFS between southern China and other East Asian countries. Miller Fisher syndrome Guillain-Barré syndrome Clinical features Ophthalmoplegia Figures Figure 1 Full Text tables Tables 1 to 4 are available in the Supplementary Files section. Additional Declarations No competing interests reported. Supplementary Files SupplementaryFigure1.pdf Table1.pdf Table2.pdf Table3.pdf Table4.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1739866","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":122167060,"identity":"d01fc022-93b0-4639-924c-833ae25437d3","order_by":0,"name":"Hang Yu","email":"","orcid":"","institution":"Renmin Hospital of Wuhan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hang","middleName":"","lastName":"Yu","suffix":""},{"id":122167061,"identity":"fdf3f57c-aebb-468f-8e2a-a5e9c03b492b","order_by":1,"name":"Man Ding","email":"","orcid":"","institution":"Renmin Hospital of Wuhan 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University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zheman","middleName":"","lastName":"Xiao","suffix":""},{"id":122167070,"identity":"d54cccab-cbd2-44fb-bb97-afbc644b9025","order_by":8,"name":"Zuneng Lu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAz0lEQVRIiWNgGAWjYBACPiA+8KGCTY6NvbHxwQditLAxMDAenHGGz5if53Cz4QwitTAf5m2RS5w5I71NmoMoLfxnDxzmbTAzNrj5sEGagcFOTreBoC3nEg7O3ZEmZ3A7scG4gCHZ2OwAIS2MPQYH3p45ZgzSkjyD4UDiNoJamHkMDvC2/U/ccPNgw2EeorSw8Rgc5G1jA3qfsbGZOC08QC0zzrABAzmxmXGGARF+4ec/Y/wBEpXHn//4UGEnR1ALGjAgTfkoGAWjYBSMAhwAACtPRa2d/1gZAAAAAElFTkSuQmCC","orcid":"","institution":"Renmin Hospital of Wuhan University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Zuneng","middleName":"","lastName":"Lu","suffix":""}],"badges":[],"createdAt":"2022-06-09 01:29:16","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-1739866/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-1739866/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":24364693,"identity":"297ff218-9ed6-436c-b458-33c51410407c","added_by":"auto","created_at":"2022-07-26 18:52:36","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":116477,"visible":true,"origin":"","legend":"\u003cp\u003eTypes of ophthalmoplegia in MFS patients\u003c/p\u003e\u003cp\u003eFigure 1A: 43 patients presented with bilateral symmetrical ophthalmoplegia, 17 patients presented with unilateral ophthalmoplegia, 7 patients presented with bilateral asymmetrical ophthalmoplegia; B: Three patients presented with only vertical motor involvement, 32 patients presented with only horizontal motor involvement, 32 patients showed involvement of both horizontal and vertical movements.\u003c/p\u003e","description":"","filename":"Figure1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-1739866/v1/95d247ab8e1beb80611c3f03.jpg"},{"id":24364695,"identity":"fb619448-bb7e-42c3-bf30-c3290a03333f","added_by":"auto","created_at":"2022-07-26 18:52:42","extension":"pdf","order_by":2,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":309447,"visible":true,"origin":"","legend":"","description":"","filename":"ClinicalfeatureanddifferencesofMFSinsouthernChina.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1739866/v1_covered.pdf"},{"id":24364068,"identity":"b3f1d3f2-ad32-45cc-8285-3aecbe9cf2c6","added_by":"auto","created_at":"2022-07-26 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18:47:37","extension":"pdf","order_by":5,"title":"","display":"","copyAsset":false,"role":"supplement","size":123686,"visible":true,"origin":"","legend":"","description":"","filename":"Table4.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1739866/v1/151f1c05b88169952941b8b3.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Clinical features and differences of Miller Fisher syndrome in southern China: Retrospective analysis of 72 patients from 13 provinces in southern China","fulltext":[{"header":"Full Text","content":"This preprint is available for \u003ca href='/article/rs-1739866/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e."},{"header":"tables","content":"\u003cp\u003eTables 1 to 4 are available in the Supplementary Files section.\u003c/p\u003e "}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Miller Fisher syndrome, Guillain-Barré syndrome, Clinical features, Ophthalmoplegia","lastPublishedDoi":"10.21203/rs.3.rs-1739866/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1739866/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eObjectives: \u003c/strong\u003eWe aimed to analyze the clinical features of Miller Fisher syndrome (MFS) in southern China and compare it features presenting in other countries. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e Medical records of patients with a diagnosis of Guillain-Barré syndrome (GBS) admitted to 31 tertiary hospitals, located in 13 provinces in southern China, from 1 January 2013 to 30 September 2016, were collected and retrospectively reviewed. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e A total of 72 patients (36 from rural area and 36 from urban area) were enrolled. Their age at onset was 47.42±15.65 years old. Winter (29.2%) and spring (41.7%) were the seasons with the peak incidence of MFS. Thirty-eight (52.8%) patients had a history of upper respiratory tract infection one week before onset, while 4 (5.6%) patients experienced gastrointestinal infections. Among the 65 patients who underwent lumbar puncture, 48 (73.8%) patients exhibited albumincytologic dissociation in the cerebrospinal fluid study. Overall, 83.5% patients presented with limited outward movement of the eye, 64.2% had bilateral symmetrical ophthalmoplegia, and only 25.4% had unilateral ophthalmoplegia. No significant differences were observed between the rural and urban areas, such as age of onset (p=0.777) or sex distribution (\u003cem\u003ep\u003c/em\u003e=0.609). Patients with complete ophthalmoplegia were older than those with incomplete ophthalmoplegia ( 64.53±7.69 years vs 43.19±14.40 years, \u003cem\u003ep\u003c/em\u003e\u0026lt;0.001). \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e Winter and spring are the peaks of MFS incidence. The incidence is higher in men than in women. The most common pattern of ophthalmoplegia in MFS is bilateral symmetrical ophthalmoplegia, There is no urban-rural difference in MFS in southern China. Patients with complete ophthalmoplegia were older than incomplete ophthalmoplegia. There is no significant difference of MFS between southern China and other East Asian countries.\u003c/p\u003e","manuscriptTitle":"Clinical features and differences of Miller Fisher syndrome in southern China: Retrospective analysis of 72 patients from 13 provinces in southern China","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2022-07-26 18:47:35","doi":"10.21203/rs.3.rs-1739866/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"f703f2a5-342e-48b2-a33f-eda2e035d6ae","owner":[],"postedDate":"July 26th, 2022","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2022-08-12T05:44:22+00:00","versionOfRecord":[],"versionCreatedAt":"2022-07-26 18:47:35","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-1739866","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1739866","identity":"rs-1739866","version":["v1"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}